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| Number | Title | Issue Date |
| 7429673 | TRPV1 agonists, formulations containing them and uses thereof The compounds of the general formula (I) in which X is represents two hydrogen atoms, a π-bond, oxygen or methylene: R2 is a C6-C12 aryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of path... | 09/30/2008 |
| 7001526 | Optical isomer separation method Methods for separation of two optical isomers in a racemate into its constituent isomers by statistical means are described, whereby the saturated racemate solution is first allotted into small samples by means of microfluidic or inkjet techniques to obtain small sa... | 02/21/2006 |
| 6989462 | Synthesis of 2-chloromethyl-6-methylbenzoic ester A process is described for preparing compounds of formula (I) where R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one or more CH2 grou... | 01/24/2006 |
| 6562995 | Delta dicarbonyl compounds and methods for using the same Amidomethyl esters, carbonylmercaptomethyl esters, keto-containing esters, amidomethyl thioesters, amidomethyl amides, and methylene dithioesters are disclosed. The novel compounds have two carbonyl groups connected by a linking moiety having an oxygen, s... | 05/13/2003 |
| 6392089 | Photoreleasable protecting groups on alcohols, phosphates and diacids and the use thereof Alcohol, phosphate, and diacid derivatives that may be deprotected by irradiation are disclosed. The protecting group is an arylacyl or heteroarylacyl group.... | 05/21/2002 |
| 6348615 | Process for producing (2R, 3S)-3-amino-1, 2-oxirane A process for producing (2R, 3S)-3-amino-4-phenylbutane-1,2-epoxide compounds which comprises treating a (2S, 3S)-3-amino-1-halo-2-hydroxy-4-phenylbutane compound or a (2S, 3S)-3-amino-4-phenylbutane-1,2-epoxide with a carboxylic acid quaternary ammo... | 02/19/2002 |
| 6187955 | Guanidine derivatives and process for their production A guanidine derivative represented by formula (1), (2), (3) or its acid addition salt and a production process thereof ##STR1## wherein each of A and B is a C2 -C8 alkylene, D is a single bond, --CO-- or a C1 -C6 | 02/13/2001 |
| 5981595 | Sulfonyl urea and carbamate ACAT inhibitors A pharmaceutically useful compound which lowers blood cholesterol levels having the formula ##STR1## wherein X is oxygen or --NH--; Ar is phenyl, substituted phenyl, naphthyl or substituted naphthyl; R1 is hydrogen, lower alkyl or benzyl; ... | 11/09/1999 |
| 5962708 | Process for preparation of highly concentrated free-flowing aqueous solutions of betaines The invention relates to a process for the preparation of highly concentrated free-flowing and pumpable aqueous solutions of betaines by quaternization of a compound which contains tertiary amine nitrogen with a ω-halo carboxylic acid characterized in th... | 10/05/1999 |
| 5948922 | Compounds with substituted cyclic hydrocarbon moieties linked by secondary or tertiary oxycarbonyl containing moiety providing reworkable cured thermosets Compounds containing two cyclic hydrocarbon moieties which are substituted to provide crosslinking functionality and which are linked to each other by secondary or tertiary oxycarbonyl containing moiety are basis for compositions which are cured to provid... | 09/07/1999 |
| 5892061 | Process for preparing isoimides A preparation process of isoimide comprising reacting a compound having one or more carboxyl group and one or more amide bond in the same molecule in the presence of a haloiminium salt and basic substance, and a preparation process of isoimide comprising ... | 04/06/1999 |
| 5869506 | Fluoropropene compound, an insecticide containing the same and an intermediate for production thereof The present invention provides a fluoropropene compound represented by Formula I: ##STR1## wherein R1 represents a C1 -C10 alkyl group or other groups, Z represents an oxygen atom or other groups, R2, R | 02/09/1999 |
| 5849048 | Substituted biphenyl poly (oxyalkylene) ethers and fuel compositions containing the same Substituted biphenyl poly(oxyalkylene) ethers having the formula: ##STR1## wherein R1 is hydrogen or hydroxyl; R2 is hydroxyl, cyano, nitro, amino, aminomethyl, N-alkylamino or N-alkylaminomethyl wherein the alkyl group contains... | 12/15/1998 |
| 5801284 | Hydrogenation of halonitroaromatic compounds Process for preparing haloaromatic amines by catalytic hydrogenation of the corresponding halonitroaromatic compounds, characterized in that iron-containing Raney nickel is used as catalyst, where the haloaromatic amines prepared can be used for the synth... | 09/01/1998 |
| 5741896 | O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 04/21/1998 |
| 5710232 | Poly(ester-amide) polyols Compounds having the formula H--A--(BA)n --OH wherein n is 1-20; A is ##STR1## B is ##STR2## R1 is alkyl having 1-6 carbon atoms; R2 is an alkylene having 1-6 carbon atoms, alkenylene having 2-6 carbon atoms, cyc... | 01/20/1998 |
| 5705680 | Process for the preparation of O-acylglycolanilides The present invention relates to a process for the preparation of O-acylglycolanilides of the formula (1) ##STR1## in which R1 and R2 are identical or different and are hydrogen, halogen, a nitro group, a cyano group, a straight... | 01/06/1998 |
| 5654452 | Lipophilic contrast agents for use in hepatocyte-selective oil-in-water emulsions Aromatic acid-derived lipophilic polyhalogenated compounds are provided for use as contrast agents in diagnostic imaging or as therapeutic agents. These compounds are particularly useful when incorporated into an oil-in-water emulsion for tissue-specific ... | 08/05/1997 |
| 5635571 | Polymerizable macromonomers and polymers prepared therefrom Polyoxazolines having the structural formula: ##STR1## wherein R is phenylene or alkylene containing 2 to 18 carbon atoms, R2 is C1-4 alkyl and R1 is selected from the group consisting of C1-12 alkyl, vinyl... | 06/03/1997 |
| 5585512 | Esters of p-hydroxyaniline mustard There is disclosed an ester compound that is resistant to decomposition in blood, but is quickly hydrolyzed in cancer cells, and functions as an anticancer agent. The ester compound has a structure represented by formula (I) or formula (II): ##STR1##... | 12/17/1996 |
| 5574017 | Antibacterial agents The present invention provides methods and pharmaceutical preparations for inhibiting the growth of bacterial microorganisms.... | 11/12/1996 |
| 5543083 | Fatty amine derivatives of butylated hydroxy toluene for the protection of surfaces from physical and chemical degradation The present invention relates to non-surface staining, light stable antioxidant compounds which reduce the fading, decoloration and degradation of various surfaces, ie., fabrics, from sunlight. These antioxidant compounds are butylated hydroxytoluene and ... | 08/06/1996 |
| 5523152 | Organic compounds suitable as reactive diluents, and binder precursor compositions including same Organic compounds having at least one ethylenically-unsaturated group are described, the organic compounds being suitable for use in coatable compositions as reactive diluents; compounds of the invention preferably have a divalent organic linking moiety d... | 06/04/1996 |
| 5399590 | Quaternary ammonium salts and pharmaceutical compositions containing them The invention relates to the field of organic chemistry and more particularly to that of therapeutic chemistry. More particularly it relates to new quaternary ammonium salts of general formula (I): ##STR1## in which Hal is a halogen atom other than f... | 03/21/1995 |
| 5306837 | Intermediates for an optically active cyclobutane nucleoside Novel intermediates useful in the preparation of the optically active antiviral compound [1R-(1,2ଲ,3)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobut yl]-1,9-dihydro-6H-purin-6-one are described.... | 04/26/1994 |
| 5294734 | 4-substituted 2-aminoalk-3-enoic acids Substituted 2-aminoalk-3-enoic acid derivative of formula I ##STR1## wherein R1 is an aliphatic hydrocarbon radical that is substituted by optionally acylated or aliphatically or araliphatically etherified hydroxy, by halogen, by optionall... | 03/15/1994 |
| 5292928 | Process for the reaction of a low-molecular hydroxyl compound with a carboxylic acid halide In a process for reacting a low molecular weight hydroxy compound with a carboxylic acid halide, a small amount of the acid halide is introduced into the reaction vessel and the remainder of the acid halide and the hydroxy compound are added gradually in ... | 03/08/1994 |
| 5260478 | Iodinated aroyloxy carboxamides Compounds having the structure ##STR1## wherein (Z--COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R1 and R2 are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R | 11/09/1993 |
| 5198559 | N-acyl and O-acyl derivatives of N,N-bis(2,2-dimethyl-3-hydroxypropyl)amine, their preparation and use The present invention relates to N acyl and O acyl derivatives of N,N-bis(2,2-dimethyl-3-hydroxypropyl)amine which are produced as follows: ammonium halide, sulphate or aldehyde, and isobutyl aldehyde are subjected to condensation reaction and the obtaine... | 03/30/1993 |
| 5196568 | Compounds useful in enzymatic resolution systems and their preparation This invention relates to novel compositions of matter which are esters with enhanced water solubility, for use in aqueous enzymatic resolution reactions of racemic mixtures of these esters for producing the separate chiral isomers of the racemic mixture.... | 03/23/1993 |
| 5194472 | Ester-containing quaternary ammonium salts as adhesion improving toner charge agents Toner particles comprising a polyester binder and a charge control agent are provided wherein such agent is a quaternary ammonium salt having one or more ester-containing moieties. Such an ester-containing salt causes toner particles to display lower fusi... | 03/16/1993 |
| 5179097 | Salts of non-steroidal anti-inflammatory carboxylic acids and anti-lipidemic carboxylic acids Novel choline salts of non-steroidal anti-inflammatory carboxylic acids and anti-lipidemic carboxylic acids are described. Additionally, blends of choline salts with the above carboxylic acids are also described. The new salts and compositions offer new t... | 01/12/1993 |
| 5175257 | Radiolabeled proteins for diagnostic or therapeutic use Chelating compounds of specified N2 S2 N3 S derived structure are useful for radiolabeling targeting molecules such as antibodies. Cleavable ester orthioester linkers connect the radionuclide metal chelates to the antibodi... | 12/29/1992 |
| 5155254 | Substituted diones as intermediates for a process for the manufacture of γ-pyrones A process for the manufacture of 3-hydroxy-2-alkyl-4-pyrones of formula I is provided. ##STR1## The process comprises cyclizing a compound of formula II, ##STR2## an acidic medium and hydrolyzing the ester formed thereby to produce compound... | 10/13/1992 |
| 5112953 | Radiolabeled proteins for diagnostic or therapeutic use Chelating compounds of specified structure are useful for radiolabeling targeting molecules such as antibodies. Cleavable linkers connect the radionuclide metal chelates to the antibodies. The radiolabeled antibodies have improved biodistribution properti... | 05/12/1992 |
| 5110977 | Ester-containing quaternary ammonium salts as adhesion improving toner charge agents Toner particles comprising a polyester binder and a charge control agent are provided wherein such agent is a quaternary ammonium salt having one or more ester-containing moieties. Such an ester-containing salt causes toner particles to display lower fusi... | 05/05/1992 |
| 5089660 | Aromatic polycyanate/monocyanate comonomer compositions and polytriazines derived therefrom A comonomer composition of an aromatic polycyanate and an aromatic monocyanate substituted at each position ortho to the cyanate group, and a polytriazine copolymer derived therefrom.... | 02/18/1992 |
| 5055451 | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors Thiol protease inhibitors are disclosed having the formula: ##STR1## or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein: n is 0 or 1; m is 0, 1 or 2; X is H or an N-protecting group; each Y is independently an optionally ... | 10/08/1991 |
| 4966914 | Oculoselective beta-blockers as antiglaucoma agents In accordance with the present invention, disclosed herein are compounds of the formula ##STR1## wherein R is hydrogen, straight or branched loweralkyl, cycloalkyl, amino, loweralkoxy or acylamino, and R1 is straight or branched loweralkyl... | 10/30/1990 |
| 4966726 | Chiral reaction products produced from mesogenic molecular structural elements and bifunctionally reactive tartaric acid derivatives, and their use as dopants in liquid crystal phases The new compounds produced from a molecular structural element with two chirality centers and at least one mesogenic structural element are defined by the general formula (I) ##STR1## in which the symbols have the following meaning: Y1 =H,... | 10/30/1990 |
