Did You Know...
...that the x-ray was discovered purely by accident? When German physicist Wilhelm Konrad von Roentgen was experimenting with cathode rays in 1895, he put an activated Crookes tube in a book and went out to lunch. When he returned, he discovered that a key that had also been placed in the book showed up as an image on the developed film!
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| Number | Title | Issue Date |
| 7273952 | Substituted C-cyclohexylmethylamine derivatives Substituted C-cyclohexylmethylamine derivatives, methods for the production thereof, pharmaceuticals containing said compounds, the use of substituted C-cyclohexylmethylamine derivatives for producing pharmaceuticals, and method of pain treatment using the pharmaceu... | 09/25/2007 |
| 6989462 | Synthesis of 2-chloromethyl-6-methylbenzoic ester A process is described for preparing compounds of formula (I) where R is H, optionally halogen-substituted alkyl, cycloalkyl, aryl, alkyl-aryl or heteroaryl, and, in alkyl and cycloalkyl, one or more CH2 grou... | 01/24/2006 |
| 6965047 | Method for producing ethers, esters or acid anhydrides Ethers, esters or acid anhydrides are advantageously obtained when a cake of a first reactant selected from salts of organic or oxygen-containing inorganic acids or alkoxides disposed on a filter element is flowed through by a solution of a second reactant selected ... | 11/15/2005 |
| 6852738 | Acyl sulfamides for treatment of obesity, diabetes and lipid disorders A class of acyl sulfamides comprises compounds that are potent ligands for PPAR gamma and generally have antagonist or partial agonist activity. The compounds may be useful in the treatment, control or prevention of obesity, non-insulin dependent diabetes mellitus (... | 02/08/2005 |
| 6846890 | Norbornene derivative and norbornene polymer obtained therefrom through ring opening polymerization A novel norbornene derivative represented by a general formula (1m) shown below is provided. By conducting a ring opening polymerization of this norbornene derivative, or by performing a subsequent hydrogenation following the ring opening polymerization, a ring open... | 01/25/2005 |
| 6838481 | Skin whitener The invention relates to 5,15-diacetyl-3-benzoyllathyrol compound and a skin whitening composition containing the same. Since the composition of the invention contains 5,15-diacetyl-3-benzoyllathyrol as a melanine production inhibitor, it is excellent in inhibiting ... | 01/04/2005 |
| 6828460 | Resorcinol derivatives The present invention relates to the use of certain resorcinol derivatives as skin lightening agents. ... | 12/07/2004 |
| 6506929 | Process to manufacture simvastatin and intermediates A process is disclosed for the preparation of simvastatin which enables highly regio selective C-methylation of the 2'-position group of lovastatin without requiring protection/deprotection of 13-OH of lovastatin and lactone ring opening/closure.... | 01/14/2003 |
| 6395922 | Compounds based on dibenzoylresorcinol and related compositions and articles A method for preparing novel dibenzoylresorcinol-based compounds is disclosed, wherein the dibenzoylresorcinol is bonded to a substituted or unsubstituted aryl group which does not include a pendent hydroxyl group. The groups attached to the dibenzoylreso... | 05/28/2002 |
| 6348615 | Process for producing (2R, 3S)-3-amino-1, 2-oxirane A process for producing (2R, 3S)-3-amino-4-phenylbutane-1,2-epoxide compounds which comprises treating a (2S, 3S)-3-amino-1-halo-2-hydroxy-4-phenylbutane compound or a (2S, 3S)-3-amino-4-phenylbutane-1,2-epoxide with a carboxylic acid quaternary ammo... | 02/19/2002 |
| 6251833 | 2-arylcyclopentan-1,3-diones The present invention relates to novel 2-aryl-3-hydroxy-Ɗ2 -cyclopentene-1-one derivatives of the formula (I) ##STR1## in which A, B, D1, D2, G, W, X, Y and Z are each as defined in the description, to processes for their... | 06/26/2001 |
| 6242636 | Liquid crystal compounds, mixtures and devices An electoclinic device having two spaced cell walls each bearing electrode structures and treated on at least one facing surface with an alignment layer, a layer of a smectic liquid crystal material enclosed between the cell walls, where the liquid crysta... | 06/05/2001 |
| 6242637 | Substituted heterocylic compounds, method of preparing them and pharmaceutical compositions in which they are present The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A1) --O--CO-- A2) --CH2 --O--CO-- A3) --O--CH2 --CO-- A4) --O--CH2 --CH2 | 06/05/2001 |
| 6225499 | Process for preparing aminoarylacetylenes This invention provides a process for preparing aminoarylacetylenes comprising reacting a N-arylmethylidene aminoarylhalide with a terminal acetylene in the presence of a base and a catalyst system comprising a palladium catalyst and a cuprous salt to pro... | 05/01/2001 |
| 6166244 | Oxygen, sulfur and nitrogen substituted cyclohexene and cyclohexane derivatives having retinoid-like biological activity Compounds of the Formula 1, Formula 2, Formula 3 and Formula 4 wherein the symbols have the meaning assigned to them in the disclosure have retinoid-like biological activity. ##STR1##... | 12/26/2000 |
| 6080784 | Protein kinase C modulators N Compositions with protein kinase C-modulatory, anti-inflammatory and other activities are disclosed.... | 06/27/2000 |
| 6054457 | Benzamide derivatives and their use as vasopressin antagonists This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R1 is aryl optionally substituted with lower alkoxy, etc., R2 is lower... | 04/25/2000 |
| 6037059 | High molecular weight dibenzoylresorcinol UV absorbers, coating compositions, articles and method of making Novel dibenzoylresorcinol compositions capable of absorbing ultraviolet light having the formula ##STR1## where Ar1 and Ar2 are independently substituted or unsubstituted monocyclic or polycyclic aryl groups, R is hydrogen, an a... | 03/14/2000 |
| 5965752 | Preparative scale isolation and purification of taxanes This invention relates to an improved method for isolating taxanes by using a preparative scale technique amenable to commercial production. This method provides high yields of known taxanes in addition to new taxanes.... | 10/12/1999 |
| 5955501 | Protein kinase C modulators O Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the diterpene- and benzolactam-classes.... | 09/21/1999 |
| 5840658 | Process for the controlled fixing of scale inhibitor in a subterranean formation A process for fixing of a scale inhibitor in a subterranean formation, which comprises: a) injecting into the formation a solution comprising a polymeric scale inhibitor, a metal cation, a precursor and a weak organic acid, wherein the polymeric scale inh... | 11/24/1998 |
| 5808124 | O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.... | 09/15/1998 |
| 5789413 | Alkylated styrenes as prodrugs to COX-2 inhibitors The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases c... | 08/04/1998 |
| 5750577 | Chromotropic acid-formaldehyde and 1-naphthol-formaldehyde polymeric compounds Novel medicinally-useful compounds are provided herein. These compounds include isomeric cyclic tetramers of formaldehyde and 1-naphthol, and the derivatives or analogues of such cyclic tetramers, and linear oligomers of chromotropic acid, or its derivati... | 05/12/1998 |
| 5684198 | Method of preparing therapeutic amides Amides having formula I: ##STR1## wherein E, X, R2 and R3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof, which are useful ... | 11/04/1997 |
| 5670673 | Method for the isolation and purification of taxol and its natural analogues An improved method for isolating taxol and certain clinically important analogues of taxol from a crude extract of a naturally occurring Taxus species comprising treating the extract by reverse phase liquid chromatography on an adsorbent, causing the taxo... | 09/23/1997 |
| 5643948 | Protein kinase C modulators. K. Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes of the phorbol-, resiniferonol- and ingenol-classes.... | 07/01/1997 |
| 5604256 | Octahydronaphthalene oxime derivatives for cholesterol biosynthesis inhibition Compounds of formula (I): ##STR1## (in which: R is hydrogen, methyl or hydroxy; X is alkyl, alkenyl, cycloalkyl, aryl, aralkyl, or a heterocyclic group; A is a single bond, or an alkylene, alkenylene, alkynylene or alkadienylene group; Y is hydrogen,... | 02/18/1997 |
| 5550246 | Calicheamicin mimics Synthetic calicheamicin mimics employ alternative activation triggers and trigger cites and include tithers for conjugation to DNA targeting systems.... | 08/27/1996 |
| 5523320 | N-methyldeacetylcolchiceinamide derivatives N-methyldeacetylcolchiceinamide derivatives represented by the formula ##STR1## wherein R denotes a residue obtained by removing COOH from a C3 -C7 sugar carboxylic acid, and hydroxyl groups present in the residue may properly b... | 06/04/1996 |
| 5514642 | Cyclohexenone oxime ethers, their preparation and their use Cyclohexenone oxime ethers of the formula I ##STR1##... | 05/07/1996 |
| 5514825 | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity Compounds of the formula ##STR1## wherein R1 is hydrogen or alkyl of 1 to 10 carbons; R2 and R3 are hydrogen, or alkyl of 1 to 6 carbons and the substituted ethynyl group occupies either the 2 or the 3 position of the... | 05/07/1996 |
| 5475120 | Method for the isolation and purification of taxol and its natural analogues An improved method for isolating taxol and certain clinically important analogues of taxol from a crude extract of a naturally occuring Taxus species comprising treating the extract by reverse phase liquid chromatography on an adsorbent, causing the taxol... | 12/12/1995 |
| 5412134 | Process for preparing diprotected 2,3-hydroxymethyl cyclobutanol The protected cyclobutanone of the formula ##STR1## is treated with a dialkylaluminum chloride, an alkylaluminum dichloride, a trialkylaluminum compound, diphenylsilane in the presence of tris(triphenylphosphine) rhodium (I) chloride, or iridium tetr... | 05/02/1995 |
| 5382598 | Therapeutic amides Amides having formula I: ##STR1## wherein E, X, R2 and R3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolyzable esters thereof, which are useful ... | 01/17/1995 |
| 5380916 | Method for the isolation and purification of taxane derivatives An improved method for isolating certain clinically important taxane derivatives from the crude extract of a naturally occurring Taxus species comprising treating the extract by reverse phase liquid chromatography on an adsorbent; causing the taxane deriv... | 01/10/1995 |
| 5374376 | Optically active aromatic compounds, preparation process therefor, liquid crystal materials and a light switching element Disclosed are herein optically active aromatic compounds represented by the formula (I): ##STR1## wherein X represents --COO-- or --OCO--; Y represents --COO--, --OCO-- or --O--; R2 represents an alkyl or alkoxyalkyl group having 1 to 20 ... | 12/20/1994 |
| 5340498 | Anti-ferroelectric liquid crystal and liquid crystal display device A novel anti-ferroelectric liquid crystal of the formula (I), ##STR1## wherein: is an integer of 3 to 8, each of X and Y is independently a hydrogen atom or a fluorine atom, Z is --CF3, --CH3 or --C2 H5, q is 0 or 5,... | 08/23/1994 |
| 5326786 | 5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[alpha]heptalene derivative and pharmaceutical use Compounds represented by the formula ##STR1## wherein R1 and R2 each represent a hydrogen atom or a protective group for a hydroxyl group, or R1 and R2 combine to represent a protective group for hydroxyl g... | 07/05/1994 |
| 5321044 | 15,16-seco-19-nor progestins 15,16-Seco-19-nor progestins are provided which display elevated progestational activity with a minimum of ancillary hormonal activity. Processes for the preparation of the novel progestins are provided as are methods of use. A preferred method of use is ... | 06/14/1994 |
