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| Number | Title | Issue Date |
| 8030512 | Polycyclic pentafluorosulfanylbenzene compound and process for producing the compound A polycyclic pentafluorosulfanylbenzene compound represented by the following general formula (1) and a process for producing the polycyclic pentafluorosulfanylbenzene compound which comprises reacting a specific pentafluorosulfanylbenzene compound with a specific b... | 10/04/2011 |
| 7476754 | Biphenyl derived thiamides as calpain inhibitors The present invention relates to compounds derived from biphenyl with activity as calpain inhibitors. One compound of the present invention is a 2,2′-disubstituted biphenyl, where the substituents in the 2 and 2′ positions of the biphenyl skeleton are chains con... | 01/13/2009 |
| 7442418 | Polymerizable liquid crystal compound, liquid crystal composition, optical anisotropic material and optical element The present compound represented by formula(I) CH2═CR1—COO—(L)k-E1-E2-E3-(E4)m-(E5)n-R2 (1) provided that the symb... | 10/28/2008 |
| 7358386 | Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic d... | 04/15/2008 |
| 7348449 | Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among tho... | 03/25/2008 |
| 7326803 | Ligand inhibitors of the RAR receptors, process for preparing same and therapeutic/cosmetic applications thereof Novel bicyclic compounds having the structural formula (I): are useful in a variety of pharmaceutical applications, whether human or veterinary, and also in cosmetics. ... | 02/05/2008 |
| 7323587 | Selective estrogen receptor modulators The present invention provides, inter alia, triphenylethylene derivatives, such as, 3-{4-[6-(3-Methoxy-phenyl)-8,9-dihydro-7H-benzocyclohepten-5-yl]-phenyl}-acrylic acid, as selective estrogen receptor modulators. Also provided are methods for treating estrogen stim... | 01/29/2008 |
| 7304174 | CaSR antagonist A compound represented by the following formula (1), a pharmaceutically acceptable salt thereof or an optically active form thereof: wherein each symbol is as defined in the specification. A compound having a cal... | 12/04/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 7163956 | Substituted fullerene compositions and their use as antioxidants This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i) from 1 to 6 (>CX1X2) groups bonded to the fuller... | 01/16/2007 |
| 7122695 | Process for the preparation of cyclopropyl carboxylic acid esters and derivatives The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of dimethylsulfoxonium methylide and dimethylsulfonium methylide; to the... | 10/17/2006 |
| 7087796 | Cyclopropanecarboxaldehydes and their use in perfume compositions The present invention is directed to novel cyclopropanecarboxaldehyde compounds of the general formula wherein R is a straight, branched, or cyclic hydrocarbon moiety consisting of 1 to 3... | 08/08/2006 |
| 7074826 | R-NSAID esters and their use The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in treating a disease or illness in a mammal. To this end, a composition c... | 07/11/2006 |
| 7074420 | Cosmetic treatment using a new retinoid There is provided a topical composition and method for improving the aesthetic appearance of skin, particularly, preventing, ameliorating, treating and/or reducing fine lines and/or wrinkles, without the skin irritation typically associated with topical application ... | 07/11/2006 |
| 6992095 | Stilbene compounds comprising an adamantyl group, compositions and methods thereof The invention relates to novel stilbene compounds having the general formula (I): as well as to pharmaceutical compositions for use in human or veterinary medicine, including dermatological, rheumatic, respiratory, card... | 01/31/2006 |
| 6972340 | Selective protein tyrosine phosphatatase inhibitors Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of di... | 12/06/2005 |
| 6942980 | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities Methods of characterizing and identifying negative hormones of nuclear receptors. Also disclosed are methods of making modulators of retinoid nuclear receptor transactivation activity, assays for agonists, antagonists, and negative hormones of the RAR receptor, and ... | 09/13/2005 |
| 6924082 | Double-bond shifts of substituted (4n)-annulenes for information storage and data processing The present application describes a method for information storage and data processing comprising the steps of thermo inducing or photo inducing double-bond shifts (DBS) in substituted (4n)-annulenes thus generating transitions between two different conjugati... | 08/02/2005 |
| 6924388 | Bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds having the structural formula (I): in which Ar1 is a radical having one of the structural formulae (a)-(c): | 08/02/2005 |
| 6849757 | Antiangiogenic drug to treat cancer, arthritis and retinopathy Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharma... | 02/01/2005 |
| 6838574 | Dicarba-closo-dodecarborane derivatives A medicament comprising as an active ingredient a compound or a physiologically acceptable salt thereof represented by general formula (I): wherein R1 represents a dicarba-closo-dodecaboran-yl which may be s... | 01/04/2005 |
| 6730804 | Process for preparing cyclopropanecarboxylates of lower alcohols Cyclopropanecarboxylates of lower alcohols are prepared by esterification of the corresponding cyclopropanecarboxylic acids with the corresponding lower alcohols in the presence of an acid catalyst, while maintaining a considerable stoichiometric excess of the cyclo... | 05/04/2004 |
| 6632963 | Bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## in which Ar1 is a radical having one of the structural formulae (a)-(c): ##STR2## Ar2 is a radical having one of th... | 10/14/2003 |
| 6627656 | Method of treatment using phenyl and biaryl derivatives as prostaglandin E inhibitors and compounds useful therefore This invention encompasses a method for the treatment or prevention of prostaglandin mediated diseases comprising administering to a mammalian patient a compound of formula I: ##STR1## in an amount that is effective to treat or prevent said prostaglandin ... | 09/30/2003 |
| 6617469 | Process for preparing malonic diesters in a reactor with internal heat exchangers A process for preparing malonic diesters by carbonylation of haloacetic esters and reaction with monohydric alcohols and a base in the presence of a transition metal catalyst, preferably a catalytic cobalt carbonyl complex, using a stirred reactor with on... | 09/09/2003 |
| 6583307 | Convenient and efficient Suzuki-Miyaura cross-coupling catalyzed by a palladium/diazabutadiene system A Pd(OAc)2 /diazabutadiene system has been developed for the catalytic cross-coupling of aryl halides with arylboronic acids. A combination of the diazabutadiene DAB-Cy (1, N,N'-Dicyclohexyl-1,4-dizabutadiene) and Pd(OAc)2 was found ... | 06/24/2003 |
| 6518306 | 1,4-substitued 4,4-diaryl cyclohexanes This invention relates to compounds of Formula (I) where Z is an amine, alcohol or derivative thereof, and the ketone analog thereof.... | 02/11/2003 |
| 6515163 | Hydrogenated phenanthrenes and their use in liquid-crystal mixture The invention concerns hydrogenated phenanthrenes of formula I ##STR1## wherein the parameters have the meanings given in the text and their use in liquid crystal compositions.... | 02/04/2003 |
| 6492542 | Method for producing carboxylic acid tertiary alkyl ester A carboxylic acid tertiary alkyl ester (Chemical formula 1) of high purity is obtained at a high yield ratio, by continually adding an esterification agent possessing a monovalent acid group, which agent is ester-interchangeable with a tertiary alcohol, t... | 12/10/2002 |
| 6469198 | Chiral copper complex catalyst composition and asymmetric production process using the same There is disclosed chiral copper complex catalyst composition, which is obtained by contacting an optically active N-salicylideneaminoalcohol compound of formula (1): ##STR1## with a mono-valent or di-valent copper compound in an inert solvent, wherein R | 10/22/2002 |
| 6455727 | Process for preparing carbetapentane tannate The invention pertains to a process for preparing carbetapentane tannate. The process involves the steps of heating carbetapentane to a temperature of about 80 to about 120° C. and slowly adding tannic acid to the carbetapentane while agitating the react... | 09/24/2002 |
| 6452037 | Multioligonanilinated fullerenes A compound, of the following formula: ##STR1## Also disclosed is a pharmaceutical composition containing a pharmaceutically effective amount of the compound.... | 09/17/2002 |
| 6433214 | Process for the preparation of 2-(4-methylphenyl)-benzoic acid derivatives A process for the preparation of 2-(4-methylphenyl)benzoic acid C1-6 alkyl esters by reaction of a sulfonic derivative of formula ##STR1## wherein R is C1-6 alkyl and R1 is optionally perfluorinated C1-6 alkyl o... | 08/13/2002 |
| 6403638 | 2,4-pentadienoic acid derivatives having selective activity for retinoid X (RXR) receptors Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R1 represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid agonist activity. ##STR1##... | 06/11/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6369266 | Process for producing tert-butyl 4'-methyl-2-biphenylcarboxlate A process for preparing tert-butyl 4'-methyl-2-biphenylcarboxylate characterized in that 4'-methyl-2-biphenylcarboxylic acid is reacted with isobutene in the presence of an acid catalyst. According to the present invention, tert-butyl 4'-methyl-2-biphenyl... | 04/09/2002 |
| 6369265 | Use of a catalyst system comprising nickel, palladium, or platinum and imidazoline-2-ylidene or imidazolidine-2-ylidene in kumada coupling reactions This invention provides a process for conducting Kumada coupling reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in Kumada couplings of aryl halides. A Kumada coupling can be carried out by mixing... | 04/09/2002 |
| 6362357 | Use a catalyst system comprising nickel palladium or platinum and imidazoline-2-ylidene or imidazolidine-2-ylidene in stille coupling reactions This invention provides a process for conducting Stille coupling reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in Stille couplings of aryl halides. A Stille coupling can be carried out by mixing... | 03/26/2002 |
| 6344583 | Oxidation of ketones to esters using a tin substituted zeolite beta Applicants have developed a process for the oxidation of ketones to esters. The process involves contacting the ketone with hydrogen peroxide and a catalyst at oxidation conditions. The catalyst is a molecular sieve represented by the empirical formula: (... | 02/05/2002 |
| 6319948 | Retinoid antagonists and uses thereof Retinoid antagonist compounds have been found to be useful in the prevention and/or minimization of surgical adhesion formation. Also provided by the invention are certain novel substituted (5,6)-dihydronaphthalenyl compounds which are retinoid antagonists and... | 11/20/2001 |
