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| Number | Title | Issue Date |
| 8110701 | Process for the preparation of functionalised benzocyclobutenes, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid Process for the preparation of compounds of formula (IV): wherein R1, R2, R3 and R4, which may be identical or different, each represent a hydrogen atom, a linear or branched (C | 02/07/2012 |
| 8110702 | Process for the manufacture of substituted 2-cyano cinnamic esters The invention relates to an improved process for the manufacture of substitute 2-cyanocinnamic esters. This novel economical process provides products in high purity and yields. ... | 02/07/2012 |
| 8034971 | Method for producing 1,2-phenylethane compound using atom transfer radical coupling reaction An object of the present invention is to provide a method capable of producing a 1,2-phenylethane compound with extremely high yield in a short amount of time. Disclosed is a method for producing a 1,2-phenylethane compound, which comprises subjecting a compound rep... | 10/11/2011 |
| 7531685 | Deuterium-enriched oxybutynin The present application describes deuterium-enriched oxybutynin, pharmaceutically acceptable salt forms thereof, and methods of treating using the same. ... | 05/12/2009 |
| 7348449 | Ligand antagonists of RAR receptors and pharmaceutical/cosmetic applications thereof Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C═O or C═N—OH radical or a sulfur or selenium atom; B is a radical selected from among tho... | 03/25/2008 |
| 7314888 | Compounds and medicinal use thereof A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: | 01/01/2008 |
| 7164036 | Benzophenone compound and ink composition including the same A benzophenone compound, and an ink composition that includes the benzophenone compound can absorb UV light, and thus improve lightfastness of images produced with the ink composition containing the compound. Due to the function of the benzophenone compound as a lig... | 01/16/2007 |
| 6979566 | Method of treatment of viral infection including HIV using water soluble fullerenes—III A water soluble derivative of buckministerfullerene (C50) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containi... | 12/27/2005 |
| 6930197 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to a process for the preparation of compounds of the formula: wherein R1 is C1-C6alkyl and the C1-C6alkyl moiety is straight or branched. | 08/16/2005 |
| 6875895 | Bis (diphenylvinyl) arene compound Provided is a bis(diphenylvinyl)arene compound having a reactive functional group on phenyl group, represented by below formula (1), wherein, Ar is an arylene group and has one or more substituents; R1-R | 04/05/2005 |
| 6852876 | Treatment of colon cancer The novel compound of the disclosure is 4-chloro-4-(4-ethoxy-phenyl)-2-(fluoren-9-ylidene-hydrazono)-but-3-enoic acid methyl ester (3F-19), and it alone or in combination with 4-(4-Ethoxy-phenyl)-2-(N′-fluoren-9-ylidene-hydrazino)-2-hydroxy-4-oxo-butyric acid meth... | 02/08/2005 |
| 6747154 | Process for preparing scopine esters A process for preparing a compound of formula 1 from a compound of formula 2 the process comprising reacting in one step the compound of formula 2 with a compound of formula ... | 06/08/2004 |
| 6720425 | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity Compounds of the formula where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity. ... | 04/13/2004 |
| 6700012 | Antihistaminic piperidine derivatives and intermediates for the preparation thereof This invention relates to compounds of the formula: ##STR1## wherein R1 is H or C1 -C6 alkyl and the C1 -C6 alkyl moiety is straight or branched; R2 and R3 are each independen... | 03/02/2004 |
| 6696611 | Chemical methods The present invention provides a method for enantioselectively reducing a prochiral carbon centered radical having one or more electron donator groups attached directly to the central prochiral carbon atom of the radical, and/or attached to a carbon atom ... | 02/24/2004 |
| 6566548 | Molecular compounds containing novel carboxylic acid derivatives as the constituent compound Novel molecular compounds containing carboxylic acid derivatives represented by general formula (I) or (II) as the constituent compound and exhibiting excellent performances in various technical fields including selective separation of useful substances, ... | 05/20/2003 |
| 6528681 | Halogenated triphenylethylene derivatives as selective estrogen receptor modulators The present invention describes novel halogenated triphenylethylene derivatives, or pharmaceutically acceptable prodrug or salt forms thereof, as selective estrogen receptor modulators for the treatment of and/or prevention of breast, uterine, ovarian, pr... | 03/04/2003 |
| 6492542 | Method for producing carboxylic acid tertiary alkyl ester A carboxylic acid tertiary alkyl ester (Chemical formula 1) of high purity is obtained at a high yield ratio, by continually adding an esterification agent possessing a monovalent acid group, which agent is ester-interchangeable with a tertiary alcohol, t... | 12/10/2002 |
| 6469198 | Chiral copper complex catalyst composition and asymmetric production process using the same There is disclosed chiral copper complex catalyst composition, which is obtained by contacting an optically active N-salicylideneaminoalcohol compound of formula (1): ##STR1## with a mono-valent or di-valent copper compound in an inert solvent, wherein R | 10/22/2002 |
| 6414178 | Method for the continuous preparation of chloroformate products of halogenated dihdroxy compounds This invention relates to a process and apparatus for the continuous preparation of mono and bis-chloroformate products of halogenated dihydroxy compounds by an interfacial process. The mono and bis-chloroformate products may optionally be converted to ca... | 07/02/2002 |
| 6235923 | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinois antagonist or retinoid inverse agonist type biological activity.... | 05/22/2001 |
| 6225494 | Trisubstituted phenyl derivatives having retinoid agonist or inverse agonist type biological activity Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinois antagonist or retinoid inverse agonist type biological activity.... | 05/01/2001 |
| 6207716 | Non-steroidal ligands for the estrogen receptor Novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.... | 03/27/2001 |
| 6204391 | Water soluble fullerenes with antiviral activity A water soluble derivative of buckministerfullerene (C60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieti... | 03/20/2001 |
| 6043247 | Modulators of molecules with phosphotyrosine recognition units The present invention relates to novel substituted acrylic acids, to methods for their preparation, compositions containing them, and their use for treatment of human and animal disorders, to their use for purification of proteins or glycoproteins, and to... | 03/28/2000 |
| 6037488 | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification, have retinoid, retinois antagonist or retinoid inverse agonist type biological activity.... | 03/14/2000 |
| 6005125 | Universal allyl linker for solid-phase nucleic acid synthesis A universal linker for solid-phase nucleic acid synthesis that is cleaved under conditions orthogonal to those used during the synthesis and deprotection of nucleic acids such as dsDNA or RNA fragments is disclosed. The invention includes compounds of the... | 12/21/1999 |
| 5877219 | Non-steroidal ligands for the estrogen receptor Described herein are non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.... | 03/02/1999 |
| 5795890 | Sulfonamide derivatives A sulfonamide derivatives of formula (I) ##STR1## a non-toxic salts, an acid addition salts or a solvates thereof which has an inhibitory effect on elastase.... | 08/18/1998 |
| 5681835 | Non-steroidal ligands for the estrogen receptor Prescribed herein are novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.... | 10/28/1997 |
| 5639894 | Carbonylation of allylic alcohols and synthesis of an ambergris fragrance compound A process for the carbonylation of allylic alcohols such as nerolidol, farnesol, or their monocyclic analogues with carbon monoxide at a pressure of at least 30 bar in the presence of a polar solvent and a palladium halide catalyst, optionally an alkali m... | 06/17/1997 |
| 5587150 | Photostable cosmetic screening composition containing a UV-A screening agent and an alkyl ଲ, ଲ-diphenylacrylate or -cyano-ଲ , ଲ-diphenylacrylate A photostable cosmetic screening composition and process for protection of the human epidermis against UV rays of wavelengths between 280 and 380 nm, the composition having, in a cosmetically acceptable vehicle containing at least one fatty phase, 1 to 5%... | 12/24/1996 |
| 5576354 | Photostable cosmetic screening composition containing a UV-A screening agent and an alkyl ଲ, ଲ-diphenylacrylate or -cyano-ଲ , ଲ-diphenylacrylate A photostable cosmetic screening composition and process for protection of the human epidermis against UV rays of wavelengths between 280 and 380 nm, the composition having, in a cosmetically acceptable vehicle containing at least one fatty phase, 1 to 5%... | 11/19/1996 |
| 5565611 | Process for preparing acid addition salt of Z-isomer of triphenylethylene compound The present invention provides a process for preparing an acid addition salt of the Z-isomer of a compound of the formula ##STR1## wherein R1 and R2 represent a lower alkyl group, or taken together with the nitrogen atom to whic... | 10/15/1996 |
| 5492917 | Endothelin antagonists incorporating a cyclobutane Novel compounds of the general structural formula I: ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cere... | 02/20/1996 |
| 5478964 | N-fluorosulfonimides and their application as fluorinating agents The invention describes N-fluorosulfonimides which are useful as fluorinating agents. The N-fluorosulfonimides are stable, easily synthesized, and allow the introduction of fluorine into organic compounds under mild conditions.... | 12/26/1995 |
| 5472970 | Allylaminoesters and their application in therapeutics Allylaminoesters of the formula (I): ##STR1## in which: R1 is H or low-molecular-weight alkyl, R2 is low-molecular-weight alkyl, cycloalkyl, or low-molecular-weight phenylcycloalkyl, pyridyl or phenyl, low-molecular-weight phenylalky... | 12/05/1995 |
| 5466880 | Process for preparing ketone enantiomer A novel multi-step process for preparing the (4S)-enantiomer of 4-(3,4 -dichlorophenyl)-3,4-1(2H)- naphthalenone in a highly-optically pure form is disclosed. The process involved starts from the known 4-(3,4-dichlorophenyl)-4-ketobutanoic acid and procee... | 11/14/1995 |
| 5322794 | Fluorescent phospholipid analogs and fatty acid derivatives Fluorescence probes are described comprising coronene fluorophores chemically attached to lipids or membrane-mimetic molecules via hydrocarbon spacers of defined length. Also described is a method for determining lipid packing and dynamics in membranes, a... | 06/21/1994 |
| 5278337 | Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic ... | 01/11/1994 |
