Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8088941 | Glycogen synthase kinase-3 inhibitors Novel compounds designed to allow interactions with binding sites of GSK-3 and hence are capable of inhibiting GSK-3 activity, via inhibition of substrate binding are disclosed. Further disclosed are pharmaceutical compositions including same and methods of using sa... | 01/03/2012 |
| 8039657 | Process for preparing malathion for pharmaceutical use The present invention provides a process for preparing a highly pure form of malathion having a reduced level of toxic impurities. In addition, the malathion prepared by the process of this invention is storage stable. The level of toxic impurities in the malathion,... | 10/18/2011 |
| 7732628 | Functional biopolymer modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided herein. Immobilized oligonucleotides an... | 06/08/2010 |
| 7595416 | Phosphoric acid esters and their use as wetting and dispersing agent The invention relates to a phosphoric acid ester and salts thereof of the general formula (I), wherein A is a monohydroxyl residue derived from C1-C20-alkyl-(AO)x-OH or Acyl-(AO)x-OH; or C1-C20-alkyl-(AO)x-(HA)y-OH or Acyl... | 09/29/2009 |
| 7453006 | Inositol derivatives for increasing chloride secretion and inhibiting inflammation Inositol derivatives, compositions comprising inositol derivatives, and methods for using compositions comprising inositol derivatives as agents for activating the secretion of chloride ions and/or treatment of inflammation are described. ... | 11/18/2008 |
| 7417035 | Phospholipid derivatives of non-steroidal anti-inflammatory drugs Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the compounds, pharmaceutical compositions comprising the compounds and t... | 08/26/2008 |
| 7410956 | Caspase inhibitor prodrugs The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. ... | 08/12/2008 |
| 7408075 | Synthesis of phosphocholine ester derivatives and conjugates thereof Aspects of the present invention include methods of synthesizing phosphocholine analogues and the phosphocholine conjugates formed therefrom and their use in preventing infections caused by microorganisms. ... | 08/05/2008 |
| 7384925 | Functionalized stilbene derivatives as improved vascular targeting agents Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubul... | 06/10/2008 |
| 7384978 | Compounds and methods for delivery of prostacyclin analogs This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing ... | 06/10/2008 |
| 7304046 | Phosphoramide compounds The invention provides a compound of formula I: wherein R1, Ra, Rb, Rc, and Rd have any of the values defined in the specification, as well as pharmaceutical... | 12/04/2007 |
| 7304093 | Ketone compounds and compositions for cholesterol management and related uses The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a com... | 12/04/2007 |
| 7217831 | Insecticide and method of controlling insects An insecticide of formula 1 and the agriculturally acceptable salts thereof, wherein: R1 is selected from the group consisting of: the group OR5 wherein R... | 05/15/2007 |
| 7214811 | Derivative of phosphoric acid ester salt or phosphoric acid ester adduct or mixtures thereof, method for the production thereof and their use A derivative of phosphoric acid ester salt or adduct or a mixture thereof is obtained from a reaction product, polycondensed with at least one aldehyde, of at least one polyol phosphoric acid ester with at least one organic nitrogen base. The derivative is advantage... | 05/08/2007 |
| 7173018 | Phospholipid derivatives of non-steroidal anti-inflammatory drugs Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the compounds, pharmaceutical compositions comprising the compounds and t... | 02/06/2007 |
| 7166736 | Neopentylglycol bis(diaryl phosphate) esters Neopentyl glycol bis(diphenyl phosphate) liquid compositions are described that comprise from about 75% to about 90%, by weight, of neopentyl glycol bis(diphenyl phosphate), less than about 5% by weight of cyclic product, less than about 8% by weight of triphenyl ph... | 01/23/2007 |
| 7138356 | Alkoxylated phosphite ester and process therefor A composition and a process for producing the composition are disclosed. The composition comprises an alkoxylated phosphite ester which has the formula of (HO[{CH(R)}mO]n)3P in which each R can be the same or different and can be ind... | 11/21/2006 |
| 7129229 | Hydrazide building blocks and hydrazide modified biomolecules This invention relates to attachment chemistries for binding macromolecules to a substrate surface or to other conjugation targets. More particularly, this invention relates to attachment chemistries involving branched or linear structures having one or more hydrazi... | 10/31/2006 |
| 7122699 | Process for preparing organic boronic acid derivatives using diboronic acid The invention relates to a process for the preparation of organic boronic acid derivatives involving the reaction of an organic compound with diboronic acid in the presence of a Group 8-11 metal catalyst. ... | 10/17/2006 |
| 7102024 | Functional biopolymer modification reagents and uses thereof Hydrazino, oxyamino and carbonyl-based reagents and methods for incorporation into oligonucleotides during their solid phase synthesis are provided. Modified oligonucleotides are provided that incorporate the reagents provided here in. Immobilized oligonucleotides a... | 09/05/2006 |
| 7094557 | 2-Methyl-3-butenyl-1-pyrophosphoric acid salt and agent for treating lymphocytes A pharmaceutically acceptable salt of 2-methyl-3-butenyl-l-pyrophosphoric acid; an agent for treating lymphocytes which comprises at least one of 2-methyl-3-butenyl-l-pyrophosphoric acid, a pharmaceutically acceptable salt thereof, and a hydrate thereof; Vγ2Vδ2 ty... | 08/22/2006 |
| 7057061 | Chiral monophosphorus compounds The present invention relates to catalysts comprising chiral monophosphorus compounds and their use, the chiral monophosphorus compounds themselves and also their precursors. ... | 06/06/2006 |
| 7057062 | Process for manufacturing purified phosphorodiamidite A scalable process for purification of phosphorodiamidite includes steps of solubilizing a crude phosphorodiamidite in an apolar organic solvent, contacting the non-polar organic solvent with a polar phase comprising a polar organic solvent to remove impurities from... | 06/06/2006 |
| 7030230 | Process of purifying phosphoramidites A process of purifying phosphoramidite precursors useful in inter alia synthesis of oligonucleotides comprises dissolving a crude phosphoramidite in a polar phase, adding a basic compound to the polar phase, adding a portion of water to the polar phase, contacting t... | 04/18/2006 |
| 7009067 | Hexa-citrated phytate and process of preparation thereof The present invention relates to a new chemical compound known as hexa-citrated phytate and a method of production thereof. The new chemical compound has six citrate molecules attached at the hydroxyl group of a citric acid to phosphates of a phytate molecule. This ... | 03/07/2006 |
| 6914148 | Guanidinium functionalized intermediates The present invention provides oligomers which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligomer is modified to include a guanidinium group. These oligomers are useful for diagnostic,... | 07/05/2005 |
| 6909010 | Facile synthesis of symmetric esters of alkylenebisphosphonic acids A facile synthesis of symmetric esters of C1-C10 alkylenebisphopsphonic acids is disclosed in which a C1-C10 alkylenebis(phosphonic dichloride) is reacted with an alcohol in the presence of a catalytic amount of 1H-tetrazo... | 06/21/2005 |
| 6794528 | Phosphorus compound The phosphorus-containing compound of the present invention is represented by the following formula (I), (II) or (III): wherein Z1, Z2 and Z3 each represents a cycloalkane, a cycloalkene,... | 09/21/2004 |
| 6759461 | Phenolic phosphite antioxidants and polymer compositions containing said antioxidant A novel antioxidant has the advantages of both the hindered phenols and the phosphite antioxidant is prepared from phosphorus trichloride and 2,5-di-tert-butylhydroquinone, such as tetrakis-(2,5-di-tert-butyl-4-hydroxyphenyl)-2,5-di-tert-butyl-hydroquinonediyl dipho... | 07/06/2004 |
| 6743921 | Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds The present invention provides a process for the preparation of a nonracemic diastereomer of 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol by hydrogenation of a corresponding nonracemic 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-y... | 06/01/2004 |
| 6713427 | Alkyl cobalt (III) dioximates and process for forming the same This invention is directed to alkyl cobalt (II) dioximates and methods for making these dioximates. The alkyl cobalt (III) dioximate has the following structural formula: wherein R1, and R2 are indi... | 03/30/2004 |
| 6703518 | Fluoride-releasing compositions Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capabili... | 03/09/2004 |
| 6677471 | Intermediates for the synthesis of oligonucleotide analogues Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.... | 01/13/2004 |
| 6626988 | Phosphate-stabilized polyurethane materials, cross-linked by condensation, method for their production and use thereof The invention relates to polyurethane materials, cross-linked by silane polycondensation, containing alkoxylsilane functional polyurethanes, alkaline fillers, phosphorous compounds aminosilanes, organometallic compounds and optionally additional auxiliary... | 09/30/2003 |
| 6613926 | Perchloramido phosphonyl reagents and analogs thereof Novel compounds are provided in the form of nucleoside pyrophosphate and triphosphate analogs. In these analogs, the pyrophosphate or triphosphate group is replaced with a moiety that is isosterically and electronically identical thereto, but is hydrolyti... | 09/02/2003 |
| 6610837 | Phosphate and thiophosphate protecting groups Novel P(III) bisamidite reagents as phosphorus protecting groups, nucleoside phosphoramidite intermediates, and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared through the protection of one or more int... | 08/26/2003 |
| 6593376 | Amphiphilic compounds with at least two hydrophilic and at least two hydrophobic groups on a di-,oligo- or polyene base A process for preparing amphiphilic compounds having at least two hydrophilic and at least two hydrophobic groups by reacting an olefinic substrate having at least two double bonds with an organic hydroperoxide to form an oxirane ring, opening, the oxiran... | 07/15/2003 |
| 6576782 | Halogenation of protected phenols in meta position The invention concerns a halogenation in position meta of a phenol fuction. Said halogenation comprises a step which consists in halogenating an aromatic derivative of a medium or advantageously strong acid, the aromatic radical being a phenyl substituted... | 06/10/2003 |
| 6534050 | 2-methyl-3-butenyl-1-pyrophosphoric acid salts and agents for treating lymphocytes A pharmaceutically acceptable salt of 2-methyl-3-butenyl-1-pyrophosphoric acid; an agent for treating lymphocytes which comprises at least one of 2-methyl-3-butenyl-1-pyrophosphoric acid, a pharmaceutically acceptable salt thereof, and a hydrate thereof; ... | 03/18/2003 |
| 6531591 | Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-ol... | 03/11/2003 |
