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| Number | Title | Issue Date |
| 7705175 | Method for producing imide ether compound Provided is a method for producing an imide ether compound in high yield. The method is characterized in that a nitrile compound, an alcohol, and a hydrogen halide are continuously introduced into a flow reaction device comprising a mixer and a flow reactor, to be s... | 04/27/2010 |
| 7351787 | Process for the preparation of activated polyethylene glycols A process for preparing activated polyethylene glycols is disclosed. In some embodiments, the process includes reacting a molten polyethylene glycol with an activator. In other embodiments, the process includes reacting a polyethylene glycol with an activator in the... | 04/01/2008 |
| 7196059 | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moi... | 03/27/2007 |
| 7169889 | Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 01/30/2007 |
| 7125558 | Process for the preparation of activated polyethylene glycols The present invention relates to a process for the preparation of activated polyethylene glycols, or PEG(NPC)2s, comprising reacting polyethylene glycol with an activator while in the presence of an aromatic nitrogen containing heterocyclic base. The proc... | 10/24/2006 |
| 7118737 | Polymer-modified synthetic proteins The present invention relates to methods and compositions for modifying peptides, polypeptides and proteins with polymers, especially glyco-mimetic polymers, so as to improve their biological activity or pharmacokinetic properties. The invention further provides met... | 10/10/2006 |
| 7119074 | Treatment of cancers, tumors and malignancies using amphiphilic prodrugs The present invention provides amphiphilic prodrugs comprising a therapeutic compound conjugated to an PEG-oligomer/polymer and methods for using said prodrugs to enable oral drug delivery and/or delivery of drugs across the blood brain barrier into the central nerv... | 10/10/2006 |
| 7084121 | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same A mixture of conjugates in which each conjugate in the mixture comprises a calcitonin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may lower serum calcium levels in a subject by 10, 15 or even 20 percent or more. M... | 08/01/2006 |
| 7084114 | Mixtures of insulin drug-oligomer comprising polyalkylene glycol A mixture of conjugates in which each conjugate in the mixture comprises an insulin drug coupled to an oligomer that includes a polyalkylene glycol moiety is disclosed. The mixture may exhibit higher in vivo activity than a polydispersed mixture of similar conjugate... | 08/01/2006 |
| 7030084 | Drug-oligomer conjugates with polyethylene glycol components The present invention relates generally to hydrolyzable drug-oligomer conjugates, pharmaceutical compositions comprising such conjugates, and to methods for making and using such conjugates and pharmaceutical compositions. For example, a conjugate of insulin, PEG, a... | 04/18/2006 |
| 7030082 | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith Pharmaceutical compositions that include a drug and/or drug-oligomer conjugate, a fatty acid component and a bile salt component, or a bile salt component without a fatty acid component are described. The drug can be covalently coupled to an oligomeric moiety. The f... | 04/18/2006 |
| 6806380 | Modified safe and efficient process for the environmentally friendly synthesis of imidoesters Disclosed is a safe, efficient and environmentally friendly method for preparing imidoesters. ... | 10/19/2004 |
| 5877297 | Boronic compound complexing reagents and highly stable complexes Boron compound completing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents. These reagents, including those shown as General Formula CII may be used, after further reactions described herein, to complex with bor... | 03/02/1999 |
| 5872224 | Boronic compound complexing reagents and highly stable complexes Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula CIV, and General Formula CVI. In one embodiment, the ... | 02/16/1999 |
| 5869623 | Boronic compound complexing reagents and complexes Boron compound complexing reagents, intermediate reagents of those reagents, and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula II may be used, after further reactions described herein, to co... | 02/09/1999 |
| 5859210 | Boronic compound complexing reagents and complexes Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula IV and General Formula VI. In one embodiment, the rea... | 01/12/1999 |
| 5847192 | Boronic compound complexing reagents and complexes Boron compound complexing reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula I and General Formula II may be used, after further reactions described herein, to complex with boronic c... | 12/08/1998 |
| 5837878 | Boronic compound complexing reagents and highly stable complexes Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula CIII, General Formula CIV, and General Formula CVI. I... | 11/17/1998 |
| 5777148 | Boronic compound complexing reagents and highly stable complexes Boron compound complexing reagents, intermediate reagents of those reagents and methods of synthesizing these reagents are disclosed. These reagents, including those shown as General Formula I and General Formula II may be used, after further reactions de... | 07/07/1998 |
| 5744627 | Boronic compound complexing reagents and complexes Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula III, General Formula IV, and General Formula VI. In o... | 04/28/1998 |
| 5736747 | Organic compounds suitable as reactive diluents, and binder precursor compositions including same Organic compounds having at least one ethylenically-unsaturated group are described, the organic compounds being suitable for use in coatable compositions as reactive diluents; compounds of the invention preferably have a divalent organic linking moiety d... | 04/07/1998 |
| 5652371 | 3-imino-3-alkoxy-propionic acid lactates and their tautomeric acrylic acid lactates The invention relates to novel 3-imino-3-alkoxy-propionic acid lactates and their tautomeric acrylic acid lactates, processes for their preparation and their use as intermediates in the synthesis of 2-amino-substituted 1,4-dihydropyridines.... | 07/29/1997 |
| 5637749 | Aryl imidate activated polyalkylene oxides Water-soluble aryl imidate activated polyalkylene oxides having improved hydrolytic stability and conjugates of the aryl imidate activated polyalkylene oxides with biologically active nucleophiles are disclosed. Methods of preparing the activated polyalky... | 06/10/1997 |
| 5616546 | Automatic dishwashing compositions comprising multiperacid-forming bleach activators Improved automatic dishwashing detergent compositions, especially granular detergents, comprising bleach activators which form multiperacids, especially specific monoquaternary substituted bis(peroxycarbonic) acids, upon perhydrolysis are provided.... | 04/01/1997 |
| 5609848 | Radiohalogenated small molecules for protein labeling Haloaryl compounds are lithiated and thereafter metalated with one of the following organometallic groups: Sn(n--Bu)3 or SnMe3. The resulting aryltin compound can be transmetalated in site-specific reaction with one of the following ... | 03/11/1997 |
| 5595967 | Detergent compositions comprising multiperacid-forming bleach activators Improved detergent compositions, especially granular detergents, comprising bleach activators which form multiperacids, especially specific monoquaternary substituted bis(peroxycarbonic) acids, upon perhydrolysis are provided.... | 01/21/1997 |
| 5543541 | Method of preparing aryl triazolinones with trialkyl orthoacetates A method for preparing an alkoxyethylidene-substituted aryl hydrazine having the formula ##STR1## and thereafter cyclizing the same with a cyanate salt under mildly acidic conditions in the presence of an organic solvent, optionally in the prese... | 08/06/1996 |
| 5534180 | Automatic dishwashing compositions comprising multiperacid-forming bleach activators Improved automatic dishwashing detergent compositions, especially granular detergents, comprising bleach activators which form multiperacids, especially specific monoquaternary substituted bis(peroxycarbonic) acids, upon perhydrolysis are provided.... | 07/09/1996 |
| 5534179 | Detergent compositions comprising multiperacid-forming bleach activators Improved detergent compositions, especially granular detergents, comprising bleach activators which form multiperacids, especially specific monoquaternary substituted bis(peroxycarbonic) acids, upon perhydrolysis are provided.... | 07/09/1996 |
| 5523152 | Organic compounds suitable as reactive diluents, and binder precursor compositions including same Organic compounds having at least one ethylenically-unsaturated group are described, the organic compounds being suitable for use in coatable compositions as reactive diluents; compounds of the invention preferably have a divalent organic linking moiety d... | 06/04/1996 |
| 5440065 | Process for preparing 4-amino-5-hexenoic acid This invention relates to a novel synthesis of 4-amino-5-hexenoic acid by thermal rearrangements, and to the novel intermediates produced thereby.... | 08/08/1995 |
| 5380936 | Process for preparing 4-amino-5-hexenoic acid This invention relates to a novel synthesis of 4-amino-5-hexenoic acid by thermal rearrangements, and to the novel intermediates produced thereby.... | 01/10/1995 |
| 5371084 | Fungicidal propenoic acid derivatives Compounds having the formula (I): ##STR1## and stereoisomers thereof, wherein A is hydrogen, halo, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 alkylcarbonyl, C1-4... | 12/06/1994 |
| 5358955 | Aryl and heteroarylmethoxyphenyl inhibitors of leukotriene biosynthesis The present invention relates to a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein W is selected from optionally substituted pyridyl, naphthyl, and quinolyl; which inhibits lipoxygenase enzyme activity and leuko... | 10/25/1994 |
| 5354495 | Alkenoylcarbamate compounds as elasticity, adhesion, and dispersibility enhancer A physical property-improving reagent which comprises an alkenoylcarbamate compound of the formula: ##STR1## wherein R is a hydrogen atom or a lower alkyl group, X is an oxygen atom (--O--), a sulfur atom (--S--) or a substituted or unsubstituted imi... | 10/11/1994 |
| 5344970 | Hydrogenation of aromatic-substituted olefins using organometallic catalyst A ruthenium-phosphite complex having the formula ##STR1## wherein a is from 1 to 3; b is 1 or 2; c is from 0 to 3; and R is hydrogen, alkyl, aryl, halo, amino, acetylamino, or sulfo; and X is ##STR2## where R1, R2, and R | 09/06/1994 |
| 5319122 | Process for the preparation of benzylformimidate This invention relates to a novel process for preparing benzylformimidates which are useful in the production of certain carbapenem antibiotics. The process of this invention provides a means of producing a high-yield, high-purity product.... | 06/07/1994 |
| 5300681 | Hydrogenation of aromatic-substituted olefins using organoruthenium catalyst A process is disclosed for the enantioselective hydrogenation of olefins of the formula: ##STR1## where R is hydrogen or C1 to C6 linear or branched alkyl, Z is ##STR2## where R' is hydrogen or C1 to C6 | 04/05/1994 |
| 5298643 | Aryl imidate activated polyalkylene oxides Water-soluble aryl imidate activated polyalkylene oxides having improved hydrolytic stability and conjugates of the aryl imidate activated polyalkylene oxides with biologically active nucleophiles are disclosed. Methods of preparing the activated polyalky... | 03/29/1994 |
| 5237084 | Preparation of dialkyl (N-cyanoimido)carbonates from dialkyl imidocarbonates and cyanogen halides Dialkyl (N-cyanoimido) carbonates are prepared in good yield in a non-aqueous solvent by a process which comprises either (a) adding a cyanogen halide at a controlled rate to a reactor containing an unsubstituted or substituted dialkyl imidocarbonate, an ... | 08/17/1993 |
