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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 7367132 | Contact-type displacement measuring apparatus A contact-type displacement measuring apparatus includes a first movable body that reciprocates in a first linear direction; a driving unit that drives the first movable body; a second movable body that reciprocates in a second linear direction parallel to the first... | 05/06/2008 |
| 7335787 | Method for producing onium salt derivatives, and novel onium salt derivatives The invention provides a high-yield method for producing onium salt derivatives useful as agents, such as acid-generators, employed in chemically amplified resists; and to provide novel onium salt derivatives. Reaction of an onium salt derivative containing a halide... | 02/26/2008 |
| 7199155 | Acetylenic aryl sulfonate hydroxamic acid TACE and matrix metalloproteinase inhibitors Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-□, such as rheumatoid arthritis, graft rejection, cachexia, inflammation, fever, insulin resistance, septic shock, c... | 04/03/2007 |
| 7053071 | Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of... | 05/30/2006 |
| 7026339 | Inhibitors of HCV NS5B polymerase The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions contai... | 04/11/2006 |
| 6875895 | Bis (diphenylvinyl) arene compound Provided is a bis(diphenylvinyl)arene compound having a reactive functional group on phenyl group, represented by below formula (1), wherein, Ar is an arylene group and has one or more substituents; R1-R | 04/05/2005 |
| 6562542 | Image-forming material and novel sulfonic acid ester derivative An image-forming material is described, comprising on an support an acid-generating agent selected from a sulfonic acid ester of a specific structure generating an acid by the action of heat and the polymer thereof, and a compound causing a light absorpti... | 05/13/2003 |
| 6521663 | Aminoguanidinyl- and Alkoxyguanidinyl-substituted phenyl acetamides as protease inhibitors Phenyl acetamide compounds are described, including compounds of Formula I: ##STR1## or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3 -R6, R11, B, Y and W are set forth in the specification. Th... | 02/18/2003 |
| 6414020 | Amidino protease inhibitors Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R1 -R4, R6 -R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically accepta... | 07/02/2002 |
| 6407267 | Method for the preparation of citalopram A method for the preparation of citalopram comprising reaction of a compound of Formula (IV), ##STR1## wherein R is C1-6 alkyl, acyl, C1-6 alkylsulfonyl or arylsulfonyl, with 3-(N,N-dimethylamino)-propyl magnesium halide, to pre... | 06/18/2002 |
| 6307084 | Contact location detecting mechanism of touch signal probe A contact location detecting mechanism (1) of a touch signal probe (10) includes a rotary motion generator (30) for scanningly moving a stylus (102) on a plane (A), a phase value detector (50) for detecting a phase value (θ) indicating a rotation positio... | 10/23/2001 |
| 6255517 | Thymol derivatives having anti-tumor activity, and anti-cancer agent comprising the same The present invention relates to a thymol derivative represented by following Chemical Formula 1, pharmaceutically acceptable salts or esters thereof, and anti-cancer agents comprising the same as an active ingredient. ##STR1##... | 07/03/2001 |
| 6221898 | Amidino derivatives and their use as thrombin inhibitors There is provided compounds of formula I, ##STR1## wherein R1, R2, R3, Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such as thrombin, and in partic... | 04/24/2001 |
| 6214435 | Aminium compounds and optical information recording media containing the same A novel aminium compound exhibiting excellent solubility for solvents and high safety in terms of handling and environment is provided. An aminium compound represented by the following formula (1): ##STR1## wherein R1 represents substituted or unsub... | 04/10/2001 |
| 6133315 | Amidino protease inhibitors Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R1 -R4, R6 -R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically ac... | 10/17/2000 |
| 6106994 | Production process of polyphenol diesters, and positive photosensitive compositions A process for producing a polyphenol diester comprises esterifying a polyphenol compound and a naphthoquinone-1,2-diazidesulfonyl halide in the presence of for example monomethyldicyclohexylamine, and a positive photosensitive composition contains the res... | 08/22/2000 |
| 6040470 | Sulfonyl compound and thermalsensitive recording medium using the same There is provided a developer composition including at least one of sulfonyl compounds represented by formula (1) and at least one of sulfonyl compounds represented by formula 2: ##STR1## wherein X is H or lower alkyl, R1, R2, R... | 03/21/2000 |
| 5830619 | Resist materials Photoacid generators advantageous for use in applications such as photoacid generators used in chemically amplified resists are disclosed. These compounds are based on an ortho nitro benzyl configuration employing an substituent having high bulk, ... | 11/03/1998 |
| 5708018 | 2-aminoindans as selective dopamine D3 ligands Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of Formula I: ##STR1## wherein R1 and R2 are independently chosen fro... | 01/13/1998 |
| 5670691 | Method for making a substituted benzene compound A method for making a substituted benzene compound includes reacting a 2-substituted benzenesulfonate or the 2-substituted benzenesulfonate further substituted in the 3, 4 or 5-position with a lithium compound to form an intermediate; and reacting the int... | 09/23/1997 |
| 5596017 | Sulfamide derivatives Novel pesticidal sulfamide derivatives of the formula ##STR1## in which X is halogen or C1 -C4 -halogenoalkyl, R1 is C1 -C4 -alkyl or C1 -C4 -halogenoalkyl, R2 is hydrogen ... | 01/21/1997 |
| 5587504 | Sulfonyloxy-biphenylcarboxylic ester derivatives which are intermediates The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin... | 12/24/1996 |
| 5563174 | Hydrazone compound and insecticide containing said compound as active ingredient A hydrazone compound of the general formula (I): ##STR1## wherein X is halogen; R1 is hydrogen, optionally substituted C1 -C4 alkyl or optionally substituted C1 -C4 alkoxy; R2 's are i... | 10/08/1996 |
| 5557002 | Process for the preparation of biphenyl containing intermediates useful in making angiotensin II receptor antagonists The present invention provides an industrially advantageous process for preparing a 2-alkyl-3-(biphenyl-4-yl)methyl-3H-imidazo[4,5-b]pyridine derivative represented by the following formula (II) which is a precursor of an antagonist against an angiotensin... | 09/17/1996 |
| 5536748 | Hydrazone compound and insecticide containing the same as active ingredient The present invention provides a hydrazone compound of the formula I: ##STR1## wherein R1 and R2 are the same or different and are independently hydrogen, C1 -C2 alkyl, C1 -C2 alkoxy, ... | 07/16/1996 |
| 5508461 | Optically active 1-phenyl-2-substituted propane derivatives and methods of producing the same An (S)-1-phenyl-2-substituted propane derivative shown by the following formula (I) ##STR1## wherein R1 and R2 represent a lower alkyl group, etc., or R1 and R2 may form together an alkylene group, etc.; R | 04/16/1996 |
| 5340837 | Benzophenonehydrazones Compounds of the formula ##STR1## wherein each of o and p, independently of the other, is 0, 1, 2, 3, 4 or 5, the radicals R1 being the same or different when o is greater than 1 and the radicals R2 being the same or different w... | 08/23/1994 |
| 5312952 | Polymerization inhibitor for vinyl aromatics This invention relates to a vinyl aromatic. Compounds of Structure (I): ##STR1## wherein R is C9 -C20 alkyl, Y is NO2, SO3 R' or H, R' is C1 -C20 alkyl, X is NO2 or C1-C20 | 05/17/1994 |
| 5235084 | Method for preparing sulfones A method for preparing a sulfone represented by the following formula: ##STR1## wherein R and R' each represent a lower alkyl group, an aryl group or an aryl group whose nucleus has at least one substituent selected from the group consisting of a hal... | 08/10/1993 |
| 5221760 | Alkenoic acid derivatives An alkenoic acid derivative of the formula ##STR1## in which X and Y are identical or different and represent sulfur, sulfoxide, sulfone, an alkylene chain, --SCH2 --, or oxygen or a direct bond, W represents --CH.dbd.CH-- or --CH2 | 06/22/1993 |
| 5200544 | Resist materials A class of resist compositions sensitive to deep ultraviolet radiation includes a resin sensitive to acid and a composition that generates acid upon exposure to such radiation. A group of nitrobenzyl materials is particularly suitable for use as the acid ... | 04/06/1993 |
| 5130462 | Cyclobutane derivatives Cyclobutane derivatives of the formulas ##STR1## wherein P is a hydroxy protecting group and X is a leaving group are useful intermediates in the preparation of antiviral compounds.... | 07/14/1992 |
| 5110975 | Isocyanatoalkyl sulphonates and a process for their preparation Isocyanatoalkyl sulphonates of the general formula ##STR1## wherein the substituent meanings are as given in the description are obtained by reacting the corresponding isocyanatoalkyl halides with sulphonic acid esters of the formula ##STR2## ... | 05/05/1992 |
| 5091560 | Method for synthesizing acyloxycarboxylic acids A method for synthesizing an acyloxycarboxylic acid by providing a reaction chamber, establishing sources of an -hydroxycarboxylic acid and an acid chloride, and repeatedly contacting substantially equal molar amounts of the -hydroxycarboxyl... | 02/25/1992 |
| 4994599 | Intermediates for producing quinolone-3-carboxylic acids A process for producing a 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid by reacting an acctophenone with a dialkoxycarbonate to obtain the corresponding ଲ-ketoester, treating the ଲ-ketoester with a trialkylorthoformate in the presence of an ac... | 02/19/1991 |
| 4931579 | Indicators for the detection of thiol groups Indicators for the detection of thio groups are disclosed together with processes for the preparation of such indicators. The indicators of the invention contain compounds having the following general formula ##STR1##... | 06/05/1990 |
| 4914128 | Acrylates and fungicides which contain these compounds Acrylates of the general formula ##STR1## where R1 and R2 independently of one another are each C1 -C8 -alkyl, X is hydrogen, C1 -C4 -alkyl, halogen, C1 -C4 -alko... | 04/03/1990 |
| 4898962 | Natural vitamin E intermediate An asymmetric synthesis for Vitamin E in an optically active pure form for 4-(2,5-diloweralkanoyloxy)-3,4,6-trimethylphenyl-butan-2-one and intermediates therein.... | 02/06/1990 |
| 4873018 | Optically active compound, process for producing same and liquid crystal composition containing same An optically active 2-fluoro-1-alkanol compound represented by the formula (Ia): ##STR1## wherein R is an alkyl group having 1-16 carbon atoms, and C* is an asymmetric carbon atom; and an optically active compound derived from the fluoroalkanol ... | 10/10/1989 |
| 4843094 | Derivatives of p-guantidinobenzoic acid and pharmaceutical agents containing them as active ingredient Compounds presented by the general formula: ##STR1## [wherein when Y is oxygen, R2 is H, alkyl, alkoxy, alkoxymethyl, --COOR3, --CH2 COOR3, --CH.dbd.CH--COOR3, halogen, --CF3, --COR | 06/27/1989 |
