Did You Know...
...that Kleenex tissue was originally designed to be a gas mask filter? It was developed at the beginning of World War I to replace cotton, which was then in short supply as a surgical dressing.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7442826 | Process for the preparation of nitrooxyderivatives of paracetamol The present invention relates to a new process for the preparation of a compound of the following formula (I): ... | 10/28/2008 |
| 7399878 | Pharmaceutical compounds Compounds or their salts of general formula (I): A-B-N(O)s wherein: s is an integer equal to 1 or 2; A=R-T1-, wherein R is the drug radical and T1=(CO)t or (X)t′, wherein X=O, S, NR1c, R1c | 07/15/2008 |
| 7238829 | Process for the preparation of naproxene nitroxyalkylesters A process for obtaining nitroxyalklesters of the 2(S)(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess higher than or equal to 95%, preferably higher than or equal to 98%, characterized in that an halide of the 2-(S)-(6 methoxy-2-naphthyl)propanoic... | 07/03/2007 |
| 7220749 | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use The invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compo... | 05/22/2007 |
| 7199154 | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods... | 04/03/2007 |
| 7199141 | Drugs for chronic pains Nitro-oxyderivative compounds or salts thereof having the following general formula (I): A—(B)b0—(C)c0—NO2 wherein: c0 is an integer and is 0 or 1, b0 is an integer and is 0 or 1, A=R—T1—, wherein R is the radica... | 04/03/2007 |
| 7199258 | Process for preparing nitrooxyderivatives of naproxen The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of naproxen or bromonaproxen and R1–R12 are hydrogen or alkyl groups, m, n, o, q, r and s are ea... | 04/03/2007 |
| 7186753 | Pharmaceutical compounds Compounds or their salts of general formula (I): A—B—N(O)s wherein: s is an integer equal to 1 or 2; A=R—T1—, wherein R is the drug radical and T1=(CO)t or (X)t′, wherein X=O, S, NR1c, R | 03/06/2007 |
| 7169809 | Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encom... | 01/30/2007 |
| 7166618 | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that don... | 01/23/2007 |
| 7163958 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or re... | 01/16/2007 |
| 7014668 | Motor fuel for diesel, gas-turbine and turbojet engines The invention relates to a motor fuel suitable for diesel, gas-turbine and jet engines and standard engines, comprising a mixture of organic compounds having oxygen-containing functional groups, and optionally a hydrocarbon fraction. The fuel is typically a stable h... | 03/21/2006 |
| 6700011 | Process for the preparation of naproxene nitroxyalkylesters A process for obtaining nitroxyalkylesters of the 2-(S)-(6-methoxy-2-naphthyl)-propanoic acid having an enantiomeric excess higher than or equal to 95%, preferably higher than or equal to 98%, characterized in that an halide of the 2-(S)-(6-methoxy-2... | 03/02/2004 |
| 6696591 | Process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives A process for obtaining (nitroxymethyl)phenyl esters of salicylic acid derivatives of formula (I) wherein R1 is the OCOR3 group characterized in that it comprises the following steps: a) reaction of a halide of a salicylic acid deriv... | 02/24/2004 |
| 6538033 | Nitric oxide donor compounds Nitric oxide donor compounds of the formula: ##STR1## are provided. In the formula, R is (CH2)n, wherein n ranges from 1 to 8 and wherein each hydrogen atom on the alkylene group and on the phenyl groups can optionally be replaced by... | 03/25/2003 |
| 6410791 | Nitric esters and nitrate salts of specific drugs A nitrate salt of a compound selected from the group consisting of: salbutamol having the formula (I) ##STR1##... | 06/25/2002 |
| 6211233 | Prostaglandin pharmaceutical compositions Compounds of the general formula A--X1 --NO2, or their pharmaceutical compositions, wherein A contains a prostaglandin residue, X1 is a bivalent connecting bridge.... | 04/03/2001 |
| 6072071 | Process for the production of dinitrate esters 1,2 and 1,3-dinitrate esters are prepared from polyols containing 1,2- or 1,3-diol fragments using an alkyl or aryl boronic acid to form a cyclic boronate ester derivative which is then reacted with dinitrogen pentoxide to directly generate the dinitrate ... | 06/06/2000 |
| 6040341 | Compounds and their compositions having anti-inflammatory and anti-thrombotic activities Compounds and their compositions, of general formula: A--X1 --NO2 are used as medicaments wherein: A=R(COX)t t=0 or 1; X=O and the remaining substituents are defined in the specification.... | 03/21/2000 |
| 6013667 | Benzenesulfonylamine compounds, process for preparing them and pharmaceutical compositions Compounds of formula (I): in which: Ra and Rb, identical or different, represent hydrogen or alkyl or together form a bond, RC represents hydroxyl optionally substituted alkoxy, or optionally substituted amino, R1 re... | 01/11/2000 |
| 5861426 | Nitro compounds of the formula A-Xi -NO2 and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities New compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic activities, of the general formula: A--X1 --NO2 or their salts, wherein: A is R(COXu)t, wherein t is zero or 1 and u i... | 01/19/1999 |
| 5844696 | Nitric esters from derivatives of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid and their preparation process Nitric esters from derivatives of 2-(2,6-dihalophenylamino) phenylacetoxyacetic acid with the formula (I), where: A.ident.F, Cl or Br; X.ident.O, NH or NR (R.ident.C1 -C8 alkyl); R1 and R2 independently.ident.... | 12/01/1998 |
| 5700947 | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation This invention is directed to nitric esters of derivatives of propionic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolylacetic acid, 5-benzoyl-1,2-dihydro-3H-pyrrolo1,2-a!pyrrole-1-carboxylic acid, 6-methoxy-2-napthylacetic acid, characterized in ... | 12/23/1997 |
| 5674894 | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators The current invention discloses novel amidine derivatives with nitric oxide donating property that can inhibit platelet aggregation and promote vasodilation in a single compound.... | 10/07/1997 |
| 5661129 | Organic nitrates containing a disulfide group as cardiovascular agents The invention relates to novel nitrates containing a disulphide group, and to processes for their preparation. The compounds can be used for the therapy of disorders of the cardiovascular system.... | 08/26/1997 |
| 5637738 | Processes for preparing 1,2-epoxy-1,2,3,4-tetrahydronaphthalenes Described herein is a process for the preparation of (1S,2R)-1,2-epoxy-1,2,3,4-tetrahydronaphthalene having the Formula (I): ##STR1## which comprises the steps of (a) hydrogenating the compound of Formula (II) to form cis-(1R, 2S)-1,2-dihydroxy-1,2,3... | 06/10/1997 |
| 5621000 | Nitric esters having a pharmacological activity and process for their preparation Nitric esters with pharmacological activity having general formula (I), their pharmaceutical utilisation and process for their preparation. ##STR1##... | 04/15/1997 |
| 5597847 | Nitric esters of derivatives of the 2-(2,6-di-halo-phenylamino) phenylacetic acid and process for their preparation Object of this invention are nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid, having the following general formula: ##STR1## wherein: A and B are selected from among hydrogen and linear or branched, substituted or... | 01/28/1997 |
| 5428061 | Organic nitrates and method for their preparation New organic nitrate compounds, formed by condensing a nitrato alkanoic acid with a sulfur-containing amino acid or peptide, which prevent nitrate tolerance or overcome existing tolerance and which are useful for the treatment of cardiac diseases including... | 06/27/1995 |
| 5284872 | Nitrato alkanoic acid derivatives, methods for their production, pharmaceutical compositions containing the derivatives and medicinal uses thereof New organic nitrate compounds, formed by condensing a nitrato alkanoic acid with a sulfur-containing amino acid or peptide followed by the reaction of the resulting product with an amino acid, N-acylamino acid, peptide or an N-acyl peptide to produce a th... | 02/08/1994 |
| 5214189 | N-(2-hydroxyethyl nitrate)-2,4,6,-trinitrobenzamide N-(2-Hydroxyethyl nitrate)-2,4,6-trinitrobenzamide which is an explosive h good thermal stability at 150° C.... | 05/25/1993 |
| 5194659 | High melting amino aromatic nitrate esters A nitrate ester which is 1,3-diamino-5-(hydroxyethylaminonitrate)-2,4,6-titrobenzene or 3-amino-3'-(hydroxyethylaminonitrate)-2,2',4,4',6,6'-hexanitrobiphenyl.... | 03/16/1993 |
| 5089652 | Nitrate ester preparation The process of the present invention provides a method of obtaining a high yield of water or acid soluble nitrate esters without the use of organic solvents in the nitration reaction or the production of unstable products or by-products. The process invol... | 02/18/1992 |
| 5049694 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance The invention relates to pharmaceutical compositions containing novel nitrate esters, of which it was found that they are useful for the treatment of ischemiatic heart diseases, decompensatio cordis, myocardial infarction and hypertension.... | 09/17/1991 |
| 4863949 | Aminopropanol derivatives, processes for the preparation thereof, the use thereof and pharmaceutical compositions containing them The present invention provides compounds of the general formula: ##STR1## wherein Ar is a substituted or unsubstituted aromatic or heteroaromatic radical, A is a straight-chained or branched alkylene chain containing up to 8 carbon atoms, a --CH... | 09/05/1989 |
| 4801596 | Nitroxy amino propanols for treating heart and circulatory diseases The present invention provides new aminopropanol derivatives of the general formula: ##STR1## wherein A is a direct bond, a straight-chained or branched alkylene chain containing up to 3 carbon atoms or a --CO--CH2 -- group; X is a di... | 01/31/1989 |
| 4780560 | Nitrate derivatives and vasodilators containing the same Novel nitrate derivatives are disclosed. As examples of said nitrate derivative are described N-(ଲ-hydroxyethyl)-5-(3,4,5-trimethoxyphenyl)2,4-pentadienoic acid amide nitrate, N-(ଲ-hydroxyethyl)-3,4,5-trimethoxycinnamic acid amide nitrate... | 10/25/1988 |
| 4340603 | Novel inotropic prodrugs Novel, transient inotropic prodrug forms of the N-(2-phenylethyl)-ω-phenylalkylamines, notably of dobutamine, have (i) the structural formula (I): ##STR1## with the proviso that at least one R1, R2 or OR1, when ... | 07/20/1982 |
| 4313956 | Novel sypathomimetic amine prodrugs Novel, transient prodrug forms of the phenolic dihydroxy sympathomimetic amines have (i) the structural formula (I): ##STR1## wherein X is O, S or NR5 ; n is 1 or 2; R1 is the monodehydroxylated residue of a phenolic, nuclear di... | 02/02/1982 |
| 4311706 | Novel dopa/dopamine prodrugs Novel, transient prodrug forms of dopa and dopamine have (i) the structural formula (I): ##STR1## wherein each R is independently selected from the group consisting of hydrogen, R3 -CO- and ##STR2## wherein X is O, S or NR6 | 01/19/1982 |
