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| Number | Title | Issue Date |
| 7371747 | Cyanoalkylamino derivatives as protease inhibitors The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by... | 05/13/2008 |
| 7268164 | Anti-epileptogenic agents Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent ictogenesis and epileptogenesis. Methods for preparing the compounds of the invention are also d... | 09/11/2007 |
| 7183240 | Additives for inhibiting the formation of gas hydrates The present invention relates to an additive, and its use for inhibiting nucleation, growth and agglomeration of gas hydrates by adding an effective amount of an inhibitor to a multiphasic mixture which tends to hydrate formation and consists of water, gas and optio... | 02/27/2007 |
| 6930112 | Anti-epileptogenic agents Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent ictogenesis and epileptogenesis. Methods for preparing the compounds of the invention are also d... | 08/16/2005 |
| 6800659 | Compounds for modulating cell proliferation Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I: ... | 10/05/2004 |
| 6790953 | Ether compounds The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a compo... | 09/14/2004 |
| 6624152 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 09/23/2003 |
| 6590106 | Amino acid derivatives and methods of making the same Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: ##STR1## R1, R2, and R22 are independently an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic ... | 07/08/2003 |
| 6410486 | Cycloalkylalkanecarboxamides and their preparation and use The present invention relates to novel cycloalkylalkane-carboxamides of the formula I ##STR1## where the substituents have the following meanings: A is C3 -C6 -cycloalkyl; R1 is C1 -C6 -alkyl or C2 | 06/25/2002 |
| 6344457 | Amino acid derivatives inhibiting extracellular matrix metalloproteinase and TNF alpha release The invention concerns compounds of general formula (X) in which Y represents in particular --CONHOH, R1 represents in particular a C1 -C5 alkyl group, AA represents an amino acid, or an amino acid sequence, and R3 | 02/05/2002 |
| 6306840 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/23/2001 |
| 6288264 | Process for preparing cyanoacetamide Cyanoacetamide is prepared without additional catalyst by esterification of crude cyanoacetic acid with a monohydric alcohol which forms an azeotrope with water and has 4 to 10 carbon atoms, reacting the resulting ester with ammonia in the presence of a b... | 09/11/2001 |
| 6284901 | Dinitrile intermediates for the synthesis of omapatrilat and methods for producing same Omapatrilat (I) is a potent inhibitor of angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) both in vitro and in vivo and is currently undergoing large scale clinical trials as an anti-hypertensive. Omapatrilat may be synthesized using th... | 09/04/2001 |
| 6265447 | Cycloalkylalkanecarboxamides and the production and use thereof The present invention relates to novel cycloalkylalkane-carboxamides of the formula I ##STR1## where the substituents have the following meanings: A is C3 -C6 -cycloalkyl; R1 is C1 -C6 -alkyl or C2 | 07/24/2001 |
| 6114566 | 4-cyano-3-hydroxybutanoyl hydrazines, derivatives and process for the preparation thereof Novel 4-cyano-3-hydroxybutanoyl hydrazides (10), particularly R-chiral intermediates are described. The intermediates are useful in preparing (R)-3-hydroxy-4-trimethylaminobutyric acid (L-carnitine) and R-4-amino-3-hydroxybutyric acid (GABOB) and chiral c... | 09/05/2000 |
| 6090970 | Production method of alkylated cyanoacetylurea A method for producing alkylated cyanoacetylurea from an easily obtainable starting material. An industrially available cyanoacetylurea and a carbonyl compound are reacted in a polar solvent under reducing conditions to alkylate cyanoacetylurea In additio... | 07/18/2000 |
| 5977170 | Elevation of HDL cholesterol by 4-[(aminothioxomethyl)hydrazono]-4-arylbutyl carbamates This invention relates to the treatment of atherosclerosis via raising the level of HDL cholesterol by administration of a compound of the formula ##STR1## wherein R1, R2, and R3 are independently hydrogen, C1 ... | 11/02/1999 |
| 5968975 | Elevation of HDL cholesterol by 2-[(aminothioxomethyl)-hydrazono]-2-arylethyl carbamates This invention relates to the treatment of atherosclerosis via raising the level of HDL cholesterol by administration of a compound of the formula ##STR1## wherein: R1, R2, and R3 are independently hydrogen, C1 ... | 10/19/1999 |
| 5767277 | Optically active ଲ-aminoalkoxyborane complex An optically active ଲ-aminoalkoxyborane complex of the formula (I): ##STR1## wherein R1 is C1 -C8 alkyl, C3 -C7 cycloalkyl, C7 -C11 aralkyl or C6 -C10... | 06/16/1998 |
| 5620831 | Cyanoguanidine derivatives, and thermosetting or photocurable, thermosetting resin composition using the same Disclosed are novel cyanoguanidine derivatives which are usable as an epoxy resin curing agent and are represented by the following general formula (1). A thermosetting resin composition and a photocurable and thermosetting resin composition containing th... | 04/15/1997 |
| 5489690 | Process for trans-6[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis An improved process for the preparation of trans-6-[2-(substituted-pyrrole-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where -metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and spe... | 02/06/1996 |
| 5468870 | Dyes and dye-donor elements for use in thermal dye sublimation transfer Dye-donor element for use according to thermal dye sublimation transfer comprising a support having thereon a dye layer containing a dye corresponding to the following formula ##STR1## wherein Z represents CN, COOR1 or CONR2 R | 11/21/1995 |
| 5401880 | Chemical prevention or reversal of cataract by phase separation inhibitors The present invention relate to methods and pharmaceutical reagents for decreasing the phase separation temperature and inhibiting the formation of high molecular with aggregates in eye lenses, thereby inhibiting or reversing cataract formation.... | 03/28/1995 |
| 5395974 | Lewis acid catalyzed ammonolysis of nylon The present invention relates to a method of reacting polyamides or mixtures thereof with ammonia to obtain a mixture of monomers. The reaction is carried out in the presence of certain Lewis Acid catalyst precursors.... | 03/07/1995 |
| 5347033 | Preparation of 5-cyanovaleramide A process for preparing 5-cyanovaleramide by reacting adiponitrile with water at from 50° to 200° C. in the presence of a supported unionized-copper catalyst comprises employing from 1 to 15 mol of water per mole of adiponitrile and a residence time of ... | 09/13/1994 |
| 5342952 | Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis An improved process for the preparation of trans-6-[2-(substituted-pyrrole-1-yl)alkyl]pyran-2-ones by a novel synthesis is described where -metalated N,N-disubstituted acetamide is converted in seven operations to the desired products, and spe... | 08/30/1994 |
| 5302756 | Ammonolysis of nylon Useful monomeric products are obtained in the reaction of nylon 6,6 with ammonia. Increased yield of monomer products from nylon 6,6 is obtained from ammonolysis when a mixture with nylon 6 is employed.... | 04/12/1994 |
| 5286893 | Alkenoic acid compounds for mechanism-based inactivation of dehydropeptidase activity Alkenoic acid compounds are described. The compounds which are dehydropeptidase inactivators contain a ##STR1## moiety which is substituted with a halomethylene or a cyano moiety as R3. The enzyme deprotonates the alpha --CH2 gr... | 02/15/1994 |
| 5149872 | Process for the preparation of oxalyl- and oxamyl-hydrazides A new process for preparing oxalyl- and oxamyl-hydrazides which comprises contacting oxamide or diacetyloxamide with the corresponding hydrazine derivative of formula R1 R2 N--NHR3 wherein R1 represents a hydrogen at... | 09/22/1992 |
| 5130456 | Bis(reissert compounds) from reaction of monoaldehyde, monoamine and diacid halide A bis Reissert can be formed by the initial reaction of an aliphatic or aromatic aldehyde (e.g., propionaldehyde) and primary amine (e.g., methylamine) to form a reaction product which is then reacted with a diacid chloride (e.g., adipoyl chloride).... | 07/14/1992 |
| 5110986 | Synthesis of N-t-alkyl-1,2-diacylhydrazines This application relates to a process for preparing a N-t-alkyl-1,2-diacylhydrazine by reacting a 1,3,4-oxadiazole with a tertiary alkyl cation precursor in the presence of a strong acid catalyst. Preferably, the 1,3,4-oxadiazole is a 2,5-disubstituted-1,... | 05/05/1992 |
| 5049698 | Process for manufacturing 2-chloro-1,3-diketo compounds A novel process for producing 2-chloro-1,3-diketo compounds of the formula ##STR1## wherein Q is an amino, substituted amino or hydrocarbyloxy group, e.g., --OCH3, wherein the 1,3-diketo precursor in solution in a low boiling alcohol is ne... | 09/17/1991 |
| 5041601 | Preparation of acyclic bis (reissert compounds) A bis Reissert can be formed by the initial reaction of an aromatic dialdehyde (e.g., terephthaldicaboxaldehyde) and primary amine (e.g., methylamine) to form a reaction product which is then reacted with an acid chloride (e.g., benzoyl chloride).... | 08/20/1991 |
| 5021602 | Reactive compounds containing perfluorocyclobutane rings Novel compounds have at least one perfluorocyclobutane ring and at least two functional groups suitable for forming condensation polymers. Preferably the compounds have a structures represented by Formula II: ##STR1## wherein R and R' independently r... | 06/04/1991 |
| 5017721 | Process for the preparation of oxalyl- and oxamyl-hydrazides A new process for preparing oxalyl- and oxamyl-hydrazides which comprises contacting oxamide or diacetyloxamide with the corresponding hydrazine derivative of formula R1 R2 N--NHR3 wherein R1 represents a hydrogen at... | 05/21/1991 |
| 5003099 | Method for the production of aminocyanoacetamide A large-scale industrial process for the production of aminocyanoacetamide is disclosed. A starting material is cyanoacetic acid ester, which is treated with a nitrous acid in a first step to a corresponding hydroxy-iminocyanoacetic acid ester. The hydrox... | 03/26/1991 |
| 4996348 | N-alkenoyl enamides, their preparation and the use thereof Novel N-alkenoyl enamide of the formula ##STR1## wherein R1 is hydrogen or methyl, R2 is hydrogen, C1 -C4 alkyl or halogen, and R3 and R4 are each independently of the other C1 -C | 02/26/1991 |
| 4978786 | Chemical process for the preparation of oxamide derivatives and compounds prepared thereby A process is described for the preparation of oxamide derivatives wherein one or both --NH2 groups are replaced by primary or secondary amino groups, through reaction of oxamide with a suitably selected amine of formula RR1 NH wherei... | 12/18/1990 |
| 4973730 | Preparation of serine-N,N-diacetic acid and derivatives as complexing agents and detergents containing same Serine-N,N-diacetic acid and derivatives thereof are prepared in various ways and used in particular as complexing agents, bleaching agent stabilizers and builders in detergents.... | 11/27/1990 |
| 4950666 | Difluoroalkane and difluoroalkenylalkane pesticides The present invention discloses compounds of the formula ##STR1## in which R is a 1,1-difluoroalkyl group or a 1,1-difluoroethenyl group having an even numbered carbon chain length of from 4 to 22 carbon atoms, pesticidal compositions thereof; and th... | 08/21/1990 |
