Class 558/442 - Additional carbonyl attached indirectly to the cyano group by nonionic bonding

Subclass of Class 558 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein plural carbonyl, -C(=O), groups
No. of patents: 125
Last issue date: 12/11/2012

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Number	Title	Issue Date
8329936	Method for producing cyanoacrylate esters in the presence of transition metal catalysts The present invention relates to a method for producing cyanoacrylic acid esters. The method is based substantially on a transesterification reaction, wherein the transesterification reaction is performed in the presence of at least one transition metal catalyst tha...	12/11/2012
8119829	Process of hydrocyanation of unsaturated carboxylic acid derivatives The present invention is directed to compositions of specific carboxylic acid, fatty acid or oil derivatives containing nitrile groups and methods of their preparation. The preparation involves a hydrocyanation reaction. A method of hydrogenating the nitrile contain...	02/21/2012
7557238	Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate In one aspect, the present invention provides a novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate, a key intermediate for the preparation of HMG-CoA reductase inhibitor. ...	07/07/2009
7534907	Absorbable α-cyanoacrylate compositions A monomer composition comprising at least one polymerizable alkyl ester α-cyanoacrylate monomer. Specifically, the α-cyanoacrylate monomer is an alkyl ester α-cyanoacrylate monomer of the general formula having a spacer R1:	05/19/2009
7371855	Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ...	05/13/2008
7361771	Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ...	04/22/2008
7309754	Stable encapsulant fluid capable of undergoing reversible Diels-Alder polymerization An encapsulant fluid is provided comprising a mixture of a diene-containing compound and a dienophilic compound. At least one of the diene-containing and the dienophilic compounds is protected so that the compounds do not substantially react with each other at room ...	12/18/2007
7238828	Absorbable α-cyanoacrylate compositions A monomer composition comprising at least one polymerizable alkyl ester α-cyanoacrylate monomer. Specifically, the α-cyanoacrylate monomer is an alkyl ester α-cyanoacrylate monomer of the general formula having a spacer R1:	07/03/2007
7223745	Proteasome inhibitors and methods of using the same The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating disease...	05/29/2007
7205418	Process for the preparation of optically active 2-[6-(substituted alkyl)-1,3-dioxan-4-yl]acetic acid derivatives The present invention relates to new process for preparing as a key chiral intermediate compound of formula (I) obtained from an epoxy-β-hydroxy carboxylic acid ester of formula (II) prepared from epoxide compound of formula (III), in which said compound of formula...	04/17/2007
7193101	Esters with antimicrobial, bioresistant and fungal resistant properties A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and fungal resistant properties for metal working fluids (MWF)s, coatings, plastics, and medical devices. The mo...	03/20/2007
7183408	Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ...	02/27/2007
7169812	Process for producing injectable gabapentin compositions Injectable compositions containing gabapentin and processes for preparing sterile injectable compositions containing gabapentin are discussed. The process includes subjecting the compositions to heat. Heating results in increased production of gabapentin lactam, whi...	01/30/2007
7102027	Adamantanetricarboxylic acid derivatives An adamantanetricarboxylic acid derivative is represented by following Formula (1): wherein X is a hydrogen atom or a hydrocarbon group; and R1, R2 and R3 may be the same as or di...	09/05/2006
7067544	Epothilones C, D, E and F, preparation and compositions The present invention relates to epothilones C, D, E and F, their preparation and their use for the production of therapeutic compositions and compositions for plant protection. ...	06/27/2006
7045532	ACE-2 modulating compounds and methods of use thereof ACE-2 inhibitors for the treatment of body weight and related disorders are disclosed. ACE-2 inhibitors include peptides and small molecules. Examples of small molecule ACE-2 inhibitors include compounds of formula (I): Z-Λ (I) Wherein Z is...	05/16/2006
6972335	Synthesis of epothilones, intermediates thereto, analogues and uses thereof The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention furth...	12/06/2005
6962994	Process for the synthesis of 1,3-diols An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alkylborane spe...	11/08/2005
6933393	Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight ...	08/23/2005
6921769	Synthesis of epothilones, intermediates thereto and analogues thereof The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions com...	07/26/2005
6828456	2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors The present invention relates to 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors. ...	12/07/2004
6781009	Method for producing 4-cyano-3-oxobutanoate and 4-ctano-3-hydroxybutanoate There are provided a method for producing a 4-cyano-3-oxobutanoate by reacting a 4-halo-3-oxobutanoate with an alkaline metal cyanide in methanol, a process for producing 4-cyano-3-hydroxybutanoate therefrom. ...	08/24/2004
6730803	Synthetic intermediate for epothilone derivative and production method thereof The β-keto ester compound, β-hydroxy acid compound and acetonide form of a 1,3-diol derivative of the formulas (I), (V) and (VIII) wherein each symbol is as defined in the specification, are useful as a synthetic inter...	05/04/2004
6359061	Amide compound libraries Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays in order to identify pharmaceutically useful compounds. ...	03/19/2002
6288263	Intermediates for the preparation of N-[2-(carboxymethoxy)ethyl]-N-(carboxymethyl)glycine Compounds represented by the formula ##STR1## wherein R and R1 independently represent H, --CH2 CN or --CH2 CO2 X, with the proviso that R and R1 can not be both H or --CH2 CO2 X...	09/11/2001
6046353	Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid A method of making (&#b1;)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with ##STR1## to form primarily ##STR2## reacting the ##STR3## with a cyanide source to form ##STR4## decarboxylating...	04/04/2000
5817603	Substituted cyclohexene-1,2-dicarboxylic acid derivatives and intermediates for their preparation Substituted cyclohexene-1,2-dicarboxylic acid derivatives I ##STR1## where R1, R2, R3, R4, R5 and R6 are herein defined, or the agriculturally useful salts of Ia and Ib and intermediates ...	10/06/1998
5559218	2-aroylcyclohexanediones and their use as herbicides or plant growth-regulating agents 2-Aroylcyclohexanediones I ##STR1## (A is C1 -C6 -alkylene; R1 is substituted phenyl or hetaryl which may furthermore carry a fused ring; R2 -R5 are each hydrogen or C1 -C4 ...	09/24/1996
5481018	Amino nitrile intermediate for the preparation of alanine diacetic acid A novel intermediate useful in the synthesis of alpha-alanine diacetic acid or its salts is disclosed. The intermediate can be formed by contacting alanine with glycolonitrile under alkaline conditions or glycine with lactonitrile to form an aminonitrile ...	01/02/1996
5468870	Dyes and dye-donor elements for use in thermal dye sublimation transfer Dye-donor element for use according to thermal dye sublimation transfer comprising a support having thereon a dye layer containing a dye corresponding to the following formula ##STR1## wherein Z represents CN, COOR1 or CONR2 R	11/21/1995
5411987	Fungicidal substituted amino acid amides Combating fungi with substituted amine acid derivatives of the formula ##STR1## in which R1 represents alkyl, alkenyl, alkinyl, halogenoalkyl, halogenoalkenyl, halogenoalkinyl, cycloalkyl or cycloalkenyl, R2, R3, R4	05/02/1995
5412146	Process for the preparation of 2-cyanoacetoxypropionic esters For the preparation of 2-cyanoacetoxypropionic esters, a mixture of lactic ester and cyanoacetic ester is introduced, an alkali metal alcoholate is added as catalyst and the mixture is heated while the alcohol eliminated during the course of the reaction ...	05/02/1995
5380850	(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, a...	01/10/1995
5312956	Synthesis of low viscosity non-functional terminated polymers A non-functional liquid rubber is prepared by the solution polymerization of vinyl monomers. The polymer may be a homopolymer or a copolymer. As a copolymer the preferred monomers are a conjugated diene and a vinyl substituted nitrile such as acrylonitril...	05/17/1994
5286893	Alkenoic acid compounds for mechanism-based inactivation of dehydropeptidase activity Alkenoic acid compounds are described. The compounds which are dehydropeptidase inactivators contain a ##STR1## moiety which is substituted with a halomethylene or a cyano moiety as R3. The enzyme deprotonates the alpha --CH2 gr...	02/15/1994
5210315	Process for producing ଱-hydroxyketones A process for producing an ଱-hydroxyketone represented by formula (I): ##STR1## wherein R1 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted aralkyl group, or an alkoxycarbonyl group; and R	05/11/1993
5210271	Intermediates for the production of diethanolamine A method of producing diethanolamine derivatives or acid salts thereof according to the reaction scheme: ##STR1## wherein X stands for a leaving group; and R1 stands for an alkylcarbamoyl group, which provides an industrially advantageous ...	05/11/1993
5177243	N,N'-diacetic acid-N'-cyanomethyl, salts thereof, and their preparation A novel intermediate useful in the synthesis of ethylenediaminetriacetic acid (ED3A) or its salts. A salt of N,N'-ethylenediaminediacetic acid (ED2AH2) is condensed with formaldehyde to form a stable 5-membered ring intermediate. The addition o...	01/05/1993
5169979	Curing component, and the use thereof The invention relates to a curing component (A) containing active CH groups, which contains at least two groups of the formula (I) ##STR1## or structural units of the formula (I') or (I") ##STR2## in which: A denotes ##STR3## X and Y a...	12/08/1992
5155251	Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate An improved process for the preparation of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate is described where a halo hydroxyester or other activated dihydroxyester is converted in two steps to the desired product....	10/13/1992

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Class 558/442 - Additional carbonyl attached indirectly to the cyano group by nonionic bonding