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| Number | Title | Issue Date |
| 8138368 | Process for producing acrylonitrile compound There is provided a process for stereoselectively producing E-form of 3-acyloxyacrylonitrile compound (3) or Z-form which comprises reacting 3-oxopropionitrile compound (1) with an acid chloride (2), characterized in that the reaction is conducted with removal of hy... | 03/20/2012 |
| 8134023 | Preparation of pregabalin and related compounds Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed. ... | 03/13/2012 |
| 8044227 | Preparation of pregabalin and related compounds Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed. ... | 10/25/2011 |
| 7737294 | Process of hydrocyanation of unsaturated carboxylic acid derivatives The present invention is directed to compositions of specific carboxylic acid, fatty acid or oil derivatives containing nitrile groups and methods of their preparation. The preparation involves a hydrocyanation reaction. A method of hydrgenating the nitrile containi... | 06/15/2010 |
| 7560585 | Process for preparing (S)- alpha-cyano-3-phenoxybenzyl-(S)-2-(4-chlorophenyl)-isovalerate The present invention relates to an environmentally benign process for the preparation of (S)-α-cyano-3-phenoxybenzyl-(S)-2-(4-chlorophenyl)isovalerate from its diastereomeric mixture (RS)-α-cyano-3-phenoxybenzyl-(S)-2-(4-chlorophenyl) isovalerate. ... | 07/14/2009 |
| 7439266 | Malononitrile compound and use thereof The present invention relates to a novel malononitrile compound represented by the formula (A): wherein, R1 represents C1 to C6 alkyl that may be substituted with halogen, C2 to C6 alkenyl that may be substituted with halogen, etc; R2 represent... | 10/21/2008 |
| 7358382 | Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothil... | 04/15/2008 |
| 7238828 | Absorbable α-cyanoacrylate compositions A monomer composition comprising at least one polymerizable alkyl ester α-cyanoacrylate monomer. Specifically, the α-cyanoacrylate monomer is an alkyl ester α-cyanoacrylate monomer of the general formula having a spacer R1: | 07/03/2007 |
| 7232920 | Process for stereoselective reduction of β-ketoesters In one aspect, the invention provides a process for the preparation of compounds of Formula I wherein R1 is —CN, —OP, alkyl, aryl or heteroaryl; wherein P represents any su... | 06/19/2007 |
| 7193101 | Esters with antimicrobial, bioresistant and fungal resistant properties A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and fungal resistant properties for metal working fluids (MWF)s, coatings, plastics, and medical devices. The mo... | 03/20/2007 |
| 7078555 | Process for making 5-cyanovaleric acid, adipic acid or dimethyl adipate Disclosed in a process for making (1) a compound of the formula NC—CH2—CH2—CH2—CH2—CO2R′, wherein R′ is H or C1 to C12 alkyl, or (2) adipic acid or (3) dimethyl adipate, using... | 07/18/2006 |
| 7041199 | Process and device for hydrolytically obtaining a carboxylic acid alcohol from the corresponding carboxylate A process and a device for the catalytic hydrolysis of a carboxylate, e.g., methyl acetate, ethyl acetate, i- or n-propyl acetate, i- or n-butyl acetate, allyl acetate and methyl formate, into the corresponding carboxylic acid and alcohol, by a combination of a pre-... | 05/09/2006 |
| 7026473 | Process for the carbonylation of pentenenitrile Processes to prepare 5-cyanovaleric acid or its ester are provided, by carbonylation of a pentenenitrile, wherein pentenenitrile is reacted with carbon monoxide and water and/or an alcohol in the presence of a catalyst system. The catalyst system contains: ... | 04/11/2006 |
| 7012158 | Processes for the production of α-difluoromethyl ornithine (DFMO) Provided are processes and synthetic intermediates useful for the preparation of α-difluoromethylornithine (DFMO) having the formula ... | 03/14/2006 |
| 6946570 | Ester synthesis This invention relates to a process for the production of lower aliphatic esters by reacting a lower olefin with a saturated lower aliphatic mono-carboxylic acid in the vapor phase in the presence of a heteropolyacid catalyst in a plurality of reactors set up in ser... | 09/20/2005 |
| 6891059 | Asymmetric synthesis of pregabalin This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders, pain, and psychotic disorde... | 05/10/2005 |
| 6864385 | Process for the preparation of 4-haloalkylnicotinonitriles 4-Haloalkylnicotinonitriles having the formula (I) which are suitable as intermediates in the preparation of pesticides, are obtained by: (a) reacting a 3-amino-1-haloalkyl-2-propen-1-one RF... | 03/08/2005 |
| 6843890 | Purification and recovery of acetonitrile from waste solvent acetonitrile A process of treating waste solvent acetonitrile streams which contain at least one water extractable impurity such as isopropyl acetate to remove substantially all of the impurity by distilling the waste solvent acetonitrile in the presence of water for a time suff... | 01/18/2005 |
| 6743911 | Process for the carbonylation of pentenenitrile Processes to prepare 5-cyanovaleric acid or its ester are provided, by carbonylation of a pentenenitrile, wherein pentenenitrile is reacted with carbon monoxide and water and/or an alcohol in the presence of a catalyst system. The catalyst system contains: (a... | 06/01/2004 |
| 6730809 | Processes for the production of α-difluoromethyl ornithine (DFMO) Provided are processes and synthetic intermediates useful for the preparation of α-difluoromethylornithine (DFMO) having the formula ... | 05/04/2004 |
| 6627772 | Preparation of N-[2-(carboxymethoxy) ethyl]-N-(carboxymethyl) glycine Compounds represented by the formula ##STR1## wherein R and R1 independently represent H, --CH2 CN or --CH2 CO2 X, with the proviso that R and R1 can not be both H or --CH2 CO2 X... | 09/30/2003 |
| 6590106 | Amino acid derivatives and methods of making the same Disclosed are novel compounds represented by Structural Formula II, IX or XXVIII: ##STR1## R1, R2, and R22 are independently an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic ... | 07/08/2003 |
| 6555706 | Process for making iminodiacetic acid compounds from monoethanolamine substrates This invention is directed to a process for making an iminodiacetic acid compound from a monoethanolamine substrate having the formula: ##STR1## wherein R1 is hydrogen, hydrocarbyl, or substituted hydrocarbyl. The process includes a series of r... | 04/29/2003 |
| 6492553 | Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds A method for preparing a N-[(aliphatic or aromatic)carbonyl)]-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that are useful for preparing such compounds.... | 12/10/2002 |
| 6433213 | Process for the synthesis of 1,3-diols An improved process for the preparation of cis-1,3-diols is described where a beta hydroxy ketone is treated with a trialkylborane or dialkylalkoxyborane or a mixture of a trialkylborane and a dialkylalkoxyborane followed by recovery and reuse of the alky... | 08/13/2002 |
| 6355490 | Attached tags for use in combinatorial chemistry synthesis The present invention relates to a process of coding and identifying individual members of a chemical combinatorial library synthesized on a plurality of solid supports which undergo mix and split synthesis. The process provides for tagging the solid supp... | 03/12/2002 |
| 6346640 | Method for producing cyanovaleric acid or esters thereof The process comprises reacting 2-, 3- or 4-pentenenitrile or mixtures thereof with carbon monoxide and a hydroxyl compound in the presence of a catalyst system comprising (i) a palladium(II) compound, (ii) a bidentate diphosphine ligand and (iii) an anion... | 02/12/2002 |
| 6326508 | Purification and recovery of acetonitrile The method of the present invention comprises feeding crude acetonitrile containing acrylonitrile as an impurity and water into the upper portion of a distillation column, distilling the crude acetonitrile in the presence of the water for a time sufficien... | 12/04/2001 |
| 6288263 | Intermediates for the preparation of N-[2-(carboxymethoxy)ethyl]-N-(carboxymethyl)glycine Compounds represented by the formula ##STR1## wherein R and R1 independently represent H, --CH2 CN or --CH2 CO2 X, with the proviso that R and R1 can not be both H or --CH2 CO2 X... | 09/11/2001 |
| 6075055 | Phenylalkane amide derivatives and agricultural or horticultural fungicides A phenylalkane amide compound having the formula (1): ##STR1## wherein R1 -R4, X, n, Y, Z and Q are as defined herein. The compound is useful as an agricultural or horticultural fungicide.... | 06/13/2000 |
| 5973200 | Process for the preparation of 2-hydroxy-4-(methylthio) butanoic acid or methionine by mercaptan addition A process for the free-radical addition of a mercaptan to a nonconjugated olefinic substrate having a terminal carbon-carbon double bond is disclosed. 2-Hydroxy-4-(ethylthio)butanoic acid (HMBA) or methionine can be prepared using this method. The nonconj... | 10/26/1999 |
| 5908953 | Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester Crude (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester, obtained by subjecting an (S)-4-halogeno-3-hydroxybutyric acid lower alkyl ester to a cyano-introducing reaction, is purified by distillation carried out in the presence of a solvent having a boil... | 06/01/1999 |
| 5908954 | Preparation of lactams from aliphatic , ω-dinitriles A process for the preparation of five-membered or six-membered ring lactams from aliphatic ,ω-dinitriles has been developed. In the process an aliphatic ,ω-dinitrile is first converted to an ammonium salt of an ω-nitrile-carboxylic acid i... | 06/01/1999 |
| 5902895 | Method for the continuous production of esters of thermally unstable acids A method for the continuous production of esters of thermally unstable acids by the esterification, with or without a catalyst, of the acids with alcohols is provided. The method involves esterification at temperatures of approximately 80° C. to approxim... | 05/11/1999 |
| 5847193 | Labelled compound The present invention provides a labelled ଲ-cyano-L-alanine and a γ-cyano--aminobutyric acid, of which cyano group carbon is labelled with radionuclide 11 C or 14 C, or stable isotope 13 C. The present invent... | 12/08/1998 |
| 5840956 | Method of making (S)-3-(Aminomethyl)-5-Methylhexanoic acid A method of making (&#b1;)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with ##STR1## to form primarily ##STR2## reacting the ##STR3## with a cyanide source to form ##STR4## decarboxylating... | 11/24/1998 |
| 5817613 | Amino nitrile intermediate for the preparation of 2-hydroxyethyl iminodiacetic acid A novel intermediate useful in the synthesis of 2-hydroxyethyl iminodiacetic acid is disclosed. The intermediate can be formed by contacting 2-hydroxyethyl amine with glycolonitrile to form an aminonitrile which can be hydrolyzed and contacted with additi... | 10/06/1998 |
| 5817603 | Substituted cyclohexene-1,2-dicarboxylic acid derivatives and intermediates for their preparation Substituted cyclohexene-1,2-dicarboxylic acid derivatives I ##STR1## where R1, R2, R3, R4, R5 and R6 are herein defined, or the agriculturally useful salts of Ia and Ib and intermediates ... | 10/06/1998 |
| 5726341 | Amine nitrile intermediate for the preparation of 2-hydroxyethyl iminodiacetic acid A novel intermediate useful in the synthesis of 2-hydroxyethyl iminodiacetic acid is disclosed. The intermediate can be formed by contacting 2-hydroxyethyl amine with glycolonitrile to form an aminonitrile which can be hydrolyzed and contacted with additi... | 03/10/1998 |
| 5488130 | Amino nitrile intermediate for the preparation of 2-hydroxypropyl iminodiacetic acid A novel intermediate useful in the synthesis of 2-hydroxypropyl iminodiacetic acid is disclosed. The intermediate can be formed by contacting 2-hydroxypropyl amine with glycolonitrile to form an aminonitrile which can be hydrolyzed and contacted with addi... | 01/30/1996 |
