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| Number | Title | Issue Date |
| 7572930 | Process for preparing 1-(mercaptomethyl)cyclopropaneacetic acid, a useful intermediate in the preparation of montelukast and salts thereof The present invention provides a novel montelukast intermediate and a simple and straightforward process for preparing it. According to the present invention, by using this intermediate and the process, essentially as described herein, montelukast acid and sa... | 08/11/2009 |
| 7407959 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s... | 08/05/2008 |
| 7384897 | Cyclopropanecarbonitrile analogues and their use in perfume compositions The present invention is directed to the novel cyclopropanated cyclohexyl ester compounds of the general formula: ... | 06/10/2008 |
| 7375134 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s... | 05/20/2008 |
| 7164047 | Processes for preparation of cyclopropylethanol, cyclopropylacetonitorile and intermediates of both A process for preparation of cyclopropylethanol, which comprises subjecting a 3-cyclopropyl-2,3-epoxypropionic acid ester to solvolysis, treating the product of the solvolysis with an acid to obtain cyclopropylacetaldehyde, and reducing the obtained cyclopropylaceta... | 01/16/2007 |
| 6500978 | Process for producing cyclopropanecarbonitrile A process for producing cyclopropanecarbonitrile involves reacting cyclopropanecarbaldoxime with acetic anhydride to obtain a mixture containing acetic acid and cyclopropanecarbonitrile. The acetic acid can be removed from the mixture through azeotropic d... | 12/31/2002 |
| 6433212 | Synthesis of new polynitriles from cycloaliphatic vicinal primary diamines Compounds of the structure: ##STR1## wherein R1 is H, a C1 to C4 alkyl, or a substituted C1 to C4 alkyl; R2 is H or a cyanoethyl; n is an integer of 1 to 4, and y is 1 or 2, and a method for making the compounds. The compounds are ma... | 08/13/2002 |
| 6323346 | Process for producing aziridine compounds In the presence of an iridium compound, an imine of the following formula (1): ##STR1## wherein R1, R2 and R3 are each, identical to or different from one another, a hydrogen atom or a non-reactive organic group, where ... | 11/27/2001 |
| 6313339 | Aryl and heteroarylcylopropyl oxime ethers and their use as fungicides and insecticides Certain cyclopropyl oxime ethers substituted by aryl and heterocyclic moieties possess broad spectrum fungicidal and insecticidal properties. These compounds are disclosed along with compositions containing these compounds and methods for controlling fung... | 11/06/2001 |
| 6297230 | Cyanoaziridines for treating cancer The present invention is directed to novel anti-cancer compounds of the formula. ##STR1## wherein X is CN, R4 is hydrogen or lower alkyl; and R5 is lower alkyl, lower cycloalkyl, alkenyl, alkynyl, aryl, monosubstituted aryl, disubsti... | 10/02/2001 |
| 6046353 | Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid A method of making (&#b1;)-3-(aminomethyl)-5-methylhexanoic acid that comprises condensing isovaleraldehyde with ##STR1## to form primarily ##STR2## reacting the ##STR3## with a cyanide source to form ##STR4## decarboxylating... | 04/04/2000 |
| 5925676 | Ester compounds pesticidal compositions containing the same and itermediates for synthesis thereof An ester compound represented by the formula ##STR1## wherein R1 and R2 may be the same or different and each represent a C1 -C6 alkyl group, or other specified groups, which may be optionally substituted w... | 07/20/1999 |
| 5856518 | Production process of cyclic compound This invention is to provide a compound represented by the following formula (I) and a compound represented by the following formula (II) useful as an antibacterial agent which is obtained by the compound of folmula (I), and also to provide a novel synthe... | 01/05/1999 |
| 5550258 | Ester compound, active agent for controlling noxious insect pests containing the same as active ingredient, intermediate for production of the ester compound, and process for producing the intermediate The present invention provides an ester compound represented by a formula I: ##STR1## wherein R1 denotes a hydrogen atom or a methyl group; R2 represents a 1-methyl-2-propenyl group, a 1-methyl-2-propynyl group, a 3,3-dihal... | 08/27/1996 |
| 5530022 | Esters of 2,2-dimethyl-3-(3,3,3-trifluoro-1-propenyl)-cyclopropane carboxylic acid A compound in all possible stereoisomeric forms and their mixtures of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## having excellent pesticidal, particularly insecticidal, properties.... | 06/25/1996 |
| 5504112 | Pyrethrinoid esters A compound in all possible stereoisomeric forms and their mixtures of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, --CN, alkyl, alkenyl and alkynyl of up to 4 carbon atoms and aralkynyl of up to 10 carbon ato... | 04/02/1996 |
| 5502234 | Process for the preparation and separation of cyclopropanecarbonitrile Disclosed is a novel process for the preparation and separation of cyclopropanecarbonitrile (CPCN) from cyclopropropanecarboxaldehyde (CPCA) using a combination of three process steps. The process involves the steps of (1) reacting (CPCA) with hydroxylami... | 03/26/1996 |
| 5380911 | Process for the manufacture of cyclopropylnitrile An improved manufacturing procedure for the preparation and isolation of cyclopropylnitrile is provided. 4-Halobutyronitrile is reacted with an alkali metal base in the presence of an aprotic polar solvent, an inorganic salt and a catalytic amount of wate... | 01/10/1995 |
| 5336670 | 2,2-dimethyl-3-(but-1-en-3-ynyl)-cyclopropane carboxylates Compounds of the formula ##STR1## wherein X is hydrogen, halogen or an optionally substituted alkyl, Y is selected from the group consisting of hydrogen, halogen optionally substituted alkyl, an optionally substituted aryl or arylalkyl, --(CH | 08/09/1994 |
| 5334745 | Preparation of 3-aminopropionitriles 3-Aminopropionitriles of the general formula I ##STR1## where R1,R2,R3,R4 and R5 independently of one another are each hydrogen, C1 -C20 -alkyl, C1 -C8 ... | 08/02/1994 |
| 5332826 | Process for preparing aminoacetonitriles in one vessel This invention relates to a process for preparing aminoacetonitriles in one vessel. The process involves the steps of: (A) reacting an alkali metal cyanide with an aldehyde in water to form a cyanohydrin; (B) extracting the cyanohydrin formed in Step (A) ... | 07/26/1994 |
| 5332825 | Single vessel synthesis of aminoacetonitriles This invention relates to two processes for preparing aminoacetonitriles in one vessel under anhydrous conditions. Process I involves the steps of: (A) reacting trimethylsilyl cyanide and an aldehyde in a water miscible amide solvent to obtain a silyl blo... | 07/26/1994 |
| 5260285 | Substituted imidazopyridazines as angiotensin II antagonists Novel substituted imidazopyridazines of formula (I) which are useful as angiotensin II antagonists, are disclosed. ##STR1##... | 11/09/1993 |
| 5241087 | Enantiomeric enrichment of cyanohydrins A method of enantiomerically enriching chiral cyanohydrins is disclosed that involves selective cleavage of the unwanted enantiomer into its cleavage products HCN and the corresponding aldehyde or ketone by use of an enantioselective dehydrocyanation cata... | 08/31/1993 |
| 5175170 | ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as cycloalkyl/cycloalkylkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest of the formula ##STR1## ... | 12/29/1992 |
| 5169973 | Synthesis of alpha-aminonitriles Alpha-aminonitriles can be synthesized by the reaction, at ambient temperature without use of catalyst, of essentially stoichiometric amounts of amine, aldehyde (either monoaldehyde or dialdehyde) and trimethylsilyl cyanide.... | 12/08/1992 |
| 5126349 | Composition and use of substituted 3-thio-2-propynenitriles as an industrial antimicrobial Substituted 3-thio-2-propynenitriles are prepared which correspond to the formula: R--S--C.tbd.C--C.tbd.N wherein R is an alkyl, cyclic alkyl, aryl, or heterocyclo group. These compounds have been found to exhibit a high degree of antimicrobial activity in ind... | 06/30/1992 |
| 5106984 | 2-hydrocarbyl-3,6-dichloropyridines and their preparation 2-Hydrocarbyl-3,6-dichloropyridines are prepared from dichloromethyl hydrocarbyl ketones and acrylonitrile in a two-step process involving an addition reaction under basic conditions to form intermediate 1,1-dichloro-3-cyanopropyl hydrocarbyl ketones and ... | 04/21/1992 |
| 5077427 | Preparation of alpha-formylamino nitriles A process for preparing -formylamino nitriles of the formula I ##STR1## where R1 and R2 are each hydrogen or unsubstituted or substituted, with substituents which are inert under the reaction conditions, aliphatic or hete... | 12/31/1991 |
| 5077426 | Preparation of alpha-formylamino nitriles A process for preparing -formylamino nitriles of the formula Ia ##STR1## and Ib ##STR2## where R1, R2, R3 and R4 are identical or different and each is hydrogen or unsubstituted or substituted, ... | 12/31/1991 |
| 5030655 | Novel cyclopropane carboxylates A compound selected from the group consisting of all possible isomeric forms and mixtures thereof of a compound of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl and... | 07/09/1991 |
| 4985582 | Pesticidal compounds Bicyclo-[2,2,1]-heptanes, bicyclo-[2,2,2]-octanes and bicyclo-[2,2,3]-nonanes, having 2 or 3 ring hetero atoms selected from O, S and N substituted at the 1-position by a carbocyclic group other than an alkynylphenyl group, and substituted at the 4-positi... | 01/15/1991 |
| 4945177 | Antimicrobially active nitriles and the production thereof Novel 2,2-dibromo-3-oxonitriles of Formula I, R--CO--CBr2 --CN (I) in which R represents in each case a possibly substituted or unsubstituted aliphatic, cycloaliphatic, aromatic or heterocyclic group, with the ex... | 07/31/1990 |
| 4920231 | Process of braking triflouromethyl compounds A process for the preparation of trifluoromethylvinyl compounds in all their possible streoisomeric forms and mixtures thereof comprising reacting a salt of trifluoroacetic acid with a halovinyl compound in the presence of a cuprous salt to obtain the sam... | 04/24/1990 |
| 4888357 | Antiarthritic ଲ-cycloalkyl-ଲ-oxopropionitriles Disclosed herein are novel ଲ-cycloalkyl-ଲ-oxopropionitriles which exhibit anti-inflammatory/antiarthritic activities.... | 12/19/1989 |
| 4886891 | Process for preparing 1,1-disubstituted ethylene derivative by reaction of lead with a carbinol derivative The present invention provides a process for preparing a 1,1-disubstituted ethylene derivative of the formula ##STR1## which comprises reacting lead with a carbinol derivative of the formula ##STR2## wherein R1, R2, R3... | 12/12/1989 |
| 4808749 | Cyclopropane carboxylic esters and acids Novel esters in all possible isomeric forms of the formula ##STR1## wherein R is selected from the group consisting of (a) optionally unsaturated alkyl of 1 to 8 carbon atoms and optionally unsaturated cycloalkyl or cycloalkyl-alkyl of 3 to 8 carbon ... | 02/28/1989 |
| 4785019 | N-cyanoalkyl-N-haloalkylthio carboxamides as fungicides N-cyanoalkyl-N-haloalkylthio alkyl-, aryl- and aralkyl-carboxamides of the general formula: ##STR1## wherein R is alkyl of 1 to 10 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, lower alkenyl of 2 to 6 carbon atoms or lower alkynyl of 2 to 6 ... | 11/15/1988 |
| 4780129 | Cycloxexenone derivatives, their manufacture and their use for controlling undesirable plant growth Cyclohexenone derivatves of the formula ##STR1## where R1 is alkyl, R2 is alkyl, unsubstituted or substituted alkenyl or alkynyl, A is alkoxycarbonyl, carboxyl, cyano or trifluoromethyl, B is hydrogen or methyl, X is straight-ch... | 10/25/1988 |
| 4728743 | Process for the production of 3-oxonitriles 3-oxonitriles are produced by reaction of carboxylic acid esters with carboxylic acid nitriles in the presence of 70 to 80% suspension of sodium hydride in white oil. The oxonitrile are intermediate products for the production of 3-oxocarboxylic acid amid... | 03/01/1988 |
