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"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 7407959 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s... | 08/05/2008 |
| 7375134 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s... | 05/20/2008 |
| 7098362 | Processes for the preparation of gabapentin The present invention relates to new processes for the preparation of gabapentin by the desilylation of a silylated gabapentin or by the silylation-desilylation of an acid addition salt of gabapentin with a silylating agent. ... | 08/29/2006 |
| 6906216 | Process for the synthesis of N-Substituted β-amino nitriles through the ring opening of aziridines The present invention comprises the simultaneous ring opening and concomitant N-substitution of various N-tosyl aziridines with different aliphatic and aromatic nitriles in presence of catalytic amount of metal triflates to afford different N-substituted β-amino ni... | 06/14/2005 |
| 6861391 | Trifluoromethyl-substituted spirocyclic ketoenols Trifluoromethyl-substituted spirocyclic ketoenols of the formula (I) are provided wherein Het represents one of the groups and G, V, W, X, Y, and Z are as defin... | 03/01/2005 |
| 6686495 | Process for the preparation of mono-, bi- or poly-functional biaryls A process for the preparation of mono-, bi- or poly-functional biaryls in the presence of a metal complex of the general formula IV ##STR1## as catalyst.... | 02/03/2004 |
| 6538148 | Process for preparing a cyclic amino acid anticonvulsant compound An improved process for the preparation of a cyclic amino acid by a novel synthesis is described where benzonitrile is treated with an alkali metal and an amine under Birch reduction conditions to generate in situ an anionic intermediate which is alkylate... | 03/25/2003 |
| 6245932 | Cyanoethylation of cycloaliphatic vicinal primary diamines A process for the cyanoethylation of substituted cycloaliphatic vicinal diamines which comprises reacting acrylonitrile and a diamine in the presence water as catalyst. Cyanoethylated methylcyclohexylamines are readily prepared in the presence of water.... | 06/12/2001 |
| 5948933 | Tropane analogs and methods for inhibition of monoamine transport New tropane analogs that bind to monoamine transporters are described, particularly, 8-aza, 8carbo and 8-oxo tropanes having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain pr... | 09/07/1999 |
| 5853613 | Chiral cyclohexyl compounds The present invention describes liquid crystal compounds which are suitable for use in liquid crystal devices including those which exploit the electroclinic effect.... | 12/29/1998 |
| 5817603 | Substituted cyclohexene-1,2-dicarboxylic acid derivatives and intermediates for their preparation Substituted cyclohexene-1,2-dicarboxylic acid derivatives I ##STR1## where R1, R2, R3, R4, R5 and R6 are herein defined, or the agriculturally useful salts of Ia and Ib and intermediates ... | 10/06/1998 |
| 5763483 | Carbocyclic compounds Novel carbocyclic compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of... | 06/09/1998 |
| 5693845 | Cyanocycloalkylacetic acid and ester intermediates for preparing cyclic amino acid anticonvulsant compounds Novel cyanocycloalkylacetic acids and esters as well as salts thereof and in particular 1-cyanocyclohexaneacetic acid and ethyl 1-cyanocyclohexaneacetate are described which are useful as intermediates in a process for the preparation of cyclic amino acid... | 12/02/1997 |
| 5616718 | 2-cyano-1-aminobenzene compounds A compound having the formula: ##STR1## wherein W, X, Y, and Z are as defined in the specification is useful for making 2,4-diaminoquinazolines.... | 04/01/1997 |
| 5552438 | Compounds useful for treating allergic and inflammatory diseases Novel compounds of Formula (I) ##STR1## where X4 is a substituted cyclohexane or cyclohexane group and the other radicals are defined herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment o... | 09/03/1996 |
| 5516928 | Preparaion of 3.cyano-3,5,5-trimethylcyclohexanone A process for the preparation of 3-cyano-3,5,5-trimethylcyclohexanone by the reaction of isophorone with hydrogen cyanide in the presence of quaternary ammonium catalysts at temperatures ranging from 80° to 180° C. and pressures ranging from 0.5 to 20 b... | 05/14/1996 |
| 5491264 | Preparation of isophorone diamine Isophorone diamine is prepared from isophorone nitrile by imination using a supported heteropoly acid catalyst to form the ketimine followed by the reduction of the ketimine to form the diamine.... | 02/13/1996 |
| 5449811 | Process for the production of 1-amino-1-methyl-3(4)-cyanocyclohexane A new process for the production of 1-amino-1-methyl-3(4)-cyanocyclohexane (AMCC), an intermediate for the manufacture of 1-isocyanato-1-methyl-3(4)-isocyanatomethylcyclohexane. In this process, 4(5)-cyano-1-methylcyclohexene is reacted with excess hydrog... | 09/12/1995 |
| 5319135 | Process for cyclic amino acid anticonvulsant compounds An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.... | 06/07/1994 |
| 5241087 | Enantiomeric enrichment of cyanohydrins A method of enantiomerically enriching chiral cyanohydrins is disclosed that involves selective cleavage of the unwanted enantiomer into its cleavage products HCN and the corresponding aldehyde or ketone by use of an enantioselective dehydrocyanation cata... | 08/31/1993 |
| 5196583 | Propargyl amino compounds The invention provides a novel class of propargyl compounds represented by the formula: ##STR1## wherein R is an C1 -C20 alkyl group, C1 -C20 alkylene group, C1 -C20 alkylene group int... | 03/23/1993 |
| 5194658 | Process for making 2-amino-3-methyl-1-naphthalenecarbonitrile 2-amino-3-methyl-1-naphthalenecarbonitriles of the formula: ##STR1## wherein R is alkyl of from 1 to 6 carbon atoms, halogen, cyano, or hydrogen are prepared by pyrolizing a by-product of a SAN or ABS manufacturing process of the formula: ##STR2... | 03/16/1993 |
| 5180521 | Chiral compounds Optically active compounds of the formula I can be used as components of chiral tilted smectic liquid crystal phases.... | 01/19/1993 |
| 5175170 | ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as cycloalkyl/cycloalkylkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest of the formula ##STR1## ... | 12/29/1992 |
| 5175336 | Fluoromethylated polycyanobenzenes, their alkali metal cyanide adducts, processes for their preparation and use of the fluoromethylated polycyanobenzenes The invention relates to new fluoromethylated polycyanobenzenes of the formula ##STR1## in which X represents hydrogen, fluorine or chlorine, m is 1 or 2 and n is (6-m), to a process for their preparation and to the salt-like alkali metal cyanide add... | 12/29/1992 |
| 5166396 | Bis(3-cyano-3,5,5-trimethyl-cyclohexylidene)-azine, a method of its preparation and further processing to 3-(aminomethyl)-3,5,5-trimethylcyclohexyl amine The invention relates to bis(3-cyano-3,5,5-trimethylcyclohexylidene)-azine (=IPN-azine), a method of its preparation by reacting 1,3,3-trimethyl-5-oxocyclohexane carbonitrile (=IPN) with a source for hydrazine in a molar ratio of essentially 2 to 1 in the... | 11/24/1992 |
| 5166444 | Bis(3-cyano-3,5,5-trimethyl-cyclohexylidene)-azine, a method of its preparation and further processing to 3-(aminomethyl)-3,5,5-trimethylcyclohexyl amine The invention relates to bis(3-cyano-3,5,5-trimethylcyclohexylidene)-azine (=IPN-azine), a method of its preparation by reacting 1,3,3-trimethyl-5-oxocyclohexane carbonitrile (=IPN) with a source for hydrazine in a molar ratio of essentially 2 to 1 in the... | 11/24/1992 |
| 5149872 | Process for the preparation of oxalyl- and oxamyl-hydrazides A new process for preparing oxalyl- and oxamyl-hydrazides which comprises contacting oxamide or diacetyloxamide with the corresponding hydrazine derivative of formula R1 R2 N--NHR3 wherein R1 represents a hydrogen at... | 09/22/1992 |
| 5132451 | Process for cyclic amino acid anticonvulsant compounds An improved process for the preparation of cyclic amino acids by a novel synthesis is described where a dinitrile derivative is converted in two steps to the desired products, as well as valuable intermediates used in the process.... | 07/21/1992 |
| 5130455 | Process for the production of 1-(aminomethyl) cyclohexane acetic acid A new process is described for the production of 1-(aminomethyl)cyclohexane acetic acid, a pharmaceutical agent used as an anticonvulsant. For this purpose a (1-cyanocyclohexyl)-malonic acid dialkyl ester is decarbalkoxylated to the corresponding (1-cyano... | 07/14/1992 |
| 5126374 | Fungicidal guanidines Guanidines I ##STR1## (A=C5 -C12 -cycloalkyl which may bear up to three further substituents; benzyl substituted in the para-position; R1, R2, R3 =H, C1 -C4 -alkyl; R4 | 06/30/1992 |
| 5109020 | Fluorinated cyclohexane derivatives, process and intermediates for their preparation and the use of the new fluorinated cyclohexane derivatives as fungicides and intermediates The present invention relates to new fluorinated cyclohexane derivatives of the formula ##STR1## in which the symbols used have the meaning indicated in the description, a process for their preparation, intermediates of the formula ##STR2## ... | 04/28/1992 |
| 5085689 | Cyclohexenone compounds and their use as herbicides or plant growth regulators Cyclohexenone compounds of the formula I ##STR1## where the substituents have the following meanings: R1 substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, phenyl or benzyl; A oxygen N--OR2, NR3 ; R2 | 02/04/1992 |
| 5072018 | Method for production of cyclohexanecarboguanamine In a method for the production of cyclohexanecarboguanamine by the reaction of cyanocylohexane with dicyandiamide in an organic solvent possessing a hydroxyl group in the molecular unit thereof at a temperature in the range of 90° to 200° C. in the pres... | 12/10/1991 |
| 5068413 | Process for the preparation of cyclic amino acids and intermediates useful in the process Processes for the preparation of cyclic amino acid derivatives useful in the treatment of cerebral diseases such as epilepsy are disclosed. Novel intermediates useful in processes are also disclosed.... | 11/26/1991 |
| 5068389 | Tertiary alcohols The invention relates to tertiary alcohols of the formula I ##STR1## wherein R1, A1, Z1, m, A2, Y, Q1, Q2, Q3 and Z2 have the meanings indicated in claim 1, and also t... | 11/26/1991 |
| 5061400 | Liquid crystal compounds 2'-fluoro-4"-trans-cyclohexyl-terphenyl derivatives represented by the general formula: ##STR1## wherein the cyclohexyl is the trans isomer, R is a straight chain alkyl having from 1 to 12 carbon atoms, X is a straight chain alkyl having from 1 ... | 10/29/1991 |
| 5049693 | Process for the selective hydrogenation of olefins containing nitrile groups The hydrogenation of olefins containing nitrile groups in the homogeneous phase can be carried out particularly successfully using specific ruthenium complexes which are non-sensitive to air and have high catalytic activity.... | 09/17/1991 |
| 5017721 | Process for the preparation of oxalyl- and oxamyl-hydrazides A new process for preparing oxalyl- and oxamyl-hydrazides which comprises contacting oxamide or diacetyloxamide with the corresponding hydrazine derivative of formula R1 R2 N--NHR3 wherein R1 represents a hydrogen at... | 05/21/1991 |
| 5011968 | Process for the preparation of 3-cyano-3,5,5-trimethylcyclohexanone A process for preparing isophorone nitrile is disclosed, whereby isophorone is reacted with hydrogen cyanide in the presence of a quaternary ammonium catalyst. Remaining catalyst is removed by thermal destruction and nitrogen sparging. Residual cyanide is... | 04/30/1991 |
