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| Number | Title | Issue Date |
| 7211589 | Atisane compounds and use thereof The present invention provides a novel compound exhibiting an excellent suppressing effect to cell injury caused by radicals and neurotoxicity induced by excitatory nuerotransmitters such as glutamate. Specifically, it provides a compound represented by the followin... | 05/01/2007 |
| 7176237 | Tricyclic-bis-enone derivatives and methods of use thereof Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotropic lateral s... | 02/13/2007 |
| 6974801 | Inhibitors and methods of use thereof New triterpenoid derivatives with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) were synthesized. Among them, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile (CNDDO), 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-... | 12/13/2005 |
| 6344590 | Adamantanemethanol derivatives and production processes thereof An adamantanemethanol derivative of the invention is represented by the following formula (1), wherein Ra is a hydrogen atom or a hydrocarbon group; Rb is a hydrocarbon group having a carbon atom, to which carbon atom at least one hy... | 02/05/2002 |
| 6090853 | Fungicidally active carboxylic acid amides Carboxamides of the formula I ##STR1## where the substituents have the following meanings: R1 is unsubstituted or substituted bicycloalkyl, tricycloalkyl or bicycloalkenyl; R2,R3 and R4 are each, independen... | 07/18/2000 |
| 6072068 | 16-hydroxy-11-(substituted phenyl)-estra-4,9-diene derivatives The present invention relates to certain 16-hydroxy-11-(substituted phenyl)-estra-4,9-diene derivatives, to processes for their preparation, to pharmaceutical formulations containing them and to their use in medicinal therapy, particularly in the treatmen... | 06/06/2000 |
| 5965612 | 4-cyano-4-deformylsordaricin derivatives 4-Cyano-4-deformylsordaricin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.... | 10/12/1999 |
| 5650511 | Process for the preparation of 9-deazaguanine derivatives Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compou... | 07/22/1997 |
| 5434274 | Benz(epsilon)indene compounds Neuroactive benz[e]indene compounds ##STR1## are prepared by a total synthesis from the following three starting materials ##STR2##... | 07/18/1995 |
| 5206415 | Tricyclic steroid analogs Novel tricyclic steriod analogs are disclosed which are 1H-benz[e]indene dodecahydro compounds that are useful for enhancing GABA-induced chloride currents at the GABA receptor/chloride ionophore complex and can be represented by the following structural ... | 04/27/1993 |
| 5110939 | Intermediates in the preparation of steriod 5-alpha-reductase inhibitors Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit... | 05/05/1992 |
| 5015761 | Tricyclo{6.2.1.01,6 }undecanes useful as fragrance chemicals Novel tricycloundecanones are disclosed having the general formula ##STR1## wherein R1, R2, and R3 are hydrogen or 1 to 3 carbon alkyl groups having a total carbon number of six or less. These compounds are useful per... | 05/14/1991 |
| 5010105 | Antihypercholesterolemic compounds Compounds of Formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.... | 04/23/1991 |
| 4871740 | Glycyrrhetic acid derivatives and use thereof A glycyrrhetic acid derivative of the formula ##STR1## wherein X and Y are hydrogen atom, respectively or X is oxygen atom together with Y, A1 is methylene or carbonyl radical, A2 is hydrogen atom, cyano, carbamoyl, carboxyl rad... | 10/03/1989 |
| 4834905 | Ring compounds Compounds of the formula wherein R1 and R2 are each independently alkyl or alkoxy each of 1-12 C atoms, F, Cl, Br, CN or --Q3 --R3, or one of R1 and R2 can also be H; Q1, Q2 | 05/30/1989 |
| 4723005 | Anisotropic compounds and liquid crystal mixtures New anisotropic compounds of the formula (1) are useful in liquid crystal mixtures for electrooptical displays; at least one of the end groups of the compounds (1) is an alkyl group which carries cyano or halogen in a terminal or non-terminal position. Th... | 02/02/1988 |
| 4707295 | Bicyclooctane derivatives Bicyclooctane derivatives of the formula I wherein R1 and R2 independently of one another are each an alkyl group which has 1-12 C atoms and in which it is also possible for one or two non-adjacent CH2 groups to be replaced by ... | 11/17/1987 |
| 4693841 | Carbonitriles Carbonitriles of the formula I ##STR1## wherein R1 and R2 are each an alkyl group having 1-12 C atoms and wherein one or two CH2 groups/can be groups which are not adjacent replaced by --O--, --O--CO--, --CO--O-- and/... | 09/15/1987 |
| 4686289 | Anisotropic compounds and liquid crystal mixtures New anisotropic compounds with a cross-polarizing substituent have the formula (1) ##STR1## The increase in &3xb5;.perp. is achieved by the polarizing group X, preferably the cyano group or a halogen atom, which is not laterally on the ring, as ... | 08/11/1987 |
| 4640800 | Quinodimethane compositions This invention provides a novel class of quinodimethane compounds which can exhibit nonlinear optical response. In one embodiment this invention can provide a high performance nonlinear optical substrate which comprises a transparent organic polymer film ... | 02/03/1987 |
| 4591461 | Preparation of tri-cyclo nitriles A novel process for the preparation of a 16-imino-17-aza-steroid of the formula ##STR1## wherein A is selected from the group consisting of hydrogen and tritium comprising reacting a compound of the formula ##STR2## wherein A has the above ... | 05/27/1986 |
| 4578475 | Novel D-homosteroids The novel D-homosteroids of the formula ##STR1## wherein R1 represents a --CN, .dbd.NOH or .dbd.CH--NHOH group; R2 represents oxo or, where R1 represents a --CN group, R2 represents oxo or a --OAc group; or... | 03/25/1986 |
| 4565876 | Process A novel process for the preparation of a 16-imino-17-aza-steroid of the formula ##STR1## wherein A is selected from the group consisting of hydrogen and tritium comprising reacting a compound of the formula ##STR2## wherein A has the above ... | 01/21/1986 |
| 4434073 | Perhydrophenanthrene derivatives, their preparation, and their use in liquid-crystalline dielectrics and electro-optical display elements Perhydrophenanthrene derivatives of formula I ##STR1## wherein R1 is alkyl of 1-10 C atoms and R2 is alkyl, alkoxy or alkanoyloxy each of 1-10 C atoms, H, Br, Cl or CN, have an extremely low optical anisotropy and are particular... | 02/28/1984 |
| 4419296 | Preparation of tertiary alkyl cyanides Tertiary alkyl cyanides of the general formula ##STR1## wherein R1, R2 and R3 represent identical or different alkyl group or, together with the tertiary carbon atom to which they are bonded, form a polycycloalkyl gro... | 12/06/1983 |
| 4395423 | Polycyclic cyanoketones (18ଲ and 18)-2-Cyano-3,11-dioxo-olean-12-en-29-oic acids and lower-alkyl esters thereof, useful as ulcer preventing and ulcer healing agents, are prepared from 18ଲ- or 18-glycyrrhetinic acid, the final step being alkaline ... | 07/26/1983 |
| 4391823 | Novel polycyclic insecticidal esters Dimethyl dichlorovinylcyclopropyl carboxylic acid esters of substituted (alkyl, aryl, halo, amino, etc.) polycyclic alcohols are insecticidal.... | 07/05/1983 |
| 4361578 | D-Homosteroids The invention is directed to 3-oxo-D-homosteroids and derivatives thereof which are useful as antiantigens.... | 11/30/1982 |
| 4317900 | Isocyanatomethyl group containing urea derivatives of 3(4), 8(9)-diisocyanatomethyltricyclo [5.2.1.02,6 ] decane, method for their production as well as their use for producing polyurethane elastomers Urea derivatives containing isocyanatomethyl groups of 3(4), 8(9)-diisocyanatomethyltricyclo [5.2.1.02,6 ] decane of the formula OCN--H2 C--[R--CH2 --NH--CO--NH--CH2 ]n --R--CH2 --NCO, in which ... | 03/02/1982 |
| 4252738 | 1,2-Halohydrincarboxylic acid esters and a process for their preparation 1,2-Halohydrincarboxylic acid esters of the formula ##STR1## wherein R1, R2, R3, and R4 are identical or different and represent hydrogen, cyano and optionally substituted alkyl, alkenyl, aralkyl, aryl, alk... | 02/24/1981 |
| 4210669 | Prostanoic acid derivatives Prostanoic acid derivatives of the formula, ##STR1## wherein R1 is hydrogen or C1-4 alkyl, R2 is C4-8 alkyl and >C.dbd.Z is >C.dbd.0 or ##STR2## are prepared by reacting a cyclopentane of the formula, ... | 07/01/1980 |
| 4151194 | Dicyanotricyclodecane A mixture of 3,8- and 4,8-dicyanotricyclo[5.2.1.0]decane is prepared by the hydrocyanation of 8-cyanotricyclo[5.2.1.0]dec-3-ene in the presence of a catalyst system comprising a zero valent nickel complex, free of carbon monoxide, a promoting amount of a ... | 04/24/1979 |
| 4143065 | Polycyclic scents New polycyclic Diels-Alder adducts which are formed on reaction of 8-vinyl-tricyclo-[5,2,1,02,6 ]-dec-8-ene or 8-hydroxy-8-vinyl-tricyclo-[5,2,1,02,6 ]-decane with alkenes or alkynes having one or two activating substituents, e.g., -... | 03/06/1979 |
| 4076748 | Polycyclic scents New polycyclic Diels-Alder adducts which are formed on reaction of 8-vinyl-tricyclo-[5,2,1,02,6 ]-dec-8-ene or 8-hydroxy-8-vinyl-tricyclo-[5,2,1,02,6 ]-decane with alkenes or alkynes having one or two activating substituents, e.g., -... | 02/28/1978 |
| 4056633 | D-homo-20-ketopregnanes and method for inducing anesthesia or narcosis D-homo-20-ketopregnanes of the formula ##STR1## wherein R1 is hydrogen, fluorine, chlorine, bromine, alkyl, alkoxy, or azido; R2 is oxygen, ##STR2## and R7 is hydrogen, lower alkyl, or acyl of up to 5 carbon atom... | 11/01/1977 |
| 4041061 | Modified cyanoacrylate monomers and methods of preparation Difunctional monomers of the formula, ##STR1## where R is an organic linking group derived from a diol or a dihalide of the formula X-R-X, where X is either chlorine, bromine, iodine, or hydroxy, are prepared by reacting a conjugated diene, exemplifi... | 08/09/1977 |
| 4013703 | Cyanoacrylic acid adducts Difunctional monomers of the formula, ##STR1## where R is an organic linking group derived from a diol or a dihalide of the formula X-R-X, where X is either chlorine, bromine, iodine, or hydroxy, are prepared by reacting a conjugated diene, exemplifi... | 03/22/1977 |
| 4003942 | Blocked bis 2-cyanoacrylate monomers Difunctional monomers of the formula, ##STR1## where R is an organic linking group derived from a diol or a dihalide of the formula X--R--X, where X is either chlorine, bromine, iodine, or hydroxy, are prepared by reacting a conjugated diene, exempli... | 01/18/1977 |
| 3994930 | 6-(3-Cyanopropyl)-2-vinyl tetrahydropyran-2-ol and its tautomer A multi-step, stereospecific total synthesis of steroids utilizing intermediates having a cyanoalkyl A-ring precursor is disclosed. The initial starting materials for this process are the relatively inexpensive and commercially available reagents γ-butyr... | 11/30/1976 |
| 3966485 | Novel resins and manufacturing the same A resin having a formula of ##SPC1## Wherein each of R1, R2, R3, R4, R5 and R6 is hydrogen or methyl group, each of R7, R8, R9 and R10 is hydroge... | 06/29/1976 |
