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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7470806 | Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and its application in the synthesis of agomelatine A process for the industrial synthesis of the compound of formula (I) Application in the synthesis of agomelatine. ... | 12/30/2008 |
| RE39682 | Farnesyl derivatives and pharmaceutical compositions containing them Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents f... | 06/05/2007 |
| 6914074 | Substituted phenyl naphthalenes as estrogenic agents This invention provides estrogen receptor modulators of formula I, having the structure wherein R1, R2, R3, R4, R5, R6, R7, R | 07/05/2005 |
| 6875882 | Synthesis of benzonitriles from substituted benzoic acid There is a significant demand for organic nitriles, based on their versatility in reactions. Compounds prepared from nitriles have properties including superoxide inhibition, ferrielectric liquid crystal dopant, antipicornaviral agents, anti-inflammatory agents, ant... | 04/05/2005 |
| 6875895 | Bis (diphenylvinyl) arene compound Provided is a bis(diphenylvinyl)arene compound having a reactive functional group on phenyl group, represented by below formula (1), wherein, Ar is an arylene group and has one or more substituents; R1-R | 04/05/2005 |
| 6827876 | Difluoromethyl ether derivative and process for producing the same A liquid crystalline compound represented by Formula (1c′): wherein R1 and R2, rings A1, A2, A3, A4 and A5, Z1, Z2 | 12/07/2004 |
| 6790853 | Contraception method using competitive progesterone antagonists and novel compounds useful therein Competitive progesterone antagonists, including two novel steroids, viz., 11β,19-[4-(cyanophenyl)-o-phenylene]-17β-hydroxy-17α-(3-hydroxyprop-1(Z)-enyl)-4-androsten-3-one and 11β,19-[4-(3-pyridinyl)-o-phenylene]-17β-hydroxy-17α-(3-hydroxyprop-1(Z)-enyl)-4-andr... | 09/14/2004 |
| 6790977 | Process for preparing 3,4-dihydroxy-benzonitrile A process for preparing 3,4-dihydroxybenzonitrile includes the steps of reacting a nitrile compound with an alkali metal halide, followed by treating with an acid. ... | 09/14/2004 |
| 6770463 | Process for the preparation of chiral isofluoroenes There is provided a process for the preparation of a chiral insecticidal and acaricidal compound of formula I. Also provided are intermediate compounds useful in the process of the present invention. ... | 08/03/2004 |
| 6630509 | Phenalkyloxy-phenyl derivatives The present invention relates to certain phenalkyloxy-phenyl derivatives of formula (I) ##STR1## and analogs, to a process for preparing such compounds, which compounds have utility in treating clinical conditions associated with insulin resistance, ... | 10/07/2003 |
| 6573397 | Process for producing 3,4-dihydroxybenzonitrile 3,4-dihydroxybenzonitrile useful as a starting compound for synthesis of medicines and agricultural chemicals is produced, with a high yield by chlorinating 3,4-methylenedioxybenzonitrile with sulfuryl chloride or a mixture of molecular chlorine with a ch... | 06/03/2003 |
| 6525092 | Pesticidal bis-oxime compounds Bis-oxime compounds of the general formula (I) are provided ##STR1## wherein X, Y, R1, R2 R3 and n are as defined in the specification. The bis-oxime compounds possess pesticidal activity, which may provide plants with pro... | 02/25/2003 |
| 6426422 | Method for the preparation of citalopram Disclosed is a method for the preparation of citalopram comprising conversion of a compound of Formula VIII ##STR1## wherein Z is halogen, to a compound of Formula IV ##STR2## followed by conversion of the compound of Formula IV into citalopram. Meth... | 07/30/2002 |
| 6379590 | Method for making unsymmetrically substituted fluorenyl compounds for nonlinear optical applications A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D ##STR1## wherein A' is se... | 04/30/2002 |
| 6372933 | Process for preparing certain phenyl urea compounds This invention relates to a process for making certain phenyl urea compounds by using a Lewis acid to effect the ring opening of a benzoxazolinone by an amine.... | 04/16/2002 |
| 6340688 | Contraception method using competitive progesterone antagonists and novel compounds useful therein Competitive progesterone antagonists, including two novel steroids, viz., 11ଲ,19-[4-(cyanophenyl)-o-phenylene]-17ଲ-hydroxy-17-(3-hy droxyprop-1(Z)-enyl)-4-androsten-3-one and 11ଲ,19-[4-(3-pyridinyl)-o-phenylene]-17ଲ-hydroxy-1... | 01/22/2002 |
| 6326507 | Therapeutic compounds and methods of use Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.... | 12/04/2001 |
| 6291689 | Method for the preparation of citalopram A method for the preparation of citalopram is described comprising reduction of the oxo group of a compound of formula (IV), ##STR1## wherein R1 is CN, C1-6 alkyloxycarbonyl or C1-6 alkylaminocarbonyl, ring closure of the ... | 09/18/2001 |
| 6288262 | Process for the preparation of 2-methoxyethoxy-benzenes and novel 2-methoxyethoxy-benzyl cyanides 2-Methoxyethoxy-benzenes are obtained in an advantageous manner from the corresponding phenol compounds by reaction with 2-chloroethyl methyl ether if the process is carried out without the addition of a strong solvent at temperatures above 95° C. and un... | 09/11/2001 |
| 6288260 | Process for making 2-alkyl-3-hydroxybenzoic acids A two step process is described for making 2-alkyl-3-hydroxybenzoic acids or derivatives of benzoic acids by first reacting an allenyl ester or equivalent with furan followed by the ring-opening reaction of the derived bicyclo intermediate with base. The ... | 09/11/2001 |
| 6211234 | Substituted phenyl compounds Compounds of formula (I) are described wherein R1 is hydrogen, -(lower alkyl)q (CO2 R6 or OH), --CN, --C(R7).dbd.NOR8, NO2, --O(lower alkyl)R9, --C.tbd.C--R10, ... | 04/03/2001 |
| 6187945 | Process for producing cyanobenzyl compounds An industrially advantageous process for producing cyanobenzyl compounds under mild conditions from relatively easily available cyanobenzylamine having a cyano group on the benzene ring or a compound thereof which is ring-substituted with a chlorine atom,... | 02/13/2001 |
| 6184249 | Androgen receptor suppressors in the therapy and diagnosis of prostate cancer, alopecia and other hyper-androgenic syndromes Substituted phenylalanines are provided comprising an hydantoin, urea or 2-hydroxyl, 2-methylpropionyl group, dimers thereof and alkyl, polyfluoroamido and haloarylamino derivatives thereof, as well as radiolabeled derivatives thereof. The compounds bind ... | 02/06/2001 |
| 6166226 | Synthesis of aryl ethers A method for preparing an aryl ether compound is provided in which an alcohol is reacted with an aromatic compound in the presence of a base, and a transition metal catalyst selected from the group consisting of platinum and nickel to form an aryl ether. ... | 12/26/2000 |
| 6160157 | Preparation of 4-cyano-4'-hydroxybiphenyl The invention relates to a preparation process for 4-cyano-4'-hydroxybiphenyl, said process comprising the protection of the hydroxy group of 4-phenyl-phenol, acylation of the protected 4-phenyl-phenol group, conversion of the resulting ketone into an aci... | 12/12/2000 |
| 6150304 | 2-aryl-cyclopentane-1,3-dione derivatives The present invention relates to novel 2-aryl-3-hydroxy-cyclopent-2-en-1-one derivatives of the formula (I) ##STR1## in which X represents halogen, nitro, cyano, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl or ... | 11/21/2000 |
| 6143311 | Iodopropargyl derivatives and antimicrobial agents comprising them as an active ingredient The present invention provides novel iodopropargyl derivatives represented by the following formula (1): ##STR1## wherein R1 is a methoxy group or a cyano group, which have a reduced unpleasant smell and also have a wide antimicrobial spec... | 11/07/2000 |
| 6121480 | Method for producing unsymmetrically substituted biphenyls The invention concerns a method for the production of unsymmetrically substituted cyanobiphenyls by the slow addition of an aryl Grignard compound to an optionally substituted bromobenzonitrile in the presence of a palladium complex catalyst.... | 09/19/2000 |
| 6090969 | Process for the preparation of an asymmetric compound using a metal complex A process for producing an asymmetric compound using a metal complex containing no rare earth metal element is disclosed. The process affords an optically active compound having high optical purity. Optically active binaphthol having the chemical formula ... | 07/18/2000 |
| 6008401 | Process for producing an optically active compound A process is disclosed for producing an optical active alkoxybenzonitrile derivative in which process a benzonitrile derivative is subjected to condensation reaction with an optical active alcohol. A process is also disclosed for producing an optical active al... | 12/28/1999 |
| 6008400 | Orthoester reagents for use as protecting groups in oligonucleotide synthesis Phosphoramidite oligonucleotide synthesis is facilitated by the use of fluoride-labile 5' silyl protecting groups. RNA synthesis is improved by the use of 2 orthoester protecting groups. Reactions are conducted on a solid phase support and acidic deprotec... | 12/28/1999 |
| 5998673 | 1, 4-diaryl-2-fluoro-2-butene insecticidal and acaricidal agents Pesticidal 1,4-diaryl-2-fluoro-2-butene compounds having the structural formula I ##STR1## and compositions and methods comprising those compounds for the control of insect and acarid pests.... | 12/07/1999 |
| 5984975 | 3-substituted para-aminophenols and use thereof in dyeing keratinous fibers A method or composition for dyeing keratinous fibres using as an oxidation dye precursor a 3-substituted para-aminophenol of formula: ##STR1## where R1 represents alkyl, alkenyl, mono- or polyhydroxyalkyl, cyano, cyanoalkyl, halogenoalkyl,... | 11/16/1999 |
| 5965766 | Process for synthesizing benzoic acids Nucleophilic substitution reactions on halobenzenes or triflyl substituted benzenes are carried out in the presence of catalysts. In particular the present invention provides a process leading to optionally substituted hydroxybenzoic, alkanoyloxybenzoic, ... | 10/12/1999 |
| 5952386 | Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(.dbd.O)NH or the like; R2, R3 and R4 are indepen... | 09/14/1999 |
| 5917079 | Process for synthesizing benzoic acids Nucleophilic substitution reactions on halobenzenes are carried out in the presence of catalysts. In particular the present invention provides a process leading to optionally substituted hydroxybenzoic and alkoxybenzoic acids and optionally substituted hy... | 06/29/1999 |
| 5883283 | Process for the preparation of substituted 3-aminobenzonitriles The invention relates to a process for the preparation of substituted 3-amninobenzonitriles, which comprises reacting the appropriate substituted 3-aminochlorobenzene with a cyano-donating reagent, and to the compounds thereby produced. The compounds are ... | 03/16/1999 |
| 5847166 | Synthesis of aryl ethers A method for preparing an aryl ether compound is provided in which an alcohol is reacted with an aromatic compound in the presence of a base, and a transition metal catalyst selected from the group consisting of platinum and nickel to form an aryl ether. ... | 12/08/1998 |
| 5841001 | Process for the preparation of optically active 2-halo-1-(substituted phenyl) ethanol The present invention provides an industrially advantageous process for the preparation of an optically active 2-halo-1-(substituted phenyl)ethanol useful as medicines, agricultural chemicals or as intermediates thereof; and a simple process for the prepa... | 11/24/1998 |
| 5811029 | Benzene derivatives, and a liquid-crystalline medium Benzene derivatives of the formula I ##STR1## in which n is 1 to 7, Q is --CO or --(CH2)r -- where r is 1 to 5, s is 0, 1 or 2, t is 0 or 1, where s+tࣙ1, X is F, Cl, --CF3, --CN, --OCF3 or --OCHF2 | 09/22/1998 |
