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| Number | Title | Issue Date |
| 8034968 | Process for preparing 2-amino-5-cyanobenzoic acid derivatives Disclosed is a method for preparing a compound of Formula 1 comprising (1) contacting a compound of Formula 2, with (2) at least one alkali metal cyanide and (3) at least one compound of Formula 4 wherein R1 is N... | 10/11/2011 |
| 7683201 | Quinazoline(di)ones for invertebrate pest control Compounds of Formula I including all geometric and stereoisomers, N-oxides, and agriculturally suitable salts thereof, are disclosed which are useful as invertebrate pest control agents wherein A, B, J, K, L and R3 | 03/23/2010 |
| 7449594 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines A process for preparing 4-pentafluorosulfanylbenzoylguanidines of formula I wherein R1 to R4 have the meanings indicated in the specification. The compounds of formula I are NEH1 inhibitors and can be employed, for example,... | 11/11/2008 |
| 7414152 | N-substituted p-menthane carboxamides Cooling compounds are provided having the formula: wherein, m is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, C1-C4 straight or branched alkyl, and a C1-C4 straight or branched alkoxy, X is... | 08/19/2008 |
| 7332629 | Modulators (inhibitors/activators) of histone acetyltransferases Disclosed are compounds of the formulae: and method of using the compounds to treat cancer, AIDS, HIV infection, and asthma. ... | 02/19/2008 |
| 7268248 | 3-Cyano-2,4,5-trifluorobenoxyl fluoride and intermediate products for the production thereof The present invention relates to 3-cyano-2,4,5-trifluorobenzoyl fluoride and to intermediates for its preparation and to the process for the preparation of 3-cyano-2,4,5-trifluoro-benzoyl fluoride, which starts from 5-fluoro-1,3-xylene (VIII); which is bichlorinated... | 09/11/2007 |
| 7176237 | Tricyclic-bis-enone derivatives and methods of use thereof Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotropic lateral s... | 02/13/2007 |
| 7153813 | Substituted aryl ketones The invention relates to novel substituted aryl ketones of the formula (I) in which Z, X, R and n are as defined in the disclosure, to processes for their preparation and to their use as ... | 12/26/2006 |
| 7126026 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines A process for preparing 4-pentafluorosulfanylbenzoylguanidines of formula I wherein R1 to R4 have the meanings indicated in the specification. The compounds of formula I are NHE1 inhibitors and can be employed, f... | 10/24/2006 |
| 7112554 | Substituted arylketones The invention relates to novel aryl ketones of the formula (I) in which A1, A2, Q, R1, R2, X, Y and Z are as defined in the descripti... | 09/26/2006 |
| 7078565 | Benzamide derivatives as antagonists of orexin receptors Disclosed are phenyl-alkylene benzamides useful as orexin antagonists ... | 07/18/2006 |
| 7057562 | RFID device with patterned antenna, and method of making A radio frequency identification device (RFID) antenna structure includes electrically-conductive material. The antenna structure includes low effective resistance-material areas and high effective resistance areas in regions where there would be little current flow... | 06/06/2006 |
| 7045660 | Compounds as PDE IV and TNF-inhibitors This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological effects of TNF in the treatment... | 05/16/2006 |
| 7030261 | Method for preparing 2-hydroxy-6-ureidocarbonyl naphthalene derivative Disclosed is a method for preparing a 2-hydroxy-6-ureidocarbonyl naphthalene derivative. The method comprises the step of reacting 2-hydroxy-6-aminocarbonyl naphthalene and a isocyanate in an organic solvent at a temperature of 90–200° C. According to the present... | 04/18/2006 |
| 7026498 | Ligands for metals and improved metal-catalyzed processes based thereon One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming react... | 04/11/2006 |
| 6974801 | Inhibitors and methods of use thereof New triterpenoid derivatives with various substituents at the C-17 position of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) were synthesized. Among them, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile (CNDDO), 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-... | 12/13/2005 |
| 6960688 | Use of compounds for the elevation of pyruvate dehydrogenase activity The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon ... | 11/01/2005 |
| 6951884 | Fluorobenzamides and uses thereof The invention relates to fluorobenzamide derivatives of the formula wherein R1, R2, R3 R4, R5, R6 and R7 are as defined herein. =, Th... | 10/04/2005 |
| 6924307 | Aminobutyric acid derivatives and pharmaceutical composition containing the same as active ingredient Aminobutylic acid derivatives of the formula (I): wherein the symbols are as defined in specification; and non-toxic salts thereof. Because of inhibiting matrix metalloproteinase, the compounds of the formula (I) are u... | 08/02/2005 |
| 6903092 | Naphthamide neurokinin antagonists for use as medicaments Compounds having the general formula wherein R1, R2, R3, R4, R5, X1 and X2 are as defined in the specification, methods of using such compoun... | 06/07/2005 |
| 6861448 | NAD synthetase inhibitors and uses thereof Disclosed are compounds that inhibit the microbial NAD synthetase enzyme. For example, disclosed are compounds of the formula Ar1—X—Ar2—Y—L—Z—Q, wherein Q is Q1Ar3 or Ar3Q1; Ar1... | 03/01/2005 |
| 6849648 | Phenylene alkyne matrix metalloproteinase inhibitors A compound of Formula I or a pharmaceutically acceptable salt thereof, or a tautomer thereof, wherein G1, G2, and B are as defined in the application, are selective inhibi... | 02/01/2005 |
| 6821963 | 4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors Phenylamino benzhydroxamic acid derivatives of formula (I) where R1, R2, R3, R4, R5, and R6 are hydrogen or substituent groups such as alkyl, and where R7 is hydrogen or an organic radical,... | 11/23/2004 |
| 6806365 | N-alkanoylphenylalamine derivatives Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related t... | 10/19/2004 |
| 6753433 | Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile Method for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) comprising the reaction of a compound of formula wherein X is a halogen, with organometallic... | 06/22/2004 |
| 6670400 | Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhib... | 12/30/2003 |
| 6639093 | Process for the preparation of hydroxybenzoic benzyl esters The invention relates to the preparation of hydroxybenzoic benzyl esters by reacting benzyl chloride with hydroxybenzoic acids in the presence of one or more amides.... | 10/28/2003 |
| 6630607 | Aromatic methylidene compounds, aromatic aldehyde compounds and methylstyryl compounds used to prepare the methylidene compounds, and methods for preparing these compounds Aromatic methylidene compounds of the following general formula ##STR1## wherein R11 and R21 independently in each occurrence represent an unsubstituted or substituted alkyl or alkoxy group, a halogen, a cyano group or a nitro gr... | 10/07/2003 |
| 6599861 | Herbicides Compounds of formula I ##STR1## wherein the substituents are defined as in claim 1, as well as the agronomically acceptable salts, isomers and enantiomers of these compounds, as well as the agronomically acceptable salts/N-oxides/isomers/enantiomers ... | 07/29/2003 |
| 6579993 | Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-ca rbonitrile Method for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluoro-phenyl)-1,3-dihydroisobenzofuran-5-c arbonitrile (citalopram) comprising the reaction of a compound of formula ##STR1## wherein X is a halogen, with organometallic dimethylaminopropyl hali... | 06/17/2003 |
| 6569899 | 4-aminobutanoic acid derivatives and drugs containing these derivatives as the active ingredient Aminobutylic acid derivatives of the formula (I) ##STR1## wherein the symbols are as defined in specification; and non-toxic salts thereof. Because of inhibiting matrix metalloproteinase, the compounds of the formula (I) are useful for prevention and/or t... | 05/27/2003 |
| 6566403 | N-acetonylbenzamide fungicides This invention relates to new compositions comprising predominantly one enantiomer of an N-acetonylbenzamide fungicide, methods of preparing N-acetonylbenzamides, and their use as fungicides.... | 05/20/2003 |
| 6562807 | Glucagon antagonists/inverse agonists A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any diseases ... | 05/13/2003 |
| 6541670 | Aminobenzophenones as inhibitors of IL 1ଲ and TNF- A compound of the general formula I ##STR1## wherein R1 represents a substituent selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1 -C3)alkyl, (C2 -C3)olefin... | 04/01/2003 |
| 6485799 | Aniline derivatives, liquid-crystal composition containing the same, and liquid-crystal display element A aniline derivative represented by general formula (1) ##STR1## wherein R and R' represent independently each other alkyl with 1 to 10 carbon, alkoxyalkyl with 1 to 10 carbon, or hydrogen; x represents cyano, halogen, haloalkyl, haloalkyloxy, or 2-cyanoe... | 11/26/2002 |
| 6441177 | Tertiary amines Tertiary amines of the formula ##STR1## wherein A1, A2, A3, A4, M, p, T and Q are as defined herein, and acid addition salts thereof, have antimycotic and cholesterol-lowering activity.... | 08/27/2002 |
| 6433211 | Process for producing cyanobenzoic acid derivatives A process for producing a cyanobenzoic acid compound, a cyanobenzamide compound, an alkyl cyanobenzoate compound, and a cyanobenzoyl chloride compound, which are useful intermediates for a variety of chemicals such as pharmaceuticals, agrochemicals, liqui... | 08/13/2002 |
| 6410794 | Process for preparation of pharmaceutically desired chiral tetralone from tetralones Improved processes for preparation of tetralones in high enantiomeric purity centers on resolution using simulated moving bed chromatography of a racemic tetralone derivative. Resolution is effected with high enantiomeric purity, and subsequent reactions ... | 06/25/2002 |
| 6407267 | Method for the preparation of citalopram A method for the preparation of citalopram comprising reaction of a compound of Formula (IV), ##STR1## wherein R is C1-6 alkyl, acyl, C1-6 alkylsulfonyl or arylsulfonyl, with 3-(N,N-dimethylamino)-propyl magnesium halide, to pre... | 06/18/2002 |
| 6407288 | Naphthylsalicylanilides as antimicrobial and antiinflammatory agents The present invention discloses novel naphthylsalicylanilides of the general formula ##STR1## wherein W is a substituted or unsubstituted naphthyl ring. The substitution on W includes replacing one or more --H with --OH, alkyl, O-alkyl, branched alky... | 06/18/2002 |
