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Patent No. 5970981

Mouthguard made at least partially from an edible candy

A mouthguard includes a U-shaped upper bite plate which removably fits over upper teeth of a person, with the entire upper bite plate being made from a soft, deformable and edible gummi candy.

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Class 558/413 - Sulfur, double bonded to oxygen, attached indirectly to the cyano group by nonionic bonding


Subclass of Class 558 - Organic compounds -- part of the class 532-570 series
Definition: Compounds wherein the cyano group is attached indirectly,
No. of patents: 376
Last issue date: 10/26/2010


1                    
NumberTitleIssue Date
7820846Bifunctional phenyliso(thio)cyanates, processes and intermediates products for their preparation
A process for preparing phenyl iso(thio)cyanates of the formula I in which a compound of the formula II or its HCl adduct is reacted with a phosgenating agent where W is oxygen or sulfur and Ar and A are as defined in claim...
10/26/2010
7402704Arylsulfones and uses related thereto
Aryl sulfone compounds of formula I and II are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders: ...
07/22/2008
7371324Chemical process
A process for extracting from aqueous solution the alkali metal or ammonium salt of a phenol, naphthol, anthrol or phenanthrol or the corresponding thiol, which comprises contacting an aqueous alkaline or neutral solution of the alkali metal or ammonium salt, in whi...
05/13/2008
7326708Phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor
The dihydrogenphosphate salt of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl peptidase-IV and is useful for the prevention and/or treatment of non-insulin ...
02/05/2008
7323584Process for preparing N-(4′-cyano-3′-trifluoromethylphenyl)-3-(4″-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide
The invention relates to a process for preparing N-(4′-cyano-3′-trifluoromethylphenyl)-3-(4″-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide (bicalutamide). ...
01/29/2008
7291620N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also direct...
11/06/2007
7273867Phenyl derivatives
Novel compounds of the formula I in which W, X, Y, T, R1 and R2 are as defined in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders
09/25/2007
7259277Advanced route for the synthesis of cPLA2 inhibitors
A process for making a compound of formula (I) in which process the compound HC≡C—(CH2)n—NH2 is reacted with the compound R1—SO2Cl to produce an inte...
08/21/2007
7253210Methylene-bridged selective androgen receptor modulators and methods of use thereof
This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and a...
08/07/2007
RE39682Farnesyl derivatives and pharmaceutical compositions containing them
Novel farnesyl derivatives which are inhibitors of the prenylated protein methyltransferase enzyme, and useful as anti-cancer drugs, have the following formula: wherein R1represents f...
06/05/2007
7199257Process for the synthesis of N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide
A new process is disclosed for the synthesis of racemic or optically pure N-[4-cyano-3-trifluoro-methyl-phenyl]-3[4-fluorophenyl-sulfonyl]-2-hydroxy-2-methylpropionamide. The process includes the formation of several novel intermediates in the synthesis. ...
04/03/2007
7186854Process for making bicalutamide and intermediates thereof
Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent. ...
03/06/2007
7135487Sulphonamide derivatives
The present invention relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them. ...
11/14/2006
7132560Crystal of bicalutamide and production method thereof
The present invention relates to a crystal of bicalutamide having a defined form, as well as economical and industrially practical production methods of bicalutamide and a crystal thereof, which are superior in environmental benignity and safety. Accordingly,...
11/07/2006
7132567Generation of combinatorial synthetic libraries and screening for proadhesins and nonadhesins
One aspect of the present invention relates to compounds, comprising at least two moieties selected from the group consisting of aryl sulfonates and aryl sulfates. A second aspect of the present invention relates to combinatorial libraries of the aforementioned comp...
11/07/2006
7115543Aryl sulfonyl amino carbonyl triazole based selective herbicides
The invention relates to novel herbicidal synergistic active compound combinations which comprise firstly arylsulphonylaminocarbonyltriazolinones and secondly herbicidally active compounds and/or safeners listed in the description, and which can be used with particu...
10/03/2006
7102026Process for preparing and isolating -bicalutamide and its intermediates
The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{...
09/05/2006
7084178Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives
A series of N-cycloalkylcarboxamide derivatives of N-benzyl benzenesulfonamides of Formula I are described. The compounds inhibit β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's...
08/01/2006
7041844Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
The present invention relates to an antiandrogen compound and a method of treating prostate cancer in a patient utilizing the compound. The present invention also relates to a pharmaceutical composition which includes the compound. ...
05/09/2006
7034045Monofluoroalkyl derivatives
The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders. ...
04/25/2006
7022870N-bridged selective androgen receptor modulators and methods of use thereof
This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and a...
04/04/2006
6995283Benzophenones as inhibitors of reverse transcriptase
The present invention is directed to beazophenone compounds useful in the inhibition of HIV reverse transcriptase, particularly its resistant varieties. ...
02/07/2006
6960688Use of compounds for the elevation of pyruvate dehydrogenase activity
The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon ...
11/01/2005
6900353Cyclopentyl sulfonamide derivatives
The present invention provides compounds of formula (I): useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders. ...
05/31/2005
6891065Advanced route for the synthesis of cPLA2 inhibitors
A process for making a compound of formula (I) in which process the compound HC≡C—(CH2)n—NH2 is reacted with the compound R1—SO2Cl to produce an intermedia...
05/10/2005
6887903N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them
The compounds of formula 1 wherein R and R2 are as defined in the disclosure, are useful in the prevention and treatment of tissue damage due to exacerbated recruitment of polymorphonuclear neutrophils (PMN ...
05/03/2005
6875895Bis (diphenylvinyl) arene compound
Provided is a bis(diphenylvinyl)arene compound having a reactive functional group on phenyl group, represented by below formula (1), wherein, Ar is an arylene group and has one or more substituents; R1-R
04/05/2005
6849635Sulfonamides
The present invention relates to sulfonamides, pharmaceutical compositions containing them, and their use as antagonists of urotensin II. ...
02/01/2005
6818766Process for making bicalutamide and intermediates thereof
Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent. ...
11/16/2004
6815556Compounds having fungicidal activity and processes to make and use same
A compound according to formula one that is useful as a fungicide is provided. Additionally, processes to make and use same are provided. ...
11/09/2004
6812362Methods of synthesizing acylanilides including bicalutamide and derivatives thereof
Methods of synthesizing an acylanilide include contacting a compound having the structure of Formula I: with a compound having the structure of Formula II: under conditio...
11/02/2004
6740770Crystal of bicalutamide and production method thereof
The present invention relates to a crystal of bicalutamide having a defined form, as well as economical and industrially practical production methods of bicalutamide and a crystal thereof, which are superior in environmental benignity and safety. Accordingly,...
05/25/2004
6693137Sulphonamide derivatives
The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing th...
02/17/2004
6653347IL-8 receptor antagonists
This invention relates to the novel use of diphenyl sulfamido in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8)....
11/25/2003
6649784Aspartyl dipeptide ester derivatives and sweeteners
Aspartyl dipeptide ester derivatives, such as a N-[N-[3-(3,4-dihydroxyphenyl)-3-methylbutyl]-L-଱-aspartyl]-L-phenyla lanine 1-methyl ester, or salts thereof, having a high degree of sweetness compared to conventional sweeteners. These derivatives are...
11/18/2003
6586617Sulfonamide derivatives
The present invention relates to microbicides for agricultural or horticultural use containing a sulfonamide derivative....
07/01/2003
6586467Preparation of phosphatase inhibitors
Disclosed are compounds of the Formula I ##STR1## and pharmaceutically acceptable salts and prodrugs thereof, wherein A, B; R1, R2, R3, R4 and R5 are as defined in the specification. Such compounds ar...
07/01/2003
6562994Process for the preparation of N-(substituted phenyl)-3-alkyl-,aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds
The present invention provides an improved process for the preparation of N-(substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds of formula I that exhibit antiandrogenic activity and are useful ...
05/13/2003
6545154Method for the production of N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides and new intermediate products
The invention relates to a process for preparing N-(5-amino-2-cyano-4-fluoro-phenyl)-sulphonamides in which, in a first step, 2-amino-4,5-difluoro-benzonitrile is reacted with sulphonyl halides in the presence of an acid acceptor and in the presence of a ...
04/08/2003
6528543Urea derivatives
Glucokinase activating compounds of the formula ##STR1## wherein R1 and R2 are independently hydrogen, halo, amino, nitro, cyano, sulfonamido, lower alkyl, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower al...
03/04/2003
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