Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7642368 | Process for producing triarylsulfonium salt A method for producing a triarylsulfonium salt having a structure that only one of the three arobatic rings of the three aromatic rings on the cationic portion is different from the other two aromatic groups, and which is useful, for example, as an acid-generating a... | 01/05/2010 |
| 7317124 | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates Pentafluorosulfanyl-benzenes according to Formula (I): a process for their preparation and their use as valuable synthetic intermediates for preparing, for example, medicaments, diagnostic aids, liquid crystals, ... | 01/08/2008 |
| 7227043 | 2-phenyl-2-substituted-1,3-diketones The invention relates to novel phenyl-substituted cyclopentane- and cyclohexane-1,3-dione derivatives of the formula (I) in which W, X, Y, Z, A, B, Q1, Q2, Q3 | 06/05/2007 |
| 7217832 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; | 05/15/2007 |
| 7196229 | Benzoylcyclohexenone derivatives The invention relates to benzoylcyclohexenone derivatives of general formula (I) wherein the variables R1 to R10 and n have the designation cited in claim 1. The invention also relates to the salts of the same and the use of said derivat... | 03/27/2007 |
| 7041844 | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer The present invention relates to an antiandrogen compound and a method of treating prostate cancer in a patient utilizing the compound. The present invention also relates to a pharmaceutical composition which includes the compound. ... | 05/09/2006 |
| 6936739 | Fluorine-containing bisphenols, their preparation, their precursors and intermediates, and use of the fluorine-containing bisphenols This invention relates to 1,2-di(4-hydroxyaryl)tetrafluoroethanes of the general formula (I) wherein R are each, independently of one another, hydrogen, F, Cl, Br, I, CN, COOR2, C1-C | 08/30/2005 |
| 6930190 | Process for the preparation of heterocyclic pentalene derivatives A process for preparing heterocyclic pentalene derivative having formula (I): wherein w is a sulfur atom (S), an oxygen atom (O) or a NR or PR group, wherein R is an hydrocarbon group; R1, R2, R3, and R4, equal to or diffe... | 08/16/2005 |
| 6541670 | Aminobenzophenones as inhibitors of IL 1ଲ and TNF- A compound of the general formula I ##STR1## wherein R1 represents a substituent selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1 -C3)alkyl, (C2 -C3)olefin... | 04/01/2003 |
| 6541422 | Method for improving the selectivity of 1,3-cyclohexanedione herbicide A method of selectively controlling undesirable vegetation in crops by using a postemergent application of an herbicidally effective amount of a metal chelate of a 2-(substituted benzoyl)-1,3-cyclohexanedione compound to the locus of such undesirable vege... | 04/01/2003 |
| 6344505 | Mono- and bis-benzotriazolyldihydroxybiaryl UV absorbers Provided is a composition which contains a mono- or bis-benzotriazole compound, an N-oxide thereof, or a mixture of at least two of the preceding compounds. Representative bis-benzotriazole compounds include 3,3'-bis-(2H-benzotriazol-2-yl)-5,5'-di-tert-oc... | 02/05/2002 |
| 6340688 | Contraception method using competitive progesterone antagonists and novel compounds useful therein Competitive progesterone antagonists, including two novel steroids, viz., 11ଲ,19-[4-(cyanophenyl)-o-phenylene]-17ଲ-hydroxy-17-(3-hy droxyprop-1(Z)-enyl)-4-androsten-3-one and 11ଲ,19-[4-(3-pyridinyl)-o-phenylene]-17ଲ-hydroxy-1... | 01/22/2002 |
| 6271261 | IL-8 receptor antagonists Novel IL-8 receptor antagonists and methods of using them are provided.... | 08/07/2001 |
| 6218431 | Substituted biphenyls Substituted biphenyls having glucagon receptor antagonistic activity. Claimed compounds have the formula ##STR1## wherein R1a and R1b independently represent (C1 -C6) alkyl; R2 represents (C1 | 04/17/2001 |
| 6150412 | Catechol derivatives The invention relates to compounds of formula (I) ##STR1## wherein R1 is an electronegative substituent, preferably nitro, cyano, formyl or carboxy, R2 is --A--R4, wherein A is a branched or straight chain C1-9 | 11/21/2000 |
| 6057358 | Amine derivatives, processes for producing them and a use of them as antiarrhythmic drugs Novel amine derivatives of the following general formula (I): ##STR1## (wherein) A may denote --(CH2)--O--, --(CH2)2 --O--, or --(CH2)2 --NH--; B may denote --(CH2)2 --; R1 | 05/02/2000 |
| 6040339 | Urea derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use Compounds of formula (I): ##STR1## wherein: R1 is alkyl; R2a, R2b, R2c and R2d are the same or different and each is hydrogen, optionally substituted alkyl or various other organic groups; R... | 03/21/2000 |
| 5880147 | Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use Compounds of formula (I): ##STR1## wherein: R1 is alkyl; R2a, R2b, R2c and R2d are the same or different and each is hydrogen, optionally substituted alkyl, --(C.dbd.O)--B1 (wherein B | 03/09/1999 |
| 5849796 | Ortho-substituted benzoil acid derivatives Ortho-substituted benzoic acid derivatives of the formula I ##STR1## in which R1, R2 and R3 have the given meanings, and Q is guanidyl, and also their physiologically harmless salts, exhibit antiarrhythmic properties ... | 12/15/1998 |
| 5739374 | Processes of preparing diphenylheteroalkyl derivatives Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as cosme... | 04/14/1998 |
| 5736579 | Substituted spiro compounds for the treatment of inflammation A class of substituted spiro compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein n is a number selected from 0, 1 and 2; wherein R | 04/07/1998 |
| 5731351 | Alkenyl-benzoylguanidine derivatives Alkyl-benzoylguanidines of the formula I ##STR1## wherein R1, R2 and R3 have the meanings given, and physiologically acceptable salts thereof show antiarrhythmic properties and act as inhibitors of the cellular Na | 03/24/1998 |
| 5688945 | Compounds The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA, of the general formula I ##STR1## wherein R1 and R2 are the same or different and selected from H and alkyl; X is selected from alkylthio, ... | 11/18/1997 |
| 5665777 | Biphenyl hydroxamate inhibitors of matrix metalloproteinases Compounds of formula ##STR1## or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases a... | 09/09/1997 |
| 5661183 | 3-hydroxy anthanilic acid derivatives The present invention relates to novel derivatives of 3-hydroxyanthranilic acid, 3-HANA of general formula (I), wherein R1 and R2 are the same or different and selected from H and alkyl; X is selected from alkylthio, arylthio, arylox... | 08/26/1997 |
| 5637770 | Hexa-cyclic compound A novel hexa-cyclic compound, a derivative of camptothecin, of the general formula: ##STR1## The compound is prepared from an aminoketone compound and a pyranoindolizine compound by the condensation-ring closing reaction. It is abundantly water-... | 06/10/1997 |
| 5571842 | Perfluoroalkyl-substituted, benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament containing them Perfluoroalkyl-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament containing them A description is given of perfluoroalkyl-substituted benzoylguanidines of the formula I ##S... | 11/05/1996 |
| 5514642 | Cyclohexenone oxime ethers, their preparation and their use Cyclohexenone oxime ethers of the formula I ##STR1##... | 05/07/1996 |
| 5493053 | Method for preparing desferrioxamine B and homologs thereof A new and versatile route to N'-[5-[[4-[[5-(acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamin o]pentyl]-N-(5-aminopentyl)-N-hydroxybutanediamide, desferrioxamine B (DFO) is described. N-Benzyloxy-1,5-diaminopentane is selectively protected at ... | 02/20/1996 |
| 5482942 | (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to their use in the treatment of hypertension as well as for ... | 01/09/1996 |
| 5480668 | N-substituted derivatives of aspartame useful as sweetening agents Lower alkyl esters of compounds of the formula ##STR1## wherein Z is hydrogen or hydroxyl and R is a hydrocarbyl group optionally substituted by hydroxy and/or alkoxy group, are useful as sweetening agents.... | 01/02/1996 |
| 5449809 | Acetylene derivatives and crop protection agents containing them Acetylene derivatives of the general formula I ##STR1## where U, V and W are hydrogen, halogen, nitro, cyano, alkyl or alkoxy, A is alkylidene, alkoxymethylidene, alkylthiomethylidene or alkoximino, B is OH, alkoxy or alkylamino and R is hydrogen, halogen, cya... | 09/12/1995 |
| 5393790 | Substituted spiro compounds for the treatment of inflammation A class of substituted spiro compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein n is a number selected from 0, 1 and 2; wherein R | 02/28/1995 |
| 5338886 | Process for preparation of aromatic thiols Disclosed is a process for preparation of an aromatic thiol corresponding to the structure A-(SH)n wherein A is a substituted or unsubstituted aromatic radical and n is 1, 2, 3, 4, 5 or 6 comprising contacting at a temperature of at least 80° C. an aroma... | 08/16/1994 |
| 5321169 | Cyclohexane derivatives A novel tetracyclic cyclohexylcyclohexene derivatives represented by formula: ##STR1## wherein ##STR2## n, X and Y are as defined in the specifications, are disclosed. The compounds are useful as electroptic display materials.... | 06/14/1994 |
| 5288901 | 2-aryl-5-(trifluoromethyl)-2-pyrroline compounds useful in the manufacture of insecticidal, nematocidal and acaricidal arylpyrroles There are provided important pyrroline and glycine intermediates, methods for the preparation of said intermediates and the use thereof in the manufacture of arylpyrrole insecticidal agents.... | 02/22/1994 |
| 5238818 | Oxidizable color producing reagent This amount of an oxidative substance or a peroxidase-like substance can be determined by using a combined color former comprising 4-aminoantipyrine or a derivative thereof, etc., as a main color former and a p-fluoroaniline derivative or a salt thereof a... | 08/24/1993 |
| 5185375 | Thioformamide derivatives Therapeutically useful thioformamide derivatives of the formula: ##STR1## wherein R represents alkyl, Ar represents optionally substituted phenyl group, Y represents ethylene, methylene or a valency bond, and X represents carbonyl, hydroxymethylene, ... | 02/09/1993 |
| 5185370 | Substituted ଲ-diketones and their use Compound of formula ##STR1## wherein n is 0 or 1, R1 and R2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof are useful in the treatment of inf... | 02/09/1993 |
| 5180744 | Aralkyl-N-terminal amino hydroxy Non-peptidyl compounds characterized generally as aralkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ##STR1## wherein ... | 01/19/1993 |
