Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 8129560 | Process for the synthesis of mandipropamid and derivatives thereof A process for the preparation of a compound of formula (I), the process comprising: (i) the reaction of a compound of formula (III), with a compound of formula (IV) to give a compound of formula (II), and (ii) the reaction of the compound of formula (II) with a leav... | 03/06/2012 |
| 7863475 | Compounds for the treatment of metabolic disorders Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed. ... | 01/04/2011 |
| 7642367 | Diamino-functional chalcones The invention provides novel diamino-functionalized chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The... | 01/05/2010 |
| 7507852 | Process for preparing gamma-cyhalothrin A process for the preparation of gamma-cyhalothrin comprising steps of a) chlorinating 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid to give 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxy... | 03/24/2009 |
| 7425649 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia. ... | 09/16/2008 |
| 7371885 | Cis-trans isomerisation of semicarbazone compounds The present invention relates to the isomerization of the Z-isomer I-Z of semicarbazone compounds of the general formula (I) into its E-isomer I-E, where the variables in formula (I) have meanings given in claim 1 ... | 05/13/2008 |
| 7368479 | Alpha-sulfonylamino-acetonitriles The invention relates to α-sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar1, and Ar2 independently of each other stand for an optionally substitut... | 05/06/2008 |
| 7304167 | Biphenylcarboxamides useful as lipid lowering agents Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyp... | 12/04/2007 |
| 7297816 | Sulfonamide compounds Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases. ... | 11/20/2007 |
| 7279478 | Cathepsin cysteine protease inhibitors This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as o... | 10/09/2007 |
| 7232923 | Method of hydroaminating N-alkenoylcarbamates with primary aromatic amines The invention provides methods for hydroaminating N-alkenoyl carbamates with aromatic amines. ... | 06/19/2007 |
| 7223988 | Color tunable photoluminescent blends Embodiments of the present invention are directed toward a photoluminescent article comprising at least one host material and at least one color tunable photoluminescent dye. In certain embodiments, the emission spectrum of the at least one tunable photoluminescent ... | 05/29/2007 |
| 7220870 | Hydrolytic kinetic resolution of cyclic substrates The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisome... | 05/22/2007 |
| 7166746 | N-bisaryl- and n-aryl-cycloakylidenyl-αhydroxy-and α-alkoxy acid amides The invention relates to N-bisaryl- and N-aryl-cycloalkylidenyl-a-hydroxy- and a-alkoxy acetic acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, C1–C12 | 01/23/2007 |
| 7153813 | Substituted aryl ketones The invention relates to novel substituted aryl ketones of the formula (I) in which Z, X, R and n are as defined in the disclosure, to processes for their preparation and to their use as ... | 12/26/2006 |
| 6949669 | Organic compounds Compounds of general formula (I) wherein the substituents are as defined in claim 1 are suitable for use as herbicides ... | 09/27/2005 |
| 6921822 | Process for stereoselectively reducing 4-aryl-4-oxobutanoic acid derivatives The present invention relates to a process for preparing stereoisomerically enriched 4-aryl-4-hydroxybutanoic acid derivatives by reducing 4-aryl-4-ketobutanoic acid derivatives in the presence of ruthenium-containing catalysts. ... | 07/26/2005 |
| 6768019 | 3,4-dihydro-1H-naphthalene derivatives as a highly selective cyclooxygenase-2 inhibitor The present invention relates to a novel 3,4-dihydro-1H-naphthalene derivative having a structure of formula 1 or formula 2, its pharmaceutically acceptable salts and their geometric isomers as a highly selective cyclooxygenase-2 inhibitor. ... | 07/27/2004 |
| 6686493 | 3,4-dihydro-1H-naphthalene derivatives as a highly selective cyclooxygenase-2 inhibitor The present invention relates to a novel 3,4-dihydro-1H-naphthalene derivative having a structure of formula 1 or formula 2, its pharmaceutically acceptable salts and their geometric isomers as a highly selective cyclooxygenase-2 inhibitor. ##STR1## ... | 02/03/2004 |
| 6667412 | Nitrile compound The present invention provides a novel nitrile compound useful as an intermediate for the production of, for example, N,N-substituted cyclic amine derivatives or phenylacetonitrile derivatives that are useful as a medicine. Specifically it provides a nitr... | 12/23/2003 |
| 6444838 | Process for the preparation of 1,4-diaryl-2-fluoro-4-cyano-2-butenes and intermediates useful therefor The present invention provides a process for the preparation of pesticidal 1,4-diaryl-2-fluoro-4-cyano-2 -butene compounds having the structural formula I ##STR1## and intermediates useful therefor.... | 09/03/2002 |
| 6399776 | Processes and intermediates in the synthesis of 5-(3-exo-bicyclo[2.2. 1]hept-2-yloxy-4-methoxyphenyl)-3,4,5,6-tetrahydropyrimidine-2(1H)-one This invention relates to novel processes for preparing the pharmaceutically active compound 5-(3-[(2S)-exo-bicyclo[2.2. 1]hept-2-yloxy]-4-methoxyphenyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one and its corresponding 2R enantiomer and for preparing cert... | 06/04/2002 |
| 6242634 | Pyrimidin-4-one derivatives, their use, intermediates for their production, and processes for producing these intermediates Novel pyrimidin-4-one derivatives of formula [1] are provided, which are useful as active ingredients of herbicides, wherein R1 is hydrogen or alkyl; R2 is alkyl optionally substituted with halogen; R3 is alkyl optionally ... | 06/05/2001 |
| 6225491 | Method for preparing certain acetonitriles The invention relates to a process for making certain acetonitriles.... | 05/01/2001 |
| 6207837 | Process for producing dibenzo[b,f]thiepine derivatives Efficient synthesis of diaryl sulfide derivatives useful as intermediates for pharmaceutical compounds. Provision of a convenient process for producing large quantities of dibenzo[b,f]thiepine derivatives using such intermediates. Halogen-substituted phen... | 03/27/2001 |
| 6197993 | Naphthyloxyacetic acid derivatives and a pharmaceutical composition comprising them as an active ingredient The naphthyloxyacetic acid derivatives of the formula (I) ##STR1## wherein A is H, -(alkylene)COOR1, -(alkylene)CONR2 R3, -(alkylene)OH, -(alkylene)tetrazole, -(alkylene)CN; E is single bond or alkylene; G is --S--, --SO--... | 03/06/2001 |
| 5968908 | Restricted 9-cis retinoids The invention is novel analogs of 9-cis-retinoic acid which are useful for the treatment and prevention of coronary artery disease and to protect against premature atherosclerosis by increasing HDL levels. The invention includes processes for preparing th... | 10/19/1999 |
| 5929117 | Immunotherapeutic agents Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor , nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory con... | 07/27/1999 |
| 5846999 | Substituted N-arylmethylamino derivatives of cyclobutene-3,4-diones The compounds of the formula: ##STR1## wherein R1 is straight chain alkyl, branched chain alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R2 and R3 are, independently, hydrogen or an acyl substituent ... | 12/08/1998 |
| 5760275 | Cyanoacetals by hydroformlation of unsaturated nitriles in the presence of orthoesters Disclosed is an improved process for producing cyanoaldehydes and acetals wherein an , ଲ-unsaturated nitrile is reacted with carbon monoxide and hydrogen in the presence of a Group 8 metal catalyst. The improvement in the hydroformylation pro... | 06/02/1998 |
| 5650511 | Process for the preparation of 9-deazaguanine derivatives Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compou... | 07/22/1997 |
| 5633405 | Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1- benzoxanzin-2-one An improved synthesis of a highly potent HIV reverse transcription inhibitor is disclosed, involving an acetylide and a trifluoromethyl ketone which produces a chiral product in the presence of a chiral amino alcohol.... | 05/27/1997 |
| 5627284 | Process for producing (E)-alkoxyimino or hydroxyiminoacetamide compounds and intermediates therefor The present invention relates to a process for producing (E)-alkoxyiminoacetamide compounds useful as agricultural fungicides and a process for producing (E)-hydroxyiminoacetamide compounds useful as intermediates for producing them. The present invention... | 05/06/1997 |
| 5563161 | Alcohols and ethers with aromatic substituents as tachykinin-antagonists Compounds of formula (I), and salt and prodrugs thereof, wherein Q is optionally substituted phenyl or benzhydryl; R1 is H; optionally substituted C1-6 alkyl; optionally substituted phenyl(C1-4 alkyl); C2-6 alke... | 10/08/1996 |
| 5536865 | Process for the preparation of 5,6-dihydroxyindole and intermediate compounds Process for the preparation of 5,6-dihydroxyindole, wherein the compound of formula: ##STR1## in which R' denotes a hydrogen atom or an optionally substituted benzyl radical, is subjected either to the action of hydrogen under pressure or to a h... | 07/16/1996 |
| 5508464 | Process for the preparation of 5,6-dihydroxyindole and intermediate compounds Process for the preparation of 5,6-dihydroxyindole, wherein the compound of formula: ##STR1## in which R' denotes a hydrogen atom or an optionally substituted benzyl radical, is subjected either to the action of hydrogen under pressure or to a h... | 04/16/1996 |
| 5446067 | Oxime ethers and fungicides containing them Oxime ethers of the formula ##STR1## wherein m, G, R, R1, X, Y, and Z are as defined herein and fungicides containing these compounds.... | 08/29/1995 |
| 5442063 | Process for producing (E)-alkoxyimino or hydroxyimino-acetamide compounds and intermediates therefor The present invention relates to a process for producing (E)-alkoxyiminoacetamide compounds useful as agricultural fungicides and a process for producing (E)-hydroxyiminoacetamide compounds useful as intermediates for producing them. The present invention... | 08/15/1995 |
| 5410067 | Process for the preparation of 5,6-dihydroxyindole and intermediate compounds Process for the preparation of 5,6-dihydroxyindole, wherein the compound of formula: ##STR1## in which R' denotes a hydrogen atom or an optionally substituted benzyl radical, is subjected either to the action of hydrogen under pressure or to a h... | 04/25/1995 |
| 5380755 | Alkyl and alkylbenzyl ethers of substituted hydroquinones The present invention provides alkyl and alkylbenzyl ethers of substituted hydroquinones and pharmaceutical compositions containing them. The present invention further provides methods of using these compounds and compositions to inhibit monoamine oxidase... | 01/10/1995 |
