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| Number | Title | Issue Date |
| 7312353 | Cathespin cysteine protease inhibitors This invention relates to a novel class of compounds, represented by the formula below, wherein the meanings of G, E, E, n, R1, R2, R3 et R4 are indicated therein, which are cysteine protease inhibitors, including but not ... | 12/25/2007 |
| 7217682 | Cyclopropanecarboxylic acid esters and pest controllers containing the same A 4-methoxymethyl-2,3,5,6-tetrafluorobenzyl 2,2-dimethyl-3-(2-cyano-3-hydrocarbyloxy-3-oxo-1-propenyl) cyclopropanecarboxylate given by the formula (1): wherein G represents C1–C4 alkyl or C3–C4 alkenyl, has ... | 05/15/2007 |
| 6806365 | N-alkanoylphenylalamine derivatives Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related t... | 10/19/2004 |
| 6667412 | Nitrile compound The present invention provides a novel nitrile compound useful as an intermediate for the production of, for example, N,N-substituted cyclic amine derivatives or phenylacetonitrile derivatives that are useful as a medicine. Specifically it provides a nitr... | 12/23/2003 |
| 6590102 | Process for producing piperidinecarbinols A process for producing a piperidinecarbinol represented by the general formula (2), which comprises reducing the trans isomer of a compound represented by the general formula (1): ##STR1## wherein R1 is a hydrogen atom, a lower alkyl group or ... | 07/08/2003 |
| 6528675 | Cyanohydrin ethers and esters as high-sensitivity enzyme substrates Ethers and esters of cyanohydrins that contain optically detectable moieties are highly effective for detecting, monitoring, and measuring the activity of enzymes that cause the cleavage of certain types of substrates. The cyanohydrins function as proalde... | 03/04/2003 |
| 6476228 | Process for producing piperidinecarbinols A process for producing a piperidinecarbinol represented by the general formula (2), which comprises reducing the trans isomer of a compound represented by the general formula (1): ##STR1## wherein R1 is a hydrogen atom, a lower alkyl group or ... | 11/05/2002 |
| 6462218 | Method for preparing 3-cyano-2,4-dihalogeno-5-fluoro-Benzoic acid The present invention relates to a process for preparing 3-cyano-2,4-dihalogeno-5-fluoro-benzoic acid, to intermediates for carrying out the process and to processes for preparing these intermediates.... | 10/08/2002 |
| 6242634 | Pyrimidin-4-one derivatives, their use, intermediates for their production, and processes for producing these intermediates Novel pyrimidin-4-one derivatives of formula [1] are provided, which are useful as active ingredients of herbicides, wherein R1 is hydrogen or alkyl; R2 is alkyl optionally substituted with halogen; R3 is alkyl optionally ... | 06/05/2001 |
| 6197960 | Process for producing piperidinecarbinols A process for producing a piperidinecarbinol represented by the general formula (2), which comprises reducing the trans isomer of a compound represented by the general formula (1): ##STR1## wherein R1 is a hydrogen atom, a lower alkyl group or ... | 03/06/2001 |
| 6037367 | Substituted-pent-4-ynoic acids Compounds of formula (I) wherein: R1 is --(CR4 R5)n C(O)O(CR4 R5)m R6, --(CR4 R5)n C(O)NR4 (CR4 R5)m | 03/14/2000 |
| 6013827 | Compounds This invention relates to componds of formula I ##STR1## which are useful as PDE IV inhibitors and for treating diseases related thereto.... | 01/11/2000 |
| 5977123 | Oximether and acrylic acid derivatives and their use as fungicides The invention relates to novel oximether and acrylic acid derivatives of the formula (I) ##STR1## in which Z, G, Ar, E, R1 and R2 have the meanings as given in the specification, to processes for their preparation and to their u... | 11/02/1999 |
| 5962695 | Aromatic amidine derivatives and salts thereof An anticoagulant agent which comprises, as an active ingredient, an aromatic amidine derivative represented by the following general formula (1) or a salt thereof: ##STR1## wherein the group represented by ##STR2## is a group selected from ... | 10/05/1999 |
| 5892093 | Resolution A reproducible process for preparing a substantially single enantiomer (R or S) of 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexanoic acid, or an analogue thereof, thereby providing single enantiomer acid for the first time, proceeds by means of a classical... | 04/06/1999 |
| 5780666 | Process for the preparation of an optically pure aminoalcohol A process is described for the preparation of (+)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine (I) by reaction of 3,4-dichlorophenylacetic acid (II) with an alkali metal halogenoacetate, treatment of the 3-cyano-3-(3,4-dichlorophenyl)propionic acid (III) wi... | 07/14/1998 |
| 5756753 | Methine and azamethine dyes based on naphthoquinones in nonlinear optics Naphthalene derivatives of the formula ##STR1## where the rings A and B may be benzofused, X is nitrogen or a radical of the formula CH or CH.dbd.CH--CH, Z is a heterocyclic radical or additionally, when x is CH.dbd.CH--CH, a 5- or 6-membered aromatic car... | 05/26/1998 |
| 5650511 | Process for the preparation of 9-deazaguanine derivatives Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compou... | 07/22/1997 |
| 5610183 | Phenylglycine derivatives pharmaceutical compositions containing them and their use in therapy Compounds of Formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein Q is optionally substituted phenyl or naphthyl; X and Y are each H, C1-6 alkyl, C2-6 alkenyl or X and Y are together .dbd.O; Z is O or S; R... | 03/11/1997 |
| 5576455 | Process for the preparation of fluorinated benzoic acids A process for the preparation of 2-chloro-4,5-difluorobenzoic acid and 2,4,5-trifluorobenzoic acid as well as synthetic intermediates useful in and prepared according thereto, comprising reacting a nitrobenzene having the formula ##STR1## wherei... | 11/19/1996 |
| 5543573 | Hydrazinecarboxyamide derivatives, a process for production thereof and uses thereof The present invention relates to a hydrazinecarboxamide derivative of the general formula (I) shown below: ##STR1## wherein the substituents are as defined in the specification, which has a wide insecticidal spectrum at a low dosage, a process for pr... | 08/06/1996 |
| 5516776 | Enantioselective synthesis of antifolates A process and intermediates for the enantioselective synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid are disclosed.... | 05/14/1996 |
| 5512680 | Process for the preparation of an optically pure aminoalcohol A process is described for the preparation of (+)-2-(3,4-dichlorophenyl)-4-hydroxybutylamine (I) by reaction of 3,4-dichlorophenylacetonitrile (II) with an alkali metal halogenoacetate, treatment of the 3-cyano-3-(3,4-dichlorophenyl)propionic acid (III) w... | 04/30/1996 |
| 5493047 | Method of preparing optically active cyanohydrin derivatives The invention relates to a method of preparing an optically active cyanohydrin carboxylic acid ester from an optically active cyanohydrin of opposite configuration, wherein said starting cyanohydrin is converted with a carboxylic acid in the presence of a... | 02/20/1996 |
| 5476935 | Dyes for use in thermal dye transfer Dye-donor element for use according to thermal dye transfer comprising least one dye corresponding to the general formula (I): ##STR1## wherein Z is --CN, --COOR1 or --CONR2 R3 ; R1 is --H, (cyclo)alkyl, or... | 12/19/1995 |
| 5473071 | Process for the preparation of fused pyridine compounds Pyrido[2,3-d]pyrimidine compounds are prepared through the reaction of 2,4-diamino-6(1H)-pyrimidone and an activated derivative of a dialdehyde. A typical embodiment utilizes the dinitrile.... | 12/05/1995 |
| 5446067 | Oxime ethers and fungicides containing them Oxime ethers of the formula ##STR1## wherein m, G, R, R1, X, Y, and Z are as defined herein and fungicides containing these compounds.... | 08/29/1995 |
| 5412144 | Organic materials with nonlinear optical properties The present invention is directed to organic materials that have the ability to double or triple the frequency of light that is directed through the materials. Particularly, the present invention is directed to the compound 4-[4-(2R)-2-cyano-7-(4'-pe... | 05/02/1995 |
| 5405987 | Process for preparing pyridine and quinoline derivatives The present invention pertains to a method of preparing substituted and unsubstituted N-hydroxy-2-aminobutane diacid derivatives which can be dehydrated to 2-aminobut-2-ene dioic acid derivatives, which can be subsequently converted to pyridine and quinol... | 04/11/1995 |
| 5403953 | 1-phenylbicyclo[2.2.2]octane compounds Compound of formula (I): ##STR1## in which: R1 represents halogen, or hydroxy, alkyl, alkoxy, cyano, amino, mercapto, alkylthio or phenoxy, R2 and R'2 represent two hydrogen when the ring is unsaturated, or alternativ... | 04/04/1995 |
| 5380755 | Alkyl and alkylbenzyl ethers of substituted hydroquinones The present invention provides alkyl and alkylbenzyl ethers of substituted hydroquinones and pharmaceutical compositions containing them. The present invention further provides methods of using these compounds and compositions to inhibit monoamine oxidase... | 01/10/1995 |
| 5312956 | Synthesis of low viscosity non-functional terminated polymers A non-functional liquid rubber is prepared by the solution polymerization of vinyl monomers. The polymer may be a homopolymer or a copolymer. As a copolymer the preferred monomers are a conjugated diene and a vinyl substituted nitrile such as acrylonitril... | 05/17/1994 |
| 5283352 | Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same Catechol compounds of formula I ##STR1## where R1, R2, R3 and X are as described herein are effective Catechol-O-methyltransferase inhibitors.... | 02/01/1994 |
| 5278337 | Enantiomeric resolution of aryl-substituted aliphatic carboxylic acids A process for obtaining a substantially pure enantiomer of an aryl-substituted aliphatic carboxylic acid is described. The process utilizes first an enantiomerically enriched mixture the of aryl-substituted aliphatic carboxylic acid obtained from kinetic ... | 01/11/1994 |
| 5247119 | Phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives A class of substituted phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds having immunosuppressive properties is described. Compounds of this class would be useful in reducing recipient rejection of transplanted organs and for ... | 09/21/1993 |
| 5220048 | Substituted benzocyclobutenes, a process for their preparation and their use Benzocyclobutene-1,2-dichlorides, -bromides and -iodides which are substituted in the benzene ring are accessible in good yields and short reaction times by reacting substituted 1,2-(dichloromethyl or dibromomethyl)-benzenes with NaI in acetonitrile as th... | 06/15/1993 |
| 5220019 | Process for the preparation of diethyl 2-]2-cyano-5-(dimethylamino)-2-(3-methoxyphenyl)-1,1-dimethylpentyl]prop andioate Disclosed is a process for the preparation of 3-aryl-3-aminoalkyl-2,6-dioxohexahydropridines and particularly the compound 3-[3-(dimethylamino)propyl]3-(3 methoxyphenyl)-4, 4-dimethyl-2,6-piperidinedione, monohydrochloride, which is useful as an anti... | 06/15/1993 |
| 5206392 | Facile synthesis of arylmaleic acids and anhydrides A process for making acrylmaleic acid and arylmaleic anhydride derivative useful as intermediates for the preparation of arylmaleimides in the synthesis of compounds having activity in the central nervous system. The process involves reacting arylacetonit... | 04/27/1993 |
| 5190999 | -carbonylphenylacetonitrile derivatives as stabilizers for organic materials Compositions comprising an organic material liable to oxidative, thermal and/or actinic degradation and at least one compound of the formula I ##STR1## are described in which n is 1-6, R, R1, R2, R3 and R4 ... | 03/02/1993 |
| 5187298 | Monomers and their use for the production of a laser-optical recording element which can be repeatedly erased and recorded on Novel laser-optical recording elements which can be repeatedly erased and recorded on contain recording layers (a) which exhibit enantiotropic, ferroelectric smectic liquid crystalline (SC*) behavior, so that they can be switched back and forth... | 02/16/1993 |
