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| Number | Title | Issue Date |
| 8119827 | Compounds for treatment of cell proliferative diseases The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of... | 02/21/2012 |
| 7199158 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1–R6, R7, R7′, R8, R30–R34, X′, Y, Y′, t,... | 04/03/2007 |
| 7135585 | Fungicidal carboxamides Compounds of Formula I are disclosed which are useful as fungicides wherein Q is | 11/14/2006 |
| 7034056 | Aryl and biaryl compounds having MCH modulatory activity In one embodiment, this invention provides a novel class of compounds as antagonists of the MCH receptor, methods of preparing such compounds, pharmaceutical compositions containing one or more of the compounds, methods of preparing pharmaceutical formulations compr... | 04/25/2006 |
| 7022869 | Methods of asymmetrically synthesizing enantiomers of casodex, its derivatives and intermediates thereof Methods of synthesizing pure enantiomers of acylanalides such as Casodex® (bicalutamide) and its derivatives utilizing a compound having a ring structure that, when opened, provides a substituent having the structure of Formula I: | 04/04/2006 |
| 6998364 | Process for the formation of urethane via transcarbamation The invention concerns a novel catalyst for forming urethanes. Said catalyst is characterized by the general formula: MY3−q[Z]q, wherein: Z is the radical corresponding to the anion of a super acid whereof the Hamett constant is at least equa... | 02/14/2006 |
| 6982263 | Nitriles useful as reversible inhibitors of cysteine proteases Disclosed are novel nitrile compounds of formula (I) further defined herein, which compounds are useful as reversible inhibitors of cysteine proteases such as cathepsin K, S, F, L and B. These compounds are useful for treating diseases and pathological conditions ex... | 01/03/2006 |
| 6794542 | Method for the preparation of enantiomerically enriched compounds Process for the preparation of a diasteromerically enriched phenylglycine amide derivative in which an enantiomerically enriched phenylglycine amide is converted into the corresponding Schiff base with the aid of compound R2—C(O)—R3, and th... | 09/21/2004 |
| 6753348 | BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors, including allergy treatments. ... | 06/22/2004 |
| 6743929 | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 06/01/2004 |
| 6515024 | Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 02/04/2003 |
| 6476077 | N-(2-phenyl-4-amino-butyl)-1-naphthamides as neurokinin-1 receptor antagonists A compound having the general formula (I): R1 R2 N--CH2 CH2 --CHAr1 --CH2 --NR3 --CO--R4 wherein: R1 is hydrogen, C1-6 alkyl, C2-6 alkenyl,... | 11/05/2002 |
| 6465457 | Carbonate, carbamate, thiocarbonate dithiocarbonate and thiocarbomate derivatives useful as fungicides Fungicidal compounds of formula (I): ##STR1## wherein W is CH3 O.CH.dbd.CCO2 CH3, CH3 ON.dbd.CCONR3 R4 or CH3 ON.dbd.CCO2 CH3 and stereoisomers thereof; n i... | 10/15/2002 |
| 6121316 | 2-cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives 2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases or dissorders whose course involves increased connective tissue or cartilage degradation.... | 09/19/2000 |
| 6020372 | Use of isoxazole and crotonamide derivatives for the treatment of carcinomatous disorders The compound of the formula I or II ##STR1## is suitable for the production of a pharmaceutical for the treatment of carcinomatous disorders, where R1 is (C3 -C5)-cycloalkyl, (C2 -C6)-alkenyl or ... | 02/01/2000 |
| 5981569 | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction and particularly KDR/FLK-1 receptor signal transduction in order to regulate and/or modulate vasculogenesis and angiogenesis. The invention is bas... | 11/09/1999 |
| 5965588 | Sulfonylalkanoylamino hydroxyethylamimo sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 10/12/1999 |
| 5942640 | Process for the manufacture of N-(1-cyanoalkyl)-2-phenoxypropionamide derivatives The present invention provides an efficient, economic and ecologically sound process for the manufacture of a compound of formula I via the reaction of a suitable acid halide and an appropriate amine in the presence of aqueous carbonate or bicarbonate or ... | 08/24/1999 |
| 5892096 | Non-subliming mid-UV dyes and ultra-thin organic arcs having differential solubility Mid-UV dyes enabling ultra thin antireflection coatings for multi-layer i-line photoetching are produced from bichalcones; bis-a-cyanoacrylates/bis-cyanoacrylamides; and 1.4 divinylbenzenes. The dyes are nonsubliminal and differentially insoluble in stand... | 04/06/1999 |
| 5888481 | Cinnamamides and their use as stabilizers The invention relates to novel cinnamamides, a process for their manufacture and their use as UV absorbers. The cinnamamides of the invention may be used as UV absorbers in a variety of engineered resins such as polyamides (especially nylon 6 and 6,6), po... | 03/30/1999 |
| 5705680 | Process for the preparation of O-acylglycolanilides The present invention relates to a process for the preparation of O-acylglycolanilides of the formula (1) ##STR1## in which R1 and R2 are identical or different and are hydrogen, halogen, a nitro group, a cyano group, a straight... | 01/06/1998 |
| 5688987 | Non-subliming Mid-UV dyes and ultra-thin organic arcs having differential solubility Mid-UV dyes enabling ultra thin antireflection coatings for multi-layer i-line photoetching are produced from bichalcones; bis-a-cyanoacrylates/bis-cyanoacrylamides; and 1.4 divinylbenzenes. The dyes are nonsubliminal and differentially insoluble in stand... | 11/18/1997 |
| 5622949 | Retroviral protease inhibitors Urea-containing hydroxyethylamine peptide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 04/22/1997 |
| 5583248 | Amino acid derivatives having antiviral activity Compounds of the formula: ##STR1## wherein R1 is alkoxycarbonyl, aralkoxycarbonyl, alkanoyl, aralkanoyl, heterocyclylcarbonyl or a group of the formula: ##STR2## R2 is alkyl, cycloalkylalkyl or aralkyl; R3 is hyd... | 12/10/1996 |
| 5443820 | Esters and amides of aminomethylenecyanoacetic acid a cosmetic preparation containing the same as a sunscreen agent and a method for protecting human skin using the same Esters and amides of aminomethylenecyanoacetic acid I ##STR1## where R1 and R2 are each, independently of one another, phenyl, naphthyl, biphenylyl or five- or six-membered hetaryl with one, two or three nitrogens or one oxygen ... | 08/22/1995 |
| 5416111 | Cyano-containing n-phenyl-amino-terminated non-peptidyl -succinamidoacyl aminodiols as anti-hypertensive agents Non-peptidyl compounds characterized generally as -succinamidoacyl aminodiols containing a cyano group and having an N-phenyl-amino-type group at the N-terminus are useful as renin inhibitors for the treatment of hypertension.... | 05/16/1995 |
| 5399690 | Filter dyes for photographic elements Solid particle dispersions of dyes according to the formula: ##STR1## wherein D is selected from the group consisting of ##STR2## and ketomethylene nuclei are disclosed as filter dyes for photographic elements. In this formula, E1 and... | 03/21/1995 |
| 5389619 | Derivatives of phenylacetic acid, their preparation and their use as pesticides Compounds of the formula I ##STR1## where n, W, X, Y, Z, R1, R2, and R3 are as defined herein exhibit fungicidal, insecticidal, and acaracidal activity.... | 02/14/1995 |
| 5389652 | 3-cycloalkyl-prop-2-enamides A compound selected from the group consisting of a compound of the formula ##STR1## wherein R1 is hydrogen or alkyl of 1 to 3 carbon atoms, W is selected from the group consisting of --O--, --S--, --SO-- and --SO2 --, Z and Y ar... | 02/14/1995 |
| 5312830 | 3-cycloalkyl-prop-2-enamides A compound selected from the group consisting of a compound of the formula ##STR1## wherein R1 is hydrogen or alkyl of 1 to 3 carbon atoms, W is selected from the group consisting of --O--, --S--, --SO-- and --SO2 --, Z and Y ar... | 05/17/1994 |
| 5312956 | Synthesis of low viscosity non-functional terminated polymers A non-functional liquid rubber is prepared by the solution polymerization of vinyl monomers. The polymer may be a homopolymer or a copolymer. As a copolymer the preferred monomers are a conjugated diene and a vinyl substituted nitrile such as acrylonitril... | 05/17/1994 |
| 5294643 | Cinnamamide derivative Novel cinnamamide derivatives and the salts thereof are provided. An antihyperlipidemic composition is also provided. The composition comprises an active ingredient which is at least one selected from the group consisting of the above-mentioned cinnamamid... | 03/15/1994 |
| 5270343 | Penta-2,4-dienamides and use as pesticides The present Application discloses pesticidally active compounds of formula (I): Q(CH2)a (O)b Q1 CR2 .dbd.CR2 .dbd.CR3 CR4 .dbd.CR5 CXNR1 Rx... | 12/14/1993 |
| 5258382 | Tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same Tetrahydropyrrolo[1,2-a]pyrazine-4-spiro-3'-pyrrolidine derivatives of the formula: ##STR1## wherein R1 and R2 are independently hydrogen, halogen, trifluoromethyl, alkyl having 1 to 6 carbon atoms, alkoxy having 1 to 6 car... | 11/02/1993 |
| 5232937 | Derivatives of N-phenylbenzamide with anti-ulcer and anti-allergy Derivatives of N-phenylbenzamide with general formula (1) in which R1 is a cyano, nitro, halogen, hydrozy, C1 -C4 alkyl methyl, methoxy or tetrazol-5-yl group, R2 is hydrogen, hydroxy, or methoxy, R3 ... | 08/03/1993 |
| 5180744 | Aralkyl-N-terminal amino hydroxy Non-peptidyl compounds characterized generally as aralkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest are of the formula ##STR1## wherein ... | 01/19/1993 |
| 5180737 | Phenyl or bicyclo-alkenylfluoro amide pesticides Compound of the formula (I): Q1 Q(CR2 .dbd.CR3)a (CR4 .dbd.CF)(CR5 .dbd.CR6)b C(.dbd.O)NHR1 (1) or a salt thereof, wherein Q1 is a phenyl... | 01/19/1993 |
| 5175170 | ଲ-amino acid derivatives Non-peptidyl compounds characterized generally as cycloalkyl/cycloalkylkyl-N-terminal amino hydroxy ଲ-amino acid derivatives are useful as renin inhibitors for treatment of hypertension. Compounds of particular interest of the formula ##STR1## ... | 12/29/1992 |
| 5130456 | Bis(reissert compounds) from reaction of monoaldehyde, monoamine and diacid halide A bis Reissert can be formed by the initial reaction of an aliphatic or aromatic aldehyde (e.g., propionaldehyde) and primary amine (e.g., methylamine) to form a reaction product which is then reacted with a diacid chloride (e.g., adipoyl chloride).... | 07/14/1992 |
| 5110986 | Synthesis of N-t-alkyl-1,2-diacylhydrazines This application relates to a process for preparing a N-t-alkyl-1,2-diacylhydrazine by reacting a 1,3,4-oxadiazole with a tertiary alkyl cation precursor in the presence of a strong acid catalyst. Preferably, the 1,3,4-oxadiazole is a 2,5-disubstituted-1,... | 05/05/1992 |
