Did You Know...
...that in 1800 ether was first used by partyers as a fun diversion? Sniffing the gas led to hilarious and raucous laughter as people watched each other become more and more intoxicated and silly. Several doctors independently realized the value ether would have to anesthetize surgery patients. Of those who claimed rights to the "discovery," none had a happy ending. One had a seizure and died defending his rights. Another spent his life in an asylum because he had been denied acclaim. A third became addicted to chloroform and, in a New York City jail, he soaked a cloth in the drug, severed an artery and bled to death.
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| Number | Title | Issue Date |
| 7371747 | Cyanoalkylamino derivatives as protease inhibitors The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by... | 05/13/2008 |
| 7304018 | Amidoacetonitrile compounds and their use as pesticides The invention relates to compounds of the general formula: (I) and optionally the enantiomers thereof. The active ingredients have advantages pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals. ... | 12/04/2007 |
| 7297817 | Thio-substituted arylmethanesulfinyl derivatives The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein ... | 11/20/2007 |
| 7241776 | Cyanoamidine P2Xantagonists for the treatment of pain Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compo... | 07/10/2007 |
| 7235587 | Diesters containing two crylene or fluorene moieties, sunscreen compositions containing the same, and methods of photostabilizing a sunscreen compositions containing the same Diesters that include one or more of a crylene and/or a fluorene moiety, and sunscreen compositions including a mixture of a photoactive compound and one or more of a diester that includes one or more of a crylene and/or a fluorene moiety are described herein. Also ... | 06/26/2007 |
| 7202252 | Aadenosine receptor antagonists Compounds of the general formula (I) are described: wherein A is a 5- or 6-membered aromatic or heteroaromatic ring. Compositions comprising such compounds and methods of use thereof are also described. ... | 04/10/2007 |
| 7153814 | Amidoacetonitrile derivatives The invention relates to compounds of the general formula (I), in which Ar, R1, R2, R3, R4, R5, R6, R7, R8, W, a, b and n are as defined in claim 1, and to any enantiomers... | 12/26/2006 |
| 7148255 | Amidoacetonitrile compounds The invention relates to compounds of formula I wherein R1, R2, R3, R4, R5, R6, R8, R8′, R9, W, X, A1 | 12/12/2006 |
| 7135585 | Fungicidal carboxamides Compounds of Formula I are disclosed which are useful as fungicides wherein Q is | 11/14/2006 |
| 7091371 | Aminoacetonitrile derivatives and their use for controlling parasites The invention relates to compounds of the general formula (I), in which R1, R2, X, Ar1 and Ar2 are as defined in claim 1, and to any enantiomers thereof. The active ingredients have advantageous pesticidal properties. They... | 08/15/2006 |
| 7063856 | Pharmaceutical composition containing aminocetonitrile compounds and the use thereof for the preparation of a pharmaceutical composition for the treatment of endoparasitic pests in animals The invention relates to a composition for controlling a pest, including endoparasites, and more specifically helminths, of formula (I) in animals, and methods related to thereof. ... | 06/20/2006 |
| 7052707 | Pharmaceutical composition containing aminoacetonitril compounds and the use thereof for the preparation of a pharmaceutical composition for the treatment of endoparasitic pests in animals The invention relates to a composition for controlling a pest, including endoparasites, and more specifically helminths, of formula (I) in animals, and methods related to thereof. ... | 05/30/2006 |
| 7053245 | N-acylamino benzyl ether derivatives This invention relates to N-acylamino aryl derivatives of the formula where R1, R21, R22, R23, R24, R3, R4, R5, R | 05/30/2006 |
| 7012075 | Cathepsin cysteine protease inhibitors This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, s... | 03/14/2006 |
| 6951884 | Fluorobenzamides and uses thereof The invention relates to fluorobenzamide derivatives of the formula wherein R1, R2, R3 R4, R5, R6 and R7 are as defined herein. =, Th... | 10/04/2005 |
| 6831163 | Bichromophoric molecules Disclosed is a molecule containing a first chromophore that exhibits a first absorption maximum above 700 nm and a second chromophore that exhibits a second absorption maximum different from the first absorption maximum, wherein the absorption of the first and secon... | 12/14/2004 |
| 6821973 | Compounds A compound having the general formula R1R2N—CH2CH2—CHAr1—CH2—NR3—CO—R4 (I) and methods of using such compounds for the treatment of diseases ... | 11/23/2004 |
| 6812237 | N-substituted peptidyl nitriles as cysteine cathepsin inhibitors Compounds of the formula (I), wherein R1 is aryl or biaryl; R2 is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C2-C7-alkyl in ... | 11/02/2004 |
| 6800659 | Compounds for modulating cell proliferation Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I: ... | 10/05/2004 |
| 6794542 | Method for the preparation of enantiomerically enriched compounds Process for the preparation of a diasteromerically enriched phenylglycine amide derivative in which an enantiomerically enriched phenylglycine amide is converted into the corresponding Schiff base with the aid of compound R2—C(O)—R3, and th... | 09/21/2004 |
| 6762320 | N-acylamino benzyl ether derivatives This invention relates to N-acylamino aryl derivatives of the formula where R1, R21, R22, R23, R24, R3, R4, R5 R6,... | 07/13/2004 |
| 6753348 | BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors, including allergy treatments. ... | 06/22/2004 |
| 6649642 | Succinate derivative compounds useful as cysteine protease inhibitors Disclosed are novel succinate derivative compounds of the formula(I)/(Ia): ##STR1## wherein R1, R2, R3, R4, R5, R6, R7, X and A are defined herein. The compounds are useful as inhibitors of cysteine proteases. Also disclosed are methods of using and metho... | 11/18/2003 |
| 6613931 | Use of phenylacetamides as plant protectives having herbicidal and fungicidal effect The resent invention relates to the use of phenylacetamides as crop protection agents, to novel crop protection compositions comprising, as active compounds, phenylacetamides, and to novel phenylacetamides. The present invention provides the use of phenylaceta... | 09/02/2003 |
| 6596716 | 2-propane-sulphonamide derivatives The present invention relates to the potentiation of glutamate receptor function using certain 2-propane-sulphonamide derivatives. It also relates to novel 2-propane-sulphonamide derivatives, to processes for their preparation and to pharmaceutical compos... | 07/22/2003 |
| 6596795 | Low-color vanillin-based ultraviolet absorbers and methods of making thereof Novel ultraviolet absorbing compounds that are liquid in nature, are extremely low in color (and thus permit use without the concomitant necessity of adding large amounts of other coloring agents to combat such discoloring), and are highly effective in pr... | 07/22/2003 |
| 6586432 | Neurokinin-1 receptor antagonists Compounds having the general formula R1 R2 N--CH2 CH2 --CHAr1 --CH2 --NR3 --CO--R4 (I) wherein R1, R2, R3, R4 and Ar are as defined... | 07/01/2003 |
| 6566403 | N-acetonylbenzamide fungicides This invention relates to new compositions comprising predominantly one enantiomer of an N-acetonylbenzamide fungicide, methods of preparing N-acetonylbenzamides, and their use as fungicides.... | 05/20/2003 |
| 6555702 | Protein kinase inhibitor A compound of the formula I: ##STR1## wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy, or alkoxy of 1-6 carbon atoms; B is hydroxy, alkoxy of 1-6 carbon atoms --CO2 Z, --O(CH2)m CO2 Z, --... | 04/29/2003 |
| 6525036 | Compounds and compositions as protease inhibitors The present invention relates to novel cysteine protease inhibitors of Formula I: ##STR1## the pharmaceutically acceptable salts and N-oxide derivatives thereof, their use as therapeutic agents and methods of making them.... | 02/25/2003 |
| 6486343 | Substituted phenyl keto enols as pesticides and herbicides The present invention relates to novel compounds of the formula (I) ##STR1## in which Het represents one of the groups ##STR2## in which A, B, D, G, V, W, X, Y and Z are as defined in the description, processes and intermediates for their preparation, an... | 11/26/2002 |
| 6369069 | Biphenylsulfonyl cyanamides, method for the production thereof and their utilization as a medicament The invention relates to compounds of the formula (I), ##STR1## in which the symbols have the following meaning: R(1) is 1. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms; 2. alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 carbon atoms, in which one to all hydrogen ... | 04/09/2002 |
| 6355678 | Inhibitors of the EGF-receptor tyrosine kinase and methods for their use Novel compounds and pharmaceutical compositions useful as EGFR tyrosine kinase inhibitors. Methods of the invention include administration of the EGFR TK inhibitors to treat diseases characterized by enhanced expression of EGF, including cancers, particul... | 03/12/2002 |
| 6303652 | BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors.... | 10/16/2001 |
| 6294575 | BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors.... | 09/25/2001 |
| 6239077 | Aminoacetonitrile derivative agricultural and horticultural insecticide containing the same and use thereof An aminoacetonitrile derivative of the formula (I): ##STR1## (wherein Ar1 and Ar2 represents phenyl group; substituted phenyl group having at least one subsituent selected from halogen atom, nitro group, cyano group, (halo) C1 | 05/29/2001 |
| 6160010 | BTK inhibitors and methods for their identification and use The invention provides BTK inhibitors, methods for their identification and use, and pharmaceutical compositions comprising BTK inhibitors.... | 12/12/2000 |
| 6121316 | 2-cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives 2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases or dissorders whose course involves increased connective tissue or cartilage degradation.... | 09/19/2000 |
| 6020372 | Use of isoxazole and crotonamide derivatives for the treatment of carcinomatous disorders The compound of the formula I or II ##STR1## is suitable for the production of a pharmaceutical for the treatment of carcinomatous disorders, where R1 is (C3 -C5)-cycloalkyl, (C2 -C6)-alkenyl or ... | 02/01/2000 |
| 5891916 | Aromatic hydroxamix acid compounds, their production and use A compound represented by the formula: ##STR1## wherein Ar1 and Ar2 independently represent an optionally substituted aromatic group; Q represents an optionally substituted divalent aliphatic hydrocarbon group optionally contain... | 04/06/1999 |
