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| Number | Title | Issue Date |
| 7442718 | Inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. T... | 10/28/2008 |
| 7304018 | Amidoacetonitrile compounds and their use as pesticides The invention relates to compounds of the general formula: (I) and optionally the enantiomers thereof. The active ingredients have advantages pesticidal properties. They are especially suitable for controlling parasites on warm-blooded animals. ... | 12/04/2007 |
| 7241776 | Cyanoamidine P2Xantagonists for the treatment of pain Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compo... | 07/10/2007 |
| 7135585 | Fungicidal carboxamides Compounds of Formula I are disclosed which are useful as fungicides wherein Q is | 11/14/2006 |
| 7105832 | Composite solid-state scintillators for neutron detection Applicant's present invention is a composite scintillator for neutron detection comprising a matrix material fabricated from an inorganic sol-gel precursor solution homogeneously doped with a liquid scintillating material and a neutron absorbing material. The neutro... | 09/12/2006 |
| 7094815 | Clay/AMO complex and derivative thereof and method for producing the same The present invention discloses a clay/amine complex which is an excellent surfactant and a good reinforcing agent of polymers. The complex of the present invention can be produced by modifying layered inorganic silicate clay such as montomorillonite, with an interc... | 08/22/2006 |
| 7064231 | Optically active diamines and their use in catalytic processes The invention relates to stereoisomerically enriched diamines, to metal complexes comprising these diamines and also to their use in a process for asymmetrically reducing ketones using silanes, in particular polymethylhydrosiloxane, as reducing agents. ... | 06/20/2006 |
| 6995180 | Glycinenitrile-based inhibitors of dipeptidyl peptidase IV and methods A compound of the formula I: wherein R1, R2, R3 and R4 are as defined herein. Further provided are methods of u... | 02/07/2006 |
| 6800659 | Compounds for modulating cell proliferation Novel styrylacrylonitrile compounds which are useful in treating a variety of cell proliferative disorders such as cancer are disclosed. The compounds are of the Formula I: ... | 10/05/2004 |
| 6743929 | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effecive as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 06/01/2004 |
| 6703420 | Amino-thio-acrylonitriles as MEK inhibitors This invention relates generally to amino-thio-acrylonitriles of formula Ia or Ib: ##STR1## as MEK inhibitors, pharmaceutical compositions containing the same, and methods of using the same as for treatment and prevention of inflammatory disorders or... | 03/09/2004 |
| 6515162 | Method of preparing retroviral protease inhibitor intermediates Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective meth... | 02/04/2003 |
| 6451854 | -amino acid phenyl ester derivatives The present invention relates to -amino acid phenyl ester derivatives having general formula (I) wherein R1 is (C1-3)alkyloxy; R2 is (C1-3)alkyl, (C1-3)alkyloxy or (C2-3)alkenyl; R | 09/17/2002 |
| 6413947 | Anilide derivative, production and use thereof This invention is to provide a compound of the formula: ##STR1## wherein R1 is an optionally substituted 5- to 6-membered ring; W is a divalent group of the formula: ##STR2## wherein the ring A is an optionally substituted 5- to 6-membered arom... | 07/02/2002 |
| 6365754 | Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives The present invention relates to a process for reacting -aminoaldehyde derivatives having a sterically bulky amino group which are commercially available with a metal cyanide in the presence of an acid chloride, an acid anhydride or the like to syn... | 04/02/2002 |
| 6359061 | Amide compound libraries Amide compounds of formula (I), combinatorial libraries of amide compounds and methods of preparing the same are provided. Libraries of the invention are useful for screening in biological assays in order to identify pharmaceutically useful compounds. ... | 03/19/2002 |
| 6306840 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/23/2001 |
| 6294531 | Calcilytic compounds Novel arylalkylamino compounds exhibiting calcilytic properties are provided.... | 09/25/2001 |
| 6277885 | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors Hydroxamic acids having the formula ##STR1## are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage ... | 08/21/2001 |
| 6248893 | Non-heterocyclic oxonol infrared radiation sensitive compounds Infrared radiation-sensitive compounds have been found that are represented by Structure DYE as follows: ##STR1## wherein R is a secondary or tertiary amine that contains no heterocyclic group, R1 and R2 are independently carbocyclic... | 06/19/2001 |
| 6232342 | Protease inhibitors The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gi... | 05/15/2001 |
| 6225346 | Tyrphostin like compounds The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with particular tyrosine kinases by inhibiting one or more abnorma... | 05/01/2001 |
| 6191165 | Pharmaceutical for treatment of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof.... | 02/20/2001 |
| 6121316 | 2-cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives 2-Cyano-3,5-dihydroxyhex-2-enecarboxamide derivatives ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases or dissorders whose course involves increased connective tissue or cartilage degradation.... | 09/19/2000 |
| 6103929 | Process for the preparation of cyclopropylglycine Disclosed is a process for the preparation of cyclopropylglycine by a 5-step process wherein cyclopropanecarboxaldehyde is reacted with an -aminoalkylaromatic compound to obtain an imine which is reacted with a cyanide to produce an aminonitrile co... | 08/15/2000 |
| 6090982 | Process for the preparation of cyclopropylglycine Disclosed is a process for the preparation of cyclopropylglycine by a 5-step process wherein cyclopropanecarboxaldehyde is reacted with an -aminoalkylaromatic compound to obtain an imine which is reacted with a cyanide to produce an aminonitrile co... | 07/18/2000 |
| 6031124 | 7-amino-2-heptenoates and their use in the preparation of methylphenidate The subject invention pertains to compounds of the formula Y1 Y2 N--(CH2)4 --CH.dbd.C(Ph)--X wherein Y1 and Y2 are independently H or a removable blocking group, or Y1 and Y2 | 02/29/2000 |
| 5981569 | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction and particularly KDR/FLK-1 receptor signal transduction in order to regulate and/or modulate vasculogenesis and angiogenesis. The invention is bas... | 11/09/1999 |
| 5965588 | Sulfonylalkanoylamino hydroxyethylamimo sulfonamides useful as retroviral protease inhibitors Sulfonamide-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.... | 10/12/1999 |
| 5891917 | Certain acrylonitrile-sulfonamide derivatives The present invention relates to molecules capable of modulating tyrosine signal transduction to prevent and treat cell proliferative disorders or cell differentiation disorders associated with particular tyrosine kinases by inhibiting one or more abnorma... | 04/06/1999 |
| 5892095 | Cyano group-containing oxime sulfonate compounds Disclosed is a novel positive-working or negative-working chemical-sensitization photoresist composition useful in the photolithographic patterning works for the manufacture of electronic devices. The photoresist composition is characterized by a unique ... | 04/06/1999 |
| 5888481 | Cinnamamides and their use as stabilizers The invention relates to novel cinnamamides, a process for their manufacture and their use as UV absorbers. The cinnamamides of the invention may be used as UV absorbers in a variety of engineered resins such as polyamides (especially nylon 6 and 6,6), po... | 03/30/1999 |
| 5856490 | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity Compounds of the formula ##STR1## where the symbols have the meaning defined in the specification have retinoid-like biological activity.... | 01/05/1999 |
| 5856518 | Production process of cyclic compound This invention is to provide a compound represented by the following formula (I) and a compound represented by the following formula (II) useful as an antibacterial agent which is obtained by the compound of folmula (I), and also to provide a novel synthe... | 01/05/1999 |
| 5811424 | Amino-acid amide derivatives, method for producing the same, and agricultural or horticultural fungicides The present invention provides an amino-acid amide derivative represented by the formula: ##STR1## (wherein R1 represents a lower alkyl group (optionally having at least one same or different substituent of a halogen atom), R2 ... | 09/22/1998 |
| 5775329 | Method and compounds for diagnosing coronary artery disease The present invention relates generally to methods of diagnosis, evaluation and treatment of coronary artery disease in mammals using substituted catecholamines and compounds therefore. It also relates to the preparation, use and administration of these c... | 07/07/1998 |
| 5763639 | Process for producing quarternary glycine nitriles A process for preparing quaternized glycine nitriles of formula I ##STR1## comprising reaction of the corresponding precursor amine, aldehyde, hydrocyanic acid or alkali metal cyanide, and subsequent quaternization with an alkylating agent, wherein t... | 06/09/1998 |
| 5703265 | Monofunctional n--(2--cyanoethenyl)sulfonamides A compound having the structure: ##STR1## is disclosed. R1 is defined in the specification. The compounds are charged control agents for use in electrostatographic toners and developers.... | 12/30/1997 |
| 5679715 | Method for treating multiple sclerosis The invention relates to a method of treating multiple sclerosis comprising administering an effective amount of (R)-(-)-N,2-dimethyl-N-2-propynylphenethylamine alone or in conjunction with an effective amount of interferon beta or an effective amount of ... | 10/21/1997 |
| 5643947 | ω-amino--phenylalkanonitrile derivatives A class of ω-amino--phenylalkanonitrile derivatives is described having use in treatment of cardiovascular dysfunctions such as hypertension. Compounds of most interest are those of the formula: ##STR1## wherein each of R1 and R | 07/01/1997 |
