Did You Know...
...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 7057062 | Process for manufacturing purified phosphorodiamidite A scalable process for purification of phosphorodiamidite includes steps of solubilizing a crude phosphorodiamidite in an apolar organic solvent, contacting the non-polar organic solvent with a polar phase comprising a polar organic solvent to remove impurities from... | 06/06/2006 |
| 6855841 | Process for the preparation of N-phosphonomethylglycine The present invention relates to a process for the preparation of N-phosphonomethylglycine by reacting a hexahydrotriazine derivative with a triacyl phosphite. The process gives N-phosphonomethylglycine in high yield and in a simple and inexpensive manner. ... | 02/15/2005 |
| 6660878 | Process for the preparation of N-phosphonomethylglycine The present invention relates to a process for the preparation of N-phosphonomethylglycine by reacting a hexahydrotriazine derivative with a triacyl phosphite. The process gives N-phosphonomethylglycine in high yield and in a simple and inexpensive manner... | 12/09/2003 |
| 6525036 | Compounds and compositions as protease inhibitors The present invention relates to novel cysteine protease inhibitors of Formula I: ##STR1## the pharmaceutically acceptable salts and N-oxide derivatives thereof, their use as therapeutic agents and methods of making them.... | 02/25/2003 |
| 6359162 | Method for producing glufosinates and intermediate products for the same Glufosinate and the 2-methyl analog thereof can be prepared in a multi-step synthesis from methylphosphorus compounds (II) with unsaturated keto compounds (III) via adducts (IV), subsequent reaction under the conditions of a Strecker synthesis and finally... | 03/19/2002 |
| 6333425 | Malononitrile-derivative anion salts, and their uses as ionic conducting materials The invention is related to ionic compounds, derivatives of malononitrile, in which the anionic load has been displaced. An ionic compound disclosed by the invention includes an anionic portion combined with at least one cationic portion M+m in... | 12/25/2001 |
| 6313159 | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors The present invention relates to metabotropic glutamate receptor ligand derivatives and methods of using the same to inhibit NAALADase enzyme activity, to effect neuronal activities, to inhibit angiogenesis, and to treat glutamate abnormalities, compulsiv... | 11/06/2001 |
| 6277885 | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors Hydroxamic acids having the formula ##STR1## are useful in treating disease conditions mediated by TNF-, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage ... | 08/21/2001 |
| 6121252 | Phosphinic acid derivatives The present invention relate to phosphinic acid derivatives that inhibit N-Acetylated -Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising the same, and methods of using the same to inhibit NAALADase activi... | 09/19/2000 |
| 6080860 | Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediate... | 06/27/2000 |
| 5817603 | Substituted cyclohexene-1,2-dicarboxylic acid derivatives and intermediates for their preparation Substituted cyclohexene-1,2-dicarboxylic acid derivatives I ##STR1## where R1, R2, R3, R4, R5 and R6 are herein defined, or the agriculturally useful salts of Ia and Ib and intermediates ... | 10/06/1998 |
| 5650511 | Process for the preparation of 9-deazaguanine derivatives Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compou... | 07/22/1997 |
| 5576454 | Process for preparing alkanephosphonic anhydrides Process for preparing phosphonic anhydrides of the formula (I) ##STR1## in which R is (C1 -C10)-alkyl which is unsubstituted or substituted by alkyl groups, alkoxy groups, fluorine, chlorine or bromine atoms, nitro groups, cyano... | 11/19/1996 |
| 5468870 | Dyes and dye-donor elements for use in thermal dye sublimation transfer Dye-donor element for use according to thermal dye sublimation transfer comprising a support having thereon a dye layer containing a dye corresponding to the following formula ##STR1## wherein Z represents CN, COOR1 or CONR2 R | 11/21/1995 |
| 5442084 | Method of selective fluorination The present invention is a method for selectively fluorinating various methylenephosphonate and methylenephosphorane derivatives using an electrophilic fluorinating agent, such as N-fluoro 1,4-diazabicyclo[ 2.2.2]octane by fluorinating the monohalogenated... | 08/15/1995 |
| 5242908 | Use of benzylphosphonic acid derivatives for the treatment of diseases caused by viruses The use of a compound of the formula I ##STR1## in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, ar... | 09/07/1993 |
| 5228898 | Substituted bicycloheptandione derivatives This invention relates to substituted bicycloheptadione derivatives with high herbicidal activity which are represented by general formula (I) ##STR1## (where R1 is a lower alkyl group, a phenyl group which may be substituted, an aralkyl g... | 07/20/1993 |
| 5190999 | -carbonylphenylacetonitrile derivatives as stabilizers for organic materials Compositions comprising an organic material liable to oxidative, thermal and/or actinic degradation and at least one compound of the formula I ##STR1## are described in which n is 1-6, R, R1, R2, R3 and R4 ... | 03/02/1993 |
| 5149847 | Naphthalocyanine compound and production thereof Disclosed is a novel naphthalocyanine compound which strongly absorbs light of near infrared region and which is chemically stable and highly soluble to an organic solvent. The naphthalocyanine compound is represented by the following formula [1]; ##... | 09/22/1992 |
| 5147867 | Phosphorus containing enzyme inhibitors Dipeptide mimics which contain phosphorus and their pharmaceutical use and preparation are disclosed. The compounds have dehydropeptidase (DHP) enzyme inhibitor activity.... | 09/15/1992 |
| 5061388 | Novel phthalonitriles and phthalocyanines as lubricity-enhancing additives Disclosed herein are phthalonitriles of the following formula: ##STR1## wherein R1, R2, and R3 are independently in each occurrence an aryl or phosphazine group; X is independently in each occurrence O, S, S(O), S(O)(... | 10/29/1991 |
| 5024691 | Substituted phenoxy benzamide herbicides and methods of use As new compounds, substituted aryloxyphenoxy benzamides having the formula ##STR1## in which X is CH or nitrogen; Y is chlorine, bromine, fluorine, iodine, methyl, cyano or hydrogen; Z is hydrogen, chlorine, bromine, fluorine, iodine, CHn,... | 06/18/1991 |
| 4962097 | Method of treating bacterial infection with phosphorus containing DHP enzyme inhibitors Dipeptide mimics which contain phosphorus and their pharmaceutical use and preparation are disclosed. The compounds have dehydropeptidase (DHP) enzyme inhibitor activity.... | 10/09/1990 |
| 4927944 | Antihypercholesterolemic nitrile compounds Compounds of the formula ##STR1## wherein R1, R2, R3 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl; A is ##STR2## and R5 ... | 05/22/1990 |
| 4921526 | Substituted bicycloakly-1,3-diones Substituted benzoyl-bicycloalkyl-1,1,3-diones and related compounds, intermediates therefor, synthesis thereof, and the use of said diones for the control of weeds.... | 05/01/1990 |
| 4908138 | Hydroxyacetonitrile diphosphonic acid, a process for its production, and its use Hydroxyacetonitrile diphosphonic acid corresponding to the following general formula ##STR1## in which M represents H or a cation of a base, and salts thereof; to a process for their preparation comprising reacting 3-R1 -3-oxo-1-amino... | 03/13/1990 |
| 4904813 | Cyanomethyl acid halides of phosphorus and process for their preparation The invention relates to compounds of the general formula ##STR1## in which R1 represents Hal or C1 -C3 -alkyl and Hal reprsents a halogen having an atomic weight of 35 to 80. The invention also relates to a process for th... | 02/27/1990 |
| 4874846 | Process for the preparation of aryloxybenzoic acids containing a sulfonamide group Process for the preparation of aryloxy-benzoic acids containing a sulphonamide group by the direct reaction of a phenoxy-benzoic acid with a sulphonamide, in the presence of a halogenating agent such as P(O)Cl3.... | 10/17/1989 |
| 4776875 | Functional acetic acid derivatives containing phosphorus and herbicidal, growth-regulating agents containing them Compounds of the formula ##STR1## in which R1 and R2 denote alkyl, OH, CF3 or cyanoethyl, A preferably denotes --COOH, R3 denotes inter alia alkoxycarbonylalkoxy, fairly high-molecular (>C12) alk... | 10/11/1988 |
| 4755614 | Preparation of herbicides containing a phosphonate group from intermediate benzoxazines Preparation of intermediates for herbicides of formula ##STR1## by the reaction of organic phosphites with benzoxazines of formula in which Bzx denotes the radical of formula: ##STR2## X is a usual substituent of phenols n is an integer from 0 to 4 R... | 07/05/1988 |
| 4751028 | Process for the preparation of thiophosphinic chlorides A process for the production of a chloride of thiophosphinic acids which comprises reacting an anhydride of a phosphinic acid with thiophosphoryl chloride.... | 06/14/1988 |
| 4715994 | Novel antibacterial agents and potentiators of carbapenem antibiotics New 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids are described which display antibacterial activity and potentiate carbapenem antibiotics.... | 12/29/1987 |
| 4715882 | Substituted phenoxypropionaldehyde derivates and their use as herbicidal agents The invention relates to certain substituted phenoxypropionaldehyde derivatives, formulations of said derivatives and the use thereof for preemergence or postemergence control of noxious plants, i.e., weeds.... | 12/29/1987 |
| 4692541 | Phosphorus-containing -amino nitriles and a process for their preparation A process for the preparation of phosphorus-containing -amino nitriles of the general formula I ##STR1## in which R1 and R2 denote (substituted) alkyl, aryl, aralkyl or cycloalkyl, R3 denotes H, alkyl, phenalky... | 09/08/1987 |
| 4654072 | Herbicidal phosphonomethyl amides Compounds having the formula ##STR1## in which R is hydrogen, cyano or --COOR2 ; R1 is hydrogen or C1 -C4 alkyl; R2 is hydrogen or C1 -C4 alkyl; and Z is ##STR2## ... | 03/31/1987 |
| 4640701 | Herbicidal phosphonic acid and phosphinic acid derivatives Novel phosphonic acid and phosphinic acid derivatives of the formula I ##STR1## wherein X is hydrogen or chlorine, n is 0 or 1, R1 and R2 are each independently hydrogen, C1 -C4 alkyl, C3 -C4 | 02/03/1987 |
| 4629491 | Oxidized sulfur derivatives of diaminophosphinyl compounds as urease inhibitors and urease inhibited urea based fertilizer compositions The invention relates to novel urease inhibited fertilizer compositions containing urea and a urease inhibiting amount of one or more diaminophosphinyl compounds having oxidized sulfur functions, and methods and composition for inhibiting the activity of ... | 12/16/1986 |
| 4624695 | O-diaminophosphinyl derivatives of oximes as urease inhibitors The invention relates to novel urease inhibited fertilizer compositions containing urea and a urease inhibiting amount of one or more o-diaminophosphinyl derivatives of oximes, and methods and composition for inhibiting the activity of urease through use ... | 11/25/1986 |
| 4594199 | Method for making phosphinic acid intermediates A method is provided for preparing phosphinic acid prodrug intermediates which are useful in preparing phosphinic acid angiotensin-converting enzyme inhibitors which method includes the step of coupling a phosphonous acid or its ester of the structure ... | 06/10/1986 |
| 4564690 | Macrocyclic compounds A macrocyclic compound represented by the following general formula: ##STR1## and a process for preparing thereof which comprises reacting an ,ω-dihalogenated hydrocarbon and an active methylene compound with a base in a solvent to obtain a m... | 01/14/1986 |
