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| Number | Title | Issue Date |
| 7528274 | Acylthiols and component thiol compositions as anti-HIV and anti-retroviral agents Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are... | 05/05/2009 |
| 7371867 | Non-racemic trifluoroleucine, and methods of making and using One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the invention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compri... | 05/13/2008 |
| 7132559 | Non-racemic hexafluoroleucine, and methods of making and using it One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compris... | 11/07/2006 |
| 7078402 | Aminothiol ester compounds, pharmaceutical and cosmetics compositions containing same and uses thereof The invention relates to novel aminothiol ester compounds having the general formula (I): and to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary... | 07/18/2006 |
| 7045547 | Acyl-CoA dehydrogenase allenic inhibitors Compounds of formula I wherein A is R3, OR3, SR3, and NR3R4; and R1, R2, R3 and R | 05/16/2006 |
| 6864383 | Ophthalmic compositions for treating ocular hypertension This invention relates to the use of potent potassium channel blockers or a formulation thereof in the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such co... | 03/08/2005 |
| 6417368 | Amine derivative fixed to resin and method for synthesizing ଲ-aminocarbonyl compound in a solid phase The invention provides a resin-immobilized imine represented by the following formula: P--Q--N--.dbd.CH--R I [in the formula, P represents the principal chain of a resin polymer; Q represents a substituted or unsubstituted hydrocarbon side chain or a su... | 07/09/2002 |
| 6348627 | Aryl and heteroarylcyclopropyl oxime ethers and their use as fungicides Compounds with fungicidal and insecticidal properties having formula ##STR1## wherein X is N or CH; Z is O, S or NR8 ; A is hydrogen, halo, cyano, (C1 -C12)alkyl, or (C1 -C12)alkoxy; R1 and ... | 02/19/2002 |
| 6303818 | Unsaturated oxime ethers and their use as fungicides The present invention relates to certain oxime ether compounds, compositions containing these compounds, and methods for controlling fungi by the use of a fungitoxic amount of the compounds or compositions.... | 10/16/2001 |
| 6277957 | Method for production of acylthio derivatives A method is provided which facilitates and enables the production of a wide range of complex conjugates composed of similar or dissimilar units linked together by amide bonds. Said method for the production of acylthio derivatives, R'--CO--SA, involves re... | 08/21/2001 |
| 6239305 | Method for producing optically active phenylpropionic acid derivative Optically active N-(S-2-acetylthiomethyl-1-oxo-3-phenylpropyl)-glycine benzyl ester useful as an enkephalin inhibitory agent or ACE inhibitory agent can be produced at low cost in an industrial manner, by a method comprising subjecting optically active 2-... | 05/29/2001 |
| 6143734 | Nitroso esters of ଲ-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a compound comprising an enolic anilide non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO2 gr... | 11/07/2000 |
| 6063956 | Aryl and heteroarylcyclopropyl oxime ethers and their use as fungicides and insecticides Compounds with fungicidal and insecticidal properties having formula ##STR1## wherein X is N or CH; Z is O, S or NR8 ; A is hydrogen, halo, cyano, (C1 -C12)alkyl, or (C1 -C12)alkoxy; R1 and... | 05/16/2000 |
| 6043232 | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a compound comprising an enolic anilide non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO2 gr... | 03/28/2000 |
| 5985919 | (Het)aryloxy-, -thio- , aminocrotonates, methods of preparing them and their use as insecticides and fungicides (Het)aryloxy-, -thio- and -aminocrotonates of the formula I ##STR1## where the substituents have the following meanings: U is oxygen, sulfur or amino; V is oxygen, sulfur, amino or alkylamino; X, Y and Z independently of one another are .dbd.N-- or .dbd.C... | 11/16/1999 |
| 5968727 | Pyruvate compounds and methods for use thereof The invention comprises a novel pyruvate compound for the treatment of prevention of reperfusion injury following ischemia, diabetic effects, cholesterol levels, injured organs ethanol intoxication oras s foodstuff. The novel pyruvate compound is particul... | 10/19/1999 |
| 5948819 | -substituted phenylacetic acid derivative, its production and agricultural fungicide containing it An -substituted phenylacetic acid derivative useful as an agricultural fungicide, represented by general formula (I), or a salt thereof, a process for producing the same, an intermediate for the production thereof, and an agricultural fungicide con... | 09/07/1999 |
| 5770758 | 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compound... | 06/23/1998 |
| 5637616 | Method for treating diseases mediated by proteases A method for the topical or systemic treatment of disorders mediated by proteases which result in skin or mucosal lesions, and in particular, pemphigus, cicatricial pemphigoid, bullous pemphigoid, lichen planus, and canker sores, is disclosed wherein the ... | 06/10/1997 |
| 5523325 | Amidrazones and their use as pesticides This invention relates to amidrazones, insecticidal amidrazone compositions, and methods of using such compositions.... | 06/04/1996 |
| 5468870 | Dyes and dye-donor elements for use in thermal dye sublimation transfer Dye-donor element for use according to thermal dye sublimation transfer comprising a support having thereon a dye layer containing a dye corresponding to the following formula ##STR1## wherein Z represents CN, COOR1 or CONR2 R | 11/21/1995 |
| 5449805 | Intermediates for preparing alkylamino mercaptoalkylamides Alkylamino-mercaptoalkylamides have the formula ##STR1## wherein A represents the divalent radical --(CH2)n--, wherein n is a whole number ranging from 2 to 5, or the divalent radical --(CH2)2 --O--(CH2) | 09/12/1995 |
| 5436352 | Metal radionuclide chelating compounds for improved chelation kinetics The present invention provides metal chelating compounds, to chelates and chelate-targeting agent conjugates formed from the chelating compounds, and to methods for making and using these compositions. The chelating compounds incorporate two nitrogen atom... | 07/25/1995 |
| 5376655 | Derivatives of p-guanidinobenzoic acid and pharmaceutical agents containing them as an active ingredient A derivative of p-guanidinobenzoic acid of the general formula (IA): ##STR1## wherein Y represents an oxygen atom or a sulfur atom and (a) when Y is an oxygen atom, (R1)m is selected from the group consisting of: 5-(4-guanidinobenzo... | 12/27/1994 |
| 5273668 | Oil soluble dispersant additives modified with bis-keto/thioketo compounds The present invention is directed to an oil-soluble lubricating oil additive comprising at least one adduct of (A) a polyolefin of 700 to 5,000 number average molecular weight substituted nitrogen- or ester-containing ashless dispersant and (B) a bis-keto... | 12/28/1993 |
| 5205947 | Dispersant additives comprising amine adducts of dicarboxylic acid monoepoxy thiol reaction products The present invention is directed to an oil-soluble lubricating oil additive comprising at least one adduct of (A) a polyolefin of 700 to 5,000 number average molecular weight substituted with carboxylic acid producing moieties (preferably acid or anhydri... | 04/27/1993 |
| 5190974 | N-substituted derivatives of -mercapto alkylamines, their preparation process and the intermediates obtained, their use as medicaments and the compositions containing them Novel -mercapto-alkylamines in all possible racemic, enantiomeric and diastereoisomeric forms of the formula ##STR1## wherein n, R1, R2, X, A, R3A and R4A are set forth in the claims and their non-to... | 03/02/1993 |
| 5185460 | Aminoacetonitrile derivatives Aminoacetonitrile derivatives, where the 2-position of aminoacetonitrile is optionally substituted by alkylthio groups, arylthio groups and heterocyclicthio groups. The process for making such compounds comprises reacting hydrogen cyanide with the desired... | 02/09/1993 |
| 5179121 | Thiobutyric acid derivatives Novel 4-chloro-4,4-difluorothiobutyric acid derivatives of the formula I ##STR1## in which R1 and R2 are, independently of one another, hydrogen, C1 -C4 alkyl or C1 -C4 halogenoalkyl and R | 01/12/1993 |
| 5130453 | Preparation of acylcyclohexadionethiocarboxylic S-esters An acylcyclohexadionethiocarboxylic S-ester of the fomrula ##STR1## where R1 and R2 are substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, benzyl or phenyl, and R2 is additionally hydrogen, are prepared... | 07/14/1992 |
| 5117035 | Fluorine-containing acrylic acid derivative and polymer thereof A novel fluorine-containing acrylic acid derivative of the invention is represented by the formula: (CH2 .dbd.CF--CO)p --A (I) wherein A is a residue derived from an organic compound having at least two active hy... | 05/26/1992 |
| 5112860 | Thiocarboxylic esters and fungicides containing them Thiocarboxylic esters of the formula I ##STR1## where the substituents have the following meanings: X is oxygen, sulfur, oxymethylene, methyleneoxy, thiomethylene, methylenethio, ethylene, ethenylene or ethynylene, Y, Z are each sulfur or oxygen, but... | 05/12/1992 |
| 5105002 | Ammonium salt of methyl 4,4,4-trifluoro-3-oxo-butanethioate Ammonium salt of methyl 4,4,4-trifluoro-3-oxobutanethioate (TMTFAA).... | 04/14/1992 |
| 5066672 | Polyfluoroalkyl acetates, thioacetates and acetamides, and their applications The invention relates to compounds of the polyfluoroalkyl acetate, thioacetate or acetamide type, which can be denoted by the general formula: ##STR1## in which Rf denotes a perfluoroalkyl radical, m is an integer ranging from 1 to 4, Q denotes ... | 11/19/1991 |
| 5051512 | Process for preparation of fluoromethyl-substituted piperidine carbodithioates Described herein is a process for preparation of substituted piperidine dicarbothioate compounds.... | 09/24/1991 |
| 5009702 | Cyclohexenone compounds and use as herbicides or as plant growth regulators Cyclohexenone compounds of the formula I ##STR1## wherein R1, R2, A and X have the meanings given in the disclosure and claims, their preparation and their use as growth-regulating agents or herbicides.... | 04/23/1991 |
| 5010097 | Novel compounds Novel compounds of the formula (I), a process for their preparation and their use as collagenase inhibitors are described: ##STR1## in which, R1 is hydrogen, alkyl, or optionally substituted aryl; R2 is hydrogen, or acyl such as ... | 04/23/1991 |
| 4983579 | Cyano-substituted sulfur containing compounds, compositions containing same, processes for preparing same and organoleptic uses thereof Described are cyano-substituted sulfur-containing compounds having the structures: ##STR1## as well as organoleptic uses thereof.... | 01/08/1991 |
| 4962089 | Cyano-substituted sulfur-containing compounds, and compositions containing same and organoleptic uses thereof Described are cyano-substituted sulfur-containing compounds defined according to a structure selected from the group consisting of: ##STR1## wherein M is an alkali metal as well as uses of the nonionic structures of said group for their organoleptic ... | 10/09/1990 |
| 4957941 | Anti-spasmdoic agents having an acetylenic bond A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## where Y is H or OH; j is an integer from 0 to 4; k is an integer from 0 to 4, and wherein m is an integer from 1 to 4; n is an i... | 09/18/1990 |
