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| Number | Title | Issue Date |
| 7279466 | Synthesis of combretastatin A-4 prodrugs and trans-isomers thereof Combretastatin A-4 has been previously selected for pre-clinical development as antineoplastic agent. However, it is essentially insoluble in water. New water soluble derivatives of combretastatin A-4 and its qualified analogs have been discovered and synthesized th... | 10/09/2007 |
| 7105501 | Compositions with vascular damaging activity Compositions for the inhibition of the formation of new vaculature by angiogenesis are provided as in compounds which are salts comprising as an acidic component a compound of formula (1) wherein: R1, R2 and R3 are each independently... | 09/12/2006 |
| 6593374 | Tubulin binding ligands and corresponding prodrug constructs A diverse set of tubulin binding ligands have been discovered which are structurally characterized, in a general sense, by a semi-rigid molecular framework capable of maintaining aryl--aryl, pseudo pi stacking distances appropriate for molecular recogniti... | 07/15/2003 |
| 6287767 | Chemiluminescent energy transfer assays A chemiluminescent assays for the determination of the presence or amount of a biopolymer in bound assays using 1,2-dioxetanes in connection with AttoPhos™ as chemiluminescent substrates for enzyme-labeled targets or probes is provided. Further disclose... | 09/11/2001 |
| 5739374 | Processes of preparing diphenylheteroalkyl derivatives Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as cosme... | 04/14/1998 |
| 5705669 | Alkyl arylphosphinites A process for the preparation of alkyl arylphosphinites of the formula (I) ##STR1## in which R1 is (C1 -C16)-alkyl, cyclohexyl, cyclopentyl, aryl which can also be substituted by halogen, (C1 -C6)-alk... | 01/06/1998 |
| 5563129 | Hydroquinone derivatives and intermediates for production thereof There are disclosed novel hydroquinone derivatives of the formula: ##STR1## The derivatives of the formula (I) have various pharmacological activities such as antioxidation in living bodies and are useful as medicaments.... | 10/08/1996 |
| 5550276 | Phosphonic acid derivatives and thionophosphonic acid derivatives Compounds of the general formula I ##STR1## in which n is 1, 2 or 3 and in which X is oxygen or sulfur, T has the meaning of --S--, --S--S--, --S--S--, --S--S--S--S--, --S--S--S--S--S--, ##STR2## and Y has the meaning of ##STR3## in wh... | 08/27/1996 |
| 5504073 | PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption Certain compounds have been synthesized and found to be effective inhibitors of phospholipase A2 (PLA2), and thereby useful in the treatment of intestinal cholesterol absorption and the disease states arising therefrom, such as hyper... | 04/02/1996 |
| 5300257 | 4,4'-biphenylenediphosphonite compound and use thereof Tetrakis(2,4-di-tert-butyl-5-methylphenyl)-4,4'-biphenylenediphosphonite, stabilizers for organic materials, which contain said compound, and stabilized organic materials containing said compound as a stabilizer. The tetrakis(2,4-di-tert-butyl-5-methylphe... | 04/05/1994 |
| 5298644 | Aryl phosphinites Aryl phosphinites of the formula (I) ##STR1## can be prepared in a simple manner and in high yields by reacting 2,4-di-tert.-butylphenylphosphonous dihalides with alkyl- or arylmagnesium bromides or alkyl- or arylmagnesium chlorides. Aryl phosphinite... | 03/29/1994 |
| 5283350 | Aryl esters of phosphonous halides and a process for the preparation thereof Aryl esters of phosphonous halides of the formula I ##STR1## in which R' is a phenyl or benzyl radical which bears 1 to 3 substituents, -methylbenzyl, , -dimethylbenzyl, naphthyl or a naphthyl radical bearing 1 to 5 substituents,... | 02/01/1994 |
| 5281640 | Diarylphosphinous acid aryl esters, a process for their preparation and their use for stabilizing plastics Diarylphosphinous acid aryl esters are made by the disclosed process. These compounds are useful for stabilizing plastics, in particular polymerization plastics, and hence can be incorporated into a plastic molding composition.... | 01/25/1994 |
| 5276021 | Phosphorus-containing HMG-COA reductase inhibitors, new intermediates and method Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## wherein R is OH, or salts thereof or lower alkoxy; Rx is H or alkyl; X is --CH2 | 01/04/1994 |
| 5242908 | Use of benzylphosphonic acid derivatives for the treatment of diseases caused by viruses The use of a compound of the formula I ##STR1## in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, ar... | 09/07/1993 |
| 5159097 | Alkenoic acid derivatives An alkenoic acid derivative of the formula ##STR1## in which X and Y are identical or different and represent sulfur, sulfoxide, sulfone, an alkylene chain, --SCH2 --, or oxygen or a direct bond, W represents --CH.dbd.CH--or --CH2 | 10/27/1992 |
| 5153347 | Phosphonate, phosphinate derivatives useful as antihypertensive agents Novel angiotensin II receptor antagonists of the formula ##STR1## wherein X, X1, X2, R1, R2, R3, R4 and R5 are as defined herein, are disclosed. These compounds are useful, ... | 10/06/1992 |
| 5081273 | Process for the preparation of insecticidally active diphenyl ether compounds This invention relates to a process for the preparation of insecticidally active compounds and to novel styrene derivatives useful as intermediates therein.... | 01/14/1992 |
| 5068394 | Herbicidal (hetero)aryloxynaphthalene derivatives and intermediates therefor Herbicidal (hetero)aryloxynaphthalene derivatives of the formula ##STR1## in which X is N or --C--R5, R1, R2, R4 and R5 are hydrogen or halogen or R1 may be cyano or trifluoromethyl, R... | 11/26/1991 |
| 4971957 | Carboxamide compounds, processes for preparing the same and a pharmaceutical composition containing the same Novel carboxamide compounds represented by the general formula (I) possess excellent activities for lowering lipids and thus they are useful as agents for treating and preventing various diseases (hyperlipidemia) such as hypercholesterolemia, hypertriglyc... | 11/20/1990 |
| 4956477 | Synthesis of 1,2-dioxetanes Compounds having the formula: ##STR1## wherein T is a polycycloalkylidene group (e.g., adamant-2-ylidene); R is a C1-20 alkyl, aralkyl or cycloalkyl group; and Y is a fluorescent chromophore (e.g., m-phenylene), produced by reacting a comp... | 09/11/1990 |
| 4933329 | Bis-S-alkylbenzene derivatives Novel bis-S-alkylbenzene derivatives capable of inhibiting lipoxygenase, inparticular, 5-lipoxygenase are disclosed. It is expected that the compounds, which are hardly metabolized in vivo, are highly useful in the treatment and/or prevention of various d... | 06/12/1990 |
| 4933475 | Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor Compounds having the formula ##STR1## R1 is hydrogen, benzyl or alkanoyl, X is C2-4 alkylene; and Z-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their use as CNS agents, antidia... | 06/12/1990 |
| 4924023 | Phosphorylated inositols A process for regioselectively preparing phosphorylated cyclitols, in particular phosphorylated inositols such as myo-inositol 1,4,5-tris(phosphate) and myo-inositol 1,3,4,5-tetrakis(phosphate). Novel cyclitols produced by means of this process are also d... | 05/08/1990 |
| 4814451 | Process for preparing phosphorothioates and phosphates and phosphonothioates and phosphonates Certain phenyl and N-heterocyclic phosphorothioates and phosphonothioates and phosphates are prepared by the reaction of an appropriate alkali metal or alkaline earth metal --0-phenyl or N-heterocyclic compound with an appropriate phosphorochloridate, ph... | 03/21/1989 |
| 4814448 | Process for preparing phosphorothioates and phosphates Certain phenyl and N-heterocyclic phosphorothioates and phosphates are prepared by the reaction of an appropriate alkali metal or alkaline earth metal -O-phenyl or N-heterocyclic compound with an appropriate phosphorochloridate or phosphorochloridothioate... | 03/21/1989 |
| 4739079 | Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor Compounds having the formula ##STR1## wherein ##STR2## R1 is hydrogen, benzyl or alkanoyl, X is C2-4 alkylene; and Z-W is alkyl, phenylalkyl or pyridylalkyl which can have an oxygen atom as part of the alkyl chain and their... | 04/19/1988 |
| 4736053 | Phosphoric ester derivatives and insecticidal and miticidal compositions containing said derivatives Disclosed are novel phosphoric ester derivatives of the formula (I): ##STR1## wherein R1 and R2 each represents a lower alkyl group; R3 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy g... | 04/05/1988 |
| 4683225 | O-(substituted) benzyl dithiophosphonate insecticides Compounds having the formula ##STR1## in which R1 is methyl or ethyl; R2 is C1 -C6 alkyl; R3 is halogen, C1 -C4 alkyl, trifluoromethyl, thio-(C1 -C4 al... | 07/28/1987 |
| 4659701 | Vinylbenzyl phosphates, and their use for treating dermalogical disorders A vinylbenzyl phosphate of the formula I ##STR1## where A, R1, R2, R3, R4, R5, R6, R7, R8 and R9 have the meanings stated in the description, and their ... | 04/21/1987 |
| 4582825 | 2-(substituted phenyl)-3-chloro-2-butene thio phosphates as insecticides Phosphates of the formula ##STR1## where R1 is alkyl of not more than 3 carbon atoms, R2 is alkoxy, alkylthio or alkylamino each of which has a straight-chain or branched alkyl substituent of not more than 5 carbon atoms, Y... | 04/15/1986 |
| 4581350 | O-(perfluoroalkylthiophenyl) (thio or amido) phosphates as pesticides The invention relates to new organic phosphoric acid esters represented by the general formula ##STR1## wherein X represents O, S or NH, Y represents O or S, R1 represents a lower alkyl group, R2 represents a lower alkyl group or a l... | 04/08/1986 |
| 4576935 | Dihalovinylphenyl phosphates and their use as pesticides Dihalovinylphenyl phosphates of the formula I ##STR1## where A and B are each halogen or trihaloalkyl, X is oxygen or sulfur, Y and Z are each oxygen, sulfur or --NH--, R1 is alkyl, R2 is alkyl, haloalkyl, alkoxyalkyl or alkylth... | 03/18/1986 |
| 4569930 | 2-Fluorophenyl(di)thiophosphates and their use in pest control 2-Fluorophenyl(di)thiophosphates of the formula ##STR1## where R1 is alkyl of 1 to 3 carbon atoms, R2 is alkyl or haloalkyl of 1 to 5 carbon atoms, alkoxyalkyl or alkylthioalkyl of 2 to 6 carbon atoms or cycloalkyl of 3 to 6 car... | 02/11/1986 |
| 4567170 | 3-Chloro-3-phenylprop-2-enyl thiophosphates and their use for controlling pests Thiophosphates of the formula I ##STR1## where R1 is hydrogen, or not more than 4 identical or different substituents R1 may be present, each of which is fluorine, chlorine or bromine, straight-chain or branched alkyl of not mor... | 01/28/1986 |
| 4565809 | S-Aralkyltrithiophosphonate insecticides Compounds having the formula ##STR1## in which R1 is C1 -C3 alkyl; R2 is C3 -C6 alkyl; R3 is hydrogen, halo, trifluoromethyl, C1 -C4 alkyl, C1 | 01/21/1986 |
| 4556650 | Phosphonic acid esters as pesticides This invention relates to novel phosphonic acid esters represented by the following general formula (I) ##STR1## wherein R1 represents a lower alkyl group or an aryl group, R2 represents a lower alkyl group or a lower alkoxy-lower al... | 12/03/1985 |
| 4551448 | Fluoroethoxyphenyl (di)thiophosphates, a process for their preparation and their use for controlling pests Fluoroethoxyphenyl (di)thiophosphates of the formula ##STR1## where R1 is alkyl of 1 to 3 carbon atoms, R2 is alkyl of 1 to 5 carbon atoms, alkoxyalkyl or alkylthioalkyl, each of 2 to 8 carbon atoms, or cycloalkyl of 3 to 6 carb... | 11/05/1985 |
| 4535076 | Organophosphate pesticides Organophosphate derivatives of the formula ##STR1## in which X is O, S or NH, Y is O or S, R1 is a lower alkyl group, R2 is a lower alkyl group or a lower alkoxy-lower alkyl group, R3 is a fluoro-substituted lower alkyl group, ... | 08/13/1985 |
| 4512984 | Difluoromethoxyphenyl thiophosphates as pesticides Difluoromethoxyphenyl thiophosphates of the formula I ##STR1## where R1 is alkyl of not more than 3 carbon atoms, R2 is unsubstituted or substituted alkyl of not more than 5 carbon atoms, Y is hydrogen or chlorine, X is oxygen o... | 04/23/1985 |
