Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7829737 | Protein tyrosine phosphatase inhibitors and methods of use thereof The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in whic... | 11/09/2010 |
| 7419970 | Cosmetic compositions comprising N-acylamino amides The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin agei... | 09/02/2008 |
| 7410965 | Delayed release pharmaceutical composition containing 1-dimethyl-amino-3-(3-methoxyphenyl)-2-methyl-pentan-3-ol A delayed release pharmaceutical formulation containing 1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol or a pharmaceutically acceptable salt thereof in a matrix; said matrix containing from 1 to 80 wt. % of at least one pharmaceutically acceptable, matrix-f... | 08/12/2008 |
| 7405317 | Phosphate-bearing prodrugs of sulfonyl hydrazines as hypoxia-selective antineoplastic agents Novel phosphate-bearing prodrugs of sulfonyl hydrazines have the formula presented below. Pharmaceutical compositions and uses thereof in the treatment of cancer are claimed. The aforementioned prodrugs include enantiomers, stereoisomers and tautomers thereof, as we... | 07/29/2008 |
| 7378539 | Compound, a molecular switch employing the compound and a method of electronic switching Classes of molecules are disclosed which can, for example, be used in molecular switches. The classes of molecules include at least three segments—an electronic donor (“D”), a switchable bridge (“B”), and an electronic acceptor (“A”)—chemically conne... | 05/27/2008 |
| 7371747 | Cyanoalkylamino derivatives as protease inhibitors The present invention is directed to novel cyanoalkylamino derivatives that are inhibitors of cysteine protease such as cathepsins K, S, B and L, in particular cathepsin K Pharmaceutical composition comprising these compounds, method of treating diseases mediated by... | 05/13/2008 |
| 7319095 | Use of GABAreceptor agonists The present invention relates to the use of GABAB receptor agonists for the treatment as well as the prevention of cough. ... | 01/15/2008 |
| 7226991 | Phenylalanine derivatives Disclosed herein are phenylalanine derivative compounds of the following formula W—Y—(AA)n—Z wherein Y is a phenylalanyl radical, AA is an amino acid, n is an integer of 1 to 15, and substituent variables W and Z are as described... | 06/05/2007 |
| RE39593 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions. ... | 04/24/2007 |
| 7199214 | Process for the preparation of polyalkoxyamines which can be used as initiators for the radical polymerization of polyfunctional living (CO)polymers The present invention is directed to a process for the preparation of polyalkoxyaminies from monoalkoxyamine(s) of formula (I) and of at least one polyunsaturated compound of formula (II): | 04/03/2007 |
| 7078552 | Combretastatin A-1 phosphate and combretastatin B-1 phosphate prodrugs The present invention relates to the syntheses and structural elucidation of Combretastatin A1-Phosphate Prodrugs and Combretastatin B1-Phosphate Prodrugs and the utilization of those prodrugs in the treatment of neoplastic diseases. The prodrugs described herein ha... | 07/18/2006 |
| 6583182 | Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy and diagnosis This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or physiological salts of the free or conjugated compound, r... | 06/24/2003 |
| 6417176 | Arylsulfonanilide phosphates The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states,... | 07/09/2002 |
| 6344558 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effect 1-phenyl-3-dimethylaminopropane compounds corresponding to the formula I ##STR1## a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.... | 02/05/2002 |
| 6248737 | 1-phenyl-3-dimethylaminopropane compounds with a pharmacological effects 1-phenyl-3 -dimethylaminopropane compounds corresponding to the formula I ##STR1## a method of preparing them, and the use of these substances as analgesic active ingredients in pharmaceutical compositions.... | 06/19/2001 |
| 6211167 | Arylsulfonanilide phosphates The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states,... | 04/03/2001 |
| 6197825 | Azulenyl nitrone spin trapping agents, methods of making and using same The present invention relates to chromotropic nitrone spin trapping agents, methods of making these agents, compositions comprising same, and methods of their use. In particular, azulenyl nitrones of the present invention are effective agents for trapping... | 03/06/2001 |
| 6162807 | Thio acid derived monocyclic N-heterocyclics as anticoagulants This invention is directed to monocyclic N-heterocyclics which are substituted by acyclic or cyclic thio derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invent... | 12/19/2000 |
| 5922697 | Compounds, compositions and methods for inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins The present invention provides compounds that inhibit the binding of proteins containing an SH2 domain to cognate phosphorylated proteins. The invention also provides pharmaceutical compositions containing the compounds and methods of inhibiting the bindi... | 07/13/1999 |
| 5747513 | Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the cardiovascular system Compounds of the formula: ##STR1## wherein R is a hydrogen atom or an OY group; R1 is a hydrogen atom or in OY' group; R2 is a hydrogen atom or an OY" group; provided that at lent one among R, R1 and R2 is ... | 05/05/1998 |
| 5739374 | Processes of preparing diphenylheteroalkyl derivatives Diphenylheteroalkyl derivatives of the formula I ##STR1## where A and R1 -R6 have the meanings specified in the description, and the preparation thereof are described. The substances are suitable for controlling diseases and as cosme... | 04/14/1998 |
| 5716944 | Phosphonic acid compounds, their production and use The present invention relates to a compound of the general formula (I): ##STR1## wherein ring A is a benzene ring that may be substituted; Y is a divalent group as a constituent member of ring B forming a 5- to 8-membered ring; Q1 is a gro... | 02/10/1998 |
| 5658897 | Cyclopentane(ene) heptanoic or cyclopentane(ene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl as therapeutic agents The present invention relates to cyclopentane (or cyclopentane) heptanoic or cyclopentane (or cyclopentene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl, 1-esters, and derivatives thereof, useful as therapeutic agents. In particu... | 08/19/1997 |
| 5658896 | Pharmaceutical composition regulating function of a living body The present invention provides silicate polymers which regulate the function of a living body by restoring and normalizing the lowered cell functions due to diseases. The silicate polymers are preferably water soluble. The molecular weight of the polymers... | 08/19/1997 |
| 5489717 | Glutamate (NMDA) receptor antagonists Novel naphthyl-substituted -amino acid derivatives, pharmaceutical compositions containing the same and a method of using the same, for the blockade of aspartate and glutamate receptors, are described. Novel intermediates of the napthyl-substituted... | 02/06/1996 |
| 5475129 | Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis The disclosure is concerned with providing phosphonic acid-containing derivatives of phenylalanine and optically active isomers thereof, which are functionalized in a manner which makes them suitable for facile incorporation into peptides using standard s... | 12/12/1995 |
| 5453524 | Phosphorus-containing isoprenoid derivatives The present invention provides a phosphorus-containing isoprenoid derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is useful as a preventive and therapeutic agent for diseases for which a sq... | 09/26/1995 |
| 5424303 | Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel aminophosphonate derivatives substituted in position by phenol groups, of formula (I): ##STR1## in which: X1, X2, X3, R1, R2, A, B, Z and n are defi... | 06/13/1995 |
| 5410056 | Method for the production of folic acid The present invention is directed to a novel process for the production of folic acid in high yield utilizing a novel diimine as an intermediate. This diimine is formed by reacting 2-substituted malondialdehyde with p-aminobenzoyl-L-glutamic acid. This di... | 04/25/1995 |
| 5395827 | ω-[2-(phosphonoalkyl)phenyl]-2-aminoalkanoic acids as antagonists of excitatory amino acid receptors The present invention pertains to antagonists of excitatory amino acid neurotransmitter receptor antagonists, their method of preparation as well as compositions containing them which have the general formula: ##STR1## wherein n and m independently a... | 03/07/1995 |
| 5298541 | Aryl phosphonites, a process for their production and their use for stabilizing plastics A process for the preparation of aryl phosphonites of the formula V ##STR1## wherein the radicals and n are defined in the disclosure. The invention further relates to a plastic molding composition, in particular a polyolefin molding composition cont... | 03/29/1994 |
| 5298644 | Aryl phosphinites Aryl phosphinites of the formula (I) ##STR1## can be prepared in a simple manner and in high yields by reacting 2,4-di-tert.-butylphenylphosphonous dihalides with alkyl- or arylmagnesium bromides or alkyl- or arylmagnesium chlorides. Aryl phosphinite... | 03/29/1994 |
| 5281640 | Diarylphosphinous acid aryl esters, a process for their preparation and their use for stabilizing plastics Diarylphosphinous acid aryl esters are made by the disclosed process. These compounds are useful for stabilizing plastics, in particular polymerization plastics, and hence can be incorporated into a plastic molding composition.... | 01/25/1994 |
| 5278152 | 2-formylbenzylphosphonic acid derivatives useful for the treatment of diseases caused by viruses The compound of the formula I ##STR1## in which R is an aldehyde group or a group which can be converted into an aldehyde, R1 and R2 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potassium, calcium, magnesi... | 01/11/1994 |
| 5212163 | Compounds Novel compounds of formula (I) and salts, solvates and hydrates thereof, processes for their preparation and their use in the treatment of conditions in which degradation of connective tissue and other proteinaceous components of the body occurs: ##S... | 05/18/1993 |
| 5210263 | Inositol phosphate analogs and methods for their use The present invention provides novel inositol phosphate analogs and a method for their use for detecting the phosphatidylinositol cycle-dependent calcium of a cell.... | 05/11/1993 |
| 5200546 | Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis There are disclosed novel compounds of the formula: ##STR1## wherein, x is --CH2 --, --CHF--, --CF2, --CHOH-- or --C(O)--; R6 is hydrogen, benzyl, pentafluorophenyl, nitrophenyl, 1-benzotriazolyl or 1-succinimidoyl; Fmoc i... | 04/06/1993 |
| 5177240 | o-Phosphono(alkyl)-N-sulfonyl-phenyl-alanine derivatives useful as intermediates for preparation of phosphono-hydroisoquinolines A class of phosphono-hydroisoquinoline compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a pho... | 01/05/1993 |
| 5175153 | Substituted alpha-amino acids having pharmaceutical activity The present invention is novel substituted -amino acids, pharmaceutical compositions, method of use, and preparations therefore having utility for treating disorders which benefit from blockade of aspartate and glutamate receptors.... | 12/29/1992 |
| 5162311 | -amino-(3-alkyl-phenyl)alkyl ethanoic acids wherein the 3-alkyl moiety bears a phosphorus oxo acid group or an ester thereof, their preparation and pharmaceutical compositions containing them The invention discloses certain substituted -aminoacids having the formula ##STR1## where m and n are 1 or 2, and R, R1, R2, R3 and Y have various significances, which compounds are useful in treating epilepsy,... | 11/10/1992 |
