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| Number | Title | Issue Date |
| 7906674 | Oxidized phospholipids The invention relates to oxidized phospholipids having one of the general formulas (I) or (II) wherein A═O, C, NH, or S; B═O, C, NH, or S; and R2 is selected from the group consisting of —CO—(CH2)n—CH3; —CO—(... | 03/15/2011 |
| 7408075 | Synthesis of phosphocholine ester derivatives and conjugates thereof Aspects of the present invention include methods of synthesizing phosphocholine analogues and the phosphocholine conjugates formed therefrom and their use in preventing infections caused by microorganisms. ... | 08/05/2008 |
| 7354895 | Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the preventio... | 04/08/2008 |
| 7326801 | 2-amino-propanol derivatives Compounds of formula I wherein m, R, R1 and R3 to R6 are as defined in the specification, m, is 1, 2 or 3 and X is O or a direct bond, and the corresponding unphosporylated compou... | 02/05/2008 |
| 7253153 | Derivatives of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and methods of use thereof Compounds of formula (I) or pharmaceutically acceptable salts thereof are provided where at least one of R2 or R3 is not hydrogen. The compounds of the present invention are N-methyl-D-aspar... | 08/07/2007 |
| 7186704 | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disor... | 03/06/2007 |
| 7141557 | Lipid analogs for treating viral infections A method of treating viral infections, and in particular HIV-1, hepatitis B virus, and herpes virus, is disclosed. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative.... | 11/28/2006 |
| 7135584 | Lipid analogs for treating viral infections A method of treating viral infections, and in particular HIV-1, hepatitis B virus, and herpes virus, is disclosed. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative.... | 11/14/2006 |
| 6846925 | Colchinol derivatives as angiogenesis inhibitors The invention related to colchinol derivatives of the formula (I): Wherein: R1; R2 and R3 are each independently hydroxy, phosphoryloxy (—OP3H2), C1-4alkoxy or an in vivo hydrolysable ester of hydro... | 01/25/2005 |
| 6838452 | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disor... | 01/04/2005 |
| 6835721 | Immunomodulatory compounds and methods of use thereof The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of... | 12/28/2004 |
| 6720323 | Colchinol derivatives as angiogenesis inhibitors The invention related to colchinol derivatives of the formula (I): Wherein: R1, R2 and R3 are each independently hydroxy, phosphoryloxy (—OPO3H2), C1-4alkoxy or an in vivo hydrolysable ester of hydr... | 04/13/2004 |
| 6551600 | Immunological adjuvant compounds compositions and methods of use thereof The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant c... | 04/22/2003 |
| 6482852 | Bicyclic signal transduction inhibitors, compositions containing them & uses thereof This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to ... | 11/19/2002 |
| 6136798 | Compounds inhibiting the association of the PDGF receptor and phosphatidylinositol 3-kinase and their use The present invention provides compounds that inhibit the association of platelet-derived growth factor and phosphatidylinositol 3-kinase. The present invention also provides pharmaceutical compositions that contain a compound that inhibits the associatio... | 10/24/2000 |
| 6136797 | Phospholipid derivatives of phosphono-carboxylic acids, the production of said derivatives and the use of said derivatives as antiviral medicaments The present invention concerns new lipid derivatives of phosphonocarboxylic acids of the general formula I, ##STR1## in which the meaning of the symbols is elucidated in the description, tautomers thereof and their physiologically tolerated esters an... | 10/24/2000 |
| 6011168 | Process for the preparation[2-((8,9)-dioxo-2,6-diazabicyclo[5.2.0]-non-1(7)-en-2-yl)ethy l]phosphonic acid This invention relates to a process for the preparation of the formula I compound [2-((8,9)-dioxo-2,6-diazabicyclo[5.2.0]-non-1(7)-en-2-yl)ethyl]phosphonic acid, a NMDA antagonist useful as an anticonvulsant and neuroprotectant in situations involvin... | 01/04/2000 |
| 5965413 | Process for producing phosphatidylserines having long chain unsaturated fatty acid as side chain A process for producing phosphatidylserine having a long chain unsaturated fatty acid in its side chain. In this process, a natural lecithin containing long chain unsaturated fatty acid side chain is used as the starting material. Using the natural lecith... | 10/12/1999 |
| 5948931 | Preparation and use of -(hydroxyimino) phosphonoacetic acids -(hydroxyimino)phosphonoacetic acids (also referred to as ",-disubstituted trifunctional oximes" and "Troika Acids") and their derivatives, and methods to prepare them are disclosed. Also disclosed are the structures and fragmentation... | 09/07/1999 |
| 5756800 | Process for the enzymatic resolution of 2-amino-4-methyl-phosphinobutyric acid derivatives Process for the enzymatic resolution of 2-amino-4-methylphosphinobutyric acid derivatives. L-PTC (L-phosphinothricin, L-2-amino-4-methylphosphinobutyric acid) is the active herbicidal component of D,L-PTC and can be obtained according to the invention whe... | 05/26/1998 |
| 5741923 | Ethylenically unsaturated compounds An improved process for producing ethylenically unsaturated phosphate ester compounds, especially 2-(methacryloyloxyethyl)-2' (trimethylammoniomethyl) phosphate, (HEMA-PC) comprises a two step reaction in the first of which a phospholane reagent is reacte... | 04/21/1998 |
| 5703263 | Process for making chiral alpha-amino phosphonates and selected novel chiral alpha-amino phosphonates This invention is selected novel chiral (essentially pure) alpha-amino phosphonates, process for the preparation which is a catalytic asymmetric hydrogenation of olefins and novel intermediates therefor. The alpha-amino phosphonates are useful as antibiot... | 12/30/1997 |
| 5686633 | Inks, particularly for ink jet printing Inks, particularly inks for ink jet printing, contain at least one compound of the formula I ##STR1## as a stabilizer. The symbols R1, R2, R3, R4, R3 ' and R4 ' are as defined in claim... | 11/11/1997 |
| 5508463 | -aminophosphonates Novel -aminophosphonates are provided along with processes and intermediates for their preparation. In preferred embodiments, scalemic -aminophosphonates are prepared by the stereoselective addition of phosphite salts to chiral imines.... | 04/16/1996 |
| 5489717 | Glutamate (NMDA) receptor antagonists Novel naphthyl-substituted -amino acid derivatives, pharmaceutical compositions containing the same and a method of using the same, for the blockade of aspartate and glutamate receptors, are described. Novel intermediates of the napthyl-substituted... | 02/06/1996 |
| 5424474 | Fluorinated carboxylic acid esters of phosphono- and phosphinocarboxylic acids containing hydroxyl and/or mercapto groups, a method for their preparation, and their use The present invention relates to fluorinated carboxylic acid esters of phosphono- and phosphinocarboxylic acids containing hydroxyl and/or mercapto groups, their use as waterproofing and/or oil-repellency agents, and a method for their preparation.... | 06/13/1995 |
| 5420329 | Process for the preparation of L-phosphinothricin and its derivatives The invention relates to a process for the enantioselective preparation of L-phosphinothricin (L-Ptc) and derivatives of the formula I ##STR1## in which R1 is H, (C1 -C6)-alkyl, (C1 -C4)-haloalky... | 05/30/1995 |
| 5414102 | Fluorinated carboxylic acid esters of phosphono- and phosphinocarboxylic acids containing acrylate and/or methacrylate groups The present invention relates to fluorinated carboxylic acid esters of phosphonocarboxylic acids containing acrylate and/or methacrylate groups, their use as waterproofing or oil-repellency agents, and a method for their preparation.... | 05/09/1995 |
| 5380905 | Magnetic recording medium having radiation curable binder with -methylstyrene unsaturation The present invention provides magnetic recording media comprising a magnetizable layer and optionally a backside coating provided on a nonmagnetizable substrate. At least one of the magnetizable layer and the optional backside coating comprises a polymer... | 01/10/1995 |
| 5362899 | Chiral synthesis of alpha-aminophosponic acids A stereospecific method of preparing alpha-aminophosphonic acids and derivatives thereof is provided. A protected amino acid is converted to a acyl aroyl or diacyl peroxide which spontaneously rearranges to form an alpha-amino ester. This rearrangement oc... | 11/08/1994 |
| 5321153 | Process for making chiral alpha-amino phosphonates selected novel chiral alpha-amino phosphonates This invention is selected novel chiral (essentially pure) alpha-amino phosphonates, process for the preparation which is a catalytic asymmetric hydrogenation of olefins and novel intermediates therefor. The alpha-amino phosphonates are useful as antibiot... | 06/14/1994 |
| 5298499 | S-2-(substituted ethylamino)ethyl phosphorothioates Substituted phosphorothioate derivatives and pharmaceutical compositions thereof as potential antiradiation agents are disclosed.... | 03/29/1994 |
| 5282988 | Lubricant additives A urethane reaction product, derived from an alkoxylated diorgano phosphorodithioate and an isocyanate, specifically, toluenediisocyanate and hexamethylene diisocyanate, is a multifunctional antiwear and antioxidant additive for lubricants. The isocyanate... | 02/01/1994 |
| 5279833 | Liposomal transfection of nucleic acids into animal cells A reagent for introducing a nucleic acid into an animal cell. The reagent comprises (a) a neutral lipid such as dioleoylphosphatidylethanolamine and (b) a cationic lipid selected from the group consisting of an ammonium salt such as dimethyldioctadecylamm... | 01/18/1994 |
| 5274162 | Antineoplastic drugs with bipolar toxification/detoxification functionalities The composition, methods of synthesis, and applications of a new class of tumor selective antineoplastic drugs is described. These novel antineoplastic agents are of the general structure: A-C-B. The agents are designed with two key functionalities: a tri... | 12/28/1993 |
| 5215976 | Phospholipids useful as spermicidal agents There is provided longlasting contraceptives against human and animal sperm which contain a synthetic phospholipid spermicide of the formula: ##STR1## wherein: x=1 to 3 or mixtures thereof; x+y=3; z=x; a=0 to 2; B=0- or OM; A=Anion; M is a cati... | 06/01/1993 |
| 5208224 | Phosphorus containing compounds as antihypercholesterolemic and antiatherosclerotic agents Novel phosphorus containing compounds are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholes... | 05/04/1993 |
| 5151521 | 1-aminoethyl phosphonic acid derivatives New phosphonic acid derivatives are described which display antibacterial activity.... | 09/29/1992 |
| 5144045 | Phosphocholine derivative inhibitors of phospholipase A2 Phospocholine derivatives having the formula: ##STR1## in which W, Z, Q and R are described in the specification are disclosed as useful for inhibiting the enzyme phospholipase A2. Methods of making and using the compounds are also disclos... | 09/01/1992 |
| 5130463 | Phosphoric acid esters, method of producing them, and use thereof as dispersants Phosphoric acid esters and their salts corresponding to the formula (I): ##STR1## wherein R represents an aliphatic, cycloaliphatic and/or aromatic moiety having no Zerewitinoff hydrogen, containing at least one ether oxygen atom (--O--) and at least... | 07/14/1992 |
