Quotables
"What can be more palpably absurd than the prospect held out of locomotives traveling twice as fast as stagecoaches?"
The Quarterly Review ; March edition, 1825
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7429575 | N-(phosphonoalkyl)-amino acids, derivatives thereof and compositions and methods of use The present invention relates to an N-(phosphonoalkyl)-amino acid, a related compound or a derivative thereof, the N-(phosphonoalkyl)-amino acid, related compound or derivative thereof being in a form as a free acid, salt, partial salt, lactone, amide or ester, or i... | 09/30/2008 |
| 7408075 | Synthesis of phosphocholine ester derivatives and conjugates thereof Aspects of the present invention include methods of synthesizing phosphocholine analogues and the phosphocholine conjugates formed therefrom and their use in preventing infections caused by microorganisms. ... | 08/05/2008 |
| 7378538 | Compound having phosphorylcholine group, polymer thereof and process for producing the same A compound of the invention is a specific compound having a phosphorylcholine group, and a polymer of the invention comprises at least 1 mol % of repeating units with a phosphorylcholine group and has a number-average molecular weight of 1,000 or more, the repeating... | 05/27/2008 |
| 7186704 | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disor... | 03/06/2007 |
| 7153842 | Florfenicol prodrug having improved water solubility The present invention discloses phosphate esters of florfenicol (prodrugs) and florfenicol analogs having superior water solubility that are hydrolyzed to florfenicol or the respective florfenicol analog in vivo, upon administration to an animal. ... | 12/26/2006 |
| 7141557 | Lipid analogs for treating viral infections A method of treating viral infections, and in particular HIV-1, hepatitis B virus, and herpes virus, is disclosed. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative.... | 11/28/2006 |
| 7135584 | Lipid analogs for treating viral infections A method of treating viral infections, and in particular HIV-1, hepatitis B virus, and herpes virus, is disclosed. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative.... | 11/14/2006 |
| 7101864 | Compositions comprising oxophosphonate-based metalloproteinase inhibitors The present invention relates to compositions useful for treating or controlling disease states or conditions associated with zinc containing proteinases, especially metalloproteinases. The active ingredient in these compositions is an alpha-oxo- or alpha-thixophosp... | 09/05/2006 |
| 7034176 | Aminopropylphosphinic acids Intermediates used in the preparation of compounds of formula I, or a stereoisomer thereof, or a pharmaceutically acceptable form of either selected from the group consisting of a salt, a solvate and a combination there... | 04/25/2006 |
| 6911553 | Osteoblast-specific mitogens and drugs containing such compounds The invention is directed to compounds of formula (I) wherein R1 alkyl, alkenyl or alkynyl having from 6 to 24 carbon atoms; n=0-12; X=oxygen or NH; and the physiologically safe salts, esters, optically active forms, racemates and derivatives thereof whic... | 06/28/2005 |
| 6875757 | LPA receptor agonists and antagonists and methods of use The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA... | 04/05/2005 |
| 6846925 | Colchinol derivatives as angiogenesis inhibitors The invention related to colchinol derivatives of the formula (I): Wherein: R1; R2 and R3 are each independently hydroxy, phosphoryloxy (—OP3H2), C1-4alkoxy or an in vivo hydrolysable ester of hydro... | 01/25/2005 |
| 6838452 | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disor... | 01/04/2005 |
| 6737416 | Phosphonic acid derivative having inhibitory activity against carboxypeptidase B A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R2... | 05/18/2004 |
| 6593312 | Cyclic -amino-γ-hydroxyamide compounds A compound of formula (I): ##STR1## wherein: ##STR2## represents an optionally substituted saturated carbon ring having from 4 to 8 ring members, R1 and R4, which may be identical or different, each represents hydrogen or acyl, ... | 07/15/2003 |
| 6576627 | Phosphonic acid derivatives having carboxypeptidase b inhibitory activity A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: ##STR1## wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R2 and R3 r... | 06/10/2003 |
| 6576766 | Signal transduction inhibitors, compositions containing them This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediate by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to p... | 06/10/2003 |
| 6569899 | 4-aminobutanoic acid derivatives and drugs containing these derivatives as the active ingredient Aminobutylic acid derivatives of the formula (I) ##STR1## wherein the symbols are as defined in specification; and non-toxic salts thereof. Because of inhibiting matrix metalloproteinase, the compounds of the formula (I) are useful for prevention and/or t... | 05/27/2003 |
| 6506739 | Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates, pharmaceutical compositions containing them, methods of treatment using them, and processes for their preparation. The compounds possess anti-tumor activities or are capable of being modified to have anti... | 01/14/2003 |
| 6498150 | Low molecular weight cell, bone marrow and immune stimulants The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccinatio... | 12/24/2002 |
| 6495533 | Drugs containing phosphoric acid derivatives as the active ingredient The present invention relates to phosphoric acid derivatives represented by general formula (I), wherein each symbol is as defined in the description and nontoxic salts thereof. Because of having a TNF production inhibitory effect, the compounds re... | 12/17/2002 |
| 6432933 | Glycol and hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases Compounds of Formula I ##STR1## are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases such as malaria and Alzheimer's disease. In preferred... | 08/13/2002 |
| 6391866 | (-aminophosphino) peptides derivative and compositions containing same The invention concerns (-aminophosphino) peptide derivative compounds of general formula (I) wherein: R1 and R2 represent each a hydrogen atom or together form an imine with the adjacent nitrogen atom; R3 represents... | 05/21/2002 |
| 6235727 | Sulfonylaminophosphinic and sulfonylaminophosphinic acid derivatives, methods for their preparation and use Compounds of the formula I ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading enzymes is involved.... | 05/22/2001 |
| 6214877 | 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia This invention provides compounds of Formula I having the structure ##STR1## wherein: B, C, D, and R1 are as defined hereinbefore in the specification, or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disord... | 04/10/2001 |
| 6197759 | Osteoblast-specific mitogens and drugs containing such compounds Osteoblast-specific mitogens and drugs containing such compounds can be used for treating metabolic bone diseases. These compounds include lysophosphatidylic acid derivatives selected from the group consisting of compounds of formula: ##STR1## wherei... | 03/06/2001 |
| 6150344 | Hydroxyphosphonate peptidomimetics as inhibitors of aspartyl proteases Compounds of Formula I ##STR1## are disclosed as inhibitors having activity against the aspartyl proteases, plasmepsin and cathepsin D. The compounds are therefore useful for treatment of diseases such as malaria and Alzheimer's disease. In pref... | 11/21/2000 |
| 6136798 | Compounds inhibiting the association of the PDGF receptor and phosphatidylinositol 3-kinase and their use The present invention provides compounds that inhibit the association of platelet-derived growth factor and phosphatidylinositol 3-kinase. The present invention also provides pharmaceutical compositions that contain a compound that inhibits the associatio... | 10/24/2000 |
| 6075159 | Phosphite, a process for producing the same and a use thereof A phosphite represented by the formula (I): ##STR1## wherein n repesents 1 or 2; A represents alkylene; B represents a direct bond or alkylene; one of Y and Z represents a hydroxyl group, alkoxy or aralkyloxy, and the other one represents a hydrogen ... | 06/13/2000 |
| 6002029 | Antiviral prodrugs Lipid prodrugs of phosphonoacids and their analogs that have increased antiviral activity over the parent drugs in inhibiting cytomegalovirus and other susceptible viruses.... | 12/14/1999 |
| 5968916 | Fluoroalkenyl compounds and their use as pest control agents Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds are particularly useful for systemic control of pests.... | 10/19/1999 |
| 5916922 | Phenyl glyoxamides as SPLA2 inhibitors A class of novel phenyl glyoxamides is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.... | 06/29/1999 |
| 5914319 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations contain... | 06/22/1999 |
| 5849725 | Phosphorylated derivatives of compositions having anti-inflammatory or analgesic activity and a method for the preparation thereof The principal activity of the amides of ethanol-ଲ-aminophosphoric acid with active moieties having anti-inflammatory and analgesic activity (FANS) remains substantially unchanged but they have considerably lower toxicity particularly in terms of dam... | 12/15/1998 |
| 5756800 | Process for the enzymatic resolution of 2-amino-4-methyl-phosphinobutyric acid derivatives Process for the enzymatic resolution of 2-amino-4-methylphosphinobutyric acid derivatives. L-PTC (L-phosphinothricin, L-2-amino-4-methylphosphinobutyric acid) is the active herbicidal component of D,L-PTC and can be obtained according to the invention whe... | 05/26/1998 |
| 5741923 | Ethylenically unsaturated compounds An improved process for producing ethylenically unsaturated phosphate ester compounds, especially 2-(methacryloyloxyethyl)-2' (trimethylammoniomethyl) phosphate, (HEMA-PC) comprises a two step reaction in the first of which a phospholane reagent is reacte... | 04/21/1998 |
| 5726159 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containi... | 03/10/1998 |
| 5710130 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containi... | 01/20/1998 |
| 5707966 | Antithrombotic agents This invention relates to thrombin inhibiting compounds having the Formula I X--Y--NH--(CH2)r --G I where X, Y, r and G have the values defined in the description, as well as pharmaceutical formulations containi... | 01/13/1998 |
| 5707967 | Pain relief compositions Disclosed are compositions containing either aspartame or monosodium glutanate combined with an amino acid.... | 01/13/1998 |
