Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 7683200 | Compounds for preparing immunological adjuvant The present invention provides methods for preparing TLR-4 receptor agonist E6020: and stereoisomers thereof, which compounds are useful as an immunological adjuvants when co-administered with antigens such as vaccines for ba... | 03/23/2010 |
| 7560584 | Immunomodulatory compounds and methods of use thereof The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of... | 07/14/2009 |
| 7423012 | Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the preventio... | 09/09/2008 |
| 7384925 | Functionalized stilbene derivatives as improved vascular targeting agents Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubul... | 06/10/2008 |
| 7378538 | Compound having phosphorylcholine group, polymer thereof and process for producing the same A compound of the invention is a specific compound having a phosphorylcholine group, and a polymer of the invention comprises at least 1 mol % of repeating units with a phosphorylcholine group and has a number-average molecular weight of 1,000 or more, the repeating... | 05/27/2008 |
| 7368440 | Methods for the administration of amifostine and related compounds The present invention provides methods of administering amifostine, WR-1065, or a combination thereof, to patients receiving radiation therapy or chemotherapy in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compound... | 05/06/2008 |
| 7354895 | Phosphinyloxy, oxime and carboxylic acid derivatives which are useful as carboxypeptidase U inhibitors The present invention relates to compounds of Formula I, and pharmaceutically acceptable salts or solvates thereof, or solvates of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the preventio... | 04/08/2008 |
| 7326801 | 2-amino-propanol derivatives Compounds of formula I wherein m, R, R1 and R3 to R6 are as defined in the specification, m, is 1, 2 or 3 and X is O or a direct bond, and the corresponding unphosporylated compou... | 02/05/2008 |
| 7319095 | Use of GABAreceptor agonists The present invention relates to the use of GABAB receptor agonists for the treatment as well as the prevention of cough. ... | 01/15/2008 |
| 7304046 | Phosphoramide compounds The invention provides a compound of formula I: wherein R1, Ra, Rb, Rc, and Rd have any of the values defined in the specification, as well as pharmaceutical... | 12/04/2007 |
| 7279550 | Irreversible cysteine protease inhibitors of legumain Presented are compounds represented by the following general formulas (I) and (II), for inhibiting cysteine protease legumain for modulating associated disease states in subjects ... | 10/09/2007 |
| 7241810 | Formamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds accord... | 07/10/2007 |
| 7141557 | Lipid analogs for treating viral infections A method of treating viral infections, and in particular HIV-1, hepatitis B virus, and herpes virus, is disclosed. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative.... | 11/28/2006 |
| 7135584 | Lipid analogs for treating viral infections A method of treating viral infections, and in particular HIV-1, hepatitis B virus, and herpes virus, is disclosed. The method comprises administering to a subject in need of such treatment an infection-controlling amount of a phospholipid or phospholipid derivative.... | 11/14/2006 |
| 7129229 | Hydrazide building blocks and hydrazide modified biomolecules This invention relates to attachment chemistries for binding macromolecules to a substrate surface or to other conjugation targets. More particularly, this invention relates to attachment chemistries involving branched or linear structures having one or more hydrazi... | 10/31/2006 |
| 7126021 | Method for preparing β-phosphorus nitroxide radicals The present invention relates to a process for the preparation of β-phosphorated nitroxide radicals which consist in preparing, in a first step, an aminophosphonate by reaction of a carbonyl compound, of a primary amine and of a phosphorous compound in the presence... | 10/24/2006 |
| 7078552 | Combretastatin A-1 phosphate and combretastatin B-1 phosphate prodrugs The present invention relates to the syntheses and structural elucidation of Combretastatin A1-Phosphate Prodrugs and Combretastatin B1-Phosphate Prodrugs and the utilization of those prodrugs in the treatment of neoplastic diseases. The prodrugs described herein ha... | 07/18/2006 |
| 7053072 | Methods for the administration of amifostine and related compounds The present invention provides methods of administering amifostine, WR-1065, or a combination thereof, to patients receiving radiation therapy in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared wi... | 05/30/2006 |
| 7038764 | Apparatus for determining projectile's velocity This invention is an apparatus and method for determining the velocity of a projectile. A light curtain unit (20) creates two light curtains (46)(48) and two sensing planes (50)(52). The projectile causes light from the light curta... | 05/02/2006 |
| 7034015 | Aminobenzoephenones The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said ... | 04/25/2006 |
| 7034176 | Aminopropylphosphinic acids Intermediates used in the preparation of compounds of formula I, or a stereoisomer thereof, or a pharmaceutically acceptable form of either selected from the group consisting of a salt, a solvate and a combination there... | 04/25/2006 |
| 6921774 | Compounds and their use as glycine transport inhibitors The invention provides novel compounds of the formula I below: wherein the meaning of each substituent is defined in the application. The compounds are useful as inhibitors of the glycine transporter and useful in the ... | 07/26/2005 |
| 6919324 | Functionalized stilbene derivatives as improved vascular targeting agents Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubul... | 07/19/2005 |
| 6835721 | Immunomodulatory compounds and methods of use thereof The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant compounds of... | 12/28/2004 |
| 6776977 | Polypodal chelants for metallopharmaceuticals Tripodal polyaminophosphonate chelants are disclosed, as well as chelates of the chelants with metal ions to form radiopharmaceutical and radioactive, MRI and X-ray or CT imaging compounds and compositions. Therapeutic and imaging methods of use are also disclosed. | 08/17/2004 |
| 6756504 | Sphingolipids The invention relates to compounds of the general formula (I), as defined, and to pharmaceutical compositions containing them. The compounds of formula (I) are inhibitors of various lipid-related enzymes. They can be used in reducing accumulation of sphingoli... | 06/29/2004 |
| 6710149 | Hydrolysis-stable and polymerizable acrylophosphonic acid Hydrolysis-stable and polymerizable acrylophosphonic acid with the general formula (I) which is particularly suitable as a component of dental materials is disclosed. ... | 03/23/2004 |
| 6624152 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 09/23/2003 |
| 6624322 | Method for preparing ଲ-phosphorous nitroxide radicals The invention concerns a method for preparing ଲ-phosphorous nitroxide radicals which comprises preparing in a first step an aminophosphonate by reacting a carbonyl compound, a primary amine and a phosphorous compound, then in a second step in oxidiz... | 09/23/2003 |
| 6566545 | Menthol derivatives and process for preparing the same The present invention provides a menthol derivative represented by the following Formula 1 and a method for preparing the menthol derivative. The menthol derivative represented by the Formula 1 is prepared by reacting menthol and phosphorous oxychloride w... | 05/20/2003 |
| 6551600 | Immunological adjuvant compounds compositions and methods of use thereof The present invention is directed to novel compounds that function as immunological adjuvants when co-administered with antigens such as vaccines for bacterial and viral diseases, to novel adjuvant formulations which include at least one of the adjuvant c... | 04/22/2003 |
| 6534489 | Organophosphorus compounds and the use thereof The invention relates to organophosphorus compounds of general formula (I) wherein A corresponds to general formula (II), wherein one or more of the carbon atoms, selected from the group C3, C4, C5 and their respective sub... | 03/18/2003 |
| 6528656 | Linear or cyclic aminophosphonates as pH markers in phosphorus 31 NMR spectroscopy Linear or cyclic aminophosphonates are disclosed which are useful as pH markers. A method of using the linear or cyclic aminophosphonates in phosphorus-31 NMR spectroscopy is also disclosed.... | 03/04/2003 |
| 6498150 | Low molecular weight cell, bone marrow and immune stimulants The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccinatio... | 12/24/2002 |
| 6437165 | Phosphate derivatives as immunoregulatory agents Immunoregulatory compounds are disclosed of the formula: ##STR1## as well as the pharmaceutically acceptable salts and hydrates thereof, are disclosed. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, org... | 08/20/2002 |
| 6417384 | Radioiodinated phospholipid ether analogs and methods of using the same The present invention provides improved radioiodinated phospholipid ether analogs which demonstrate significant tumor avidity and longer plasma half-life than shorter-chain analogs. The radioiodinated phospholipid ether analogs of the present invention pr... | 07/09/2002 |
| 6342625 | Amphiphilic compounds with at least two hydrophilic and at least two hydrophobic groups based on amides The invention relates to amphiphilic compounds of general formula (I), (R1, R3 --C1 -C22 hydrocarbon radical, R2 --spacer, X, Y--functional groups, Z--1 to 10) with at least two hydrophilic and at lea... | 01/29/2002 |
| 6306840 | Cell adhesion inhibitors The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of us... | 10/23/2001 |
| 6274760 | Preparation of formylphosphonic acid from tertiary aminomethylphosphonic acid N-oxides Formylphosphonic acid derivatives are prepared by the catalytic decomposition of a (phosphonomethyl)amine N-oxide compound to form the formylphosphonic acid derivative and a dephosphonomethylated amine.... | 08/14/2001 |
| 6255519 | Radioiodinated phospholipid ether analogs and methods of using the same Improved radioiodinated phospholipid ether analogs are described which exhibit significant tumor avidity and longer plasma half-life relative to shorter chain analogs. Use of these compounds results in superior imaging and visualization of neoplastic lesi... | 07/03/2001 |
