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| Number | Title | Issue Date |
| 7928260 | Salt of a sulfur-containing, phosphorus-containing compound, and methods thereof There is disclosed a salt of a sulfur-containing, phosphorus-containing compound. There is also disclosed a method of making the salt. ... | 04/19/2011 |
| 7683199 | Fluorine-containing polyether phosphonic acid ester compound and process for producing the same A fluorine-containing polyether phosphonic acid ester compound represented by the following general formula: (R2O)(R1O)P(O)(CH2)aCF(CF3)[OCF2CF(CF3)]bO(CF2)C... | 03/23/2010 |
| 7090924 | Thermosetting resin composition for high performance laminates This invention concerns a thermosetting resin system that is useful in the manufacture of high performance prepreg, laminate and composite materials as well as the prepregs, laminates and composites made from the thermosetting resin composition. ... | 08/15/2006 |
| 7074432 | Method of modifying the release profile of sustained release compositions The present invention relates to a method for the sustained release in vivo of a biologically active agent comprising administering to a subject in need of treatment an effective amount of a sustained release composition comprising a biocompatible polymer having the... | 07/11/2006 |
| 7005533 | Bisphosphonate derivatives, their preparations and uses The present invention relates to derivatives of 1-hydroxymethylene-1,1-bisphosphonic acid, the pharmaceutical compositions comprising them, and their application in therapeutics, particularly for the treatment of cancerous tumors. It is also directed to a methods of... | 02/28/2006 |
| 6787528 | Inhibitors of intestinal apical membrane Na/phosphate co-transportation The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate u... | 09/07/2004 |
| 6579860 | Interleukin-6 production inhibitors An interleukin-6 production inhibitor is provided containing a methanebisphosphonic acid derivative as an active component, which has inhibitory effects on interleukin-6 production and is useful in prevention and treatment of diseases due to abnormal prod... | 06/17/2003 |
| 6448429 | Protein tyrosine phosphatase 1B (PTP-1B) inhibitors containing two ortho-substituted aromatic phosphonates The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. ##STR1## The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases,... | 09/10/2002 |
| 6384260 | Molecular probes and modulators for PI-PLC and PI 3-kinase This invention provides analogues of phosphatidylinositol-phosphates modified at one or more selected inositol-hydroxyls and optionally carrying reporter or anchoring groups attached in the lipid or the inositol residues, and, the synthetic intermediates ... | 05/07/2002 |
| 6376697 | Labelled phosphoinositides and analogues The present invention provides novel compounds comprising cellular phosphoinositides and analogues tagged with stable or radioactive isotopes. The present invention also provides novel methods for the preparation of the said phosphoinositides by syntheses... | 04/23/2002 |
| 6355823 | Inhibitors of intestinal apical membrane na/phoshate co-transportation The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent ... | 03/12/2002 |
| 6255518 | Preparation of fluorinated compounds A method for the preparation of a fluorinated Phosphonate having the formula (RO)2 PO CFR'R" comprises treating a phosphonate of the formula (RO)2 PO CHR'R", or a metal salt thereof, with fluorine. R is an alkyl group R' is hydrogen ... | 07/03/2001 |
| 6232486 | Molecular probes and modulators for PI-PLC and PI 3-kinase This invention provides analogues of phosphatidylinositol-phosphates modified at one or more selected inositol-hydroxyls and optionally carrying reporter or anchoring groups attached in the lipid or the inositol residues, and, the synthetic intermediates ... | 05/15/2001 |
| 6191298 | Thioalkenylphosphonic acid ester and process for the preparation thereof A phosphonic acid ester compound of the formula: R1 C(SR3).dbd.CHP(.dbd.O)(OR2)2 or [P(.dbd.O)(OR2)2 ]CH.dbd.C(SR3)--R4 --C(SR3).dbd.CH[P(.dbd.O)(OR2)... | 02/20/2001 |
| 6160153 | Phosphatase activated crosslinking conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO3--2). Crosslinking and conjugation methods as well as solid phase reagents an... | 12/12/2000 |
| 6147245 | Preparation and use of -Keto Bisphosphonates A unique method for the synthesis of substantially pure -keto bisphosphonate esters and the usage of these esters in reactions with C, N, O, or P nucleophiles for synthesis of -functionalized bisphosphonates. The method starts with a reactio... | 11/14/2000 |
| 6121222 | Anionic surfactants having multiple hydrophobic and hydrophilic groups A novel class of anionic surfactants with improved surfact active properties is comprised of two hydrophilic and two hydrophobic groups represented by the formula: ##STR1## The surfactants exhibit unusually low critical micelle concentration (cmc) ... | 09/19/2000 |
| 6048995 | Process for the preparation of diphosphonate derivatives A process for the preparation of a compound of formula I, ##STR1## wherein R1 and R2 are independently C1-6 alkyl, R3 is hydroxy and R4 and R5 are independently C1-6 alkyl is ... | 04/11/2000 |
| 6008398 | Non-nucleotide phosphorus ester oligomers A phosphorus ester oligomer having the structure: wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, substituted or unsubstituted alkylamino, substitut... | 12/28/1999 |
| 5955453 | Membrane-permeant phosphoinositides Membrane-permeant phosphoinositides, including phosphatidylinositol phosphate esters, are described. A membrane-permeant phosphoinositide includes groups that neutralize the charges of the phosphate moieties of the phosphoinositide. A cell can be treated ... | 09/21/1999 |
| 5886206 | Process for production of methanediphosphonic acid compound A process for production of l-alkylthiomethanediphosphonic acid compound or 1-arylthiomethanediphosphonic acid compound characterized by removing a thiolate byproduct as an insoluble salt, in the condensation represented by the following formula: ##S... | 03/23/1999 |
| 5824815 | Composition comprising a novel phosphatized alicyclic compound and process for the preparation thereof A composition that comprises a phosphatized alicyclic compound represented by the formulas (I), (II), (III), (VII) and (IX) as shown in the specification is described.... | 10/20/1998 |
| 5756774 | Synthesis of myo-inositol phosphates Provided herein are novel syntheses of the phosphate-based inositol derivatives 1-O-(+)-menthoxycarbonyl!-6-O-benzyl-2,3:4,5-di-O-isopropylidene-myo-inos itol (D4P), D-myo-inositol 1,4,5-trisphosphate (D-IP3), 6-O-benzyl-2,3:4,5-di-O-isop... | 05/26/1998 |
| 5683992 | Pharmaceutical applications for methanediphosphonate derivative The present invention relates to a methanediphosphonate derivative, its manufacturing process, and pharmaceutical applications, that is represented with the following formula: ##STR1## wherein, D is either sulfur, oxygen, NH, alkyl-substituted N, CH | 11/04/1997 |
| 5618804 | Methanediphosphonic acid derivative, process for production thereof and use for pharmaceuticals A methane diphosphonic acid derivative represented by the general formula (I): ##STR1## wherein, X and Y are defined in the specification; m represents an integer of 0 to 3; n represents an integer of 0 to 4; and each X of the (X)m an... | 04/08/1997 |
| 5616770 | 1,4-cyclohexanedimethanol bis (diaryl phosphate) Novel flame retardant compounds for polymers are disclosed that include 1,4-cyclohexanedimethanol bis(diphenyl phosphate)s. These can be synthesized by reacting 1,4-cyclohexanedimethanol and a diphenyl halophosphate, such as diphenyl chlorophosphate, in t... | 04/01/1997 |
| 5527941 | Composition comprising a novel phosphatized alicyclic compound Disclosed is a composition which comprises a phosphatized alicyclic compound represented by the formula (I), (II), (III), (VII) or (IX) shown in the specification. The composition of the present invention is useful as an antigassing agent for a water-base... | 06/18/1996 |
| 5504237 | PLA2 inhibitors PIA2 inhibitors selected from the group consisting of ##STR1## wherein A is selected from the group consisting of ##STR2## and Z, W, R1, R2, R3, R4, R5, R6, R7, ... | 04/02/1996 |
| 5482638 | Metal-free dithiophosphoric acid derivatives Addition products of monoepoxides or diepoxides of mono- or polyunsaturated monocyclic or bicyclic hydrocarbons and dithiophosphoric acids, a process for the production of the adducts from the corresponding dithiophosphoric acids and epoxides and the use ... | 01/09/1996 |
| 5453524 | Phosphorus-containing isoprenoid derivatives The present invention provides a phosphorus-containing isoprenoid derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is useful as a preventive and therapeutic agent for diseases for which a sq... | 09/26/1995 |
| 5451401 | Diphosphonic acid esters as tartar control agents Polyphosphonic acid ester compounds with flavorant, coolant and/or sweetener components, and tartar, plaque and/or calculus control compositions with improved taste comprising one or more polyphosphonic acid ester compounds are described.... | 09/19/1995 |
| 5442085 | Synthesis of tetraalkyl vinylidene diphosphonate monomer A method of making a monomer of tetraalkyl vinylidene-1, 1-diphosphonate. The monomer is manufactured by combining an aqueous secondary amine solution with a formaldehyde and a tetra (alkyl) methylene diphosphonate. The resulting mixture is maintained at ... | 08/15/1995 |
| 5438048 | Methylenebisphosphonic acid derivatives Novel pharmacologically active methylenebisphosphonates having formula (I) wherein R1, R2, R3 and R4 independently are straight or branched, optionally unsaturated C1 -C10 -alkyl, optionally ... | 08/01/1995 |
| 5428181 | Bisphosphonate derivative A compound represented by the general formula: ##STR1## wherein A-O-denotes a residue of a compound having an estrogenic activity; R1 denotes H or a C1 -C6 alkyl group; X denotes a single bond, a C1 -C... | 06/27/1995 |
| 5413726 | Phosphite adduct of a telomerized vegetable oil for lubricant compositions There is disclosed a group of lubricant additives that have improved oxidative stability, high viscosity and relatively lower cost and that comprise telomerized vegetable oils having no more than 4% polyunsaturated fatty acids. There is also disclosed sul... | 05/09/1995 |
| 5407923 | Substituted derivatives of deoxymyoinositol, process for their preparation and their use in medicaments Substituted derivatives of deoxymyoinositol of general formula (I): ##STR1## in which R1, R2 and R5 are identical or different and represent a linear or branched alkyl group of 3 to 14 carbon atoms. R3 and R | 04/18/1995 |
| 5395828 | Inositol phosphate analogues as calcium-antagonistic substances A compound of the formula (I) ##STR1## in which R1 is e.g. phosphate, R2 is e.g. phosphate or OH, and R4 is e.g. ##STR2## are suitable Calcium antagonists and useful e.g. for the treatment of cardio-vascular dise... | 03/07/1995 |
| 5393912 | D-myo-inositol 1,4,5-trisphosphate analogues Two types of structural analogues of D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P4 ] are prepared by a chemo-enzymatic route. These 6-O-substituted analogues retain the biological activity of Ins(1,4,5)P3 and are able to elicit Ca... | 02/28/1995 |
| 5376649 | Partial esters of (Di) chloromethanediphosphonic acid useful for treating disorders relating to the metabolism of calcium Novel pharmaceutically active bisphosphonic acid derivatives of formula (I), in which R1, R2, R3 and R4 independently are C1 -C22 -alkyl, C2 -C22 -alkenyl, C2 -C... | 12/27/1994 |
| 5338731 | Bisphosphonates, processes for preparation and pharmaceutical compositions containing the same Bisphosphonate compounds are of the Formula (I): ##STR1## wherein Y is .dbd.O or .dbd.N--OH and n is from 3 to 24, and further wherein when Y is .dbd.O, (i) R1 is hydrogen and R2 is sodium, or (ii) R1 is sodium and R | 08/16/1994 |
