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| Number | Title | Issue Date |
| 7462733 | Preparation and use of α-keto phosphonates Novel phosphonate compounds are provided including a phosphonoglyoxylamide ester, an α-keto phosphonophosphinate ester, a carbonylbisphosphonate analog of a nucleotide, and a diazomethylenebisphosphonate analog of a nucleotide, as well as methods of making syntheti... | 12/09/2008 |
| 7037486 | Labelled phosphoinositides and analogues The present invention provides novel compounds comprising cellular phosphoinositides and analogues tagged with stable or radioactive isotopes. The present invention also provides novel methods for the preparation of the said phosphoinositides by syntheses, and novel... | 05/02/2006 |
| 6787528 | Inhibitors of intestinal apical membrane Na/phosphate co-transportation The compounds of formula (I) are hydrophilic aryl phosphate, thiophosphate, and aminophosphate intestinal apical membrane Na-mediated phosphate co-transportation inhibitors. The compounds can be administered orally, where they act to inhibit Na-dependent phosphate u... | 09/07/2004 |
| 6699910 | Ketone compounds and compositions for cholesterol management and related uses The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administ... | 03/02/2004 |
| 6384260 | Molecular probes and modulators for PI-PLC and PI 3-kinase This invention provides analogues of phosphatidylinositol-phosphates modified at one or more selected inositol-hydroxyls and optionally carrying reporter or anchoring groups attached in the lipid or the inositol residues, and, the synthetic intermediates ... | 05/07/2002 |
| 6380139 | Bisdithiophosphoric acid derivatives as lubricant additives There are disclosed compounds of formula I ##STR1## wherein R1 and R2 are each independently of the other C3 -C18 alkyl, C5 -C12 cycloalkyl, C5 -C6 cycloalkylmethyl, C... | 04/30/2002 |
| 6376697 | Labelled phosphoinositides and analogues The present invention provides novel compounds comprising cellular phosphoinositides and analogues tagged with stable or radioactive isotopes. The present invention also provides novel methods for the preparation of the said phosphoinositides by syntheses... | 04/23/2002 |
| 6333424 | Therapeutic derivatives of diphosphonates Compounds having utility in achieving the foregoing objects of the invention are prepared by reacting a 2,2-bis-(disubstituted-phosphoryl)-ethylsulfanyl-acetic acid compound with a pharmaceutically active chemical entity effective to treat the underl... | 12/25/2001 |
| 6232486 | Molecular probes and modulators for PI-PLC and PI 3-kinase This invention provides analogues of phosphatidylinositol-phosphates modified at one or more selected inositol-hydroxyls and optionally carrying reporter or anchoring groups attached in the lipid or the inositol residues, and, the synthetic intermediates ... | 05/15/2001 |
| 6191253 | Polyether phosphates A dispersant for aqueous mill-bases obtainable by reacting a polyethylene glycol with a molar excess of a hydroxycarboxylic acid containing from 4 to 17 carbon atoms or lactone thereof and/or with a C3-4 -alkylene oxide to form a polymeric diol... | 02/20/2001 |
| 6160153 | Phosphatase activated crosslinking conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating The present invention provides crosslinking, conjugating and reducing agents which are functional with at least one phosphorothioate monoester group (--SPO3--2). Crosslinking and conjugation methods as well as solid phase reagents an... | 12/12/2000 |
| 6096916 | Synthesis of D-3 phosphorylated phosphoinositides and analogues Disclosed are unique starting materials, reaction sequences and intermediate compounds for the preparation of D-3-phosphorylated phosphoinositides (3-PPI) of unambiguous structure and absolute stereochemistry. The enantiomerically pure D-3-phosphorylated ... | 08/01/2000 |
| 6020506 | Synthesis of D-3 phosphorylated phosphoinositides and analogues Disclosed are unique starting materials, reaction sequences and intermediate compounds for the preparation of D-3-phosphorylated phosphoinositides (3-PPI) of unambiguous structure and absolute stereochemistry. The enantiomerically pure D-3-phosphorylated ... | 02/01/2000 |
| 6008398 | Non-nucleotide phosphorus ester oligomers A phosphorus ester oligomer having the structure: wherein A can be the same or different in each monomeric unit and each is independently selected from the group consisting of oxygen, sulfur, lower alkyl, substituted or unsubstituted alkylamino, substitut... | 12/28/1999 |
| 5955453 | Membrane-permeant phosphoinositides Membrane-permeant phosphoinositides, including phosphatidylinositol phosphate esters, are described. A membrane-permeant phosphoinositide includes groups that neutralize the charges of the phosphate moieties of the phosphoinositide. A cell can be treated ... | 09/21/1999 |
| 5866548 | Caged membrane-permeant inositol phosphates Caged acyloxyalkyl esters of phosphate-containing inositol phosphates which are capable of permeating cell membranes. The second messengers are protected (caged) at the 6-hydroxyl, with a photolabile group. Once inside the cell, the ester derivatives unde... | 02/02/1999 |
| 5834436 | Membrane-permeant second messengers Acyloxyalkyl esters of phosphate-containing second messengers which are capable of permeating cell membranes. Once inside the cell, the ester derivatives undergo enzymatic conversion to the biologically active form of the second messenger. The acyloxyalky... | 11/10/1998 |
| 5785894 | Dispersant for dispersing particulate solids A dispersant for aqueous mill-bases obtainable by reacting a polyethylene glycol with a molar excess of a hydroxycarboxylic acid containing from 4 to 17 carbon atoms or lactone thereof and/or with a C3-4 -alkylene oxide to form a polymeric diol... | 07/28/1998 |
| 5686633 | Inks, particularly for ink jet printing Inks, particularly inks for ink jet printing, contain at least one compound of the formula I ##STR1## as a stabilizer. The symbols R1, R2, R3, R4, R3 ' and R4 ' are as defined in claim... | 11/11/1997 |
| 5650531 | Highly pendant phosphorus-containing reactive oligomer flame retardant The synthesis of a non-halogen flame retardant oligomer containing highly pendnat phosphorus moieties is disclosed. Diols, unsaturated double bond-containing dicarboxylic acids or acid anhydrides and saturated dicarboxylic acids or acid anhydrides are fir... | 07/22/1997 |
| 5631392 | Hydroformylation process and bidentate phosphite ligand catalysts used therein The invention relates to a process for preparing an aldehyde compound by hydroformylation of an ethylenically unsaturated organic compound, using a catalyst system which includes a Group VIII metal and a novel bidentate phosphite ligand. The bidentate pho... | 05/20/1997 |
| 5627173 | Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders Compounds of the formula I ##STR1## are suitable for producing pharmaceuticals for the treatment and prophylaxis of degenerative joint disorders, of rheumatic di... | 05/06/1997 |
| 5614573 | Flame retardants and flame retardant finishing method for polyester-based synthetic fiber materials Flame retardant compounds including at least one of a group of specified phosphoryl compounds which have a phenylene group in the molecule are applied to fiber materials composed of polyester-based synthetic fibers. Sufficiently long-lasting flame retarda... | 03/25/1997 |
| 5512189 | Antiwear and antioxidant additives A reaction product useful as an antiwear or antioxidant additive in lubricants is made by reacting a sulfur-containing carboxylic acid, i.e. 3,3'-thiodipropionic acid and a phosphorodithioate, i.e. butoxylated bis(2-ethylhexyl) phosphorodithioic acid.... | 04/30/1996 |
| 5476888 | Diphosphines The diposphines have the formula (I) ##STR1## wherein: R2, R3 and R4 independently from each other represent a hydrocarbyl group which is substituted with one or more radicals selected from the group consisting of hal... | 12/19/1995 |
| 5451401 | Diphosphonic acid esters as tartar control agents Polyphosphonic acid ester compounds with flavorant, coolant and/or sweetener components, and tartar, plaque and/or calculus control compositions with improved taste comprising one or more polyphosphonic acid ester compounds are described.... | 09/19/1995 |
| 5438048 | Methylenebisphosphonic acid derivatives Novel pharmacologically active methylenebisphosphonates having formula (I) wherein R1, R2, R3 and R4 independently are straight or branched, optionally unsaturated C1 -C10 -alkyl, optionally ... | 08/01/1995 |
| 5401845 | Asymmetric aryl phosphites Compounds of the formula I ##STR1## in which x is 1, 2 or 3, and, if x=1, R1 is C1 -C30 alkyl, C1 -C18 alkyl substituted by halogen, --COOR2, --CN, --NR3 R4 or by... | 03/28/1995 |
| 5391801 | Hydroformylation process and bisphosphite compound used therein A hydroformylation process for preparing a hydroformylated product by reacting an olefinic compound with hydrogen and carbon monoxide in the presence of a Group VIII metal catalyst, in the reaction of which there is present a phosphite compound having the... | 02/21/1995 |
| 5347040 | Sensitized onium salts Onium salt capable of generating acid upon exposure to actinic radiation having the following structure: (R1)a (R2)b (R3)c Q+ --A--M+ X- --B--X'- wher... | 09/13/1994 |
| 5306841 | Derivatives of inositol, preparations containing them and their use A compound having the formula ##STR1## where X is a radical of myo-inositol or a radical of a configuration isomer thereof where at least one R is ##STR2## where Y is (1) oxygen, (2) a straight or branched alkyl with 1-10 carbon atoms, wher... | 04/26/1994 |
| 5153000 | Phosphate, liposome comprising the phosphate as membrane constituent, and cosmetic and liposome preparation comprising the liposome A novel monophosphate and a novel diphosphate prepared by a phosphatidyl transfer reaction of a phospholipid and an alcohol in the presence of phospholipase D are disclosed. The phosphates can independently or together form small and stable liposomes whic... | 10/06/1992 |
| 5023312 | Meadowfoam oil and meadowfoam oil derivatives as lubricant additives There is disclosed lubricant additives that comprise a combination of meadowfoam oil as a triglyceride or a wax ester, sulfurized triglyceride meadowfoam oil or sulfurized wax ester of meadowfoam oil, amnd phosphite adducts of triglyceride meadowfoam oil ... | 06/11/1991 |
| 4853455 | Selected phosphoric acid esters as hardeners for epoxy resins The present invention relates to hardenable mixtures containing: (i) a polyglycidyl ether or ester based on an aliphatic, cycloaliphatic or aromatic alcohol or a corresponding carboxylic acid and (ii) a hardener obtainable by reaction of: (A) a mixture of 2-4 mol o... | 08/01/1989 |
| 4837276 | Phosphorus-containing oligomers and polymers containing polyphenylene ether blocks and mixtures of other plastics therewith The invention relates to oligomeric and polymeric esters of difunctional polyphenylene ethers and phosphinic acids, phosphonic acids and phosphoric acid and to their use as a flame-retarding mixing component for other plastics.... | 06/06/1989 |
| 4515722 | Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents Phosphatidyl inositol analogs are found to be effective phospholipase C inhibitors and thereby potent anti-inflammatory and analgesic agents. These phosphatidyl inositol analogs are prepared by condensation of a protected inositol with a substituted phosp... | 05/07/1985 |
| 4435338 | Dithiophosphates The compounds according to the invention correspond to the formula I ##STR1## in which R is a hydrocarbon radical, A is one of the groups --O.CO--, --O-- or ##STR2## (in which m is 0-30) and Q, depending on the definition of A, is a hydroca... | 03/06/1984 |
| 4419299 | Phosphonopolyester oligomers Phosphonopolyester oligomers are prepared from hydroxyalkylated 2,2',-bis(3-allylphenyl-4-hydroxy) alkanes and phosphonyl dihalides. The oligomers are useful in the preparation of polyester resins, epoxy resins, and polyurethanes.... | 12/06/1983 |
| 4416830 | Polyether phosphoric acids or esters This invention relates to phosphorus-containing compounds having the formula: ##STR1## wherein A=O or S, Z=O or S and X and Y=various substituents.... | 11/22/1983 |
| 4332746 | Diphosphonodicarboxylic acid esters Novel phosphonocarboxylic acid compounds having the formula ##STR1## wherein the radicals R which may be identical or different and which represent alkyl radicals with 1-18 carbon atoms which may be optionally substituted by halogen, hydrogen, alkali... | 06/01/1982 |
