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| Number | Title | Issue Date |
| 8178711 | Method for the purification of triorganophosphites by treatment with a basic additive One or more triorganophosphite components are separated from a crude phosphite mixture containing acidic hydrolysis products. The crude phosphite mixture is contacted with a basic additive to produce a second mixture comprising a first phase and a second phase. The ... | 05/15/2012 |
| 7629484 | Method for the purification of triorganophosphites by treatment with a basic additive One or more triorganophosphite components are separated from a crude phosphite mixture containing acidic hydrolysis products. The crude phosphite mixture is contacted with a basic additive to produce a second mixture comprising a first phase and a second phas... | 12/08/2009 |
| 7438818 | Cross-linked polyimine and use thereof for the immobilization of acidic or electrophilic compounds present in a solution The invention relates to a process for immobilizing acidic or electrophilic compounds in a solution. The process is characterized in that it consists in bringing a crosslinked polyimine, which is insoluble in the medium and in which the imino groups are —NH-groups... | 10/21/2008 |
| 7368440 | Methods for the administration of amifostine and related compounds The present invention provides methods of administering amifostine, WR-1065, or a combination thereof, to patients receiving radiation therapy or chemotherapy in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compound... | 05/06/2008 |
| 7318936 | Minimization of drug oxidation in drug irradiated excipients formulations This invention relates to compositions and methods for preventing oxidation of beneficial agents. ... | 01/15/2008 |
| 7166736 | Neopentylglycol bis(diaryl phosphate) esters Neopentyl glycol bis(diphenyl phosphate) liquid compositions are described that comprise from about 75% to about 90%, by weight, of neopentyl glycol bis(diphenyl phosphate), less than about 5% by weight of cyclic product, less than about 8% by weight of triphenyl ph... | 01/23/2007 |
| 7141539 | Process for producing detergent molecules comprising an ether linkage from butadiene Novel detergent molecules and methods for producing such detergent molecules by dimerizing and alkoxylating butadiene with one or more reactant alkanol selected from the group consisting of a primary alkanol and an α, ω-diol, hydrogenating the alkoxydimerization p... | 11/28/2006 |
| 7053072 | Methods for the administration of amifostine and related compounds The present invention provides methods of administering amifostine, WR-1065, or a combination thereof, to patients receiving radiation therapy in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared wi... | 05/30/2006 |
| 7037431 | Method for removing acid from an aprotic liquid Acids can be removed from aprotic organic liquids by bringing the liquids into contact with polyalkyleneimines that have been applied to a support. Polyethyleneimine that has been applied to amorphous silicon dioxide is particularly suitable for this method. The met... | 05/02/2006 |
| 6841545 | Stable amorphous amifostine compositions and methods for the preparation of same The present invention relates to a sterile, stable dosage forms suitable for reconstitution and parenteral administration to a patient, said dosage form comprising an amorphous aminoalkyl dihydrogen phosphorothioate, and of amifostine in particular. The invention fu... | 01/11/2005 |
| 6734325 | Process for the separation of reaction mixtures and the recirculation of quaternary salts A process for the separation and recycling of catalyst components from a chemical reaction mixture is disclosed. The process entails at least one extraction step. ... | 05/11/2004 |
| 6717005 | Epoxy-stabilized polyphosphate compositions A polyphosphate ester composition consisting essentially of an effective amount of a cycloaliphatic epoxy composition for reduction of the total acid number of the composition. The phosphate ester is of the formula: wher... | 04/06/2004 |
| 6706907 | Method of purifying organic phosphoric ester A method of purifying an organic phosphoric ester characterized by treating a crude organic phosphoric ester with an epoxy compound and treating the treated organic phosphoric ester with an alkaline aqueous solution to purify it. The purification method is effective... | 03/16/2004 |
| 6407278 | Stable amorphous amifostine compositions and methods for the preparation and use of the same The present invention relates to a sterile, stable dosage forms suitable for reconstitution and parenteral administration to a patient, said dosage form comprising an amorphous aminoalkyl dihydrogen phosphorothioate, and of amifostine in particular. The i... | 06/18/2002 |
| 6384259 | Stable amorphous amifostine compositions and dosage form The present invention relates to a sterile, stable dosage forms suitable for reconstitution and parenteral administration to a patient, said dosage form comprising an amorphous aminoalkyl dihydrogen phosphorothioate, and of amifostine in particular. The i... | 05/07/2002 |
| 6362358 | Process for the preparation of aromatic phosphonites and aromatic phosphinites and the products made by the process thereof A novel process is described for preparing phosphonites or phosphinites by reacting a product of a Friedel-Crafts reaction with alcohols or phenols and separating off the byproducts formed. The novelty is the aftertreatment with a protic compound, or with... | 03/26/2002 |
| 6218377 | Methods for the administration of amifostine and related compounds The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with... | 04/17/2001 |
| 6127351 | Method for the administration of amifostine and related compounds The present invention provides methods of administering aminoalkyl phosphorothioate and/or aminoalkyl thiol compounds to patients in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared with... | 10/03/2000 |
| 6075157 | Purification of O,S-dimethyl phosphoramidothioate The present invention provides a method for making O,S-dimethyl phosphoramidothioate. In accordance with this process, O,O-dimethyl phosphoramidothioate is isomerized in the presence of dimethyl sulfate to form a reaction mixture; the reaction mixture is ... | 06/13/2000 |
| 6028209 | Process for the preparation of alkylphosphocholines and the production thereof in pure form A process for the preparation of C14 -C18 -alkylphosphocholines by reacting an n-alkanol with a chain length of C14 -C18 with phosphorus oxychloride in an inert solvent or also without solvent in the presence or... | 02/22/2000 |
| 5942639 | Process for the preparation of alkylphosphocholines and the production thereof in pure form A process for the preparation of C14 -C18 -alkylphosphocholines by reacting an n-alkanol with a chain length of C14 -C18 with phosphorus oxychloride in an inert solvent or also without solvent in the presence or... | 08/24/1999 |
| 5831112 | Process for producing stable, low odor S,S,S-tributylphosphorothrithiote The invention is directed to a process for producing a stable, low odor S,S,S-tributylphosphorotrithioate having a level of dibutyl disulfide of 0.3% by weight or less. The process broadly includes the steps of a) reacting S,S,S-tributylphosphorotrithioite wit... | 11/03/1998 |
| 5684174 | Method for purifying O, S-dimethyl N-acetylphosphoramidothioate A method for purifying O,S-dimethyl N-acetyphosphoramidothioate, which is characterized by subjecting a crude crystal of O,S-dimethyl N-acetylphosphoramidothioate to recrystallization by using a two-phase solvent system comprising water and an organic whi... | 11/04/1997 |
| 5616768 | Process for purifying phosphoric esters A process for purifying a phosphoric ester, which comprises treating a crude phosphoric ester with an epoxy compound, heating the resultant in the presence of water, washing the resultant with water, and removing the residual water. The obtained phosphori... | 04/01/1997 |
| 5616769 | Method for purifying O,S-dimethyl N-acetylphosphoramidothioate A method for purifying O,S-dimethyl N-acetyphosphoramidothioate, which is characterized by subjecting a crude crystal of O,S-dimethyl N-acetylphosphoramidothioate to recrystallization by using a two-phase solvent system comprising water and an organic whi... | 04/01/1997 |
| 5523450 | Crystallization process for preparing glycerophosphocholine A process for preparing substantially dry GPC (glycerophosphocholine in enantiomeric form) from wet GPC without racemisation, comprises subjecting the wet GPC to reduced pressure and elevated temperature, to reduce the water content and give highly viscou... | 06/04/1996 |
| 5519159 | Phosphatidylcholine with high oxidative stability and process for its preparation Disclosed are a phosphatidylcholine excellent in oxidation stability, in which the ratio of the total weight of palmitoyl-linoleoyl-glycerophosphocholine (PLPC) and palmitoyl-oleoyl-glycerophosphocholine (POPC) to the total weight of stearoyl-linoleo... | 05/21/1996 |
| 5424471 | Crystalline amifostine compositions and methods of the preparation and use of same The present invention relates to a sterile, stable vacuum dried crystalline amifostine composition and, optionally, pharmaceutically acceptable excipient(s). Typically, the crystalline compositions of the present invention exhibit enhanced stability at te... | 06/13/1995 |
| 5412137 | Process for preparing phosphinyloxy propanaminium inner salt derivatives A process for preparing compounds of the formula ##STR1## where X1 and X2 are independently O or S, and R1 is as defined herein, R2, R3, and R4 are each independently straight or branched c... | 05/02/1995 |
| 5315023 | Process for the preparation of glycerophospholipids A process for the preparation of highly pure deacylated glycerophosphorylcholine, glycerophosphorylethanolamine and glicerophosphorylserine starting from mixtures of the corresponding acylated derivatives. The process according to the invention is charact... | 05/24/1994 |
| 5306840 | Process for preparing pure L--glycerylphosphoryl-D-myoinositol and its salts A process for preparing pure L-alpha-Glycerylphosphoryl-D-Myoinositol and its salts consists of a) preparing the crude Na+ or K+ salt of L--Glycerylphosphoryl-D-Myoinositol, passing an aqueous solution of the salt through an acid resin in H form wh... | 04/26/1994 |
| 5278331 | Waste treatment in dialkyl phosphorochloridothioate production An improvement in the process for making a dialkyl phosphorochloridothioate from P2 S5, alkyl alcohol and chlorine in which the desired product is separated from the reaction mixture by distillation, leaving an unstable, acidic resid... | 01/11/1994 |
| 5258539 | Process for recovering a trialkyl phosphate ester from a trialkyl and aryl phosphate ester-based functional fluid A process for recovering a trialkyl phosphate ester from a phosphate ester-based functional fluid by treating the fluid with an alkoxide salt, and thereafter, distilling the fluid to recover the trialkyl phosphate ester essentially free of aryl-containing... | 11/02/1993 |
| 5250719 | Process for the preparation of L--glycerylphosphoryl-choline and of L--glycerylphosphorylethanolamine A process for the purification of glycerylphosphorylcholine (GPC) and glycerylphosphorylethanolamine (GPE) from crude mixtures by eluting the latter on a cationic resin in acid form equilibrated in an anhydrous solvent, washing the resin with alcohol or a... | 10/05/1993 |
| 5214180 | Highly pure phosphatidylinositol of natural source useful for the treatment of central nervous system disorders and process for its preparation Phosphatidylinositol of high purity useful for the treatment of central nervous system disorders, prepared from vegetal substances containing it by treating them with reagents suitable for the functionalization of the inositol hydroxy group with protectiv... | 05/25/1993 |
| 5214171 | Process for fractionating phosphatide mixtures Process for fractionating phosphatide mixtures into two or more fractions which are enriched in one or more of phosphatidyl choline (PC), phosphatidyl ethanolamine (PE), phosphatidyl inositol (PI) and phosphatidic acid (PA) by carrying out extraction step... | 05/25/1993 |
| 5208362 | Process for stabilizing organophosphorus compounds Organophosphorus compounds are stabilized against decomposition during and after recovery from their synthesis reaction mixtures by the addition to the synthesis reaction mixture of at least 0.5% by weight of an acid scavenger, based on the weight of the ... | 05/04/1993 |
| 5206404 | Triaryl phosphate ester composition and process for its preparation The invention is a novel composition of alkylated phenyl phosphate esters comprising by weight 1% to 20% trialkylphenyl phosphate, 10% to 50% dialkylphenyl monophenyl phosphate, 15% to 60% monoalkylphenyl diphenyl phosphate and less than 2% triphenyl phos... | 04/27/1993 |
| 5138085 | Process for purifying polybrominated triaryl phosphate esters The invention is a process for purifying a solid, storage-stable tris(bromophenyl)phosphate ester dissolving a crude tris(bromophenyl)phosphate in an ester at an elevated temperature, and cooling the solution sufficiently to recover a solid phase.... | 08/11/1992 |
| 5128496 | Process for preparing storage-stable tris(bromophenyl)phosphates The invention is a process for preparing a solid, storage-stable tris(bromophenyl)phosphate ester by the phosphorylation of a bromophenol and recovering the product by cooling a solution of the reaction mixture from a hydrocarbon solvent containing 2 to 2... | 07/07/1992 |
