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| Number | Title | Issue Date |
| 8044224 | Chiral iridium aqua complex and method for producing optically active hydroxy compound by using the same The invention relates to a chiral iridium aqua complex of formula (1): wherein R1 and R2 are the same or different and each is an aryl group optionally having at least one substituent selected from the... | 10/25/2011 |
| 8026382 | Lipid raft, caveolin protein, and caveolar function modulation compounds and associated synthetic and therapeutic methods The present invention is directed to the modulation of lipid rafts, caveolin proteins, or caveolar functions and processes by platinum(IV) compounds. Caveolae and/or lipid rafts are associated with cell transcription regulation, membrane and cellular transport, cell... | 09/27/2011 |
| 7977500 | Platinum complexes for targeted drug delivery The subject invention concerns biotin-conjugated platinum complexes that exhibit direct and indirect (immunological) antitumor cell activity. The subject invention also concerns the biotin-platinum complexes of the invention that have another molecule, such as an an... | 07/12/2011 |
| 7973188 | Processes for the production of organometallic compounds This invention relates to processes for the production of organometallic compounds represented by the formula M(L)3 wherein M is a Group VIII metal, e.g., ruthenium, and L is the same or different and represents a substituted or unsubstituted amidinato gr... | 07/05/2011 |
| 7956208 | Preparation of platinum (II) complexes This invention relates a method for the preparation of platinum(II) oxalato complexes from their dihalogenoplatinum(II) precursors having either neutral monodentate or bidentate non-leaving co-ligands. Of particular interest is oxaliplatin. The method includes the s... | 06/07/2011 |
| 7943793 | Optically active organic acidate-bridged dinuclear platinum(II) complex The present invention is an optically active organic acidate-bridged dinuclear platinum(II) complex represented by the general formula (I): or the general formula (I′): (wherein... | 05/17/2011 |
| 7928257 | Method for producing optically active aziridine compounds and amine compounds as well as complexes and their intermediates used in this method This invention provides a method for producing an optically active aziridine compound or amine compound, which uses as a catalyst a Ru(salen)(CO) complex represented by the following formula (I) or its enantiomer having a high stability, in a high turnover number (T... | 04/19/2011 |
| 7888523 | Preparation of platinum(II) complexes This invention relates to a method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a halogenoplatinum complex containing a neutral bidentate ligand with an oxalate sal... | 02/15/2011 |
| 7884223 | Chiral compound suitable as a catalyst for asymmetric transfer hydrogenation The invention relates to an enantiomerically enriched chiral compound comprising a transition metal M, which comprises four, five or six coordinating groups of which at least one pair is linked together to form a bidentate ligand, in which M is directly bound via on... | 02/08/2011 |
| 7872150 | Process for the preparation of an oxaliplatin The present invention relates to an improved process for the preparation of oxaliplatin, the obtained oxaliplatin preparation and its use in cancer therapy. ... | 01/18/2011 |
| 7816550 | Processes for the production of organometallic compounds This invention relates to processes for the production of organometallic compounds represented by the formula M(L)3 wherein M is a Group VIII metal, e.g., ruthenium, and L is the same or different and represents a substituted or unsubstituted amidinato gr... | 10/19/2010 |
| 7777060 | Platinum analogs with bis-nitrile-containing ligands Disclosed herein are novel platinum-based analogs possessing two nitrile substituent groups (bis-nitrile) covalently-bonded to the platinum. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as well as quantitative in vitro... | 08/17/2010 |
| 7759510 | Platinum complexes and methods of use The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of... | 07/20/2010 |
| 7687651 | Method for the preparation of trans-or cis-diammoniumdichlorodihydroxoplatinum(IV) and the use thereof in the production of pharmaceutical active substances The invention relates to a method for the preparation of trans- or cis-diammoniumdichlorodihydroxoplatinum(IV) and derivatives thereof. What is suggested is reacting trans- or cis-diammoniumdichloroplatinum(II) with a solution comprising >30% peroxide at temperature... | 03/30/2010 |
| 7608730 | Process for the preparation of an anti-tumor platinum (II)—complex We disclose here processes for making Platinum complex of general formula (I) where in, the conformation of 1,2-diaminocyclohexane is cis, trans-l or trans-d isomer and R1 and R2 combinedly make dicarboxylic acid having formulae (II), (III) and... | 10/27/2009 |
| 7605282 | Process for the preparation of an oxaliplatin preparation The present invention relates to an improved process for the preparation of oxaliplatin, the obtained oxaliplatin preparation and its use in cancer therapy. ... | 10/20/2009 |
| 7589225 | Preparation of platinum(II) complexes This invention relates to a method for the preparation of a platinum(II) complex containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a halogenoplatinum complex containing a neutral bidentate ligand with an oxalate sal... | 09/15/2009 |
| 7566798 | Platinum complexes and methods of use The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of... | 07/28/2009 |
| 7462731 | Processes for the preparation of heterocyclic hydroxyamines and intermediates and catalysts for use therein A process for the preparation of a compound of Formula (1): wherein: X is S, O or NR3, wherein R3 is H or an organic group; R is H or an organic group; R1 and R2 each independentl... | 12/09/2008 |
| 7442800 | Nucleophilic heterocyclic carbene derivatives of Pd(acac)for cross-coupling reactions Embodiments in accordance with the present invention provide for a palladium complex characterized by the general formula: where A is a bidentate monoanionic ligand, NHC is a nucleophilic heterocyclic carbene, and Z is an a... | 10/28/2008 |
| 7413816 | Organic metallic complex and electroluminescent element using the same A white or whitish luminescent material for phosphorescence is provided by synthesizing an organometallic complex that is able to convert a triplet excited state into light emission. In particular, a white electroluminescent device that has a high luminous efficienc... | 08/19/2008 |
| 7399857 | Synthesis of organometallic cyclometallated transition metal complexes A process for forming a tris-cyclometallated complex comprises the step of reacting; a) an M(I) complex, wherein M represents Rh or Ir, and said complex comprises at least two ligands and contains at least two alkenyl groups pi-bon... | 07/15/2008 |
| 7399874 | Catalyst compound containing divalent tridentate ligand This invention relates to a catalyst compound represented by the formula: wherein: M is a Group 3 to 12 transition metal; each Ra is, independently, a hydrogen,... | 07/15/2008 |
| 7393871 | Anionic and neutral complexes of ruthenium (II) with nitrogen oxide A class of anionic and neutral complexes of ruthenium (II) containing nitrogen oxide (NO) and optionally a nitrogen ligand is described; a process for their preparation is also described. The preparation process includes the use of starting complexes of ruthenium (I... | 07/01/2008 |
| 7371247 | Method and apparatus for penetrating tissue A tissue penetrating system includes a plurality of penetrating members each having a tip. A penetrating member driver is coupled to the plurality of penetrating members. Each tip of a penetrating member is uncovered during launch of the penetrating member by the pe... | 05/13/2008 |
| 7351846 | Oxaliplatin with a low content of accompanying impurities and a method for preparation thereof Oxaliplatin with a low content of accompanying impurities originating from its preparation which contains, by weight, at most 0.01%, preferably less than 0.001%, of alkali metals, at most 0.0005%, preferably less than 0.0002%, of silver, and at most 0.01%, preferabl... | 04/01/2008 |
| 7331931 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generato... | 02/19/2008 |
| 7329727 | Methods and compositions for controlled polypeptide synthesis Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for initiating the polymerization of aminoacid-N-carboxyanhydride (NCA) monomer by combining the monomer with an amido-containin... | 02/12/2008 |
| 7319083 | Polymerized catalyst composition A composition is provided that includes a product of combining, in the presence of a free radical initiator a catalyst precursor and at least one monomer wherein the monomer and the catalyst precursor are poiymerizable by free-radical polymerization and wherein the ... | 01/15/2008 |
| 7316700 | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties A lancing device, an embodiment of which controls the advancement and retraction of a lancet by monitoring the position of the lancet in conjunction with a lancet controller which incorporates a feedback loop for modulating the lancet driver to follow a predetermine... | 01/08/2008 |
| 7309796 | Process for the preparation of 1,2-diaminocyclohexane-platinum(II) complexes A process for the preparation of diaminocyclohexane-platinum(II)-dicarboxylates has the following steps: B Conversion of K2PtX2 with 1,2-diaminocyclohexane (DACH) to (2): ... | 12/18/2007 |
| 7294415 | Organometallic complex and organic electroluminescent device employing the same An organometallic complex which includes a carboxylic acid as an ancillary ligand, and an organic electroluminescent device employing the same. The organometallic complex is useful as a phosphorescence dopant material of an organic electroluminescent device due to i... | 11/13/2007 |
| 7291117 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a voice coil based penetrating member driver. A plurality of penetrating members are included. A transport mechanism is configured to... | 11/06/2007 |
| 7271231 | Polymerization of olefins Disclosed herein are processes for polymerizing ethylene, acyclic olefins, and/or selected cyclic olefins, and optionally selected olefinic esters or carboxylic acids, and other monomers. The polymerizations are catalyzed by selected transition metal compounds, and ... | 09/18/2007 |
| 7268245 | Multinuclear platinum compounds Multinuclear platinum compounds, compositions that include the platinum compounds, methods for making the platinum compounds, and methods for treating cellular proliferative diseases by administering the platinum compounds. ... | 09/11/2007 |
| 7268244 | Monoimine ligand platinum analogs Disclosed herein are novel platinum-based analogs with a single substituted imine ligand: R7RC═NR8, wherein the R7RC═NR8 functional group is covalently bonded to the platinum through nitrogen. The analogs also have nit... | 09/11/2007 |
| 7258693 | Device and method for variable speed lancet A method of penetrating tissue is provided. The method comprises using a lancet driver to advance a lancet into the tissue; advancing the lancet at a first desired velocity in a first layer of tissue; advancing the lancet at a second desired velocity in a second lay... | 08/21/2007 |
| 7259270 | Supermolecular carboplatin derivatives, their preparation and pharmaceutical composition containing them as active ingredient and applications of the compositions The present invention relates to a novel class of supermolecular carboplatin derivatives represented by general formula (I), wherein B is a polycarboxylic acid represented by general formula (II), wherein R1, R2 and n are defined as in the desc... | 08/21/2007 |
| 7250526 | Transfer hydrogenation process and catalyst A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted with at least one group selected from an optionally substituted sulphonated hydr... | 07/31/2007 |
| 7244265 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a drive force generator and a penetrating member operatively coupled to the force generator. The force generator moves the member alo... | 07/17/2007 |
