...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 7550613 | Compounds Compounds of formula (I); wherein R1 and R2 are the same or different and may be selected from the group consisting of a hydrogen atom, a hydroxy group, an alkyl grou... | 06/23/2009 |
| 7420071 | Thermally stable surfactants and compositions and methods of use thereof There are provided novel thermally stable surfactants for use with fillers in the preparation of polymer composites and nanocomposites. Typically, surfactants of the invention are urethanes, ureas or esters of thiocarbamic acid having a hydrocarbyl group of from 10 ... | 09/02/2008 |
| 7309721 | Aminoalkylphosphonates and related compounds as Edg receptor agonists The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejecti... | 12/18/2007 |
| 7303760 | Method for treating multi-drug resistant tumors Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a l... | 12/04/2007 |
| 7279563 | Compounds for protecting hydroxyls and methods for their use A hydrocarbyldithiomethyl-modified compound of the Formula: R1—O—CH2—S—S—R2 or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/... | 10/09/2007 |
| 7253296 | Acylated aminopropanediols and analogues and therapeutic uses thereof The invention relates to novel acylated aminopropanediols and the nitrogen and sulfur analogues thereof, pharmaceutical compositions comprising same, therapeutic uses thereof, in particular for the treatment of cerebral ischemia. The invention also provides a method... | 08/07/2007 |
| 7235586 | Cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents The invention relates to the use of cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and carbamoyloxy as therapeutic agents e.g. as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: | 06/26/2007 |
| 7087770 | Compound containing a labile disulfide bond A labile disulfide-containing compound under physiological conditions containing a labile disulfide bond and a transduction signal. ... | 08/08/2006 |
| 6991888 | Photoresist composition for deep ultraviolet lithography comprising a mixture of photoactive compounds The present invention relates to a novel photoresist composition that can be developed with an aqueous alkaline solution, and is capable of being imaged at exposure wavelengths in the deep ultraviolet. The invention also relates to a process for imaging the novel ph... | 01/31/2006 |
| 6984396 | Conjugate having a cleavable linkage for use in a liposome Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its ori... | 01/10/2006 |
| 6979460 | Vinyl ether lipids with cleavable hydrophlic headgroups A novel amphiphilic lipid compound having a cleavable, vinyl ether linked hydrophilic headgroup is described. Also described are liposomes containing the vinyl ether lipid compound, which may be triggered to release their contents and/or permeablize or fuse with tar... | 12/27/2005 |
| 6936729 | Compound containing a labile disulfide bond A labile disulfide-containing compound under physiological conditions, comprising: the disulfide-containing compound having a labile disulfide bond that is either a disulfide bond that is cleaved more rapidly than oxidized glutathione or a disulfide bond constructed... | 08/30/2005 |
| 6906210 | Method for producing lipoic acid and dihydrolipoic acid Processes for the preparation of R-lipoic acid or S-lipoic acid comprising a process step selected from a) distillation of dihydrolipoic acid, b) reaction of ... | 06/14/2005 |
| 6831186 | Lipoxin A4 analogs This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analog... | 12/14/2004 |
| 6657071 | Process for producing -sulfo-fatty acid alkyl ester salt By conducting a sulfonation step for bringing a fatty acid alkyl ester into contact with a sulfonating gas in the presence of a coloring inhibitor to sulfonate the fatty acid alkyl ester, an esterification step for esterifying the product of the sulfonati... | 12/02/2003 |
| 6639088 | Compounds for protecting hydroxyls and methods for their use A hydrocarbyldithiomethyl-modified compound of the Formula: or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The... | 10/28/2003 |
| 6441036 | Fatty analogues for the treatment of obesity, hypertension and fatty liver The present invention relates to novel fatty acid analogous of the general forumla I: CH3 --[CH2 ]m --[xi --CH2 ]n --COOR, as defined in the specification, which can be used for the treatme... | 08/27/2002 |
| 6407137 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 06/18/2002 |
| 6365628 | Fatty analogues for the treatment of diabetes The present invention relates to novel fatty acid analogues of the general formula (I): CH3 --[CH2 ]m --[xi --CH2 ]n --COOR, as defined in the specification, which can be used for the treat... | 04/02/2002 |
| 6362352 | F18-labeled thia fatty acids and methods of making and using the same Sulfur heteroatom substitution at the C4 position of 18 F-labeled fatty acids yields a tracer that is retained in proportion to the beta-oxidation rates in mammalian tissue, particularly hypoxic myocardium. Most preferably, the invention is emb... | 03/26/2002 |
| 6258836 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 07/10/2001 |
| 6224903 | Polymer-lipid conjugate for fusion of target membranes A fusogenic liposome composition for delivering a liposome-entrapped compound into the cytoplasm of a target cell is described. The liposomes have an outer surface coating of chemically releasable hydrophilic polymer chains which shield hydrophobic polyme... | 05/01/2001 |
| 6165997 | Phospholipids having antimicrobial activity with or without the presence of antimicrobials A pharmaceutical formulation for stimulating growth of Gram-positive Bacilli and increasing the acidity in vagina comprises sucrose and/or maltose, optionally with other sugars, viscous base, and anti-fungal and/or anti-bacterial agents.... | 12/26/2000 |
| 6013815 | Production and use of salts of 6,8-bis (amidiniumthio)-octanoic acid The invention relates to the production and purification of salts of 6,8-bis (amidiniumthio)octanoic acid, its enantiomers (+)-6,8-bis(amidiniumthio)octanoic acid and (-)-6,8-bis (amidiniumthio)octanoic acid and of the esters of these compounds as well ... | 01/11/2000 |
| 6002029 | Antiviral prodrugs Lipid prodrugs of phosphonoacids and their analogs that have increased antiviral activity over the parent drugs in inhibiting cytomegalovirus and other susceptible viruses.... | 12/14/1999 |
| 6001869 | Method of inhibiting parasitic activity A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myrist... | 12/14/1999 |
| 5994392 | Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 11/30/1999 |
| 5783534 | Process for the production of solid esterquats A process for the production of a solid esterquat free from solvents comprising the steps of A) forming a mixture comprising (i) at least one fatty acid triethanolamine ester corresponding to formula (I) ##STR1## in which R1 CO is a satur... | 07/21/1998 |
| 5780397 | Extreme pressure additive There is disclosed a lubricant additive ingredient that imparts extreme pressure anti-wear properties to lubricant additive compositions. Specifically, there is disclosed a derivative of a vegetable oil triglyceride, a wax ester or a telomerized oil react... | 07/14/1998 |
| 5731448 | (+) and (-)-8-chloro-6-sulfonyloxy-octanoic acid, its derivatives, and methods for making The synthesis of pure enantiomers of 8-chloro-6-sulfonyloxy-octanoic acids and their alkyl esters and of pure enantiomers of 6,8-dichloro-octanoic acid and its alkyl esters as intermediates for the synthesis of the enantiomers of -liponic acid as w... | 03/24/1998 |
| 5696277 | Antiviral prodrugs Lipid prodrugs of phosphonoacids and their analogs that have increased antiviral activity over the parent drugs in inhibiting cytomegalovirus and other susceptible viruses.... | 12/09/1997 |
| 5637616 | Method for treating diseases mediated by proteases A method for the topical or systemic treatment of disorders mediated by proteases which result in skin or mucosal lesions, and in particular, pemphigus, cicatricial pemphigoid, bullous pemphigoid, lichen planus, and canker sores, is disclosed wherein the ... | 06/10/1997 |
| 5634948 | Low-fogging finish treatment for upholstery leather, and method A method of imparting low fogging characteristics to tanned leather, which includes the step of treating the leather in an aqueous emulsion including an effective quantity of an oil having less than 3 percent of fatty acid components of less than C-16, th... | 06/03/1997 |
| 5587499 | (Meth) acrylic compounds, process for their preparation and their application to the synthesis of new polymers These compounds are denoted by the following formula (I): ##STR1## in which: Z denotes H or a linear or branched alkyl radical, X denotes O or S, each of A and B independently denotes an alkylene radical, it being possible for this radical to be substitut... | 12/24/1996 |
| 5506267 | Thioglycerol derivatives A compound of the invention is represented by the formula: ##STR1## wherein R1 and R2 are the same or different, an acyl group; R3, R4, R6 and R7 are the same or different, hydrogen or... | 04/09/1996 |
| 5473089 | Process for the production of ammonium fatty acid hydroxyalkanesulfonates Ammonium fatty acid hydroxyalkanesulfonates are made by a process in which (a) ammonium hydroxyalkanesulfonate corresponding to general formula (I): HO--(Cn H2n)--SO3 NH4 (I) wherein n=2 to 4, is subjecte... | 12/05/1995 |
| 5391782 | Process for the production of highly concentrated pastes of -sulfofatty acid alkyl ester alkali metal salts In the production of highly concentrated pastes of -sulfofatty acid alkyl ester alkali metal salts by reaction of fatty acid alkyl esters with gaseous SO3, subsequent after-reaction in liquid phase and neutralization with aqueous alkali ... | 02/21/1995 |
| 5391781 | Methods for dispersing sulfur in aqueous systems Disclosed are methods for dispersing sulfur in aqueous systems comprising adding an alkylcarboxylic acid compound to the system. This prevents fouling of the aqueous system by the precipitated sulfur.... | 02/21/1995 |
| 5391783 | Process for the production of light-colored pastes of -sulfofatty acid alkyl ester alkali metal salts In the production of light-colored pastes of -sulfofatty acid alkyl ester alkali metal salts by reaction of fatty acid alkyl esters with gaseous SO3, subsequent after-reaction in liquid phase, neutralization with aqueous alkali metal hyd... | 02/21/1995 |
| 5391784 | Liquid or flowable derivatives of natural fats and oils a process for their production and their use The present invention relates to derivatives of natural fats and oils that are liquid or flowable, respectively, and to a process for the production of said derivatives, in which oxalkylation is carried out at elevated temperatures in the presence of basi... | 02/21/1995 |