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| Number | Title | Issue Date |
| 7420071 | Thermally stable surfactants and compositions and methods of use thereof There are provided novel thermally stable surfactants for use with fillers in the preparation of polymer composites and nanocomposites. Typically, surfactants of the invention are urethanes, ureas or esters of thiocarbamic acid having a hydrocarbyl group of from 10 ... | 09/02/2008 |
| 7303760 | Method for treating multi-drug resistant tumors Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a l... | 12/04/2007 |
| 6984396 | Conjugate having a cleavable linkage for use in a liposome Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its ori... | 01/10/2006 |
| 6602861 | Acylated phospholipid drugs This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the fo... | 08/05/2003 |
| 6486334 | Biomembrane mimetic surface coatings Disclosed are thiol-functionalized phospholipids that have been covalently linked to a gold and/or silver substrate, methods for making them, and intermediates useful for such purposes. The resulting material creates a biomimetic surface that can be inclu... | 11/26/2002 |
| 6030602 | Peptide conjugates for transfecting cells The invention relates to conjugates of lipids and basic, membrane disturbing peptides, particularly compounds of the formula (R--CONH)n --R3 (I) and (R--S--S)n --R3 ... | 02/29/2000 |
| 5846516 | Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications Perfluoroalkylated amphiphilic phosphorus compounds, corresponding to the formulae: ##STR1## wherein V is O or S; R1, R2 and R3 are H or substituted or unsubstituted perfluoroalkylated or hydrocarbon radicals; provide... | 12/08/1998 |
| 5827836 | Retinoid glycerol phospholipid conjugates Retinoyl substituted glycerophosphoethanolamines are disclosed having the general Formula I: ##STR1## wherein one of A, B or C is a fatty ether substituent, one is a natural or synthetic retinoid ester substituent, and one is a phosphoethanolamine ... | 10/27/1998 |
| 5801260 | Carbonothioate phospholipid analogs as substrate of phospholipases and lipases Novel substrates of phospholipases, lysophospholipases and lipases are disclosed.... | 09/01/1998 |
| 5679459 | Perfluorinated amphiphilic phosphorous compounds: liposomal compositions Perfluoroalkylated amphiphilic phosphorus compounds, corresponding to the formulae: ##STR1## wherein V is O or S; R1, R2 and R3 are H or substituted or unsubstituted perfluoroalkylated or hydrocarbon radicals; provide... | 10/21/1997 |
| 5663387 | Liposomes containing polymerized lipids for non-covalent immobilization of proteins and enzymes The lipids of this invention are derivatives of phosphatidyl choline having the general chemical formula: ##STR1## wherein at least one of R and R' is a polymerizable unsaturated alkyl group, acid or ester, wherein X includes an iminodiacetic acid in... | 09/02/1997 |
| 5543402 | [3-(C16 -C18)-alkanesulphinyl and sulphonyl-2-methoxy-methylpropyl]-(2-trimethylammonioethyl) phosphates, processes for the preparation thereof and pharmaceutical compositions containing them The present invention provides [3-(C16 -C18)-alkaesulphinyl- and -sulphonyl-2-methoxy-methylpropyl]-(2-trimethylammonioethyl) phosphates having superior anti-tumor activity.... | 08/06/1996 |
| 5352673 | Prodrugs The present invention provides prodrugs that serve as useful therapeutics for various disease states and conditions mediated by underlying specific hydrolytic enzyme activity. The prodrugs hereof (additionally) impart a physiologically bioactive component... | 10/04/1994 |
| 5329029 | Phosphatidylalkanolamine derivatives and their use in generating phospholipid conjugates An efficient, technically straightforward and inexpensive process for generating conjugates of phospholipids with biologically important molecules is described.... | 07/12/1994 |
| 5310958 | Lysolecithin derivatives A modified biologically active protein consisting essentially of a biologically active protein bonded to lecithin via a covalent linking group and a pharmaceutical composition comprising the modified biologically active protein in a pharmaceutically accep... | 05/10/1994 |
| 5290960 | Diacetylenic phospholipids containing heteroatom near diacetylenic functionality for modulation of microstructure morphology Novel diacetylenic phospholipids having the diacetylenic moieties chemically decoupled from the rest of the acyl chains by the inclusion of one or more heteroatom, preferably oxygen, spacers on the acyl chains have the chemical formula: ##STR1## ... | 03/01/1994 |
| 5080833 | Immobilization of bioactive substance on lipid composition containing modified lipid compound A lipid represented by the following formula (I) can react with and immobilize a bioactive substance at functional group --Y--(CH2)n --X: R--Y--(CH2)n--X (I) wherein X is a halogen atom, Y ... | 01/14/1992 |
| 5004566 | Process for fabrication of lipid microstructures from dry organic solvent Process for forming tubular microstructures having predetermined shape and dimension from surfactants comprising the steps of selecting a lipid which self-aggregates into a tubular microstructure; selecting a lipid solvating organic solvent in which tubul... | 04/02/1991 |
| 4837340 | Phospholipid-like compounds Compounds related to phospholipids and a method for their preparation are sclosed.... | 06/06/1989 |
| 4814112 | Single-stage process for preparing mixed-substituted 1,2-diacyl-sn-clycero-3-phosphocholines Single-stage process for preparing mixed-substituted enantiomerically pure 1,2-diacyl-sn-glycero-3-phosphocholines of general formula I ##STR1## in which R1 and R2 are different and independently of each other denote a substitut... | 03/21/1989 |
| 4594193 | Thiol based lipids and membranes made therefrom Thiol containing lipids as provided which are used to construct polymerizable-deplymerizable vesicles that may be used as slow release in vivo medication delivery systems.... | 06/10/1986 |
| 4504474 | Synthetic phosphoglycerides possessing platelet activating properties Novel synthetic glyceryl-phosphorylcholine compounds are prepared having biological activity paralleling that of naturally generated platelet activating factor.... | 03/12/1985 |
| 4235792 | Immunological materials Immune lysis of sensitized liposomes containing a marker is employed in an assay method wherein an antigenic material to be determined is reacted with a specific antiserum and the degree of inhibition of the antiserum is detected by the extent of release ... | 11/25/1980 |
| 4086278 | 1-ALKENYL THIOETHERS 1-Alkenyl thioethers of glycols are described. The alkenyl thioethers possess central nervous system activity and are useful as tranquilizers.... | 04/25/1978 |
