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| Number | Title | Issue Date |
| 7420071 | Thermally stable surfactants and compositions and methods of use thereof There are provided novel thermally stable surfactants for use with fillers in the preparation of polymer composites and nanocomposites. Typically, surfactants of the invention are urethanes, ureas or esters of thiocarbamic acid having a hydrocarbyl group of from 10 ... | 09/02/2008 |
| 7351702 | Caspase inhibitors and uses thereof This invention provides compounds of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; next to R3 represents a... | 04/01/2008 |
| 7303760 | Method for treating multi-drug resistant tumors Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a l... | 12/04/2007 |
| 7255792 | Method for modifying an organic composition There is provided a process for modifying a first organic composition comprising (i) at least one first solvent, (ii) at least one solute, and (iii) optionally, at least one second solvent to produce a modified organic composition in which the concentration of the a... | 08/14/2007 |
| 7238367 | Liposome loading with metal ions This invention relates to encapsulation of drugs and other agents into liposomes. ... | 07/03/2007 |
| 7189544 | Enzymatic modification of lecithin The disclosure pertains to enzymatic modification of lecithin and to hydrolyzed lecithin products obtained by such modification. One particular implementation provides methods for producing a hydrolyzed lecithin product containing hydrolyzed phospholipids, monoglyce... | 03/13/2007 |
| 7179491 | Process of converting rendered triglyceride oil from marine sources into bland, stable oil Triglyceride oil derived from marine sources, mammalian and fish, is treated with a silica at relatively low temperature under vacuum and is then further treated with a bleaching clay under vacuum and at higher temperature. The silica and the bleaching clay are then... | 02/20/2007 |
| 7138105 | Compositions for delivery of therapeutics and other materials, and methods of making and using the same In part, the present invention is directed to compositions comprising a carrier with a metal binding domain, a metal ion, and an active agent. ... | 11/21/2006 |
| 7122216 | Vegetable oil extraction methods This invention relates to methods for treating oil bearing vegetable material, especially oilseeds. Methods of the invention provide for the isolation of certain components of oil bearing vegetable material, including isoflavones, vegetable oil, and a phosphatide fr... | 10/17/2006 |
| 7091012 | Processes for obtaining sterols and polar lipids from vegetable oil lecithin fractions Processes for the simultaneous production of sterols and polar lipids, in which preparations of vegetable oil lecithin fractions are subjected to ultrafiltration and, on the one hand, the sterols in the permeate and, on the other hand, the polar lipids in the retent... | 08/15/2006 |
| 7078069 | Sprayable cookware release composition with reduced heat induced browning A sprayable cookware release composition includes an oil, a propellant, and a cookware release agent having lecithin treated with an alkali and a fatty acid at the same time or treated with a mixture of an alkali and a fatty acid. A variety of alkali and fatty acids... | 07/18/2006 |
| 7067109 | Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids Disclosed is the surprising discovery that aminophospholipids, such as phosphatidylserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-t... | 06/27/2006 |
| 7048908 | Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention rel... | 05/23/2006 |
| 7037550 | Sprayable cookware release composition with fractionated oil and method of preparing food item A sprayable cookware release composition includes a cookware release agent, a fractionated oil, such as a fractionated palm oil or a fractionated coconut oil, and a propellant. A combination of fractionated oils or a combination of a fractionated oil and a non-fract... | 05/02/2006 |
| 7034168 | Process for the production of phospholipids A new enzymatic process for preparing 1,2-diacylated phospholipids using an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced ... | 04/25/2006 |
| 6984396 | Conjugate having a cleavable linkage for use in a liposome Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its ori... | 01/10/2006 |
| 6979460 | Vinyl ether lipids with cleavable hydrophlic headgroups A novel amphiphilic lipid compound having a cleavable, vinyl ether linked hydrophilic headgroup is described. Also described are liposomes containing the vinyl ether lipid compound, which may be triggered to release their contents and/or permeablize or fuse with tar... | 12/27/2005 |
| 6972338 | Alkoxylated mono alkyl glyceryl ester phosphobetaine compounds The invention relates to a series of novel alkoxylated mono alkyl glyceryl ester phosphobetaine compounds, which are exceptional surface active agents that provide outstanding foam and are very mild to the hair and skin, in addition because of the presence of the es... | 12/06/2005 |
| 6949528 | Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof The invention provides anti-apoptotic compositions lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene g... | 09/27/2005 |
| 6905722 | Sprayable cookware release composition with reduced heat induced browning A sprayable cookware release composition includes an oil, a propellant, and a cookware release agent having lecithin treated with an alkali and a fatty acid at the same time or treated with a mixture of an alkali and a fatty acid. A variety of alkali and fatty acids... | 06/14/2005 |
| 6828453 | Phospholipid-analogous compounds Phospholipid-analogous compounds of the general formula (I) in which A where R1 and R2 are, independently of one another, h... | 12/07/2004 |
| 6797835 | Phospholipid composition and use of same A phospholipidic composition with an L-α-glycerophosphatidyl-choline concentration of at least 10% by weight is described, where said composition is granular and also contains, in addition to L-α-glycerophosphatidylcholine, at least one granulation aid selected fr... | 09/28/2004 |
| 6733754 | Adjuvants for use in vaccines The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal. ... | 05/11/2004 |
| 6733814 | Food composition suitable for shallow frying comprising sunflower lecithin The invention concerns a food composition, suitable for shallow frying, comprising triglycerides, wherein least 60 wt. % of triglycerides is of vegetable origin, and 0.05-3 wt. % sunflower lecithin. The invention further concerns a process for the preparation of hyd... | 05/11/2004 |
| 6699499 | Amphiphilic materials and liposome formulations thereof Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydr... | 03/02/2004 |
| 6683032 | Multifunctional phospholipid surfactants The present invention relates to novel compositions and, more particularly, to a class of compounds having specific quaternized amine based upon a phosphate ester. The use of a phosphate ester based upon a fatty alcohol or fatty alcohol alkoxylate as the ... | 01/27/2004 |
| 6679822 | Polyalkylene oxide-modified phospholipid and production method thereof A polyalkylene oxide-modified phospholipid represented by formula (1) defined in the specification, has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight.... | 01/20/2004 |
| 6677319 | Phosphatidylcholine as medication with protective effect large intestinal mucosa The presented invention relates to a medication containing a therapeutically effective amount of phosphatidylcholine as active substrate for treatment of disease where phosphatidylcholine has an advantageous, protective effect on the mucosa of large intes... | 01/13/2004 |
| 6602861 | Acylated phospholipid drugs This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the fo... | 08/05/2003 |
| 6572861 | Adjuvants for use in vaccines The invention relates to adjuvants that contain a lecithin, an oil and an amphiphilic surfactant and that are capable of forming a stable oil-in-water emulsion vaccine so as to minimize local reactions to the vaccine in the injected animal.... | 06/03/2003 |
| 6517884 | Water and oil containing emulsion The invention relates to a food product comprising 0.1 to 1.5 wt % of one or more anti-spattering agents comprising no native soy lecithin or native soy lecithin in an amount of from 0 to 0.05 wt % on total product, whereby the anti-spattering agent is pr... | 02/11/2003 |
| 6413949 | Prodrugs with enhanced penetration into cells The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and an intracellular transporting adjuvant, characterized by the presence of a covalent bond which is scission-sensitive to... | 07/02/2002 |
| 6403554 | Polyunsaturated fatty acid derivatives and their use Novel amides are disclosed, in particular amides of the all-trans-retinoic acid or 13-cis-retinoic acid and arachidonic acid and docosahexaenoic acid and eicosapentaenoic acid or linoleic acid with 2-aminoethanol, alpha-L-serine, alpha-L-threonine, alpha-... | 06/11/2002 |
| 6344576 | Phospholipid-analogous compounds The present invention relates to phospho-lipid compounds of formula ##STR1## having solubilizing activity for water-insoluble or poorly water soluble active agents and their use in the delivery of active agents to cells and in the treatment of diseases, i... | 02/05/2002 |
| 6313106 | Phospholipid derivatives of valproic acid and mixtures thereof The present invention relates to compounds, which are phospholipid derivatives of valproic acid, to compositions comprising said compounds and their use for treating epilepsy, migraine, bipolar disorders and pain.... | 11/06/2001 |
| 6297391 | Process for the synthesis of diricinoleyphosphatidylcholine Diricinoleylphosphatidylcholine (I) in an optically active form is obtained with good yields and a high purity by means of a process which comprises: a) esterifying the terminal carboxylic group of ricinoleic acid (III) with an alcohol having from 1 to 4 carbo... | 10/02/2001 |
| 6284267 | Amphiphilic materials and liposome formulations thereof Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydr... | 09/04/2001 |
| 6274747 | Polyunsaturated fatty acid derivatives and their use Novel amides are disclosed, in particular amides of the all-trans-retinoic acid or 13-cis-retinoic acid and arachidonic acid and docosahexaenoic acid and eicosapentaenoic acid or linoleic acid with 2-aminoethanol, alpha-L-serine, alpha-L-threonine, alpha-... | 08/14/2001 |
| 6271209 | Cationic lipid formulation delivering nucleic acid to peritoneal tumors Methods of transfecting cells in vivo, including tumor cells in the peritoneal cavity are provided. Related lipid:nucleic acid formulations adapted to transfecting cells in the peritoneal cavity are provided. Assays, including high-throughput assays for s... | 08/07/2001 |
| 6180806 | Glyceryl phosphobetaine compounds The present invention relates to a series of novel glyceryl phosphobetaine compounds which are exceptional f surface active agents that provide outstanding foam and are very mild to the hair and skin. The compounds, because they contain a pendant ionizabl... | 01/30/2001 |
