Did You Know...
...that in the early 1940s GE engineer James Wright was charged with a task of utmost importance to the war effort: develop a cheap substitute for rubber that could be used to produce tires, gas masks and a whole host of military gear. Wright tackled the task diligently -- and wound up inventing Silly Putty.
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| Number | Title | Issue Date |
| 8178704 | Inositol-phosphate derivatives and method of detecting inositol-1-phosphate The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule(s) M being... | 05/15/2012 |
| 7977497 | Inositolphospholipids and analogues phosphatidylinositol products and processes Embodiments of the invention relate to natural and synthetic inositolphospholipid (IPL) materials, their preparation and applications. They provide compositions of the parent IPL comprising phosphatidylinositol (PI), PI-phosphates (phosphoinositides) and derivatives... | 07/12/2011 |
| 7968737 | Producing method of phospholipids including long-chain polyunsaturated fatty acids as constituents, and use of such phospholipids The present invention provides a method of efficiently and stably producing LCPUFA-PL. Specifically, the invention provides a method for producing phospholipids that contain LCPUFA as a constituent (LCPUFA-PL), wherein lipid producing cells producing lipids that con... | 06/28/2011 |
| 7939683 | Phospholipid-analogous compounds Phospholipid-analogous compounds of the general formula (I) in which A is where R1 and ... | 05/10/2011 |
| 7868196 | Preparation of glycerol derivatives and intermediates therefor Disclosed is a process for the regioselective preparation of glycerol derivative in a high efficiency and yield. The process for the regioselective preparation of 1-R1-2-R2-3-acetyl-glycerol derivative comprises the steps of: obtaining 1-R... | 01/11/2011 |
| 7847113 | Phospholipids including long-chain polyunsaturated fatty acids as constituents, and use of such phospholipids The present invention provides a method of efficiently and stably producing LCPUFA-PL. Specifically, the invention provides a method for producing phospholipids that contain LCPUFA as a constituent (LCPUFA-PL), wherein lipid producing cells producing lipids that con... | 12/07/2010 |
| 7371877 | Glycerol ester derivative A compound represented by the following general formula (IA) or a salt thereof: wherein Ar1 represents hydrogen atom or an aryl group having at least one iodine atom as a substituent; Ar2 represents an... | 05/13/2008 |
| 7351428 | Phosphatidyl oligoglycerols In order to form liposomes with a longer half-life in blood, use is made of defined formula (A) ... | 04/01/2008 |
| 7259273 | Compositions containing lysophosphotidic acids which inhabit apoptosis and uses thereof The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions may also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as pol... | 08/21/2007 |
| 7235583 | Fatty acid-anticancer conjugates and uses thereof The invention provides conjugates of fatty acids and anticancer agents useful in treating cancer, and compositions and formulations thereof. Methods for using the conjugates also are provided. ... | 06/26/2007 |
| 7214384 | Lipid-conjugated polyamide compounds In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologica... | 05/08/2007 |
| 7173018 | Phospholipid derivatives of non-steroidal anti-inflammatory drugs Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the compounds, pharmaceutical compositions comprising the compounds and t... | 02/06/2007 |
| 7101914 | Isomer enriched conjugated linoleic acid compositions Compositions and methods of using conjugated linoleic acid preparations enriched for the t10,c12 and c9,t11 isomers are disclosed. It is found that preparations of conjugated linoleic acid containing a ratio of t10,c12 to c9,t11 of about greater than 1.2:1 are desir... | 09/05/2006 |
| 7094420 | Methods of using isomer enriched conjugated linoleic acid compositions Compositions and methods of using conjugated linoleic acid preparations enriched for the t10,c12 and c9,t11 isomers are disclosed. It is found that preparations of conjugated linoleic acid containing a ratio of t10,c12 to c9,t11 of about greater than 1.2:1 are desir... | 08/22/2006 |
| 7078051 | Conjugated linoleic acid alkyl esters in feedstuffs and food A novel method of delivering conjugated linoleic acid to an animal involves compounding feed or food for human consumption with a biologically active amount of conjugated linoleic acid alkyl ester (CLA-ester). The CLA-ester comprises a mixture of c9,t11-octadecanoic... | 07/18/2006 |
| 7048908 | Particles for inhalation having sustained release properties The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention rel... | 05/23/2006 |
| 7034168 | Process for the production of phospholipids A new enzymatic process for preparing 1,2-diacylated phospholipids using an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced ... | 04/25/2006 |
| 7029691 | Conjugated linoleic acid compositions Novel compositions containing conjugated linoleic acids are efficacious as animal feed additives and human dietary supplements. Linoleic acid is converted to its conjugated forms in which the resulting composition is low in certain unusual isomers compared to conven... | 04/18/2006 |
| 6984396 | Conjugate having a cleavable linkage for use in a liposome Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its ori... | 01/10/2006 |
| 6982092 | Method of complexing a nucleic acid with a lipid-conjugated polyamide In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologica... | 01/03/2006 |
| 6979460 | Vinyl ether lipids with cleavable hydrophlic headgroups A novel amphiphilic lipid compound having a cleavable, vinyl ether linked hydrophilic headgroup is described. Also described are liposomes containing the vinyl ether lipid compound, which may be triggered to release their contents and/or permeablize or fuse with tar... | 12/27/2005 |
| 6953583 | Use of conjugated linoleic acid (CLA) for the topical treatment of cellulite The present invention relates to the use of conjugated linoleic acid (CLA) for the topical treatment of fatty deposits and cellulite and to new topical compositions and to cosmetic and dermatological topical compositions for the treatment of fatty deposits and cellu... | 10/11/2005 |
| 6949528 | Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof The invention provides anti-apoptotic compositions lysophosphatidic acids and methods for making and using the compositions. Such compositions can also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene g... | 09/27/2005 |
| 6852870 | Omega-3 fatty acids in the treatment of depression The present invention is directed to a method of treating patients with major depression by administering omega-3 fatty acids. These may be administered in a substantially purified form, as part of a pharmaceutical composition, or as part of a larger molecule, e.g.,... | 02/08/2005 |
| 6828453 | Phospholipid-analogous compounds Phospholipid-analogous compounds of the general formula (I) in which A where R1 and R2 are, independently of one another, h... | 12/07/2004 |
| 6797835 | Phospholipid composition and use of same A phospholipidic composition with an L-α-glycerophosphatidyl-choline concentration of at least 10% by weight is described, where said composition is granular and also contains, in addition to L-α-glycerophosphatidylcholine, at least one granulation aid selected fr... | 09/28/2004 |
| 6794524 | Ester based phosphobetaine compounds The invention relates to a series of novel ester containing phosphobetaine compounds, which are exceptional surface active agents that provide outstanding foam and are very mild to the hair and skin, in addition because of the presence of the ester linkage these mat... | 09/21/2004 |
| 6737536 | Inositolphospholipids and analogues This invention relates to inositolphospholipids, particularly to synthetic phosphatidyl-myo-inositols (PtdIns), ceramide-phosphoinositols (CerPhosIns) and their structural and stereochemical analogues. The invention specifically provides a novel approach to synthesi... | 05/18/2004 |
| 6706280 | Carboxylated phosphatidic acid esters Novel compounds of formula in which R1 and R2 are phospholipid fatty acid residues and A is an aliphatic and/or cycloaliphatic hydrocarbon chain optionally substituted by hydroxy and/or further carb... | 03/16/2004 |
| 6699499 | Amphiphilic materials and liposome formulations thereof Disclosed is a new structural class of amphiphilic molecules which incorporate a hydrophilic material or polymer attached, at spatially distinct sites, to at least two hydrophobic residues. Certain of the amphiphilic molecules comprise a plurality of hydr... | 03/02/2004 |
| 6602861 | Acylated phospholipid drugs This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the fo... | 08/05/2003 |
| 6572881 | Lipid-conjugated polyamide compounds and related compositions and methods thereof In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for deliverin... | 06/03/2003 |
| 6569450 | Lipid-conjugated polyamide compounds and related compositions and methods thereof In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for deliverin... | 05/27/2003 |
| 6569451 | Targeted polymerized liposome diagnostic and treatment agents Polymerized liposome particles which are linked to a targeting agent and may also be linked to a contrast enhancement agent and/or linked to or encapsulating a treatment agent. The targeting imaging enhancement polymerized liposome particles interact with... | 05/27/2003 |
| 6528667 | Phosphated castor oil and derivatives The present invention relates to phosphated derivatives of castor oil and hydrogenated castor oil as well as phosphated esters of ricinoleic acid. The inclusion of the phosphate group results in improved water solubility and a series of dispersants and em... | 03/04/2003 |
| 6517884 | Water and oil containing emulsion The invention relates to a food product comprising 0.1 to 1.5 wt % of one or more anti-spattering agents comprising no native soy lecithin or native soy lecithin in an amount of from 0 to 0.05 wt % on total product, whereby the anti-spattering agent is pr... | 02/11/2003 |
| 6518311 | Use of branched-chain fatty acids and derivatives thereof for the treatment of pain The present invention relates to compounds and pharmaceutical compositions useful for treating pain. The invention also relates to methods of treating or alleviating pain in mammals, comprising administering to a mammal suffering from pain, a pain-allevia... | 02/11/2003 |
| 6448422 | Chromogenic compound This application relates to a novel compound of formula I, as defined herein, processes and intermediates for its preparation and the use of the compound of formula I as a substrate for a pharmaceutical screen.... | 09/10/2002 |
| 6413543 | Phosphatidyl oligoglycerols In order to form liposomes with a longer half-life in blood, use is made of defined with the general formula (A) ##STR1##... | 07/02/2002 |
| 6355629 | Prodrugs with enhanced penetration into cells The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and an intracellular transporting adjuvant, characterized by the presence of a covalent bond which is scission-sensitive to... | 03/12/2002 |
