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| Number | Title | Issue Date |
| 8129552 | Phospholipids with unsaturated alkyl and acyl chains The invention relates to phospholipid-like compounds having defined apolar constituents and to the use of such compounds as liposomes, active ingredients, and solubilizers. ... | 03/06/2012 |
| 8124800 | Process for the preparation of oxidized phospholipids Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized m... | 02/28/2012 |
| 7880024 | Ionic liquids miscible with various polar/non-polar solvents and method of preparing the same Provided are an ionic liquid and a method of preparing the same. The ionic liquid includes at least one type of compound represented by (Cat+)(R′COO−). Here, the Cat+ is a cation selected from the group consisting of quaternary a... | 02/01/2011 |
| 7825270 | Inositolphospholipids and analogues: phosphatidylinositol products and processes Embodiments of the invention relate to natural and synthetic inositolphospholipid (IPL) materials, their preparation and applications. They provide compositions of the parent IPL comprising phosphatidylinositol (PI), PI-phosphates (phosphoinositides) and derivatives... | 11/02/2010 |
| 7807847 | Process for the preparation of oxidized phospholipids Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized m... | 10/05/2010 |
| 7700792 | Highly active lysophosphatidic acid and method of screening therewith To provide a highly active LPA and a method of screening therewith. There is provided a method of screening a preventive and/or therapeutic substance for diseases in which LPA takes part, characterized in that a compound represented by any of formula (I), (II... | 04/20/2010 |
| 7595411 | Phospholipid-analogous compounds The present invention relates to compositions comprising a water-insoluble pharmaceutically active ingredient or a substance having low water solubility, and a compound represented by Structural Formula (I): ... | 09/29/2009 |
| 7592469 | Lipid-analogous phosphoric acid triesters The present invention relates to novel phosphoric triesters which comprise apolar lipid structures. ... | 09/22/2009 |
| 7553981 | Natural semi-synthetic and synthetic lipid derivatives of ceramide and sphingosine groups, drugs and the medical use thereof in the form of therapeutic agents in particular for dermatology The subject of the present invention is new substances which are derived from naturally occurring ceramides and sphingosine and also from synthetic compounds with principally the same structure in that they represent dimers, trimers, tetramers etc., hence i.e. oligo... | 06/30/2009 |
| 7524981 | Phospholipid derivatives and process for the production there A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independe... | 04/28/2009 |
| 7495116 | Phospholipid derivative A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 c... | 02/24/2009 |
| 7465817 | Inositolized phospholipids The present invention relates to a phospholipid dreivative having a substituted or unsubstituted polyhydroxylated aliphatic carbocycle attached to the sn-1 or sn-2 position of the glycerol backbone, a pharmaceutical composition comprising said phospholipid, a method... | 12/16/2008 |
| 7420071 | Thermally stable surfactants and compositions and methods of use thereof There are provided novel thermally stable surfactants for use with fillers in the preparation of polymer composites and nanocomposites. Typically, surfactants of the invention are urethanes, ureas or esters of thiocarbamic acid having a hydrocarbyl group of from 10 ... | 09/02/2008 |
| 7351428 | Phosphatidyl oligoglycerols In order to form liposomes with a longer half-life in blood, use is made of defined formula (A) ... | 04/01/2008 |
| 7309721 | Aminoalkylphosphonates and related compounds as Edg receptor agonists The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejecti... | 12/18/2007 |
| 7303760 | Method for treating multi-drug resistant tumors Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a l... | 12/04/2007 |
| 7265155 | Treating a variety of pathological conditions, including spasticity and convulsions, by effecting a modulation of CNS activity with isovaleramide, isovaleric acid, or a related compound Preparations and extracts of valerian, as well as isovaleramide, isovaleric acid, and certain structurally related compounds, exhibit clinically significant pharmacological properties that implicate a treatment for a variety of pathological conditions, including spa... | 09/04/2007 |
| 7101532 | Liposome containing hydrophobic iodine compound A liposome containing a hydrophobic iodine compound such as a 1,3,5-triiodobenzene derivative having at least one substituent containing 18 or more carbon atoms as a membrane component, and an X-ray contrast medium containing the liposome for use in radiography of a... | 09/05/2006 |
| 7008614 | Liposome containing hydrophobic iodine compound and X-ray contrast medium for radiograph comprising the liposome A liposome containing a hydrophobic iodine compound represented by the following general formula (I) as a membrane component: R1—CO2—R2 wherein R1 represents a substituted or unsubstituted 2,3,5-tri... | 03/07/2006 |
| 6984396 | Conjugate having a cleavable linkage for use in a liposome Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its ori... | 01/10/2006 |
| 6797835 | Phospholipid composition and use of same A phospholipidic composition with an L-α-glycerophosphatidyl-choline concentration of at least 10% by weight is described, where said composition is granular and also contains, in addition to L-α-glycerophosphatidylcholine, at least one granulation aid selected fr... | 09/28/2004 |
| 6602861 | Acylated phospholipid drugs This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the fo... | 08/05/2003 |
| 6600059 | Cytoprotective compounds The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for ... | 07/29/2003 |
| 6492146 | Process for the preparation of phosphatidylserines A process for the preparation of phosphatidylserines, comprising the reaction of phosphatides, such as phosphatidylcholine and phosphatidylethanolamine, with racemic or enantiomerically pure Serine, preferably with (L)-Serine, wherein said reaction is car... | 12/10/2002 |
| 6469148 | Process for large scale preparation of sphingosines and ceramides Synthetic methods for convenient large scale preparation of D-erythro sphingosines and ceramides of high isomeric purity are described.... | 10/22/2002 |
| 6448422 | Chromogenic compound This application relates to a novel compound of formula I, as defined herein, processes and intermediates for its preparation and the use of the compound of formula I as a substrate for a pharmaceutical screen.... | 09/10/2002 |
| 6423855 | Cytoprotective compounds The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for ... | 07/23/2002 |
| 6413543 | Phosphatidyl oligoglycerols In order to form liposomes with a longer half-life in blood, use is made of defined with the general formula (A) ##STR1##... | 07/02/2002 |
| 6407137 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 06/18/2002 |
| 6380177 | LPA analogs as agonists of the Edg2 LPA receptor Applicant has probed the Edg2 lysophosphatidic acid (LPA) receptor with a series of LPA analogs to determine receptor activation. The present invention is drawn to a series of LPA analogs which function as Edg2 receptor agonists, and methods of using such... | 04/30/2002 |
| 6313106 | Phospholipid derivatives of valproic acid and mixtures thereof The present invention relates to compounds, which are phospholipid derivatives of valproic acid, to compositions comprising said compounds and their use for treating epilepsy, migraine, bipolar disorders and pain.... | 11/06/2001 |
| 6303803 | Removal of sterols from fats and oils Disclosed is a method for reducing the sterol, for example cholesterol, content of sterol-containing substances such as fats and oils. The method provides an efficient and cost effective process based on the affinity of cholesterol and other sterols for a... | 10/16/2001 |
| 6258836 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 07/10/2001 |
| 6221856 | Inositol derivatives for inhibiting superoxide anion production Inositol derivatives, compositions comprising inositol derivatives, and methods for using compositions comprising inositol derivatives as agents for inhibiting superoxide anion production are described. The inositol derivatives are obtainable via conventi... | 04/24/2001 |
| 6107499 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 08/22/2000 |
| 6077837 | Prodrugs with enhanced penetration into cells The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and an intracellular transporting adjuvant, characterized by the presence of a covalent bond which is scission-sensitive to... | 06/20/2000 |
| 6002029 | Antiviral prodrugs Lipid prodrugs of phosphonoacids and their analogs that have increased antiviral activity over the parent drugs in inhibiting cytomegalovirus and other susceptible viruses.... | 12/14/1999 |
| 5902802 | Cationic amphiphiles Cationic amphiphiles are provided that are alkyl or alkoxyalkyl O-phosphate esters of diacylphosphatidyl zwitterionic compounds such as phosphatidylcholine or phosphatidyl ethanolamine. The amphiphiles can be used as carriers for delivering macromolecules... | 05/11/1999 |
| 5859271 | Cytoprotective compounds The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for ... | 01/12/1999 |
| 5846955 | Acylated phospholipid drugs This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the fo... | 12/08/1998 |
