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| Number | Title | Issue Date |
| 7288624 | Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmace... | 10/30/2007 |
| 7235586 | Cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents The invention relates to the use of cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and carbamoyloxy as therapeutic agents e.g. as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: | 06/26/2007 |
| 6831186 | Lipoxin A4 analogs This invention is directed to lipoxin A4 analogs of the following formula (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analog... | 12/14/2004 |
| 6800769 | Process for the preparation of substituted octanoyl amides Compounds of formula (XII), are simultaneously halogenated in the 5 position and hydroxylated in the 4 position under lactonization, the halolactone is reacted with an amine to form a carboxamide, the halogen is replaced with azide, if necessary after the introducti... | 10/05/2004 |
| 6693208 | Compounds and compositions for delivering active agents Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or lipid. Methods of administration, including oral administr... | 02/17/2004 |
| 6482985 | 2-benzyloxy-5-halo-acylanilide compounds and method of using them Disclosed is a compound comprising a 2-benzyloxy-5-haloacylanilide having the structural formula I: ##STR1## wherein R is hydrogen or an alkyl group, RA is a substituent and n is 0-5; and X is a halogen. Also disclosed is a method for preparing a co... | 11/19/2002 |
| 6399798 | Method of preparing alkylated salicylamides The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide (hereinafter referred to as a "protected/activated salicylamide"). The method comprises the steps of (a) alkylating the protected/... | 06/04/2002 |
| 5917067 | Process for producing an omega-functionalized aliphatic carboxylic acid and intermediate products of said process, including 2-oxepanone-7-substituted products A process for producing an omega-functionalized aliphatic carboxylic acid starting from cyclohexanone and omega-functionalized -olefins or acrylic esters. The process comprises an addition step, an oxidation step, an isomerization step, and one or ... | 06/29/1999 |
| 5801178 | Aniline derivative having polyunsaturated fatty acid residue and use thereof An aniline derivative of the formula (1) ##STR1## wherein R1 is an eicosapentaenoyl or docosahexaenoyl; R2 and R3 are each independently an alkyl or alkoxy having 1 to 6 carbon atoms, or a halogen atom; R4 ... | 09/01/1998 |
| 5712414 | Hydroxycarboxylic acid anilides The present invention relates to a process for the preparation of hydroxycarboxylic acid amides of the general formula (1): ##STR1## in which R1 and R2 are identical or different and are hydrogen, halogen, cyano, a linear or bra... | 01/27/1998 |
| 5654452 | Lipophilic contrast agents for use in hepatocyte-selective oil-in-water emulsions Aromatic acid-derived lipophilic polyhalogenated compounds are provided for use as contrast agents in diagnostic imaging or as therapeutic agents. These compounds are particularly useful when incorporated into an oil-in-water emulsion for tissue-specific ... | 08/05/1997 |
| 5587513 | Polyether-substituted imide compounds and their use The present invention relates to novel polyether-substituted compounds of imides and their use as surface-active agents.... | 12/24/1996 |
| 5502225 | Perfluoroalkyl terminated urethane lubricants This invention relates to perfluoroalkyl group terminated urethanes, thiourethanes and ureas of the general formula (R--X--CONH)m A where m is 1, 2 or 3, R is Rf -E and optionally R1 with the proviso that at least one R is R | 03/26/1996 |
| 5252745 | Preparation and use of iodopropargyl esters of -amino acid derivatives as antimicrobial agents Antimicrobial compounds of the formula ##STR1## wherein R1 is selected from the group consisting of H, an amine protective group, and a moiety of the formula ##STR2## wherein R2, R5, and R6 are indepen... | 10/12/1993 |
| 5162367 | Pesticidal compounds Insecticidal and acaricidal compounds of Formula AR(CH2)x O(CH2)m A(CH2)n (CE1 =CE2)a (CE3 =CE4)CONR1 R2 (I) wherein Ar ... | 11/10/1992 |
| 5147868 | Thienamycin renal peptidase inhibitors Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are z-2-acylamino-3-monosubstituted propenoates.... | 09/15/1992 |
| 5089175 | Hydroxyalkane carboxylic acid derivatives and their production Hydroxyalkane carboxylic acid derivatives of general formula I ##STR1## in which n means the numbers 7 to 18, R1 represents a hydrogen atom or an acyl group with a maximum of 16 carbon atoms, and optionally an alkylene group with 4 to 8 carbon ... | 02/18/1992 |
| 4980095 | Sodium salt of N-C4-carboxybenzyl nonanamide Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpe... | 12/25/1990 |
| 4980366 | Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity Novel 4'-hydroxybenzylamine derivatives of the formula ##STR1## pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trig... | 12/25/1990 |
| 4950666 | Difluoroalkane and difluoroalkenylalkane pesticides The present invention discloses compounds of the formula ##STR1## in which R is a 1,1-difluoroalkyl group or a 1,1-difluoroethenyl group having an even numbered carbon chain length of from 4 to 22 carbon atoms, pesticidal compositions thereof; and th... | 08/21/1990 |
| 4855086 | Novel pesticides, preparation and use The specification describes and claims methods of controlling acarine pests by application of a compound of Formula (I), methods of controlling arthropod pests by application of a compound of Formula (IA), compounds of Formula (IA) per se, pesticidal comp... | 08/08/1989 |
| 4827004 | Isoprene derivatives Novel Isoprene Derivatives which have mucosa-protective and gastric acid secretion-inhibiting properties and are useful for combatting ulcers both by treating and as a prophylaxis against gastric and/or duodenal ulcers.... | 05/02/1989 |
| 4672140 | Acyloxyalkenoic acids and process therefor This disclosure concerns acyloxyhexenoic acids and their salts with the acids being produced by reaction of butadiene and acetic acid with metal salt oxidants in a process involving electrolytic regeneration of the metal oxidants during the reaction. Iosm... | 06/09/1987 |
| 4634551 | Bleaching compounds and compositions comprising fatty peroxyacids salts thereof and precursors therefor having amide moieties in the fatty chain This invention relates to bleaching compounds and compositions that provide effective and efficient surface bleaching of textiles over a wide range of bleach solution temperatures. The bleaching compounds of the invention yield a peroxyacid with a polar a... | 01/06/1987 |
| 4568763 | Process for producing N-acyl-acyloxy aromatic amines N-acyl-acyloxy aromatic amines, e.g. 4-acetoxyacetanilide (AAA), are prepared by reacting a hydroxy aromatic ketone, e.g. 4-hydroxyacetophenone, with hydroxylamine or a hydroxylamine salt and a base to obtain the ketoxime of the ketone, e.g. 4-hydroxyacet... | 02/04/1986 |
| 4551279 | Protease inhibitors This invention relates to methods of preventing or reducing the degradation of elastin and other proteins and thereby preventing or retarding the disease states caused by said degradation by administering compounds, some of which are novel, of the formula... | 11/05/1985 |
| 4505930 | Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis and allergic responses Polyolefinic compounds represented by the general formula ##STR1## in which R and R1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R2 is an alkyl group of from 1 to 5 carbon atoms; R3 is hydroxyl, a... | 03/19/1985 |
| 4497964 | Process for production of N-acyl--amino acids A process for the production of an N-acyl--amino acid represented by the general formula ##STR1## wherein R1, R2, R3 and R4, independently from each other, represent a hydrogen atom, an alkyl or cycl... | 02/05/1985 |
| 4476056 | Trifluoromethoxy analogs of aromatic retinoids Aromatic retinoids bearing a trifluoromethoxy substituent on the aromatic nucleus which are useful as antitumor agents and in the treatment of dermatological disorders as well as a method for their manufacture are disclosed.... | 10/09/1984 |
| 4472430 | Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis Polyolefinic compounds, useful in the treatment of psoriasis, are disclosed. The compounds are represented by the general formula ##STR1## in which R and R1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R2 is ... | 09/18/1984 |
| 4352760 | Organic compounds substituted heptadeca-5,9- and 5,10-dienoic acid The present invention provides novel substituted heptadeca-5,9- and 5,10-dienoic acid and similar fatty acid compounds which are derivatives of certain prostaglandins and are potent thromboxane A2 inhibitors. By virtue of this pharmacological p... | 10/05/1982 |
| 4349690 | 9-Deoxy-9-methylene-6-keto-PGE-type compounds The present invention provides novel 9-deoxy-9-methylene-6-keto-PGE derivatives which are useful for platelet aggregation inhibition and gastric cyctoprotection.... | 09/14/1982 |
| 4338253 | Fluorinated aromatic polyenes Compounds represented by the formula ##STR1## wherein R1, R2 and R3 are lower alkyl, R4 is lower alkoxy, R6 and R8 are methyl or trifluoro methyl, R9 is formyl, hydroxymethy... | 07/06/1982 |
| 4314055 | 3,5-Disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids Certain 3,5-disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids are useful as x-ray contrast agents. Representative of this class of compounds is the compound 3-gluconamido-2,4,6-triiodo-N-methyl-5-(N-methyl-acetamido)-benzamide and th... | 02/02/1982 |
| 4310693 | o-Aminophenol compounds o-Aminophenol derivatives are described represented by the formula (I) ##STR1## wherein R represents --NH2 or --NH--CO--R6 ; R1 and R2 which may be the same or different, each can represent an alkyl group or ... | 01/12/1982 |
| 4269779 | 19-Hydroxy-19-methyl-6-oxo-PGF1 amides The present invention provides novel 19-hydroxy-19-methyl-6-oxo-PGF1 amides which are useful for pharmacological purposes, e.g., anti-asthmatic indications.... | 05/26/1981 |
| 4268669 | 9-Deoxy-9-methylene-5,6-didehydro-PGF1 amides The present invention particularly relates to novel 9-deoxy-9-methylene-5,6-didehydro-PGF1 amides and methods for their preparation in pharmacological use.... | 05/19/1981 |
| 4248893 | Arterial wall cholesterol ester reducing cyclopropanyl-bearing amides Cyclopropanyl-group-bearing-amides, eg N-[1-(benzyl)-2-(phenyl)ethyl]-cis-2-octyl-cyclopropanoctanamide and N-(-methyl-benzyl)-(cis)-2-octyl-cyclopropanoctanamide, are useful as pharmaceutical agents and are obtainable, eg by reacting a mixed ... | 02/03/1981 |
| 4194050 | Process for producing an enamide Enamides are prepared by hydrogenating oximes having at least one hydrogen atom at the -position in the presence of a carboxylic anhydride using a ruthenium catalyst. These enamides are important to obtain amino group-containing compounds by reduct... | 03/18/1980 |
| 4185118 | Benzocycloalkylamides Unsaturated fatty acid amides of benzocycloalkylamines, eg. N-(1-indanyl)-cis,cis-9,12-octadecadienylamide, are useful as pharmaceutical agents and are obtainable by reacting a mixed anhydride of a long chain unsaturated carboxylic acid with an appropriat... | 01/22/1980 |
