Did You Know...
...that power steering was invented by independent inventor Francis W. Davis? As chief engineer in the 1920s of the truck division of the Pierce Arrow Motor Car Company, he saw how hard it was to steer heavy vehicles. So that he would be able to keep the profits from his future invention, Davis left his job, rented a small engineering shop in Waltham, Mass., and developed a hydraulic power steering system that led to power steering.
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| Number | Title | Issue Date |
| 7235586 | Cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents The invention relates to the use of cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and carbamoyloxy as therapeutic agents e.g. as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: | 06/26/2007 |
| 6511670 | (poly)thiaalkynoic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active (poly)thiaalkynoic compounds have the structural formula (I): R1 --Y--CH2 --C.ident.C--CH2 --S--CH2 --R2 (I) and are useful for the treatment of a wide variety of dis... | 01/28/2003 |
| 6407137 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 06/18/2002 |
| 6353032 | Phospholipids of hydroxyeicosatetraenoic acid-like derivatives and methods of use Phospholipid-HETE derivatives, compositions and methods of use are disclosed. The compounds are particularly useful for treating dry eye.... | 03/05/2002 |
| 6288250 | Compounds Compounds of the general formula ##STR1## wherein R represents a straight or branched chain alkyl group containing from 1 to 16 carbon atoms, pharmaceutically acceptable salts thereof and/or optical isomers thereof have an immunostimulating effect, and ar... | 09/11/2001 |
| 6258836 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 07/10/2001 |
| 6057464 | Sulphates of fatty-acid polyhydroxyalkylamides and their use The invention relates to high-foaming zwitterionic and anionic surfactants which are prepared by sulfation of N,N-dialkylaminoalkyl-sugar amides, preferably using gaseous sulfur trioxide. The invention furthermore relates to compositions which comprise kn... | 05/02/2000 |
| 5990083 | Multicatalytic protease inhibitors Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed ... | 11/23/1999 |
| 5981580 | Fatty acid analogs and prodrugs Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcoho... | 11/09/1999 |
| 5955452 | Covalent lipid-phosphono-carboxylic acid conjugates and application thereof as antiviral medicaments The present invention concerns new lipid derivatives of phosphonocarboxylic acids of the general formula I, ##STR1## in which the meaning of the symbols is elucidated in the description, tautomers thereof and their physiologically tolerated salts of ... | 09/21/1999 |
| 5952377 | Fatty acid analogs and prodrugs Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcoho... | 09/14/1999 |
| 5948418 | Sulfur-based amides and bis-amides useful against skin disorders Novel sulfhydryl group-containing amides and disulfide group-containing bis-amides useful for treating or preventing an abnormal biological condition or a disease, and/or improving the texture or appearance of the skin, as well as compositions containing ... | 09/07/1999 |
| 5929110 | Fatty acid analogs and prodrugs Novel derivatives of fatty acid analogs that have from one to three heteroatoms in the fatty acid moiety which can be oxygen, sulfur or nitrogen, are disclosed in which the carboxy-terminus has been modified to form various amides, esters, ketones, alcoho... | 07/27/1999 |
| 5863750 | Methods for the detoxification of nitrile and/or amide compounds The present invention describes methods for the detoxification of a mixture of nitrile compounds, or a mixture of nitrile and amide compounds by conversion of the nitrile compound(s) to the corresponding amide or acid compounds using a pure culture of an ... | 01/26/1999 |
| 5861520 | Glycolipid analogs The present invention provides a compound which is a glycolipid analog having a novel structure represented by the formula (1): ##STR1## wherein Z represents an imino group, an oxygen atom or a sulfur atom; m is an integer of from 3 to 12; and n is a... | 01/19/1999 |
| 5830870 | Multicatalytic protease inhibitors Disclosed herein are inhibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed ... | 11/03/1998 |
| 5763481 | Vinylcarboxylic acid derivatives Compounds of the formula ##STR1## wherein R1 is C3 -C8 cycloalkyl, halo-C3 -C8 cycloalkyl, C3 -C8 cycloalkyl-C1 -C6 alkyl, halo-C3 -C8 | 06/09/1998 |
| 5750567 | Farnesyl transferase inhibitors, preparation thereof and pharmaceutical compositions containing same Novel farnesyl transferase inhibitors of general formula (I) ##STR1## preparation thereof and pharmaceutical compositions containing same. In general formula (I), R1 is Y--S--A1 -- (where Y is a hydrogen atom, an amino acid resi... | 05/12/1998 |
| 5627056 | Method of synthesizing lipids and cosmetic composition comprising them An efficient method of producing phytosphingosine-containing ceramide one comprising: (a) obtaining a phytosphingosine base from tetraacetylphytosphingosine (TAPS) by a deacetylation reaction wherein the TAPS is produced by fermentation of cells of the F-... | 05/06/1997 |
| 5614548 | Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions Quaternary amine-containing ether lipid analogs of the formula R1 --X--R2 --N+ (R3) (R4) (R5) Z- are disclosed. R1 represents a hydrophobic group and R2 represents th... | 03/25/1997 |
| 5589588 | Sulfated acid amides having anticoagulant properties A sulfated acid amide having heparin-like properties of the formula: (R1)--NH--R--NH--(R1) where R1 is a di-, tri- or tetra-saccharide acid selected from cellobiose, cellotriose, cellotetrose, maltose, maltotriose and maltotetrose o... | 12/31/1996 |
| 5559111 | δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amides δ-Amino-γ-hydroxy-ω-aryl-alkanoic acid amides of formula I ##STR1## and the salts thereof, have renin-inhibiting properties and can be used as antihypertensive medicinal active ingredients.... | 09/24/1996 |
| 5550262 | Multicatalytic protease inhibitors Disclosed herein are inbibitors of the multicatalytic protease enzyme which are represented by the general formula: ##STR1## Constituent members and preferred constituent members are disclosed herein. Methodologies for making and using the disclosed ... | 08/27/1996 |
| 5502225 | Perfluoroalkyl terminated urethane lubricants This invention relates to perfluoroalkyl group terminated urethanes, thiourethanes and ureas of the general formula (R--X--CONH)m A where m is 1, 2 or 3, R is Rf -E and optionally R1 with the proviso that at least one R is R | 03/26/1996 |
| 5498786 | Synthesis of intermediates in the preparation of ACAT inhibitors This invention relates to novel processes for synthesizing intermediates in the preparation of N-aryl and N-heteroarylamide inhibitors of the enzyme acyl coenzyme A: cholesterol acyltransferase (ACAT), and to novel intermediates used in such processes.... | 03/12/1996 |
| 5424468 | Polymeric contact lens material of improved oxygen permeability This specification provides a polymeric material useful for manufacturing contact lenses having improved oxygen permeability. The contact lenses prepared from the polymeric material of the invention show improved hydrophilicity and enhanced oxygen permeab... | 06/13/1995 |
| 5352673 | Prodrugs The present invention provides prodrugs that serve as useful therapeutics for various disease states and conditions mediated by underlying specific hydrolytic enzyme activity. The prodrugs hereof (additionally) impart a physiologically bioactive component... | 10/04/1994 |
| 5344949 | Method for the synthesis of surface-active anion-cation complexes Surface active anion-cation complexes are synthesized where an organic or organosilicon compound with at least one epoxide group is reacted with a quaternary ammonium hydrogen sulfite of the general formula HN+ (R1)3 SO3 | 09/06/1994 |
| 5342977 | Aminosulfonic acid derivatives and processes for their preparation Salts of aminosulfonic acid derivatives of formula I ##STR1## wherein R1, R2 and R3 are each independently of the others an aliphatic hydrocarbon radical having from 7 to 21 carbon atoms, n is 0 or 1, As is the amidically ... | 08/30/1994 |
| 5268494 | Sulphur-containing eicosanoides and their application in pharmacy and in cosmetics Compounds corresponding to the formula: ##STR1## wherein A represents --CH2)2 or --C.tbd.C--; n is equal to 0, 1 or 2; R represents hydroxyl, alkoxy having the formula --OR1, or amino having the formula ##STR2## ... | 12/07/1993 |
| 5266713 | Aryl alkenoic acid derivatives as leukotriene antagonists Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The deriv... | 11/30/1993 |
| 5182407 | Solubilizing and/or dispersant compounds, preparation process and compositions containing them The present invention relates to the compounds of formula (I): ##STR1## in which: R1 and R2, which are identical or different, denote a methyl or ethyl radical; R3 denotes a methyl, ethyl or hydroxyethyl radical; A denotes... | 01/26/1993 |
| 5162367 | Pesticidal compounds Insecticidal and acaricidal compounds of Formula AR(CH2)x O(CH2)m A(CH2)n (CE1 =CE2)a (CE3 =CE4)CONR1 R2 (I) wherein Ar ... | 11/10/1992 |
| 5147868 | Thienamycin renal peptidase inhibitors Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are z-2-acylamino-3-monosubstituted propenoates.... | 09/15/1992 |
| 5132441 | Amino acid derivatives Disclosed is an amino acid derivative represented by the general Formula (I): ##STR1## wherein R is a group whose conjugate acid has a pKa ranging from 10 to 16, R' is a straight chain alkyl group having 12 to 20 carbon atoms, n is an integer of... | 07/21/1992 |
| 5041545 | 2-hydroxybenzophenone hydrazides and derivatives thereof Hydrazide functionalized 2-hydroxybenzophenone ultraviolet light and heat stabilizers and derivatives are disclosed having the general formula: ##STR1## wherein R1, R2, R3, R4, R5, R6, X, Y... | 08/20/1991 |
| 5041654 | Preparation of monosubstituted dithiooxamide compounds This invention relates to the synthesis of N-(monosubstituted)dithiooxamides by the transamination of dithiooxamide. Preferred methods, according to the present invention, take advantage of the discovery that yields of N-(monosubstituted)dithiooxamides ca... | 08/20/1991 |
| 5025017 | Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates Seco-mevinic acid derivatives are provided which has the structure ##STR1## including all stereoisomers thereof, wherein Z is ##STR2## R is H, alkali metal or lower alkyl, R1 is H, lower alkyl, aryl, lower alkoxy, cycloalkyl, heteroar... | 06/18/1991 |
| 5008432 | Production of mercapto compounds Activated olefinically unsaturated organic compounds such as esters, acids, ketones, nitriles, and the like, are reacted with hydrogen sulfide in the presence of at least one of magnesium oxide and anion exchange resins catalysts to produce saturated sulf... | 04/16/1991 |
| 4980366 | Amide, sulfonamide, urea, carbamate, thiocarbamate, and thiourea derivatives of 4'hydroxybenzylamine having anti-inflammatory and analgesic activity Novel 4'-hydroxybenzylamine derivatives of the formula ##STR1## pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trig... | 12/25/1990 |
