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| Number | Title | Issue Date |
| 8115023 | Benzo lipoxin analogues Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal... | 02/14/2012 |
| 8093417 | Lipoxin analogs and methods for the treatment of periodontal disease This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including gingivitis, periodontitis, and other forms of periodontal disease. The invent... | 01/10/2012 |
| 7294728 | Lipoxin compounds and their use in treating cell proliferative disorders Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed. ... | 11/13/2007 |
| 7223877 | Uses of hydroquinone substituted polyunsaturated fatty acids as antioxidants This invention provides novel antioxidants comprising hydroquinone substituted polyunsaturated fatty acids. Such fatty acids can be obtained from crude kombo butter and are suitable for preventing oxidation of various organic materials. In particular, the inv... | 05/29/2007 |
| 7211654 | Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling com... | 05/01/2007 |
| 6713512 | Uses of kombic acid as an anticancer and cholesterol-lowering agent This invention provides a novel antioxidant, kombic acid or a derivative thereof, obtained from crude kombo butter suitable for preventing oxidation of various organic materials. In particular, the invention relates to the use of kombic acid as an antioxidant in the... | 03/30/2004 |
| 6653493 | Lipoxin compounds and their use in treating cell proliferative disorders Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.... | 11/25/2003 |
| 6489494 | Uses of kombic acid as an antioxidant This invention provides a novel antioxidant, kombic acid or a derivative thereof, obtained from crude kombo butter suitable for preventing oxidation of various organic materials. In particular, the invention relates to the use of kombic acid as an antioxi... | 12/03/2002 |
| 6441036 | Fatty analogues for the treatment of obesity, hypertension and fatty liver The present invention relates to novel fatty acid analogous of the general forumla I: CH3 --[CH2 ]m --[xi --CH2 ]n --COOR, as defined in the specification, which can be used for the treatme... | 08/27/2002 |
| 6326397 | Retinoid antagonists and use thereof The present invention relates to novel retinoid antagonists of the formula I ##STR1## wherein the dotted bond can be either hydrogenated or form a double bond; and, when the dotted bond forms a double bond, R1 is lower alkyl and R2 | 12/04/2001 |
| 6326499 | Omega chain modified 15-hydroxyeicosatetraenoic acid derivatives and methods of their use for the treatment of dry eye Omega chain modified 15-HETE derivatives and methods of their use for treating dry eye are disclosed.... | 12/04/2001 |
| 6313088 | 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.... | 11/06/2001 |
| 6201144 | Preparation of secondary ether fatty acids and esters from their hydroxy fatty acid equivalents Fatty ether compounds and a process for their production is disclosed. The compounds possess low viscosity and low temperature melting point properties and may be used as viscosity modifiers in the creation of cosmetics and complete vegetable oil based bi... | 03/13/2001 |
| 6083984 | Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in the treatment of various disorders Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These for... | 07/04/2000 |
| 6005125 | Universal allyl linker for solid-phase nucleic acid synthesis A universal linker for solid-phase nucleic acid synthesis that is cleaved under conditions orthogonal to those used during the synthesis and deprotection of nucleic acids such as dsDNA or RNA fragments is disclosed. The invention includes compounds of the... | 12/21/1999 |
| 5998642 | Thienyl-containing fatty acid glycosyl phosphatidylinosital analogues used for inhibiting parasitic activity A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myrist... | 12/07/1999 |
| 5968979 | Triglycerides and ethyl esters of phenylalkanoic acid and phenylalkenoic acid useful in treatment of various disorders Two new forms of prodrug for phenylacetate, of even congeners of phenylalkanoic acid and phenylalkenoic acids, which are the phenylalkanoic or phenylalkenoic esters of glycerol, or the ethyl esters of phenylalkanoic acid or phenylalkenoic acids. These for... | 10/19/1999 |
| 5654452 | Lipophilic contrast agents for use in hepatocyte-selective oil-in-water emulsions Aromatic acid-derived lipophilic polyhalogenated compounds are provided for use as contrast agents in diagnostic imaging or as therapeutic agents. These compounds are particularly useful when incorporated into an oil-in-water emulsion for tissue-specific ... | 08/05/1997 |
| 5453525 | Carboxylic esters for the preparation of a bicyclic decalin ketone Perhydro-5,5-8a-trimethyl-2-naphthalenone is prepared by acid cyclization of carboxylic esters of formula ##STR1## having a double bond in one of the positions indicated by the dotted lines and wherein symbol R designates a C1 -C6 | 09/26/1995 |
| 5410078 | Styrene-based dicarboxylic acid-functional monomers and polymers prepared from same An unsaturated acid-functional monomer having the structure: ##STR1## wherein R1 is hydrogen or methyl and Z is nothing or is a divalent radical of 1 to about 20 carbons.... | 04/25/1995 |
| 5369126 | Nonatetraenoic acid derivative for use in treating acne A compound of the formula ##STR1## its pharmaceutically acceptable salts, and its pharmaceutically acceptable hydrolyzable esters for reducing sebum secretion and combatting acne as well as oral and topical compositions for use thereof.... | 11/29/1994 |
| 5364948 | Biologically active compounds isolated from aerobic fermentation of Trichoderma viride This invention relates to compounds of structural formula (I) isolated from an aerobic fermentation of Trichoderma viride MF5628, ATCC 74084: ##STR1## which are squalene synthase inhibitors and thus useful as cholesterol lowering agents. These compou... | 11/15/1994 |
| 5279759 | Alpha-(p-alkoxybenzylidene) carboxylic acids as color stabilizers, process, aids, and whiteners for soaps Alpha-(p-alkoxybenzylidene) carboxylic acids are used as color stabilizers, processing aids and whiteners for soap.... | 01/18/1994 |
| 5266713 | Aryl alkenoic acid derivatives as leukotriene antagonists Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The deriv... | 11/30/1993 |
| 5218138 | Stereoselective reduction of 3-hydroxyket-1-ones to 1,3-syn-dihydroxylated compounds This invention is directed to a method for stereoselectively preparing a syn-dihydroxylated compound comprising reacting a 3-hydroxyket-1-one and a sterically hindered dialkylated borane to form a complex at about -50° C. to about 0° C., and reducing th... | 06/08/1993 |
| 5166377 | 1,3-dioxan-5-ylalkenoic acids The invention concerns novel 4-phenyl-1,3-dioxan-5-ylalkenoic acid derivatives of the formula I having cis relative stereochemistry at positions 4 and 5 of the dioxane ring and wherein Ra and Rb are variously hydrogen, alkyl, halogenoalkyl, alkenyl, and o... | 11/24/1992 |
| 5145611 | Carboxylic acid derivatives, and pharmaceutical compositions containing them Carboxylic acid derivatives of the formula ##STR1## R1 is alkoxy, alkylthio, alkylsulphinyl, alkulsulphonyl, alkylamino, cycloalkyl, or cycloalkoxy or optionally substituted aryl, aryloxy, arylthio, arylsulphinyl, arylsulphonyl or arylamin... | 09/08/1992 |
| 5055230 | Corrosion inhibiting compositions A composition, in contact with a corrodable metal surface, comprising: a) an aqueous-based or oil-based system; and b) as an inhibitor for protecting the metal surface against corrosion, at least one compound having the formula I or II: ##STR1## in which... | 10/08/1991 |
| 5041694 | Substituted glutaric acid lactones in the treatment of hyperlipidemia Compounds of formula I ##STR1## are described which are useful to inhibit the formation of serum cholesterol by virtue of their ability to inhibit ଲ-hydroxy-ଲ-methylglutaryl-CoA(HMG CoA), the rate-controlling substance in the synthes... | 08/20/1991 |
| 5034161 | Synthesis of aryl-substituted aliphatic acids A method for preparation of aryl-substituted aliphatic hydrocarbons is disclosed. The method comprises reacting in the presence of a solid superacid resin catalyst an unsaturated aliphatic hydrocarbon in liquid form with an aromatic hydrocarbon that is su... | 07/23/1991 |
| 5025017 | Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates Seco-mevinic acid derivatives are provided which has the structure ##STR1## including all stereoisomers thereof, wherein Z is ##STR2## R is H, alkali metal or lower alkyl, R1 is H, lower alkyl, aryl, lower alkoxy, cycloalkyl, heteroar... | 06/18/1991 |
| 5011947 | Antihypercholesterolemic alkylene compounds Compounds of the formula ##STR1## wherein R1, R2, R3 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl; R is C1-7 alkyl, C3-6... | 04/30/1991 |
| 4992469 | Method of obtaining an antiplatelet effect A quinone derivative of the formula (I): ##STR1## in which A is a group of the formula (IV): ##STR2## or a group of the formula (V): ##STR3## in which X and Y are either the same as or different from each other and each are hydroxy, me... | 02/12/1991 |
| 4933367 | Carboxylic acid derivatives, processes for the preparation thereof, the use thereof, and pharmaceutical compositions which contain these compounds This invention relates to carboxylic acid derivatives and their use thereof. The compounds are useful in treatment of various diseases such as diabetes, prediabetic conditions, adipositas ailments or atherosclerosis.... | 06/12/1990 |
| 4908384 | Fatty acid leukotriene synthesis inhibitors Fatty acid compounds of the formula (I): ##STR1## wherein R1, R2, R3, R4, R5, A, Y and k are as defined herein are novel and useful in the treatment of allergic and inflammatory disorders.... | 03/13/1990 |
| 4900478 | Novel retinoids The novel compounds of the formula Ret-OA I wherein Ret is the acyl residue of a retinoid carboxylic acid, A is a residue (--CHR)--CH2 O)n R1, (--CH2)m SR | 02/13/1990 |
| 4888132 | Aqueous rust inhibitor composition An aqueous rust inhibitor containing a soap of a hydroxyaryl fatty acid and an alkali metal. The inhibitor exhibits good rust inhibiting effects without emitting any malodor.... | 12/19/1989 |
| 4883614 | Phenyl substituted-2,4,6,8-nonatetraenoic acid The compounds 9-phenyl-3,7-dimethyl-2,4,6,8 nonatetraenoic acids wherein the phenyl group is substituted with an alkyl, aminoalkyl, hydroxyalkyl, alkoxy, hydroxyalkylamino, and a hydroxy alkoxy group, and derivatives thereof which are used as disease modi... | 11/28/1989 |
| 4883613 | Phenyl substituted-2,4,6,8-nonatetraenoic acid The compounds 9-phenyl-3,7-dimethyl-2,4,6,8 nonatetraenoic acids wherein the phenyl group is substituted with an alkyl, aminoalkyl, hydroxyalkyl, alkoxy, hydroxyalkylamino, and a hydroxy alkoxy group, and derivatives thereof which are used as disease modi... | 11/28/1989 |
| 4873024 | Method of synthesizing leukotriene B4 and derivatives thereof An improved method for synthesizing leukotriene B4 and derivatives thereof is disclosed, as are novel intermediates used in the process. Unlike prior art processes, the method of this invention involves a step in which 2(R)-[[(1,1-dimethylethyl... | 10/10/1989 |
