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| Number | Title | Issue Date |
| 7259188 | Methods and pharmaceutical compositions for treatment of anti-estrogen resistant breast cancer using RXR modulators Methods and compositions for the treatment of anti-estrogen resistant breast cancer using retinoid compounds which are modulators of Retinoid X Receptors. ... | 08/21/2007 |
| 7126016 | Process for preparing fluorocarboxylic acids A fluorocarboxylic acid preparation process continuously carries out acidification reaction treatment and washing treatment, and includes subjecting a fluorocarboxylate-containing aqueous solution to acidification reaction treatment in the presence of sulfuric acid ... | 10/24/2006 |
| RE39333 | Process for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives This invention provides a process for producing a 5-hydroxy-3-oxopentanoic acid, a useful pharmaceutical intermediate, easily from a readily available, inexpensive starting material without using any extraordinary production equipment such as a very-low-temperature ... | 10/10/2006 |
| 6984742 | Method for preparing polyprenyl compounds A method for preparing a polyprenyl compound wherein an aldehyde represented by the following general formula [I]: [wherein n represents an integer of from 0 to 3]and a Wittig reagent represented by the following genera... | 01/10/2006 |
| 6964973 | Bicyclic androgen and progesterone receptor modulator compounds and methods The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR and PR. More particularly, the invention relates to nonsteroidal compounds and compositions that are high affinity, high specificity agon... | 11/15/2005 |
| 6800771 | Stabilization of amido acids with antioxidants The invention relates to stabilized amido acid compositions. More particularly, the invention relates to compositions of amido acids, such as 6-nonanoylamidohexanoic acid, stabilized with antioxidants. The stabilized amido acid compositions are useful in the manufac... | 10/05/2004 |
| 6479684 | Process for structuring lipids and the structured products thereof The present invention generally relates to a process for hardening lipids, especially unsaturated lipids such as unsaturated fatty oils, by mixing and interacting lipids with polyamines such that the peak melting point of the resulting combination is high... | 11/12/2002 |
| 6436244 | Process for the elution of fluorinated emulsifiers Fluorinated emulsifier acids bound to an anion exchanger resin can be eluted using a mixture of water, a compound of the formula M--X, in which M is an alkali metal or an alkylammonium ion, and X is hydroxyl, fluoride or chloride, and at least one organic... | 08/20/2002 |
| 6420577 | Method for commercial preparation of conjugated linoleic acid Methods for simultaneous saponification and quantitative isomerization of glyceride oils containing interrupted double bond systems, with alkali in water to yield soaps with conjugated double bond systems are disclosed. Novel methods of hydrolysis of the ... | 07/16/2002 |
| 6392073 | Intermediates and processes for the preparation of optically active octanoic acid derivatives Novel intermediates, i.e., N-(2S-(2-propenyl)octanoyl)-(1S)-(-)-2, 10-camphorsultam, N-(2S-(2-propynyl)octanoyl)-(1S)-(-)-2,10-camphorsultam and N-(2R-(2-propyl)octanoyl)-(1S)-(-)-2,10-camphorsultam; processes for the preparation of the intermediates; and... | 05/21/2002 |
| 6376688 | Modified polyunsaturated fatty acids The present invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity. The polyunsaturated fatty acids contain 18-25 carbons and 1-6 double bonds and are characterized in that they have one or two s... | 04/23/2002 |
| 6215009 | Manufacture of cycloalkenylpolyene esters The invention provides a process for the manufacture of a retinyl acylate of the formula I: ##STR1## wherein R1 is an optionally substituted C1-23 -alkyl, a C2-23 -alkenyl having 1 to 5 double bonds, an optionally aromatic... | 04/10/2001 |
| 6160141 | Synthesis of conjugated eicosadienoic acid A synthesis process for producing 11-cis, 13-trans eicosadienoic acid at room temperature in high yield is disclosed, including providing a tosylate or mesylate of a methyl lesquerolate and 11-cis, 13-trans eicosadienoic acid formed when the tosylate or m... | 12/12/2000 |
| 5932696 | Solid phase preparation of amines A method for the solid phase preparation of an amine by a novel synthesis is described where a diol is monoalkylated with a chloromethyl resin followed by reaction with N,N'-carbonyldimidazole to afford a resin-bound tertiary-alkoxycarbonyl-imidazole whic... | 08/03/1999 |
| 5892074 | Synthesis of conjugated linoleic acid (CLA) A synthesis process for producing 9-cis, 11-trans octadecadienoic acid at room temperature in high yield is disclosed, including providing a tosylate or mesylate of a methyl ester of ricinoleic acid and 9-cis, 11-trans octadecadienoic acid formed when the... | 04/06/1999 |
| 5817845 | Methods for stereospecific synthesis of 11,13-cis polyene esters Methods for stereospecific synthesis of 9-cis olefins and retinoids. In one particular aspect, a cis olefin is generated via a lactol ring opening with complete retention of double bond configuration.... | 10/06/1998 |
| 5808120 | Method of synthesis of retinoic acid A method of synthesizing 9-cis-retinoic acid, all-trans-retinoic acid or 9-nor-retinoic acid is disclosed. The method comprises the steps of adding a Grignard reagent of ##STR1## to 2,2,6 trimethyl cyclohexanone is disclosed. R is a methyl group or H... | 09/15/1998 |
| 5723639 | Esterification of fermentation-derived acids via pervaporation A low temperature method for esterifying ammonium- and amine-containing salts is provided whereby the salt is reacted with an alcohol in the presence of heat and a catalyst and then subjected to a dehydration and deamination process using pervaporation. T... | 03/03/1998 |
| 5646320 | Process for making isethionate ester salts Fatty acid esters of isethionate salts are made by reacting ethylene oxide and a bisulfite salt, that may be made in situ, in aqueous ammonia while maintaining (1) the pH in the range of about 5.5 to about 6.5 and (2) the temperature in the range of 25° ... | 07/08/1997 |
| 5508456 | 9-cis tritium-labeled retinoids and intermediates, methods for their synthesis and methods for their use in discovering retinoid X receptor ligands Methods for the synthesis of 9-cis monotritium-labeled retinoids, and their use in the discovery of Retinoid X Receptor ligands are provided. In addition, 9-cis monotritium-labeled retinoids, as well as novel intermediates and tritium-labeled intermediate... | 04/16/1996 |
| 5504230 | Preparation of 9-(Z)-retinoic acid A process for preparing 9-(Z)-retinoic acid from mother liquors from the industrial preparation of C15 -triarylphosphonium salts of the general formula I ##STR1## where R1 to R3 are each aryl and X.crclbar.... | 04/02/1996 |
| 5502226 | Process of preparing ω-hydroxy acids A new synthesis of ω-hydroxy acids, which employs commercially available starting materials and lowers the cost of production. The process involves coupling a fatty acyl group by enamine chemistry, followed by a ring expansion and selective reduction of ... | 03/26/1996 |
| 5498786 | Synthesis of intermediates in the preparation of ACAT inhibitors This invention relates to novel processes for synthesizing intermediates in the preparation of N-aryl and N-heteroarylamide inhibitors of the enzyme acyl coenzyme A: cholesterol acyltransferase (ACAT), and to novel intermediates used in such processes.... | 03/12/1996 |
| 5498733 | Synthesis of nylon-11 monomer Nylon-11 monomer, 11-aminoundecanoic acid, is synthesized from 12-oxododecanoic acid oxime in a three-step reaction sequence which involves a Beckmann rearrangement, Hofmann degradation and hydrolysis. The aldoxime acid is hydrolyzed in the presence of ni... | 03/12/1996 |
| 5442107 | Preparing carboxylic acids A process for preparing a carboxylic acid having (n+1) carbon atoms (e.g. acetic acid) from an alcohol having n carbon atoms (e.g. methanol) by liquid phase, rhodium catalyses carbonylation is provided. The process is characterized by using a catalyst sta... | 08/15/1995 |
| 5440061 | Hydrolysis of methyl esters in dimethylsulfoxide for production of fatty acids The present invention relates to an improved process for preparing fatty acids from alkyl, preferably methyl esters comprising mixing the fatty acid ester with water, acid catalyst, and DMSO in order to form a single phase reaction mixture. The single pha... | 08/08/1995 |
| 5393901 | Aqueous process for preparing amido-carboxylic acids This invention relates to a process for preparing amido-carboxylic acids in water wherein hydrolysis and amidation reactions are conducted simultaneously in a single vessel. The process involves three steps. The first step involves heating at a temperatur... | 02/28/1995 |
| 5391780 | Aqueous process for preparing amido-carboxylic acids by reacting an aminoacid with a carboxylic acid anhydride This invention relates to a process for preparing amido-carboxylic acids in water. The process involves four steps. Step (A) involves hydrolyzing a lactam at a temperature of 150° C.-300° C. to form a mixture containing an amino acid. Step (B) involves ... | 02/21/1995 |
| 5380912 | ω-hydroxy-(ω-3)-ketonitrile ω-Hydroxy-(ω-3)-ketonitrile of the formula NC(CH2)n --CO--(CH2)3 OH wherein n is an integer of 7 to 11.... | 01/10/1995 |
| 5352810 | Phosphatidylinositol analogues, inhibitors of phosphatidylinositol specific phospholipase C Phosphatidylinositol analogues, inhibitors of phosphatidylinositol-specific phospholipase C of general formula (I) ##STR1## wherein X and R have the meanings specified in the description, suitable for preparing pharmaceutical compositions for the tre... | 10/04/1994 |
| 5350868 | ω-hydroxy-(ω-3)-ketonitrile and method for preparing ω-hydroxyaliphatic acid There are disclosed (i) ω-hydroxy-(ω-3)-ketonitrile represented by the formula ( I ): NC(CH2)n --CO--(CH2)3 OH (I) wherein n is an integer of 7 to 11, (ii) a method for preparing the ω-hydroxy-(ω-3)... | 09/27/1994 |
| 5310959 | Eicosatriynoic acid esters and amides and methods of preparation Processes for preparing 5,8,11-eicosatriynoic acid as well as esters and amides thereof involves initially preparing the acid by reacting 1-decyne with 1,4-dihalo-2-butyne in the presence of a strong base to form 1-halo-2,5-tetradecadiyne which is then re... | 05/10/1994 |
| 5292910 | Use of hydrophobized hydrotalcites as catalysts for ethoxylation or propoxylation A process for the catalyzed ethoxylation or propoxylation of compounds selected from the group consisting of organic compounds containing active H atoms, esters of fatty acids containing 2 to 22 carbon atoms with monoalkanols containing 1-22 carbon atoms ... | 03/08/1994 |
| 5278328 | Process for producing carboxylic acid chloride Disclosed is a process for producing a carboxylic acid chloride by reacting phosgene with a carboxylic acid or an anhydride thereof, which comprises effecting the reaction in the presence of a homopolymer or copolymer of a monomer represented by formula (... | 01/11/1994 |
| 5247105 | Fatty acid halogenide manufacture The invention provides a process for preparing fatty acid halide by reacting a fatty acid with a halogenating agent optionally followed by hydrolysis of unreacted halogenating agent and separating the fatty acid halide upper layer from the inorganic lower... | 09/21/1993 |
| 5245063 | Preparation of carbonyl chlorides A process for preparing carbonyl chlorides of the formula I ##STR1## where R is C1 -C30 -alkyl, C2 -C30 -alkenyl or C2 -C30 -alkynyl, from essentially equimolar amounts of a carboxylic ... | 09/14/1993 |
| 5218143 | Process for preparing carboxylic acids An improved liquid-phase process for preparing carboxylic acids having (n+1) carbon atoms by rhodium catalyzed carbonylation of an alcohol having n carbon atoms is provided. The process is particularily suitable for preparing acetic acid from methanol in ... | 06/08/1993 |
| 5191096 | Process for producing ω-hydroxy fatty acids ω-Hydroxy fatty acids usable for the synthesis of medicaments, perfumes and polymers are produced by subjecting an alkali or alkaline earth metal salt of long-chain dicarboxylic acid monoester to a reduction with a borohydride compound or catalytic hydro... | 03/02/1993 |
| 5185457 | Process for the continuous production of fatty acid soaps A process for the continuous production of fatty acid soaps by reaction with solid metal oxides, hydroxides, hydrogen carbonates and carbonates of Mg, Ca, Ba, Pb, Al, Zn, Co, Fe, Cd and Zr, in which the fatty acids are subjected to a rotational movement b... | 02/09/1993 |
| 5180742 | Quinone derivatives, their production and use Quinone derivatives of the general formula: ##STR1## (wherein R1 and R2 are the same or different, and independently are a hydrogen atom or a methyl or methoxy group, or R1 and R2 combine with each other to... | 01/19/1993 |
