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| Number | Title | Issue Date |
| 8148560 | Vaginal tablets comprising misoprostol and methods of making and using the same The present invention is directed to vaginal tablets comprising misoprostol and a pharmaceutically acceptable pH insensitive, hydrophilic cellulose material, wherein the vaginal tablets do not contain a hydrophobic release controlling agent, and wherein the misopros... | 04/03/2012 |
| 7396946 | Compound for treatment of external secretion disorders Disclosed is a method for treatment of external secretion disorders, which comprises administering a fatty 5 acid derivative to a subject in need of said treatment. The method of the present invention is useful for treatment of at least one condition selected from h... | 07/08/2008 |
| 5571936 | Intermediates for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof Intermediate compounds represented as formula (I) useful for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof are disclosed. ##STR1## wherein R is tetrahydropyranyl, tetrahydrofuranyl, 2-ethoxyethyl, 3-t... | 11/05/1996 |
| 5292915 | Compounds containing carbonate groups and carbonyl groups and the preparation and use thereof The invention relates to compounds containing carbonate groups and carbonyl groups and having the general formula ##STR1## in which R stands for a C1 -C4 -alkyl radical, an aryl radical, or a radical R1, where R1... | 03/08/1994 |
| 4992469 | Method of obtaining an antiplatelet effect A quinone derivative of the formula (I): ##STR1## in which A is a group of the formula (IV): ##STR2## or a group of the formula (V): ##STR3## in which X and Y are either the same as or different from each other and each are hydroxy, me... | 02/12/1991 |
| 4495104 | Quinone carboxylic acids and ester derivatives A compound of the general formula ##STR1## wherein n is an integer of 10 to 21, inclusive; R is H or lower alkyl having 1 to 4 carbon atoms has pharmaceutical activities such as hypotensive, tissue metabolism stimulating, immuno-regulatory, lysosomal... | 01/22/1985 |
| 4429148 | 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.... | 01/31/1984 |
| 4404393 | 15-Deoxy-16-hydroxy-16-(1'fluorovinyl) prostaglandins and derivatives 15-Deoxy-16-(halovinyl)-16-hydroxy prostaglandins have been prepared.... | 09/13/1983 |
| 4360688 | Precursors and synthesis of d1-(methyl)-16,16-(dimethyl)-11-alpha, 15-alpha, beta-dihydroxy-9-oxo-2,13,-trans, trans-prostadienoates Novel compounds are disclosed of the classes: ##STR1## wherein the subscript n is an integer from 3-5, inclusive, R1 is hydrogen or R2 ; R2 and R3 consist essentially of C1 -C6 alkyl a... | 11/23/1982 |
| 4343949 | Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones This disclosure describes 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones useful as intermediates for the preparation of certain 11-hydroxy- and 11-deoxy-9-keto(or hydroxy)-pro... | 08/10/1982 |
| 4338252 | 1-Descarboxy-1-ketoester (ketoacid)-prostaglandins This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.... | 07/06/1982 |
| 4328359 | 15-Deoxy-16-substituted-19-chloro-20-nor-prostane derivatives of the E and F series The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E and F series wherein C-16 is substituted with hydrogen, methyl, vinyl or ethynyl and C-19 substituted with chloro and the ଲ-chain consists of 7 car... | 05/04/1982 |
| 4322546 | 15-Deoxy-16-hydroxy-16-allenyl prostane derivatives of the E and F series This invention disclosed herein relates to pharmacologically active 15-deoxy-16-hydroxy prostaglandin derivatives of the E and F series wherein C16 is substituted with allenyl. These compounds are active as hypotensives, antisecretory, bronchodilati... | 03/30/1982 |
| 4312994 | Chain dienic prostanoic acid derivatives Diene 16-hydroxy prostanoic acid derivatives displaying valuable pharmacological properties, e.g., gastric antisecretory, are described herein.... | 01/26/1982 |
| 4303796 | 16-Phenoxy prostaglandin F2 analogs Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of pl... | 12/01/1981 |
| 4301294 | 16-Phenoxy PGE2 compounds Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of pl... | 11/17/1981 |
| 4298754 | 15-Deoxy-16-hydroxy-16-(1'fluorovinyl) prostaglandins and derivatives 15-Deoxy-16-hydroxy-16-(1 halovinyl) prostaglandins have been prepared.... | 11/03/1981 |
| 4293704 | Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones This invention relates to novel 4-oxy-2-substituted-cyclopent-2-en-1-ones of the following general formula: ##STR1## and the optical antipodes, racemic mixtures, and diastereomeric mixtures thereof wherein p is an integer from 2 to 6, inclusive, and ... | 10/06/1981 |
| 4289898 | 13,14-Didehydro-19-oxo-PGE2 compounds The present invention provides novel 13,14-didehydro-19-oxo-PGE2 compounds, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.... | 09/15/1981 |
| 4289899 | 13,14-Didehydro-19-oxo-PGE1 analogs The present invention provides novel 13,14-didehydro-19-oxo-PGE1 analogs, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.... | 09/15/1981 |
| 4288618 | 19-Oxo-PGF2 analogs The present invention provides novel 19-oxo-PGF2 analogs, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.... | 09/08/1981 |
| 4284804 | 13,14-Dihydro-19-oxo-PGE2 analogs The present invention provides novel 13,14-dihydro-19-oxo-PGE2 analogs, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.... | 08/18/1981 |
| 4284810 | 19-Oxo-PGE1 analogs The present invention provides novel 19-oxo-PGE1 analogs, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.... | 08/18/1981 |
| 4284795 | 19,20-Didehydro-PG2 compounds The present invention provides novel 19,20-didehydro-PG2 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 08/18/1981 |
| 4284800 | 13,14-Dihydro-19-oxo-PGE1 analogs The present invention provides novel 13,14-dihydro-19-oxo-PGE1 analogs, which are useful for a variety of pharmacological purposes, e.g., antiasthmatic indications.... | 08/18/1981 |
| 4283550 | 1-Descarboxy-1-ketoester(ketoacid)-prostaglandins This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.... | 08/11/1981 |
| 4278806 | 15-Deoxy-16-substituted-19-chloro-20-nor prostane derivatives of the E and F series The invention disclosed herein relates to pharmacologically active prostaglandin derivatives of the E and F series wherein C-16 is substituted with hydrogen, methyl, vinyl or ethynyl and C-19 substituted with chloro and the ଲ-chain consists of 7 car... | 07/14/1981 |
| 4276427 | 19,20-Didehydro-PG1 compounds The present invention provides novel 19,20-didehydro-PG1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/30/1981 |
| 4276428 | 19,20-Didehydro-13,14-dihydro-PG1 compounds The present invention provides novel 19,20-didehydro-13,14-dihydro-PG1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/30/1981 |
| 4275231 | 19-Hydroxy-19-methyl-13,14-dihydro-PG1 compounds The present invention provides novel 19-hydroxy-19-methyl-13,14-dihydro-PG1 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/23/1981 |
| 4275233 | 19-Hydroxy-19-methyl-13,14-dihydro-PG2 compounds The present invention provides novel 19-hydroxy-19-methyl-13,14-dihydro-PG2 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 06/23/1981 |
| 4269995 | 19,20-Didehydro-13,14-dihydro-PG2 compounds The present invention provides novel 19,20-didehydro-13,14-dihydro-PG2 compounds, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 05/26/1981 |
| 4259514 | 19-Hydroxy-13,14-dihydro-PG2 compounds The present invention provides novel 19-hydroxy-13,14-dihydro-PG2 compounds methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 03/31/1981 |
| 4257971 | 19-Hydroxy-PG2 analogs The present invention provides novel 19-hydroxy PG2 analogs, methods for their preparation and pharmacological use for the induction of prostaglandin-like effect.... | 03/24/1981 |
| 4254278 | 1-Descarboxy-1-ketoester (ketoacid)-prostaglandins This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.... | 03/03/1981 |
| 4250321 | 1-Descarboxy-1-ketoester(ketoacid)-protaglandins This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.... | 02/10/1981 |
| 4250323 | 1-Descarboxy-1-ketoester(ketoacid)-prostaglandins This disclosure describes certain 11-hydroxy and 11-deoxy-1-ketocarboxylic acid prostanoic acids and derivatives useful as bronchodilators, hypotensive agents, anti-ulcer agents or intermediates.... | 02/10/1981 |
| 4249016 | ω-Aryl-13,14-didehydro-PGE compounds This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the prepar... | 02/03/1981 |
| 4245121 | Prostenoic acids and esters This disclosure describes derivatives, analogs, and congeners of prostanoic acid having a terminal cyclic moiety in the ଲ-chain which possess the pharmacological activities associated with the prostaglandins.... | 01/13/1981 |
| 4237307 | 15-Deoxy-16-hydroxy-16-methyl-Ɗ19-prostaglandins of the E and F series The inventions disclosed herein relates to pharmacologically active Ɗ19 prostaglandins of the E and F series in which C-16 is substituted with hydroxyl and methyl as well as the pharmacologically acceptable, non toxic lower alkyl esters and salts thereof... | 12/02/1980 |
