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| Number | Title | Issue Date |
| 7279563 | Compounds for protecting hydroxyls and methods for their use A hydrocarbyldithiomethyl-modified compound of the Formula: R1—O—CH2—S—S—R2 or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/... | 10/09/2007 |
| 7253296 | Acylated aminopropanediols and analogues and therapeutic uses thereof The invention relates to novel acylated aminopropanediols and the nitrogen and sulfur analogues thereof, pharmaceutical compositions comprising same, therapeutic uses thereof, in particular for the treatment of cerebral ischemia. The invention also provides a method... | 08/07/2007 |
| 6977292 | Nucleophile-stable thioester generating compounds, methods of production and use The invention is directed to nucleophile-stable thioester generating compounds comprising a carboxyester thiol. The compounds have wide applicability in organic synthesis, including the generation of peptide-, polypeptide- and other polymer-thioesters. The invention... | 12/20/2005 |
| 6780418 | Reagents and immunoassay for the detection and quantitative determination of mycothiol and precursors thereof A method of detecting a member of the taxa actinomycetos is provided. A method also is provided for detecting mycothiol or precursor thereof. An antibody is provided which binds to mycothiol or a mycothiol precursor. A method is further provided for diagnosis of a s... | 08/24/2004 |
| 6639088 | Compounds for protecting hydroxyls and methods for their use A hydrocarbyldithiomethyl-modified compound of the Formula: or a salt thereof wherein R1 is an organic molecule and R2 is a hydrocarbyl is useful for protecting and/or blocking hydroxyl groups in organic molecules such as nucleotides. The... | 10/28/2003 |
| 6569411 | Serine carbonates Serine carbonates of formula I are precursors for organoleptic compounds, masking agents and antimicrobial agents. Further they are alternative substrates for malodor producing enzymes. The symbols in formula I are defined in claim 1.... | 05/27/2003 |
| 6511670 | (poly)thiaalkynoic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active (poly)thiaalkynoic compounds have the structural formula (I): R1 --Y--CH2 --C.ident.C--CH2 --S--CH2 --R2 (I) and are useful for the treatment of a wide variety of dis... | 01/28/2003 |
| 6407137 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 06/18/2002 |
| 6376688 | Modified polyunsaturated fatty acids The present invention provides polyunsaturated fatty acid compounds having antimalarial and/or neutrophil stimulatory activity. The polyunsaturated fatty acids contain 18-25 carbons and 1-6 double bonds and are characterized in that they have one or two s... | 04/23/2002 |
| 6258836 | Dopamine analog amide The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 07/10/2001 |
| 6224903 | Polymer-lipid conjugate for fusion of target membranes A fusogenic liposome composition for delivering a liposome-entrapped compound into the cytoplasm of a target cell is described. The liposomes have an outer surface coating of chemically releasable hydrophilic polymer chains which shield hydrophobic polyme... | 05/01/2001 |
| 6180667 | Esters of acyl L-carnitines and pharmaceutical compositions containing same for treating endotoxic shock Esters of alkanoyl L-carnitines wherein the alkanoyl is a saturated or unsaturated, staight or branched alkanoyl having 2-26 carbon atoms, optionally ω-substituted with trialkylammonium, dialkylsulfonium, hydroxyl, carboxyl, halogen, methanesulfonyl and ... | 01/30/2001 |
| 6150542 | Fragrance precursor compounds for preventing human malodor The invention relates to agents preventing (the formation of) human malodor. In particular, the invention relates to the use of several classes of compounds which can act as such agents in cosmetic products, such as deodorants and antiperspirants. These c... | 11/21/2000 |
| 6013815 | Production and use of salts of 6,8-bis (amidiniumthio)-octanoic acid The invention relates to the production and purification of salts of 6,8-bis (amidiniumthio)octanoic acid, its enantiomers (+)-6,8-bis(amidiniumthio)octanoic acid and (-)-6,8-bis (amidiniumthio)octanoic acid and of the esters of these compounds as well ... | 01/11/2000 |
| 6002029 | Antiviral prodrugs Lipid prodrugs of phosphonoacids and their analogs that have increased antiviral activity over the parent drugs in inhibiting cytomegalovirus and other susceptible viruses.... | 12/14/1999 |
| 6001869 | Method of inhibiting parasitic activity A method of inhibiting parasitic activity is disclosed in which the biosynthesis, structure and/or function of the glycosyl phosphatidylinositol (GPI) anchor of said parasite may be affected by incorporating into said GPI anchor selected analogs of myrist... | 12/14/1999 |
| 5994392 | Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the ... | 11/30/1999 |
| 5925339 | Fragrance precursor compounds for preventing human malodor The invention relates to agents preventing (the formation of) human malodor. In particular, the invention relates to the use of several classes of compounds which can act as such agents in cosmetic products, such as deodorants and antiperspirants. These c... | 07/20/1999 |
| 5811384 | Nonionic gemini surfactants Novel nonionic gemini surfactants are extremely effective emulsifiers for oil-in-water emulsions that provide improved detergency at even low concentration levels. The surfactants are characterized by the formula: ##STR1## wherein R1 is in... | 09/22/1998 |
| 5801260 | Carbonothioate phospholipid analogs as substrate of phospholipases and lipases Novel substrates of phospholipases, lysophospholipases and lipases are disclosed.... | 09/01/1998 |
| 5696277 | Antiviral prodrugs Lipid prodrugs of phosphonoacids and their analogs that have increased antiviral activity over the parent drugs in inhibiting cytomegalovirus and other susceptible viruses.... | 12/09/1997 |
| 5643948 | Protein kinase C modulators. K. Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes of the phorbol-, resiniferonol- and ingenol-classes.... | 07/01/1997 |
| 5637616 | Method for treating diseases mediated by proteases A method for the topical or systemic treatment of disorders mediated by proteases which result in skin or mucosal lesions, and in particular, pemphigus, cicatricial pemphigoid, bullous pemphigoid, lichen planus, and canker sores, is disclosed wherein the ... | 06/10/1997 |
| 5625085 | Esters of acyl L-carnitines and pharmaceutical compositons containing same for treating endotoxic shock Esters of alkanoyl L-carnitines wherein the alkanoyl is a saturated or unsaturated, straight or branched alkanoyl having 2-26 carbon atoms, optionally ω-substituted with trialkylammonium, dialkylsulfonium, hydroxyl, carboxyl, halogen, methanesulfonyl and... | 04/29/1997 |
| 5587499 | (Meth) acrylic compounds, process for their preparation and their application to the synthesis of new polymers These compounds are denoted by the following formula (I): ##STR1## in which: Z denotes H or a linear or branched alkyl radical, X denotes O or S, each of A and B independently denotes an alkylene radical, it being possible for this radical to be substitut... | 12/24/1996 |
| 5506267 | Thioglycerol derivatives A compound of the invention is represented by the formula: ##STR1## wherein R1 and R2 are the same or different, an acyl group; R3, R4, R6 and R7 are the same or different, hydrogen or... | 04/09/1996 |
| 5498786 | Synthesis of intermediates in the preparation of ACAT inhibitors This invention relates to novel processes for synthesizing intermediates in the preparation of N-aryl and N-heteroarylamide inhibitors of the enzyme acyl coenzyme A: cholesterol acyltransferase (ACAT), and to novel intermediates used in such processes.... | 03/12/1996 |
| 5463093 | Palladium complexes and methods for using same in the treatment of tumors or Psoriasis Novel palladium complexes and pharmaceutical compositions comprising the same are provided. Such complexes comprise (palladium)m (lipoic acid)n, wherein m and n are each independently 1 or 2. A process for preparing such complexes is... | 10/31/1995 |
| 5292915 | Compounds containing carbonate groups and carbonyl groups and the preparation and use thereof The invention relates to compounds containing carbonate groups and carbonyl groups and having the general formula ##STR1## in which R stands for a C1 -C4 -alkyl radical, an aryl radical, or a radical R1, where R1... | 03/08/1994 |
| 5266713 | Aryl alkenoic acid derivatives as leukotriene antagonists Aryl alkenoic acid derivatives, and physiologically acceptable salts thereof, are provided which are potent leukotriene antagonists and may be used for the treatment of circulatory diseases and preferably for respiratory diseases such as asthma. The deriv... | 11/30/1993 |
| 5151534 | Sulphur-containing eicosanoides and their application in pharmacy and in cosmetics Compounds corresponding to the formula: ##STR1## wherein A represents --(CH2)2 or --(C.tbd.C)--; n is equal to 0, 1 or 2; R represents hydroxyl, alkoxy having the formula --OR1, or amino having the formula ##STR2## ... | 09/29/1992 |
| 5147868 | Thienamycin renal peptidase inhibitors Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are z-2-acylamino-3-monosubstituted propenoates.... | 09/15/1992 |
| 5145611 | Carboxylic acid derivatives, and pharmaceutical compositions containing them Carboxylic acid derivatives of the formula ##STR1## R1 is alkoxy, alkylthio, alkylsulphinyl, alkulsulphonyl, alkylamino, cycloalkyl, or cycloalkoxy or optionally substituted aryl, aryloxy, arylthio, arylsulphinyl, arylsulphonyl or arylamin... | 09/08/1992 |
| 5098613 | Anti-inflammatory agents This invention provides benzene derivatives, pharmaceutical formulations of those derivatives, and a method of using the derivatives for the treatment of inflammation in mammals.... | 03/24/1992 |
| 5091558 | Naphthalene anti-psoriatic agents Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R1 is alkoxy, alkylthio, optionally substituted phenoxy or optionally substituted phenylthio; R2 is hydrogen, lower alkyl... | 02/25/1992 |
| 5084214 | Phenolic thioethers, and their production and use Phenolic thioethers of the formula: ##STR1## wherein R is a hydrogen atom or a protective group for carboxyl, X is a straight or branched C4 -C15 alkylene group, a straight or branched C1 -C15 alkylene grou... | 01/28/1992 |
| 5082967 | Novel fatty acid analog enzyme substrates Novel diheteroatom-substituted fatty acid analog substrates of myristoylating enzymes are provided which contain oxyen and/or sulfur in place of two methylene groups in carbon positions from 3 to 13 in the fatty acid chain of a C13 -C14 | 01/21/1992 |
| 5071598 | Cryoprotective reagent Compositions for cryopreservation of phosphoglyceride-containing biological and synthetic membranes are provided in which a lipophilic anchor molecule is modified by the attachment of a preferably carbohydrate moiety placed at a predetermined, variable di... | 12/10/1991 |
| 5053547 | Benzonorbornene derivatives, processes for their preparation and medicinal and cosmetic compositions containing them A compound of formula (I) ##STR1## its isomers and its salts in which --R1, R3 and R4 are each independently hydrogen, C1 -C8 -alkyl, C1 -C8 -alkoxy, halogen, C1 ... | 10/01/1991 |
| 5025017 | Seco-mevinic acid derivatives useful as antihypercholesterolemic agents and new intermediates Seco-mevinic acid derivatives are provided which has the structure ##STR1## including all stereoisomers thereof, wherein Z is ##STR2## R is H, alkali metal or lower alkyl, R1 is H, lower alkyl, aryl, lower alkoxy, cycloalkyl, heteroar... | 06/18/1991 |
