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| Number | Title | Issue Date |
| 8148558 | Method of producing tibolone metabolites by fermentation with Method of producing Δ4-Tibolone by contacting tibolone with Fusarium lini (ATCC 9593) is reported. ... | 04/03/2012 |
| RE39592 | Extended release growth promoting two component composition An extended release composition comprising a first composition comprising growth promoters and a second composition comprising growth promoters and a biodegradable polymer is described. A method of increasing weight gain in food animals utilizing the composition, a ... | 04/24/2007 |
| 7196074 | Methods of making, using and pharmaceutical formulations comprising 7α, 11β-dimethyl-17β-hydroxyestra-4, 14-dien-3-one and 17 esters thereof Methods of using 7α,11β-dimethyl-17β-hydroxyestra-4,14-dien-3-one (III) and 17 esters thereof for various hormonal therapies, oral and parenteral dosage forms comprising these actives, and processes for their ... | 03/27/2007 |
| 7169769 | 17α-hydroxy-14β-steroids with hormonal effect This invention relates to steroidal compounds having the formula I wherein: R1 is O, (H,H), (H,OH), NOH, whereby OH is optionally etherified or esterified; R2 and R3 are independe... | 01/30/2007 |
| 6797834 | Phosphoric acid isomerization of A 5 (10), 9 (11)—diene steroid to the corresponding 4, 9-diene steroid The invention is a process for the preparation of a Δ4,9-steroid of formula (II) which comprises contacting a Δ5(10),9(11)-steroid of formula (I) with... | 09/28/2004 |
| 6790971 | 19-Nor-steroids A 19-nor-steroid having a formula selected from the group consisting of wherein the A and B rings have a structure selected from the group consisting of having hormonal prope... | 09/14/2004 |
| 6498153 | Extended release growth promoting two component composition An extended release composition comprising a first composition comprising growth promoters and a second composition comprising growth promoters and a biodegradable polymer is described. A method of increasing weight gain in food animals utilizing the comp... | 12/24/2002 |
| 6492536 | Steroids, their use as medicaments, their preparation process, the intermediates of this process and the compositions containing them The subject of the invention is the products of formula (I): ##STR1## in which either R1 represents halogen, hydroxyl, (C1 -C8) alkyloxy or (C1 -C12) acyloxy, and R2 represents halogen or h... | 12/10/2002 |
| 6369047 | Androgenic steroid compounds and a method of making and using the same An androgenic steroid compound of the formula: ##STR1## wherein: X Y, Z, R1, R2, R3, R5 and R6 are as defined herein.... | 04/09/2002 |
| 6239121 | 4- Halogenated steroids, preparation method and intermediates, application as medicines and pharmaceutical compositions containing same A subject of the invention is the compounds of formula (I): ##STR1## in which X is a halogen atom, D represents the remainder of an optionally substituted pentagonal or hexagonal ring and optionally carrying an unsaturation, R1, R2, ... | 05/29/2001 |
| 5986115 | 7-(.xi.-aminoalkyl)-estratrienes, process for their production, pharmaceutical preparations which contain these 7-(.xi.-aminoalkyl)-estratrienes as well as their use for the production of pharmaceutical agents This invention describes new, substituted 7-(.xi.-aminoalkyl)-estratrienes of general formula I ##STR1## in which side chain SK is a radical of partial formula ##STR2## as well as their physiologically compatible addition salts with organ... | 11/16/1999 |
| 5939570 | Estrenes for inducing hypothalamic effects The invention relates to estrene steroids, which bind to neuroepithelial receptors. The steroid is preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.... | 08/17/1999 |
| 5843933 | 11ଲ-aryl-4-estrenes, process for their production as well as their use as pharmaceutical agents Compounds of formula I ##STR1## wherein X, R1, R2, R3 and R4 have the meanings indicated in the description, are described, as well as processes for their production, pharmaceutical preparations containing ... | 12/01/1998 |
| 5831104 | Steroid intermediate products and method of their production The invention is directed to novel steroid intermediate products of general formula I ##STR1## The steroid intermediate products which can be isolated according to the invention are suitable for the synthesis of 13-ethyl-11-methylene-18,19-bisno... | 11/03/1998 |
| 5723455 | Antiandrogenic agents and related pharmaceutical compositions and methods of use Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R1 through R10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compo... | 03/03/1998 |
| 5679788 | 11 beta-substituted-19 nor-steroids Intermediate compounds of a formula selected from the group consisting of ##STR1## which are useful intermediates for the preparation of final products of the formula ##STR2## wherein the substituents are defined in the specification.... | 10/21/1997 |
| 5446036 | 13-alkyl-11beta-phenylgonanes There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH; R2 is alpha- or beta-position methyl or ethyl; R1 is selected from heteroaryl radicals, cycloalkyl radicals, cycloalkenyl r... | 08/29/1995 |
| 5426102 | 14ଲ-H-, 14-and 15-En-11ଲ-aryl-4-oestrenes Novel compounds of the general formula I ##STR1## and the pharmacologically tolerable addition salts thereof with acids are described, in which either Ia) R11 represents a hydrogen atom in the ଲ-configuration and each of R12 | 06/20/1995 |
| 5273971 | 13-alkyl-11ଲ-phenylgonanes There are provided 13-alkyl-11beta-phenyl-gonanes of formula I ##STR1## wherein Z is an oxygen atom or N--OH; R2 is alpha- or beta-position methyl or ethyl; R1 is selected from heteroaryl radicals, cycloalkyl radicals, cycloalkenyl r... | 12/28/1993 |
| 5149696 | 19.fwdarw.nor.fwdarw.steroids Novel 19-nor-steroids of the formula ##STR1## wherein the A and B rings have a structure selected from the group consisting of ##STR2## having hormonal properties and their preparation and intermediates.... | 09/22/1992 |
| 5132299 | 11ଲ-phenyl-4,9,15-estratrienes, their manufacture and pharmaceutical preparations containing same New 11ଲ phenyl-4,9,15-estratrienes of formula I ##STR1## are described, where X implies an oxygen atom or a hydroxyimino grouping N~OH, R1 stands for a hydrogen atom or a methyl group, R2 implies a hydrogen atom, an alkyl radic... | 07/21/1992 |
| 4954446 | Aromatic steroid 5--reductase inhibitors Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5--reductase including using these compounds to reduce prosta... | 09/04/1990 |
| 4943566 | Novel 17-aryl-steroids A compound selected from the group consisting of compounds of the formula ##STR1## wherein R1 is an organo of 1 to 18 carbon atoms optionally containing at least one heteroatom connected to the C ring by a carbon atom, R2 is met... | 07/24/1990 |
| 4870069 | 11ଲ-alkynyl-estrenes and -estradienes, their production and pharmaceutical preparations containing them 11ଲ-substituted steroids of the formula ##STR1## wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H; X is O, two H atoms or hydroximino; Z is the residue of a pentagonal ... | 09/26/1989 |
| 4814327 | 11 ଲ-(4-isopropenylphenyl)estra-4,9-dienes, their production, and pharmaceutical preparations containing same 11 ଲ-(4-isopropenylphenyl)-estra-4,9-dienes of general Formula I ##STR1## wherein X is an oxygen atom or a hydroxyimino grouping N OH, R1 is a hydrogen atom or a methyl group, R2 is a hydrogen atom or an acyl residue of 1-10 carbon... | 03/21/1989 |
| 4808710 | 18-Phenyloestrane derivatives A novel class of steroids having pregnancy-terminating and/or pregnancy-preventing activity and a very low antiglucocorticoid activity have been found. The compounds have the general formula: ##STR1## wherein R1 and R2 each sepa... | 02/28/1989 |
| 4719054 | Process for the production of 17-ethynyl-17ଲ-hydroxy-18-methyl-4,15-estradien-3-one, and novel 3,5-estradien-17-one starting compounds for this process A process and novel starting materials for the production of 17-ethynyl-17ଲ-hydroxy-18-methyl-4,15-estradien-3-one of Formula I ##STR1## are disclosed. Novel 17-ketone starting materials have the Formula II ##STR2## wherein R i... | 01/12/1988 |
| 4609650 | Double ester of 16ଲ-ethylestran-17ଲ-ol derivatives A novel steroid compound of the formula ##STR1## wherein A is a lower alkylene group; ##STR2## is an acyl group; and is a single bond or a double bond, and methods of producing the compound (I) as follows: ##STR3## and a pharmaceuti... | 09/02/1986 |
| 4603013 | Estrane derivatives Estrane derivatives of the general formula I ##STR1## wherein one of the substituents X or Z signifies a hydrogen atom and the other together with Y represents a carbon-carbon bond, or wherein the substituents X and Z represent hydrogen atoms and Y r... | 07/29/1986 |
| 4557867 | 11ଲ-Difluoromethyl and (E)- and (Z)-11-fluoromethylene steriods Known reactions are arranged in a novel manner to produce 11ଲ-difluoromethyl and (E)- and (Z)-11-fluoromethylene 19-norandrostenediones and 19-nor-13ଲ-ethylandrostenediones which are useful as contraceptive agents.... | 12/10/1985 |
| 4547493 | Novel 11ଲ-substituted-19-nor-steroids Novel 19-nor-steroids of the formula ##STR1## wherein R1 is an organic group of 1 to 18 carbon atoms optionally containing at least one heteroatom with the atom immediately adjacent the 11-carbon atom being carbon, R2 is a hydro... | 10/15/1985 |
| 4537722 | Steroid esters preparation This invention relates to an improved steroid ester synthesis in which carbodiimides and catalytic amounts of 4-(tertiary amino)-pyridines, in combination with acid catalysts, are used as condensing agents, resulting in pure, non discolored compounds in h... | 08/27/1985 |
| 4464365 | 11ଲ-Chloro-Ɗ15 -steroids, a process for their preparation and pharmaceutical preparations containing them 11ଲ-Chloro-Ɗ15 -steroids of Formula I ##STR1## wherein R1 is hydrogen or acyl and R2 is ethynyl, chloroethynyl, or propynyl have strong progestational activity.... | 08/07/1984 |
| 4400524 | Grignard reagents prepared from 5-halopentan-2-one propylene ketals A process for preparing 19-norandrostenedione. Also provides key intermediates of 19-norandrostenedione and methods for preparing them in high yields.... | 08/23/1983 |
| 4390530 | 3-Deoxy-Ɗ15 -steroids 3-Deoxy-Ɗ15 -steroids of the formula ##STR1## wherein R1 is hydrogen or an acyl group of a C1-15 hydrocarbon carboxylic acid, and R2 is ethynyl, chloroethynyl or propynyl are valuable progestationally effe... | 06/28/1983 |
| 4386085 | Novel steroids Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula ##STR1## wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the... | 05/31/1983 |
| 4333928 | 16 -Alkyl steroids, their preparation, and pharmaceutical preparations thereof 16 -Alkyl steroids of the formula ##STR1## wherein R1 is hydrogen or methyl, R2 is hydrogen, alkyl, acyl, or glycosyl R3 is hydrogen or a substituted or unsubstituted, saturated or unsaturated lower hydrocarbon resi... | 06/08/1982 |
| 4311646 | Process for the preparation of 4,6-dien-3-one steroids A 4,6-dien-3-one steroid is produced by brominating an enolic ether of a 4-en-3-one steroid in a water-containing organic solvent which is substantially free from acetic acid and sodium acetate to give a 6-bromosteroid and then dehydrobrominating the 6-br... | 01/19/1982 |
| 4298538 | 16-Dimethylaminomethylene-3-methoxy-1,3,5-(10)-estratrien-17-one, a process for the preparation thereof and its use as a preparative intermediate 16-dimethylaminomethylene-3-methoxy-1,3,5(10)-estratrien-17-one is a valuable new preparative intermediate which may be used, e.g., to prepare 17ଲ-hydroxy-16ଲ-ethyl-4-estren-3-one or 16ଲ-ethylestradiol.... | 11/03/1981 |
| 4292251 | 11ଲ-Substituted steroids Novel and biologically active 11ଲ-substituted steroids of the oestrane series are disclosed having the formula ##STR1## wherein (a) R1 is O or (Y)(ଲZ), wherein Y is selected from the group consisting of H, unsaturated al... | 09/29/1981 |
