Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 7196074 | Methods of making, using and pharmaceutical formulations comprising 7α, 11β-dimethyl-17β-hydroxyestra-4, 14-dien-3-one and 17 esters thereof Methods of using 7α,11β-dimethyl-17β-hydroxyestra-4,14-dien-3-one (III) and 17 esters thereof for various hormonal therapies, oral and parenteral dosage forms comprising these actives, and processes for their ... | 03/27/2007 |
| 7018993 | Antiandrogenic agent A compound pf general formula (I): wherein, for example, X1 and X2 independently represent a hydrogen atom. Ra represents a hydrogen a... | 03/28/2006 |
| 6780854 | Orally active androgens Novel, orally active androgens are 7α-substituted Δ14-nandrolone derivatives. The compounds satisfy the general formula: wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1... | 08/24/2004 |
| 6756366 | Orally active androgens Orally Active androgens are derivative of 7α-methyl-19-nortestosterone. The compounds satisfy formula (I) wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6)alkyl, or (C1-6)acyl; R2 is selected from the gro... | 06/29/2004 |
| 6541465 | Orally active androgens Novel, orally active androgens are 7-substituted Ɗ14 -nandrolone derivatives. The compounds satisfy the general formula: ##STR1## wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, or (C... | 04/01/2003 |
| 6468981 | Compositions and methods for targeting pharmaceutically active materials to cells containing androgen receptors A water soluble delivery system for nucleic acids to cells having androgen receptors, preferably prostate cells, is provided comprising a steroid moiety capable of binding to said receptors, said steroid moiety being covalently linked to a polycationic ma... | 10/22/2002 |
| 5977096 | Steroids with radical-attracting aromatic substituents, process for the production thereof and pharmaceutical compounds containing the said substances Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment of diseases due to radical-mediated cell damage. The novel... | 11/02/1999 |
| 5952319 | Androgenic steroid compounds and a method of making and using the same An androgenic steroid compound of the formula: ##STR1## wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.... | 09/14/1999 |
| 5925630 | Neuroactive steroids of the androstane and pregnane series The invention relates to 3-hydroxy, 17-(un)substituted derivatives of the androstane series and 3-hydroxy, 21-substituted derivatives of the pregnane series. These derivatives are capable of acting at a recently identified site on the GRC, t... | 07/20/1999 |
| 5914324 | 6-Hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same 6-hydroxy and 6-oxo-androstane derivatives of formula (I), active on the cardiovascular system. ##STR1## wherein: the symbol A represents CH--OR, C.dbd.N--OR, CH--CH.dbd.N--OR and C.dbd.CH--N--OR; and R1, R2 and R3 ar... | 06/22/1999 |
| 5908944 | Methylation or ethylation agent and process for 1,4-addition of a methyl or ethyl group to an , ଲ-unsaturated keto compound This invention describes a new methylation or ethylation agent containing trimethyl aluminum or dimethyl zinc or triethyl aluminum as methyl or ethyl source, which additionally contains catalytic amounts of one or more copper(I) and/or copper(II) compound... | 06/01/1999 |
| 5723455 | Antiandrogenic agents and related pharmaceutical compositions and methods of use Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R1 through R10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compo... | 03/03/1998 |
| 5597701 | Process for determining androstenone contents in adipose tissues A process and appropriate device are disclosed for determining the androstenone content of adipose tissues in clearly shorter times. The disclosed process has the following steps: (a) liquefying an adipose tissue sample by heating up to a predetermined te... | 01/28/1997 |
| 5424304 | 17-aryl-substituted steroidal compounds active on the cardiovascular system Cardioactive steroidal compounds of the formula I ##STR1## wherein R, R1, R2, R3, R4, R5, R6 and R7 have the meanings shown in the description, and pharmaceutical compositio... | 06/13/1995 |
| 5266712 | Process for crystallizing the organic substances from steroidal origin and the thus obtained compounds A process for crystallizing a pharmaceutically active steroidal product, without mechanical procedure, to obtain a homogeneous granulometric class which may be prepared beforehand, wherein the product which is desired to be crystallized is dissolved in a ... | 11/30/1993 |
| 5227375 | Aromatase inhibitors Novel aromatase inhibitors are disclosed for use in therapeutic preparations for treatment of estrogen-dependent diseases. The compounds are specified 7-substituted androstanedione and androstenedione derivatives which show a strong inhibitory acti... | 07/13/1993 |
| 5093490 | Process for optical resolution of bicyclo[3.3.0]octane-3,7-dione-2 carboxylic acid esters and their 7-monoketals The invention relates to a process for the production of (+)-bicyclo[3.3.0]octan-3-one-2 carboxylic acid steroid esters of formula I ##STR1## in which X means oxygen or the radicals --O--(CH2)n --O-- or --O--CH2 ... | 03/03/1992 |
| 4885117 | Process for the preparation of (Z)-17-halovinyl steroids (Z)-17-halovinyl steroids of general Formula I ##STR1## wherein . . . . is a single bond or a double bond, V is a carbon-to-carbon bond or a methylene group, R1 is a hydrogen atom or a methyl group, X is a chlorine atom, a bromine atom or an ... | 12/05/1989 |
| 4609496 | Steroid esters of N-(2-halogenoethyl)-N-nitroso-carbamoyl-amino acids and peptides thereof, as well as methods for preparing them Steroid-N-(2-halogen ethyl)-N-nitroso-carbamoyl-amino acid or peptide esters of the general formula: ##STR1## where R1 and R2, which may be identical or different, mean the radical of an amino acid beyond the C atom in the beta ... | 09/02/1986 |
| 4602008 | Alkylated etiocholanolones and use as an anti-diabetic, anti-obesity and erythropoietic agent 16-Alkylated and 16-alkylated-7-hydroxy 5ଲ-androstan-3-ol-17-one, and the esters and ethers thereof, are used as an anti-diabetic, anti-obesity and erythropoietic agent in mammals.... | 07/22/1986 |
| 4600538 | Corticosteroids from 17-keto steroids via 20-cyano-Ɗ17 (20)-pregnanes The process of the present invention transforms 17-keto steroids (I) to the corresponding corticoids (IV) in three steps.... | 07/15/1986 |
| 4587235 | Novel androstane derivatives, process for their production, and pharmaceutical preparations containing them Androstane derivatives of Formula I ##STR1## wherein is a single bond or a double bond, R1 is methyl or ethyl, R2 is hydrogen or alkyl of 1-8 carbon atoms, --X-- is --(CH2)n --, --CH.dbd.CH(CH2)m | 05/06/1986 |
| 4537722 | Steroid esters preparation This invention relates to an improved steroid ester synthesis in which carbodiimides and catalytic amounts of 4-(tertiary amino)-pyridines, in combination with acid catalysts, are used as condensing agents, resulting in pure, non discolored compounds in h... | 08/27/1985 |
| 4528137 | Process for preparing fluorine-containing steroids A fluorine-containing 3-oxygenated-Ɗ3,5 -steroid is prepared in a good yield by fluorinating a steroid with a compound of the formula: wherein R is a hydrocarbon group.... | 07/09/1985 |
| 4507242 | Manufacture of androstandione 5-ଲ-androstandione is produced in high yield by contacting androstendione with a palladium catalyst and thereafter recovering the 5-ଲ-androstandione thus produced.... | 03/26/1985 |
| 4457925 | Androstane derivatives, process for their production, and pharmaceutical preparations containing them Androstane derivatives of Formula I ##STR1## wherein ---- is a single bond or a double bond, R1 is methyl or ethyl, R2 is hydrogen or alkyl of 1-8 carbon atoms, --X-- is --(CH2)n --, --CH.dbd.CH(CH2)m... | 07/03/1984 |
| 4360663 | Steroid hormone-antitumor derivatives A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a c... | 11/23/1982 |
| 4325879 | Amino-14 steroid derivatives and process for preparation of the same The invention relates to medicinally useful steroid derivatives, particularly amino-14 steroids substituted at the 17-position by a functional group represented by the general formula: ##STR1## wherein R1 is a hydroxy, hydroxyalkyl, alkoxy... | 04/20/1982 |
| 4307087 | Branched chain and cycloaliphatic esters of the androstane and oestrane series and pharmaceutical compositions containing same There are disclosed branched chain and cycloaliphatic esters of steroids having the formula: ##STR1## where R is H or CH3 ; R1 is H or CH3 ; R2 is H or CH3 ; R3 is H, OH, CH3 or ... | 12/22/1981 |
| 4297350 | Male contraceptive steroids and methods of use The steroids of the present invention have been found to be useful as male contraceptives when administered orally. Upon cessation of administration of the male contraceptive steroids of the present invention the male promptly regains normal fertility.... | 10/27/1981 |
| 4252719 | Steroid conversion method and products produced thereby Method for the removal of selected tertiary hydrogen atoms from 5 -steroids of the cholestane, androstane and pregnane series by chlorination of 5 -steroids esterified with selected iodoaryl substituted esterifying agents which direct a chlo... | 02/24/1981 |
| 4220599 | Oral pharmaceutical preparation having androgenic activity The invention relates to an oral pharmaceutical preparation with androgenic activity on the basis of one or more esters of testosterone and/or 5-dihydrotestosterone, the ester group of which has been derived exclusively from aliphatic carboxylic ac... | 09/02/1980 |
| 4220775 | Preparation of 4-aza-17-substituted-5-androstan-3-ones useful as 5-reductase inhibitors A method of preparing a compound of the formula: ##STR1## where Formula (I) may also have the structure of partial Formula (III); wherein, ##STR2## R' is hydrogen or methyl; R" is hydrogen or ଲ-methyl; R'" is ଲ-methyl or hydroxy; Z i... | 09/02/1980 |
| 4212864 | Branched chain and cycloaliphatic esters of the androstane and oestrane series and pharmaceutical compositions containing same There are disclosed branched chain and cycloaliphatic esters of steroids having the formula: ##STR1## or the 5H analog thereof, where R is H or CH3 ; R1 is H or CH3 ; R2 is H or CH3 ; R3 | 07/15/1980 |
| 4181669 | Steroid esters preparation This invention relates to an improved steroid ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.... | 01/01/1980 |
| 4180504 | Method for the preparation of esters This invention relates to an improved ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.... | 12/25/1979 |
| 4108851 | 3ଲ,17-Dihydroxy-5,17-pregn-20-ene-21-carboxylic acid γ-lactone and esters thereof Preparation of 3ଲ,17-dihydroxy-5,17-pregn-20-ene-21-carboxylic acid γ-lactone and esters thereof, the analgesic utility of the esters, and the utility of the diol both as an intermediate and by reason of its antiviral activity ar... | 08/22/1978 |
| 4098802 | Oral pharmaceutical preparation having androgenic activity The invention relates to an oral pharmaceutical preparation with androgenic activity on the basis of one or more esters of testosterone and/or 5-dihydrotestosterone, the ester group of which has been derived exclusively from aliphatic carboxylic ac... | 07/04/1978 |
| 4057543 | Process for the preparation of 17ଲ-hydroxy-3-oxo-17-pregn-4-ene-21-carboxylic acid γ-lactone A new process utilizing certain novel intermediates for the preparation of 17ଲ-hydroxy-3-oxo-17-pregn-4-ene-21-carboxylic acid γ-lactone is described herein. The procedure utilizes readily available and inexpensive sarsasaponin as starting m... | 11/08/1977 |
| 4055603 | Alkinyl terminating groups in biogenetic-like cyclizations to steroids Polyenine compounds are provided having the naturally occurring geometry and a group which in the presence of acid initiates a carbocation cyclization to a steroid or A-nor-steroid structure, particularly the pregnane parent structure. The compounds are f... | 10/25/1977 |
