Celebrity Inventors
Glam girl Heddy Lamar may have used her good looks to good effect on the silver screen, but she put her smarts to better use as an inventor. During World War II, she co-patented a frequency-switching system for torpedo guidance that was considered years ahead of its time.
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| Number | Title | Issue Date |
| 7196074 | Methods of making, using and pharmaceutical formulations comprising 7α, 11β-dimethyl-17β-hydroxyestra-4, 14-dien-3-one and 17 esters thereof Methods of using 7α,11β-dimethyl-17β-hydroxyestra-4,14-dien-3-one (III) and 17 esters thereof for various hormonal therapies, oral and parenteral dosage forms comprising these actives, and processes for their ... | 03/27/2007 |
| 6780854 | Orally active androgens Novel, orally active androgens are 7α-substituted Δ14-nandrolone derivatives. The compounds satisfy the general formula: wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1... | 08/24/2004 |
| 6756366 | Orally active androgens Orally Active androgens are derivative of 7α-methyl-19-nortestosterone. The compounds satisfy formula (I) wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6)alkyl, or (C1-6)acyl; R2 is selected from the gro... | 06/29/2004 |
| 6541465 | Orally active androgens Novel, orally active androgens are 7-substituted Ɗ14 -nandrolone derivatives. The compounds satisfy the general formula: ##STR1## wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, or (C... | 04/01/2003 |
| 6406718 | Orthorhombic crystalline form of fluticasone propionate and pharmaceutical compositions thereof The invention relates to a new polymorphic crystalline form of S-fluoromethyl 6,9-difluoro-11ଲ-hydroxy-16-methyl-3-oxo-17.alph a.-propionyloxyandrosta-1,4-diene-17ଲ-carbothiate (fluticasone propionate). The new polymor... | 06/18/2002 |
| 5977096 | Steroids with radical-attracting aromatic substituents, process for the production thereof and pharmaceutical compounds containing the said substances Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment of diseases due to radical-mediated cell damage. The novel... | 11/02/1999 |
| 5952319 | Androgenic steroid compounds and a method of making and using the same An androgenic steroid compound of the formula: ##STR1## wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.... | 09/14/1999 |
| 5925630 | Neuroactive steroids of the androstane and pregnane series The invention relates to 3-hydroxy, 17-(un)substituted derivatives of the androstane series and 3-hydroxy, 21-substituted derivatives of the pregnane series. These derivatives are capable of acting at a recently identified site on the GRC, t... | 07/20/1999 |
| 5866558 | 6-alkynyl steroids Compounds of formula I: ##STR1## wherein R, R1, R2, R3, and R4 have any of the values defined in the specification, and their pharmaceutically acceptable salts, are inhibitors of aromatase, and are useful f... | 02/02/1999 |
| 5723455 | Antiandrogenic agents and related pharmaceutical compositions and methods of use Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R1 through R10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compo... | 03/03/1998 |
| 5438134 | Process for the production of unsaturated 17 -cyanomethyl-17 ଲ- h The unsaturated 17-cyanomethyl-17ଲ-hydroxy steroids of the formula I, ##STR1## in which R1 =Me, Eth; R2 =H, Me; R3 =H, OH, an acetoxy or alkoxy group; R4 =H, R5 =OH, an acetoxy, alko... | 08/01/1995 |
| 5081113 | Novel 3-keto-steroids A compound selected from the group consisting of a compound of the formula ##STR1## wherein R6 is selected from the group consisting of halogen, --CH3, fluorine and chlorine, R9 and R11 together form a seco... | 01/14/1992 |
| 5068368 | Stabilized lithium acetylide and reactions therewith A process for the preparation of ethynyl carbinols of the formula: ##STR1## wherein R" is hydrogen, a substituted or unsubstituted aliphatic or aromatic hydrocarbon, R'" is a substituted or unsubstituted aliphatic or aromatic hydrocarbon or R" and R'... | 11/26/1991 |
| 4945064 | Estrane and androstane derivatives, process for producing them and preparations containing these compounds Estrane and androstane derivatives of formula I ##STR1## wherein X is bromine, iodine, triphenyltin or trialkyltin of 1 to 6 carbon atoms per alkyl radical, Y represents two hydrogen atoms or methylene, Z represents two hydrogen atoms, oxo or alkylenediox... | 07/31/1990 |
| 4885117 | Process for the preparation of (Z)-17-halovinyl steroids (Z)-17-halovinyl steroids of general Formula I ##STR1## wherein . . . . is a single bond or a double bond, V is a carbon-to-carbon bond or a methylene group, R1 is a hydrogen atom or a methyl group, X is a chlorine atom, a bromine atom or an ... | 12/05/1989 |
| 4708823 | 17 -chloroethynyl pregnane derivatives Known pregnane derivatives are prepared by esterificiation of known androstane derivatives to give new ester of Formula III ##STR1## wherein in each case symbolizes a single bond or a double bond, n is 1 or 2, R1 is hydrogen or methyl, R | 11/24/1987 |
| 4618456 | Ethynylation of 16-methyl-17-keto steroids The process of the present invention transforms 16- or 16ଲ-methyl-17-keto steroids (I) to the corresponding 17-ethynyl-17ଲ-hydroxy-16- or 16ଲ-methyl steroids (II) without epimerization and loss of stereochemistry of ... | 10/21/1986 |
| 4600538 | Corticosteroids from 17-keto steroids via 20-cyano-Ɗ17 (20)-pregnanes The process of the present invention transforms 17-keto steroids (I) to the corresponding corticoids (IV) in three steps.... | 07/15/1986 |
| 4587235 | Novel androstane derivatives, process for their production, and pharmaceutical preparations containing them Androstane derivatives of Formula I ##STR1## wherein is a single bond or a double bond, R1 is methyl or ethyl, R2 is hydrogen or alkyl of 1-8 carbon atoms, --X-- is --(CH2)n --, --CH.dbd.CH(CH2)m | 05/06/1986 |
| 4585591 | 17ଲ-ethynylsteroids and process for preparing same This is disclosed novel intermediates, i.e. 17ଲ-ethynylsteroids, which are useful for the preparation of corticoids such as hydrocortisone and prednisolone, and a process for preparing the same.... | 04/29/1986 |
| 4567002 | Process for the preparation of 17-haloethynyl steroids, and novel 17-haloethynyl steroids 17-haloethynyl steroids of the partial formula ##STR1## wherein R1 is hydrogen or methyl, R2 is alkyl of 1-4 carbon atoms, acyl of 1-7 carbon atoms, trimethylsilyl, 2-tetrahydropyranyl, or nitrate, X is bromine or iodine, and V is me... | 01/28/1986 |
| 4542128 | 17-Pregn-4-ene-3-oxo-21-carboxylic acid esters, process for the preparation thereof, and use thereof as medicinal agents 17-Pregn-4-ene-3-oxo-21-carboxylic acid esters of Formula I ##STR1## wherein C1 C2 is a CC single or C.dbd.C double bond, --A--B--is ##STR2## --C--D--is ##STR3## and R is an alkyl or alkenyl residue of up t... | 09/17/1985 |
| 4526720 | Process to prepare stabilized monolithium acetylide The process of the present invention uses an amine to prepare monolithium acetylide which is sufficiently stable at up to 0° and yet is sufficiently reactive to react with 16-substituted-17-keto steroids producing the useful 17-ethynyl-17ଲ-h... | 07/02/1985 |
| 4507238 | Process for the preparation of 3-(Ɗ4 -3-ketosteroid-17-yl)propionic acid lactones A simple process for preparing 3-(Ɗ4 -3-keto-steroid-17-yl)propionic acid lactones of the androstane series represented by the general partial formula ##STR1## wherein ABCD represents an optionally substituted cyclopentanophenanthr... | 03/26/1985 |
| 4502989 | Aldosterone-antagonistic steroids Novel spironolactone derivatives characterized by the C11 -C12 double bond which have a potent aldosterone-antagonistic activity without causing potassium loss, used alone in diagnosis and improvement of condition of primary aldoster... | 03/05/1985 |
| 4482494 | Process for preparing 17-hydroxy-pregn-4-en-3,20-dione The invention relates to a novel process for the preparations of pregnane derivatives of formula I, ##STR1## wherein R1 stands for a methyl or an ethyl group, R2 represents a hydrogen atom or a methyl group, and X is a hydrogen atom ... | 11/13/1984 |
| 4474701 | Process for the separation of 4-androsten-3,17-dione and 1,4-androstadien-3,17-dione A process is disclosed for the separation of 4-androsten-3,17-dione/1,4-androstadien-3,17-dione mixtures, which are produced, e.g., upon microbiological sterol-side chain decomposition, through conversion of said mixture into a mixture of 17ଲ-c... | 10/02/1984 |
| 4457925 | Androstane derivatives, process for their production, and pharmaceutical preparations containing them Androstane derivatives of Formula I ##STR1## wherein ---- is a single bond or a double bond, R1 is methyl or ethyl, R2 is hydrogen or alkyl of 1-8 carbon atoms, --X-- is --(CH2)n --, --CH.dbd.CH(CH2)m... | 07/03/1984 |
| 4452994 | Process for isolating organic compounds and lithium salt complexes useful in said process An improved process for isolating organic compounds from crude product or reaction mixtures by dissolving said crude product or reaction mixture in a suitable solvent, contacting the resulting solution with a lithium salt to form a solid metal salt comple... | 06/05/1984 |
| 4440684 | Process for the preparation of 6-methyl-Ɗ4,6 -3-keto steroids A process for preparing 6-methyl-Ɗ4,6 -3-keto steroids of the formula ##STR1## comprises reacting a corresponding Ɗ4 -3-keto steroid with methoxymethyl acetate (CH3 --O--CH2 --OAc) in an inert solvent ... | 04/03/1984 |
| 4440689 | Acyloxysteroids and process for producing same There is disclosed novel intermediates, i.e. acyloxysteroids, which are useful for the preparation of corticoids such as hydrocortisone and prednisolone, and a process for producing the same.... | 04/03/1984 |
| 4383947 | Introduction of a fluorine atom Perchloryl fluoride when reacted with the appropriately protected 9-hydroxyandrostenedione stereoselectively produces the corresponding 6ଲ-fluoro steroid.... | 05/17/1983 |
| 4368160 | Process for preparing 17-hydroxy-pregn-4-en-3,20-dione derivatives The invention relates to a novel process for the preparation of pregnane derivatives of formula I, ##STR1## wherein R1 stands for a methyl or an ethyl group, R2 represents a hydrogen atom or a methyl group, and X is a hydrogen atom o... | 01/11/1983 |
| 4360663 | Steroid hormone-antitumor derivatives A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a c... | 11/23/1982 |
| 4357279 | Preparation of corticoids from 17-keto steroids A process for the preparation of corticoids (XI) which comprises reacting a protected 17-keto steroid (II) with a metallated 1,2-dihaloethene (III).... | 11/02/1982 |
| 4346037 | Base catalyzed acylation with enol esters This invention relates to processes for base catalyzed acylations using enol esters, for example, isopropenyl acetate. Particularly, the processes are useful for acylating acid sensitive alcohols including hydroxy steroids.... | 08/24/1982 |
| 4342702 | Metallated halogenated acetylene corticoid synthesis A process for the preparation of corticoids (IX) which comprises reacting a 17-keto steroid (I) with a metallated halogenated acetylene (II) followed by reaction with a sulfenylating agent (IV) and C17 side chain rearrangement.... | 08/03/1982 |
| 4323511 | Steroid derivatives and their use in radioimmunoassays Radiolabeled steroid derivatives having the formula ##STR1## wherein St is a 6-dehydro derivative of a 3-oxo-4,5-dehydro steroid intended for radioimmunoassay, said steroid being saturated in the 1,2-position; R is hydrogen or alkyl of 1 to 3 carbon ... | 04/06/1982 |
| 4297350 | Male contraceptive steroids and methods of use The steroids of the present invention have been found to be useful as male contraceptives when administered orally. Upon cessation of administration of the male contraceptive steroids of the present invention the male promptly regains normal fertility.... | 10/27/1981 |
| 4272445 | Process for preparing active compounds A process for the preparation of a compound of the formula (A): ##STR1## wherein: R3 is a C1-5 alkyl group, a C3-6 alkenyl group, a C3-6 cycloalkyl group or an alkylphenyl group in which the alkyl moiety co... | 06/09/1981 |
