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| Number | Title | Issue Date |
| 6610866 | Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces ... | 08/26/2003 |
| 6433200 | Intermediates for preparation of 16-ene-vitamin D derivatives Intermediates for the preparation of a vitamin D derivative have the following formulas: ##STR1## wherein R9 and R10 may be the same or different and each represents a hydrogen atom or a protecting group, and in Formula (5) the ... | 08/13/2002 |
| 6369247 | Process for oxidation of steroidal compounds having allylic groups The instant invention involves a process for oxidizing compounds containing an allylic group, i.e. those containing an allylic hydrogen or allylic alcohol group, to the corresponding enones, using a ruthenium-based catalyst in the presence of a hydroperox... | 04/09/2002 |
| 6284750 | -hydroxyacid esters of DHEA useful against skin disorders Disclosed are compounds of formula II: ##STR1## wherein A is as defined by the specification. Also disclosed are compositions containing the esters and methods for their use in the regulation of skin atrophy and in the treatment of skin disorders such as ... | 09/04/2001 |
| 6025347 | Steroid esters useful against skin disorders Novel steroid esters useful for regulating skin atrophy, and skin maladies, as well as compositions containing the esters and methods for their use are described. A preferred steroid ester is DHEA salicylate. Such types of skin atrophy to be treated inclu... | 02/15/2000 |
| 5969168 | Androstanes for inducing hypothalamic effects The invention relates to novel, androstane steroids which are the ligand semiochemicals which bind to neuroepithelial receptors. The steroids are useful as ligands to neuroepithelial receptors in the human vomeronasal gland to stimulate autonomic and hypo... | 10/19/1999 |
| 5736537 | Dehydroep:androsterone sailcylate useful against skin atrophy Disclosed is the use of dehydroepiandrosterone salicylate in the treatment of skin atrophy. ##STR1## Such types skin atrophy to be treated include the thinning and/or general degradation of the dermis often characterized by a decrease in collagen ... | 04/07/1998 |
| 5583239 | Antimicrobial sterol conjugates The invention discloses steroid conjugates having the following structure: ##STR1## where Y is NHCH2 CH2 CH2 CH2 NH2, NH(CH2)3 NH(CH2)4 NH(CH2) | 12/10/1996 |
| 5424463 | Ɗ5-androstenes useful for promoting weight maintenance or weight loss and treatment process A method for promoting weight control by treating a subject with a therapeutic amount of one of the Ɗ5-androstenes listed below to stimulate weight control without affecting appetite or inducing the synthesis of sex hormones. Ɗ5-Androstenes providing th... | 06/13/1995 |
| 5424304 | 17-aryl-substituted steroidal compounds active on the cardiovascular system Cardioactive steroidal compounds of the formula I ##STR1## wherein R, R1, R2, R3, R4, R5, R6 and R7 have the meanings shown in the description, and pharmaceutical compositio... | 06/13/1995 |
| 5387583 | Compositions containing corticosteroids or analogues thereof and corticosteroid buffering effective amounts of 5-androstene 3B, 17B or 5-androstene 3B, 7B, 17B triol or analogues thereof 3ଲ,17ଲ-androstenediol ("�") and 3ଲ,7ଲ,17ଲ-androstenetriol ("T") may be used to counteract the antiproliferative and immunosuppressive effects of hydrocortisone and other corticosteroids (i.e., to act as buff... | 02/07/1995 |
| 5002936 | Lipophilic complexes of pharmacologically active inorganic mineral acid esters of organic compounds The present invention provides a composition with the structure (L)m (E)n wherein (L)m and (E)n are bound as a complex, wherein L is a lipophilic compound; wherein E is a nonlipophilic, ionic, inorganic ester of an o... | 03/26/1991 |
| 4946834 | Phosphonic acid substituted steroids as steroid 5-reductase inhibitors Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-reductase. Also invented are intermediates used in prepari... | 08/07/1990 |
| 4925834 | 3-methylene-4-androsten-17-ones, process for their production and pharmaceutical preparations containing them A 3-methylene-4-androsten-17-one of formula I ##STR1## wherein Ra represents a hydrogen atom or a saturated or unsaturated straight-chain or branched-chain, optionally substituted alkyl radical with 1-6 carbon atoms, in which Ra... | 05/15/1990 |
| 4898694 | 17-Hydroxy-steroids Compounds of the formulae: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.... | 02/06/1990 |
| 4780455 | Lipophilic complexes of pharmacologically active organic compounds The present invention provides a composition with the structure wherein m and n are each integers, and m and n are different or the same; L is an ampholytic lipid or polymer, or a nonampholytic lipid with hydrophobic properties; E is a nonlipophilic ionic inor... | 10/25/1988 |
| 4749567 | Method and product for increasing fertility in sheep using milk protein conjugates A product and method for increasing fertility in sheep. By "increasing felity" is meant increasing the potential of a flock of sheep to multiply by increasing ovulation in ewes. The product is an immunogenic conjugate of 4-androstene-3, 17-dione and a so... | 06/07/1988 |
| 4708823 | 17 -chloroethynyl pregnane derivatives Known pregnane derivatives are prepared by esterificiation of known androstane derivatives to give new ester of Formula III ##STR1## wherein in each case symbolizes a single bond or a double bond, n is 1 or 2, R1 is hydrogen or methyl, R | 11/24/1987 |
| 4567001 | 16-Methylene-17-hydroxy-progesterones 16-Methylene-17-keto steroids (III) are transformed to the corresponding 16-methylene-17-hydroxyprogesterones (VII) which are intermediates useful in the production of betamethasone, diflorasone diacetate and melengesterol acetate.... | 01/28/1986 |
| 4537722 | Steroid esters preparation This invention relates to an improved steroid ester synthesis in which carbodiimides and catalytic amounts of 4-(tertiary amino)-pyridines, in combination with acid catalysts, are used as condensing agents, resulting in pure, non discolored compounds in h... | 08/27/1985 |
| 4502989 | Aldosterone-antagonistic steroids Novel spironolactone derivatives characterized by the C11 -C12 double bond which have a potent aldosterone-antagonistic activity without causing potassium loss, used alone in diagnosis and improvement of condition of primary aldoster... | 03/05/1985 |
| 4452994 | Process for isolating organic compounds and lithium salt complexes useful in said process An improved process for isolating organic compounds from crude product or reaction mixtures by dissolving said crude product or reaction mixture in a suitable solvent, contacting the resulting solution with a lithium salt to form a solid metal salt comple... | 06/05/1984 |
| 4451404 | 16ଲ-Methyl steroid process Ɗ4 -3-keto, Ɗ1,4 -3-keto and 3ଲ-hydroxy 17-keto steroids (I) are transformed into the corresponding 16-ଲ-methyl-17-keto steroids (IV) by first activating the C-16 position, then methylating. By protecting the C-3 positi... | 05/29/1984 |
| 4443377 | Isomerization-acylation process 17-Hydroxy-6,16-dimethylenepregn-4-ene-3,20-dione simultaneously isomerized and acylated to 17-hydroxy-6-methyl-16-methylenepregna-4,6-diene-3,20-dione 17-acetate.... | 04/17/1984 |
| 4416821 | Process for preparing 16-methylene steroids A process is disclosed for the production of 17-keto-16-methylene steroids (III) from the corresponding readily available 17-keto steroid (I) via a novel intermediate (II).... | 11/22/1983 |
| 4383947 | Introduction of a fluorine atom Perchloryl fluoride when reacted with the appropriately protected 9-hydroxyandrostenedione stereoselectively produces the corresponding 6ଲ-fluoro steroid.... | 05/17/1983 |
| 4360663 | Steroid hormone-antitumor derivatives A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a c... | 11/23/1982 |
| 4357279 | Preparation of corticoids from 17-keto steroids A process for the preparation of corticoids (XI) which comprises reacting a protected 17-keto steroid (II) with a metallated 1,2-dihaloethene (III).... | 11/02/1982 |
| 4346037 | Base catalyzed acylation with enol esters This invention relates to processes for base catalyzed acylations using enol esters, for example, isopropenyl acetate. Particularly, the processes are useful for acylating acid sensitive alcohols including hydroxy steroids.... | 08/24/1982 |
| 4322416 | 10-Alkynyl steroids Aromatase inhibitors are provided having the formula ##STR1## wherein represents a single or double bond; R is hydrogen or C1-4 alkyl; R1 is methyl or ethyl; R2 is (H) (OR8) or .dbd.O; R3 is ... | 03/30/1982 |
| 4311646 | Process for the preparation of 4,6-dien-3-one steroids A 4,6-dien-3-one steroid is produced by brominating an enolic ether of a 4-en-3-one steroid in a water-containing organic solvent which is substantially free from acetic acid and sodium acetate to give a 6-bromosteroid and then dehydrobrominating the 6-br... | 01/19/1982 |
| 4290961 | Process for catalytically reducing carbonyl compounds Catalytic reduction of carbonyl compounds by transfer of hydrogen from alcohols to aliphatic, alicyclic, aromatic, homo- and heterocyclic ketones or aldehydes, catalyzed by rhodium or iridium complexes, characterized in that a primary or secondary alcohol... | 09/22/1981 |
| 4289762 | 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors Irreversible aromatase inhibitors are provided having the formulae ##STR1## wherein represents a single or a double bond; R1 is CH3 or C2 H5 ; R2 is (H) (OR8) or O; R3 is H or ... | 09/15/1981 |
| 4272445 | Process for preparing active compounds A process for the preparation of a compound of the formula (A): ##STR1## wherein: R3 is a C1-5 alkyl group, a C3-6 alkenyl group, a C3-6 cycloalkyl group or an alkylphenyl group in which the alkyl moiety co... | 06/09/1981 |
| 4239681 | Androst-4-en-19-ols Derivatives of androst-4-en-19-ol are useful for enhancing libido and related psychic attitudes.... | 12/16/1980 |
| 4203981 | Novel 17 -aryl-steroids Novel steroids of the formula ##STR1## wherein R1 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms, R2 is selected from the group consisting of optionally substitut... | 05/20/1980 |
| 4181669 | Steroid esters preparation This invention relates to an improved steroid ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.... | 01/01/1980 |
| 4180504 | Method for the preparation of esters This invention relates to an improved ester synthesis in which a carbodiimide, in combination with an acid catalyst, is used as condensing agent.... | 12/25/1979 |
| 4150044 | Process for the manufacture of 17-hydroxy-21-acetoxy-progesterone The present invention relates to a process for the manufacture of 17 -hydroxy-21-acyloxy-progesterone, in particular of 17-hydroxy-21-acetoxy-progesterone (Reichstein's substance S acetate) which is of great importance as a starting material... | 04/17/1979 |
| 4150126 | Novel enol esters of steroids, compositions containing such compounds, processes for their preparation and methods of treatment therewith This invention relates to novel enol esters of steroids having an antitumor activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds and methods of treatment therewith.... | 04/17/1979 |
