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| Number | Title | Issue Date |
| 7300926 | Steroidal quinols and their use for estrogen replacement therapy The present invention relates to novel estrogen-related steroidal quinols and their use as drugs for estrogen replacement therapy. The quinols of the present invention provide improved physicochemical properties, increased bioavailability, and improved distribution ... | 11/27/2007 |
| 7026306 | Steroidal quinols and their use for antioxidant therapy The present invention relates to novel estrogen-related steroidal quinols and their use as prodrugs for phenolic estrogens and estrogen analogs. The quinols of the present invention provide improved physicochemical properties, increased bioavailability, and improved... | 04/11/2006 |
| 6958327 | 18 Norsteroids as selectively active estrogens The invention relates to novel 18-norsteroids (gonatrienes) of general formula (I), wherein R1, R2, R3, R6, R7, R8, R9, R11, R11′, R14, R15, R | 10/25/2005 |
| 6689768 | Pharmaceutical preparations for treating side effects during and/or after GnRHa therapy The pharmaceutical preparations for treating side effects, such as hot flashes, prostate enlargement and gynecomastia, during and/or after treatment with analogs or antagonists of gonadotropin-releasing hormone (GnRHa therapy) contain an effective amount ... | 02/10/2004 |
| 6436917 | Non-estrogenic estradiol derivative compounds with anti-oxidative activity New non-estrogenic derivative compounds of estradiol, which have no estrogenic activity and comparatively high anti-oxidative activity, are disclosed. These new non-estrogenic derivative compounds are potentially useful as non-estrogenic antioxidants, esp... | 08/20/2002 |
| 5892069 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found belo... | 04/06/1999 |
| 5633393 | Estradiol derivative-alkylating agent conjugate with reduced hormonal activity, process for preparing the same, compounds useful for the preparation thereof, and growth inhibiting compositon containing the conjugate or estradiol derivative. Conjugates of the formula ##STR1## are prepared by reacting an estradiol derivative with a compound of the formula: ##STR2## in the presence of thionyl chloride or a metal hydride at -30° to 150° C. for 3 minutes to 48 hours and then reco... | 05/27/1997 |
| 5621124 | Process for the alkylation of estrone derivatives The invention relates to a process for the alkylation of estrone derivatives, which is characterized in that a suspension of the estrone derivatives in dimethylformamide is produced and carbonic acid diester and guanidine and/or alkyl guanidines are disso... | 04/15/1997 |
| 5561125 | Estradiol derivative and growth inhibiting composition thereof Estradiol derivatives of the formula: ##STR1## wherein R1 is C1-4 alky or C1-4 alkoxy; R2 is acyl or benzyl; m is an integer of 1 to 3; n is an integer of 1 to 3; and X is hydroxy or halogen are useful as t... | 10/01/1996 |
| 5491138 | Estradiol derivative alkylating agent conjugate with reduced hormonal activity, process for preparing the same, compounds useful for the preparation thereof, and growth inhibiting composition containing the conjugate or estradiol derivative Disclosed is a method of inhibiting the growth of tumors by administering an estradiol derivative-alkylating agent conjugate of the formula (I'): ##STR1## wherein R1 is C1-4 alkyl or C1-4 alkoxy; R2 is acyl or ... | 02/13/1996 |
| 5480878 | Method for treating prostatic hypertrophy with estradiol derivatives Disclosed is a method for treating prostatic hypertrophy with an estradiol derivative-alkylating agent conjugate of the formula (1'): ##STR1## wherein R1 is C1-4 alkyl or C1-4 alkoxy; R2 is acyl or benzyl; ... | 01/02/1996 |
| 5478818 | Estradiol derivative-alkylating agent conjugate with reduced hormonal activity, process for preparing the same, compounds useful for the preparation thereof, and growth inhibiting composition containing the conjugate or estradiol derivative Disclosed is an estradiol derivative-alkylating agent conjugate of the formula (I'): ##STR1## wherein R1 is C1-4 alkyl or C1-4 alkoxy; R2 is acyl or benzyl; m is an integer of 1 to 3; and n is an integer of... | 12/26/1995 |
| 5354745 | Estradiol derivative-chlorambucil conjugate process for preparing the same, and pharmaceutical composition An estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R2 is acyl, dansyl, or alkyl; R3, R4, and R5 independently are H, ... | 10/11/1994 |
| 5250712 | 1ଲ,15-di hydroxy-1-methyl-5-androstane-3,17-dione, its production and use The invention relates to the 1ଲ, 15-dihydroxy-1-methyl-5-androstane-3,17-dione of formula I ##STR1## and preparation thereof using microorganisms of the genera Glomerella or Fusarium. The invention also relates to furt... | 10/05/1993 |
| 4954446 | Aromatic steroid 5--reductase inhibitors Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5--reductase including using these compounds to reduce prosta... | 09/04/1990 |
| 4898694 | 17-Hydroxy-steroids Compounds of the formulae: ##STR1## are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.... | 02/06/1990 |
| 4885117 | Process for the preparation of (Z)-17-halovinyl steroids (Z)-17-halovinyl steroids of general Formula I ##STR1## wherein . . . . is a single bond or a double bond, V is a carbon-to-carbon bond or a methylene group, R1 is a hydrogen atom or a methyl group, X is a chlorine atom, a bromine atom or an ... | 12/05/1989 |
| 4725426 | Estrogenic 17-halogen-vinylestranes 17-bromo- and 17-iodo-vinyl-estrane derivatives of general formula I ##STR1## wherein X is a bromine or iodine atom in Z or E position, R1 is hydrogen, hydroxy or acyloxy with up to 3 C atoms, R2 is hydrogen, alk... | 02/16/1988 |
| 4600538 | Corticosteroids from 17-keto steroids via 20-cyano-Ɗ17 (20)-pregnanes The process of the present invention transforms 17-keto steroids (I) to the corresponding corticoids (IV) in three steps.... | 07/15/1986 |
| 4599330 | Method of treating milk fever The present invention relates to a method of preventing milk fever which comprises administering to a preparturient female ruminant an effective amount of 24,24-difluoro-1,25-dihydroxycholecalciferol.... | 07/08/1986 |
| 4421690 | Process for the preparation of 24,24-difluoro-1,25-dihydroxy vitamin D3 and intermediates obtained therefrom The present invention relates to a process and intermediates for the preparation of 24,24-difluoro-1,25-dihydroxycholecalciferol from the readily-available 1,3ଲ-dihydroxyandrost-5-en-17-one which is made by a known microbiological proc... | 12/20/1983 |
| 4407753 | 8-Oestra-1,3,5(10)-triene derivatives, processes for their preparation and pharmaceutical compositions The invention relates to new 8-oestra-1,3,5(10)-triene derivatives having the formula: ##STR1## in which R1 =H or a free, esterified or etherified hydroxy group; R2 =H or a free, esterified or etherified hydroxy group, with th... | 10/04/1983 |
| 4397847 | Method of treatment The present invention relates to a method of treating osteoporosis by administering to a host suffering from osteoporosis an effective amount of 24,24-difluoro-1,25-dihydroxycholecalciferol.... | 08/09/1983 |
| 4357279 | Preparation of corticoids from 17-keto steroids A process for the preparation of corticoids (XI) which comprises reacting a protected 17-keto steroid (II) with a metallated 1,2-dihaloethene (III).... | 11/02/1982 |
| 4307088 | 1-Hydroxy steroids, a process for the production thereof, and pharmaceutical preparations containing them 1-Hydroxy steroids of formula I ##STR1## wherein R1 and R2 are independently hydrogen or alkanoyl of 1-8 carbon atoms are distinguished by strong progestational activity and only very minor androgenic side effects.... | 12/22/1981 |
| 4222940 | Cyclization substrates, cyclization process and related 11ଲ-axially-substituted steroids There are disclosed substrates of the formula: ##STR1## wherein: (a) R1 is H or C1 -C4 alkyl; (b) R2 is H or C1 -C4 alkyl with the proviso that R1 is H when R2 is alky... | 09/16/1980 |
| 4177197 | Cyclization substrates and 7-substituted 19-norsteroid derivatives Novel cyclization substrates are disclosed of the formula ##STR1## wherein: (a) R1 is H or alkyl of one to four carbon atoms; (b) R2 is H or alkyl of one to four carbon atoms, with the proviso that R1 is H when R2 | 12/04/1979 |
| 4144334 | Novel -hydroxy steroids 1-Oxysteroid of the formula ##STR1## wherein R1 is methyl or ethyl, R2 and R3 each are hydrogen or alkanoyl of 1-8 carbon atoms, and R4 is hydrogen or hydrocarbon of 1-4 carbon atoms, Are progestestionally act... | 03/13/1979 |
| 4096253 | 1-Oxygenated steroids 1-Oxygenated steroids and a method of preparing same as described. The 1-oxygenated steroids are useful as antifertility agents.... | 06/20/1978 |
| 4066674 | Process for the preparation of 1,3-oxygenated 8-estratrienes and novel intermediates obtained therefrom Novel 1,3-dialkoxy 8-estratriene compounds of the formula ##STR1## WHEREIN R1 is alkyl of 1-18 carbon atoms, R2 is alkyl of 1-5 carbon atoms and Ac is alkanoyl of 1-8 carbon atoms, are obtained by a three-step synthesis f... | 01/03/1978 |
| 4064173 | 9,10-Seco-steroids A process for the preparation of 9,10-seco-steroids of the formula ##STR1## WHEREIN R1 and R2 independently are hydrogen, amino, OR5, OCOR6 or NHCOR5 wherein R5 is hydrogen or lower alkyl a... | 12/20/1977 |
| 4029779 | 1-Hydroxy steroids 1-Oxysteroid of the formula ##STR1## wherein R1 is methyl or ethyl, R2 and R3 each are hydrogen or alkanoyl of 1-8 carbon atoms, and R4 is hydrogen or hydrocarbon of 1-4 carbon atoms, Are progestestionally act... | 06/14/1977 |
| 4002746 | Synthesis of gon-4-enes 1. A therapeutic composition having progestational activity comprising as active ingredient a 17-aliphatic carboxylic acid ester of 17-ethynyl-18-methyl-19-nortestosterone and a pharmaceutical carrier for said compound.... | 01/11/1977 |
| 3951958 | 1,3-Oxygenated-8-estratrienes 1,3-Dihydroxy-8-estratrienes of the formula ##SPC1## Wherein R is lower-alkyl and --A--B is ##SPC2## Wherein R' is a saturated or unsaturated hydrocarbon group and R" is lower-alkyl, aralkyl or phenyl, and the esters and ethers thereof, possess ... | 04/20/1976 |
